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UniProtKB - P23511 (NFYA_HUMAN)

Entry version 197 (23 Feb 2022)
Sequence version 2 (01 May 1992)
Previous versions | rss
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Protein

Nuclear transcription factor Y subunit alpha

Gene

NFYA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi296 – 321NFYA/HAP2-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23511

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381183, ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-9614657, FOXO-mediated transcription of cell death genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P23511

SIGNOR Signaling Network Open Resource

More...SIGNORi		P23511

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear transcription factor Y subunit alpha
Alternative name(s):
CAAT box DNA-binding protein subunit A
Nuclear transcription factor Y subunit A
Short name:
NF-YA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFYA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7804, NFYA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		189903, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23511

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000001167

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4800

Open Targets

More...OpenTargetsi		ENSG00000001167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31609

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23511, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NFYA

Domain mapping of disease mutations (DMDM)

More...DMDMi		115844

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001987681 – 347Nuclear transcription factor Y subunit alphaAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P23511

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23511

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23511

MaxQB - The MaxQuant DataBase

More...MaxQBi		P23511

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23511

PeptideAtlas

More...PeptideAtlasi		P23511

PRoteomics IDEntifications database

More...PRIDEi		P23511

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54123 [P23511-1]
54124 [P23511-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23511, 4 sites, 2 O-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000001167, Expressed in cortical plate and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23511, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23511, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000001167, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.

Interacts with SP1; the interaction is inhibited by glycosylation of SP1.

Interacts with ZHX1.

Interacts (via N-terminus) with ZHX2 (via homeobox domain).

Interacts with ZFX3.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110866, 73 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1956, CCAAT-binding factor complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P23511

Protein interaction database and analysis system

More...IntActi		P23511, 39 interactors

Molecular INTeraction database

More...MINTi		P23511

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345702

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23511, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		P23511

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23511

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni299 – 347DisorderedSequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi266 – 289Subunit association domain (SAD)Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi312 – 332Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFYA/HAP2 subunit family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1561, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015714

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_071609_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23511

Identification of Orthologs from Complete Genome Data

More...OMAi		GNMMNSG

Database of Orthologous Groups

More...OrthoDBi		1269806at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23511

TreeFam database of animal gene trees

More...TreeFami		TF323257

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018362, CCAAT-binding_factor_CS
IPR001289, NFYA

The PANTHER Classification System

More...PANTHERi		PTHR12632, PTHR12632, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02045, CBFB_NFYA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00616, CCAATSUBUNTB

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00521, CBF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00686, NFYA_HAP2_1, 1 hit
PS51152, NFYA_HAP2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P23511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ 
        60         70         80         90        100
TLQVVQGQPL MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG 
       110        120        130        140        150
LQQIQLVPPG QIQIQGGQAV QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ 
       160        170        180        190        200
QIAVQGQQVA QTAEGQTIVY QPVNADGTIL QQVTVPVSGM ITIPAASLAG 
       210        220        230        240        250
AQIVQTGANT NTTSSGQGTV TVTLPVAGNV VNSGGMVMMV PGAGSVPAIQ 
       260        270        280        290        300
RIPLPGAEML EEEPLYVNAK QYHRILKRRQ ARAKLEAEGK IPKERRKYLH 
       310        320        330        340 
ESRHRHAMAR KRGEGGRFFS PKEKDSPHMQ DPNQADEEAM TQIIRVS
Length:347
Mass (Da):36,877
Last modified:May 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD00BE17041EB1A9E
GO
Isoform Short (identifier: P23511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-54: Missing.

Show »
Length:318
Mass (Da):33,939
Checksum:i9BF57D6031D83D8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti273H → N in AAH39244 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00084926 – 54Missing in isoform Short. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X59711 mRNA Translation: CAA42231.1
AL031778 Genomic DNA No translation available.
BC039244 mRNA Translation: AAH39244.1
M59079 mRNA Translation: AAA35950.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4849.1 [P23511-1]
CCDS4850.1 [P23511-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S22816, A39123

NCBI Reference Sequences

More...RefSeqi		NP_002496.1, NM_002505.4 [P23511-1]
NP_068351.1, NM_021705.3 [P23511-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341376; ENSP00000345702; ENSG00000001167
ENST00000353205; ENSP00000229418; ENSG00000001167 [P23511-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4800

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4800

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000341376.11; ENSP00000345702.6; NM_002505.5; NP_002496.1

UCSC genome browser

More...UCSCi		uc003opo.4, human [P23511-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59711 mRNA Translation: CAA42231.1
AL031778 Genomic DNA No translation available.
BC039244 mRNA Translation: AAH39244.1
M59079 mRNA Translation: AAA35950.1
CCDSiCCDS4849.1 [P23511-1]
CCDS4850.1 [P23511-2]
PIRiS22816, A39123
RefSeqiNP_002496.1, NM_002505.4 [P23511-1]
NP_068351.1, NM_021705.3 [P23511-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AWLX-ray3.08A262-332[»]
6QMPX-ray2.00A267-295[»]
6QMQX-ray2.50A267-285[»]
6QMSX-ray1.80A267-285[»]
SASBDBiP23511
SMRiP23511
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110866, 73 interactors
ComplexPortaliCPX-1956, CCAAT-binding factor complex
CORUMiP23511
IntActiP23511, 39 interactors
MINTiP23511
STRINGi9606.ENSP00000345702

PTM databases

GlyGeniP23511, 4 sites, 2 O-linked glycans (4 sites)
iPTMnetiP23511
PhosphoSitePlusiP23511

Genetic variation databases

BioMutaiNFYA
DMDMi115844

Proteomic databases

EPDiP23511
jPOSTiP23511
MassIVEiP23511
MaxQBiP23511
PaxDbiP23511
PeptideAtlasiP23511
PRIDEiP23511
ProteomicsDBi54123 [P23511-1]
54124 [P23511-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3982, 221 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		4800

Genome annotation databases

EnsembliENST00000341376; ENSP00000345702; ENSG00000001167
ENST00000353205; ENSP00000229418; ENSG00000001167 [P23511-2]
GeneIDi4800
KEGGihsa:4800
MANE-SelectiENST00000341376.11; ENSP00000345702.6; NM_002505.5; NP_002496.1
UCSCiuc003opo.4, human [P23511-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4800
DisGeNETi4800

GeneCards: human genes, protein and diseases

More...GeneCardsi		NFYA
HGNCiHGNC:7804, NFYA
HPAiENSG00000001167, Low tissue specificity
MIMi189903, gene
neXtProtiNX_P23511
OpenTargetsiENSG00000001167
PharmGKBiPA31609
VEuPathDBiHostDB:ENSG00000001167

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1561, Eukaryota
GeneTreeiENSGT00390000015714
HOGENOMiCLU_071609_1_0_1
InParanoidiP23511
OMAiGNMMNSG
OrthoDBi1269806at2759
PhylomeDBiP23511
TreeFamiTF323257

Enzyme and pathway databases

PathwayCommonsiP23511
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-2426168, Activation of gene expression by SREBF (SREBP)
R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381183, ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-9614657, FOXO-mediated transcription of cell death genes
SignaLinkiP23511
SIGNORiP23511

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4800, 173 hits in 1067 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NFYA, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NFYA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4800
PharosiP23511, Tbio

Protein Ontology

More...PROi		PR:P23511
RNActiP23511, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000001167, Expressed in cortical plate and 232 other tissues
ExpressionAtlasiP23511, baseline and differential
GenevisibleiP23511, HS

Family and domain databases

InterProiView protein in InterPro
IPR018362, CCAAT-binding_factor_CS
IPR001289, NFYA
PANTHERiPTHR12632, PTHR12632, 1 hit
PfamiView protein in Pfam
PF02045, CBFB_NFYA, 1 hit
PRINTSiPR00616, CCAATSUBUNTB
SMARTiView protein in SMART
SM00521, CBF, 1 hit
PROSITEiView protein in PROSITE
PS00686, NFYA_HAP2_1, 1 hit
PS51152, NFYA_HAP2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFYA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23511
Secondary accession number(s): Q8IXU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: February 23, 2022
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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