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Entry version 151 (02 Dec 2020)
Sequence version 2 (15 Dec 1998)
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Protein

Glycerate 2-kinase

Gene

garK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

GK1 has a half-life of 92 minutes while GK2 has a half-life of 11 minutes at 49 degrees Celsius.

Caution

E.coli has 2 glycerate kinases, GK1 and GK2; it is not clear which gene encodes which enzyme.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=51 µM for glycerate2 Publications
  2. KM=70 µM for glycerate2 Publications
  3. KM=61 µM for ATP2 Publications

    pH dependencei

    Optimum pH is 7.3-7.9.2 Publications

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:GKI-MONOMER
    MetaCyc:GKI-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.165, 2165

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glycerate 2-kinase (EC:2.7.1.165)
    Alternative name(s):
    Glycerate kinase 1
    Short name:
    GK1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:garK
    Synonyms:yhaD
    Ordered Locus Names:b3124, JW3093
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715321 – 381Glycerate 2-kinaseAdd BLAST381

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P23524

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P23524

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P23524

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    In glycerate, glucarate and glycolate-grown cells but not in glucose-grown cells (at protein level).2 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4261538, 11 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-28063N

    Protein interaction database and analysis system

    More...
    IntActi
    P23524, 7 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b3124

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P23524

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycerate kinase type-1 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG1929, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_028255_0_1_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P23524

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P23524

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.10350, 1 hit
    3.90.1510.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR018193, Glyc_kinase_flavodox-like_fold
    IPR004381, Glycerate_kinase
    IPR018197, Glycerate_kinase_RE-like
    IPR036129, Glycerate_kinase_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR21599, PTHR21599, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02595, Gly_kinase, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF006078, GlxK, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF110738, SSF110738, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00045, TIGR00045, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P23524-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKIVIAPDSY KESLSASEVA QAIEKGFREI FPDAQYVSVP VADGGEGTVE
    60 70 80 90 100
    AMIAATQGAE RHAWVTGPLG EKVNASWGIS GDGKTAFIEM AAASGLELVP
    110 120 130 140 150
    AEKRDPLVTT SRGTGELILQ ALESGATNII IGIGGSATND GGAGMVQALG
    160 170 180 190 200
    AKLCDANGNE IGFGGGSLNT LNDIDISGLD PRLKDCVIRV ACDVTNPLVG
    210 220 230 240 250
    DNGASRIFGP QKGASEAMIV ELDNNLSHYA EVIKKALHVD VKDVPGAGAA
    260 270 280 290 300
    GGMGAALMAF LGAELKSGIE IVTTALNLEE HIHDCTLVIT GEGRIDSQSI
    310 320 330 340 350
    HGKVPIGVAN VAKKYHKPVI GIAGSLTDDV GVVHQHGIDA VFSVLTSIGT
    360 370 380
    LDEAFRGAYD NICRASRNIA ATLAIGMRNA G
    Length:381
    Mass (Da):39,104
    Last modified:December 15, 1998 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A048E2E5F9FBE32
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA57927 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence BAA14239 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
    The sequence BAE77171 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D90212 Genomic DNA Translation: BAA14239.1 Different initiation.
    U18997 Genomic DNA Translation: AAA57927.1 Different initiation.
    U00096 Genomic DNA Translation: AAC76158.2
    AP009048 Genomic DNA Translation: BAE77171.1 Different initiation.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JQ0614

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_417593.4, NC_000913.3
    WP_001300387.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC76158; AAC76158; b3124
    BAE77171; BAE77171; BAE77171

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    947632

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW3093
    eco:b3124

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.3608

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D90212 Genomic DNA Translation: BAA14239.1 Different initiation.
    U18997 Genomic DNA Translation: AAA57927.1 Different initiation.
    U00096 Genomic DNA Translation: AAC76158.2
    AP009048 Genomic DNA Translation: BAE77171.1 Different initiation.
    PIRiJQ0614
    RefSeqiNP_417593.4, NC_000913.3
    WP_001300387.1, NZ_LN832404.1

    3D structure databases

    SMRiP23524
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4261538, 11 interactors
    DIPiDIP-28063N
    IntActiP23524, 7 interactors
    STRINGi511145.b3124

    Proteomic databases

    jPOSTiP23524
    PaxDbiP23524
    PRIDEiP23524

    Genome annotation databases

    EnsemblBacteriaiAAC76158; AAC76158; b3124
    BAE77171; BAE77171; BAE77171
    GeneIDi947632
    KEGGiecj:JW3093
    eco:b3124
    PATRICifig|1411691.4.peg.3608

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB1162

    Phylogenomic databases

    eggNOGiCOG1929, Bacteria
    HOGENOMiCLU_028255_0_1_6
    InParanoidiP23524
    PhylomeDBiP23524

    Enzyme and pathway databases

    BioCyciEcoCyc:GKI-MONOMER
    MetaCyc:GKI-MONOMER
    BRENDAi2.7.1.165, 2165

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P23524

    Family and domain databases

    Gene3Di3.40.50.10350, 1 hit
    3.90.1510.10, 1 hit
    InterProiView protein in InterPro
    IPR018193, Glyc_kinase_flavodox-like_fold
    IPR004381, Glycerate_kinase
    IPR018197, Glycerate_kinase_RE-like
    IPR036129, Glycerate_kinase_sf
    PANTHERiPTHR21599, PTHR21599, 1 hit
    PfamiView protein in Pfam
    PF02595, Gly_kinase, 1 hit
    PIRSFiPIRSF006078, GlxK, 1 hit
    SUPFAMiSSF110738, SSF110738, 1 hit
    TIGRFAMsiTIGR00045, TIGR00045, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLXK1_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23524
    Secondary accession number(s): Q2M985
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: December 15, 1998
    Last modified: December 2, 2020
    This is version 151 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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