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Protein

Nuclear transcription factor Y subunit alpha

Gene

NFYA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi296 – 321NFYA/HAP2-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
SignaLinkiP23511
SIGNORiP23511

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit alpha
Alternative name(s):
CAAT box DNA-binding protein subunit A
Nuclear transcription factor Y subunit A
Short name:
NF-YA
Gene namesi
Name:NFYA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000001167.14
HGNCiHGNC:7804 NFYA
MIMi189903 gene
neXtProtiNX_P23511

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4800
OpenTargetsiENSG00000001167
PharmGKBiPA31609

Polymorphism and mutation databases

BioMutaiNFYA
DMDMi115844

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987681 – 347Nuclear transcription factor Y subunit alphaAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP23511
MaxQBiP23511
PaxDbiP23511
PeptideAtlasiP23511
PRIDEiP23511
ProteomicsDBi54123
54124 [P23511-2]

PTM databases

iPTMnetiP23511
PhosphoSitePlusiP23511

Expressioni

Gene expression databases

BgeeiENSG00000001167 Expressed in 217 organ(s), highest expression level in female gonad
CleanExiHS_NFYA
ExpressionAtlasiP23511 baseline and differential
GenevisibleiP23511 HS

Organism-specific databases

HPAiCAB009250
HPA050779

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi110866, 59 interactors
ComplexPortaliCPX-1956 CCAAT-binding factor complex
CORUMiP23511
IntActiP23511, 25 interactors
MINTiP23511
STRINGi9606.ENSP00000345702

Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23511
SMRiP23511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 289Subunit association domain (SAD)Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 161Gln-richAdd BLAST148

Sequence similaritiesi

Belongs to the NFYA/HAP2 subunit family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1561 Eukaryota
COG5224 LUCA
GeneTreeiENSGT00390000015714
HOGENOMiHOG000247016
HOVERGENiHBG005253
InParanoidiP23511
KOiK08064
OMAiTQMIRVS
OrthoDBiEOG091G0JVF
PhylomeDBiP23511
TreeFamiTF323257

Family and domain databases

InterProiView protein in InterPro
IPR018362 CCAAT-binding_factor_CS
IPR001289 NFYA
PANTHERiPTHR12632 PTHR12632, 1 hit
PfamiView protein in Pfam
PF02045 CBFB_NFYA, 1 hit
PRINTSiPR00616 CCAATSUBUNTB
SMARTiView protein in SMART
SM00521 CBF, 1 hit
PROSITEiView protein in PROSITE
PS00686 NFYA_HAP2_1, 1 hit
PS51152 NFYA_HAP2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P23511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ
60 70 80 90 100
TLQVVQGQPL MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG
110 120 130 140 150
LQQIQLVPPG QIQIQGGQAV QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ
160 170 180 190 200
QIAVQGQQVA QTAEGQTIVY QPVNADGTIL QQVTVPVSGM ITIPAASLAG
210 220 230 240 250
AQIVQTGANT NTTSSGQGTV TVTLPVAGNV VNSGGMVMMV PGAGSVPAIQ
260 270 280 290 300
RIPLPGAEML EEEPLYVNAK QYHRILKRRQ ARAKLEAEGK IPKERRKYLH
310 320 330 340
ESRHRHAMAR KRGEGGRFFS PKEKDSPHMQ DPNQADEEAM TQIIRVS
Length:347
Mass (Da):36,877
Last modified:May 1, 1992 - v2
Checksum:iD00BE17041EB1A9E
GO
Isoform Short (identifier: P23511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-54: Missing.

Show »
Length:318
Mass (Da):33,939
Checksum:i9BF57D6031D83D8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273H → N in AAH39244 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00084926 – 54Missing in isoform Short. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59711 mRNA Translation: CAA42231.1
AL031778 Genomic DNA No translation available.
BC039244 mRNA Translation: AAH39244.1
M59079 mRNA Translation: AAA35950.1
CCDSiCCDS4849.1 [P23511-1]
CCDS4850.1 [P23511-2]
PIRiS22816 A39123
RefSeqiNP_002496.1, NM_002505.4 [P23511-1]
NP_068351.1, NM_021705.3 [P23511-2]
UniGeneiHs.10441

Genome annotation databases

EnsembliENST00000341376; ENSP00000345702; ENSG00000001167 [P23511-1]
ENST00000353205; ENSP00000229418; ENSG00000001167 [P23511-2]
GeneIDi4800
KEGGihsa:4800
UCSCiuc003opo.4 human [P23511-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59711 mRNA Translation: CAA42231.1
AL031778 Genomic DNA No translation available.
BC039244 mRNA Translation: AAH39244.1
M59079 mRNA Translation: AAA35950.1
CCDSiCCDS4849.1 [P23511-1]
CCDS4850.1 [P23511-2]
PIRiS22816 A39123
RefSeqiNP_002496.1, NM_002505.4 [P23511-1]
NP_068351.1, NM_021705.3 [P23511-2]
UniGeneiHs.10441

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AWLX-ray3.08A262-332[»]
ProteinModelPortaliP23511
SMRiP23511
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110866, 59 interactors
ComplexPortaliCPX-1956 CCAAT-binding factor complex
CORUMiP23511
IntActiP23511, 25 interactors
MINTiP23511
STRINGi9606.ENSP00000345702

PTM databases

iPTMnetiP23511
PhosphoSitePlusiP23511

Polymorphism and mutation databases

BioMutaiNFYA
DMDMi115844

Proteomic databases

EPDiP23511
MaxQBiP23511
PaxDbiP23511
PeptideAtlasiP23511
PRIDEiP23511
ProteomicsDBi54123
54124 [P23511-2]

Protocols and materials databases

DNASUi4800
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341376; ENSP00000345702; ENSG00000001167 [P23511-1]
ENST00000353205; ENSP00000229418; ENSG00000001167 [P23511-2]
GeneIDi4800
KEGGihsa:4800
UCSCiuc003opo.4 human [P23511-1]

Organism-specific databases

CTDi4800
DisGeNETi4800
EuPathDBiHostDB:ENSG00000001167.14
GeneCardsiNFYA
HGNCiHGNC:7804 NFYA
HPAiCAB009250
HPA050779
MIMi189903 gene
neXtProtiNX_P23511
OpenTargetsiENSG00000001167
PharmGKBiPA31609
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1561 Eukaryota
COG5224 LUCA
GeneTreeiENSGT00390000015714
HOGENOMiHOG000247016
HOVERGENiHBG005253
InParanoidiP23511
KOiK08064
OMAiTQMIRVS
OrthoDBiEOG091G0JVF
PhylomeDBiP23511
TreeFamiTF323257

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-380994 ATF4 activates genes
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
SignaLinkiP23511
SIGNORiP23511

Miscellaneous databases

ChiTaRSiNFYA human
GeneWikiiNFYA
GenomeRNAii4800
PROiPR:P23511
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000001167 Expressed in 217 organ(s), highest expression level in female gonad
CleanExiHS_NFYA
ExpressionAtlasiP23511 baseline and differential
GenevisibleiP23511 HS

Family and domain databases

InterProiView protein in InterPro
IPR018362 CCAAT-binding_factor_CS
IPR001289 NFYA
PANTHERiPTHR12632 PTHR12632, 1 hit
PfamiView protein in Pfam
PF02045 CBFB_NFYA, 1 hit
PRINTSiPR00616 CCAATSUBUNTB
SMARTiView protein in SMART
SM00521 CBF, 1 hit
PROSITEiView protein in PROSITE
PS00686 NFYA_HAP2_1, 1 hit
PS51152 NFYA_HAP2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNFYA_HUMAN
AccessioniPrimary (citable) accession number: P23511
Secondary accession number(s): Q8IXU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: September 12, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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