Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oligodendrocyte-myelin glycoprotein

Gene

OMG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Caution

Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).Curated

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-193634 Axonal growth inhibition (RHOA activation)
SIGNORiP23515

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte-myelin glycoprotein
Gene namesi
Name:OMG
Synonyms:OMGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000126861.4
HGNCiHGNC:8135 OMG
MIMi164345 gene
neXtProtiNX_P23515

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4974
OpenTargetsiENSG00000126861
PharmGKBiPA31922

Polymorphism and mutation databases

BioMutaiOMG
DMDMi129122

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000002188825 – 417Oligodendrocyte-myelin glycoproteinAdd BLAST393
PropeptideiPRO_0000021889418 – 440Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi417GPI-anchor amidated serineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated in its Ser/Thr-rich repeat domain.Curated

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP23515
PaxDbiP23515
PeptideAtlasiP23515
PRIDEiP23515
ProteomicsDBi54125
TopDownProteomicsiP23515

PTM databases

iPTMnetiP23515
PhosphoSitePlusiP23515

Expressioni

Tissue specificityi

Oligodendrocytes and myelin of the central nervous system.

Gene expression databases

BgeeiENSG00000126861
CleanExiHS_OMG
GenevisibleiP23515 HS

Organism-specific databases

HPAiHPA008206
HPA012693

Interactioni

Subunit structurei

Binds to RTN4R.1 Publication

Protein-protein interaction databases

BioGridi111022, 1 interactor
STRINGi9606.ENSP00000247271

Structurei

3D structure databases

ProteinModelPortaliP23515
SMRiP23515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 55LRRNTAdd BLAST31
Repeati56 – 77LRR 1Add BLAST22
Repeati79 – 100LRR 2Add BLAST22
Repeati101 – 121LRR 3Add BLAST21
Repeati124 – 145LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Repeati169 – 189LRR 6Add BLAST21
Repeati192 – 213LRR 7Add BLAST22
Repeati216 – 239LRR 8Add BLAST24
Repeati229 – 270Ser/Thr-richAdd BLAST42
Repeati271 – 292Ser/Thr-richAdd BLAST22
Repeati293 – 335Ser/Thr-richAdd BLAST43
Repeati336 – 377Ser/Thr-richAdd BLAST42
Repeati378 – 416Ser/Thr-richAdd BLAST39

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148996
HOGENOMiHOG000115267
HOVERGENiHBG007868
InParanoidiP23515
KOiK16666
OMAiSSNKLWT
OrthoDBiEOG091G08JZ
PhylomeDBiP23515
TreeFamiTF335688

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYQILKMSL CLFILLFLTP GILCICPLQC ICTERHRHVD CSGRNLSTLP
60 70 80 90 100
SGLQENIIHL NLSYNHFTDL HNQLTQYTNL RTLDISNNRL ESLPAHLPRS
110 120 130 140 150
LWNMSAANNN IKLLDKSDTA YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV
160 170 180 190 200
LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT QILPGTLINL TNLTHLYLHN
210 220 230 240 250
NKFTFIPDQS FDQLFQLQEI TLYNNRWSCD HKQNITYLLK WMMETKAHVI
260 270 280 290 300
GTPCSTQISS LKEHNMYPTP SGFTSSLFTV SGMQTVDTIN SLSVVTQPKV
310 320 330 340 350
TKIPKQYRTK ETTFGATLSK DTTFTSTDKA FVPYPEDTST ETINSHEAAA
360 370 380 390 400
ATLTIHLQDG MVTNTSLTSS TKSSPTPMTL SITSGMPNNF SEMPQQSTTL
410 420 430 440
NLWREETTTN VKTPLPSVAN AWKVNASFLL LLNVVVMLAV
Length:440
Mass (Da):49,608
Last modified:May 1, 1992 - v2
Checksum:i762FD0E8905EA050
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05125221G → D. Corresponds to variant dbSNP:rs11080149Ensembl.1
Natural variantiVAR_051253435V → A. Corresponds to variant dbSNP:rs16972169EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63623 mRNA Translation: AAA59970.1 Sequence problems.
X57436 Genomic DNA Translation: CAA40684.1
X51694 mRNA Translation: CAA35991.1 Sequence problems.
CH471147 Genomic DNA Translation: EAW80279.1
CH471147 Genomic DNA Translation: EAW80280.1
BC018050 mRNA Translation: AAH18050.1
CCDSiCCDS11265.1
PIRiA36688 A39613
RefSeqiNP_002535.3, NM_002544.4
UniGeneiHs.113874

Genome annotation databases

EnsembliENST00000247271; ENSP00000247271; ENSG00000126861
GeneIDi4974
KEGGihsa:4974
UCSCiuc002hgj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOMGP_HUMAN
AccessioniPrimary (citable) accession number: P23515
Secondary accession number(s): E1P659
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: June 20, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health