Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Colorectal mutant cancer protein

Gene

MCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).4 Publications

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

SignaLinkiP23508

Names & Taxonomyi

Protein namesi
Recommended name:
Colorectal mutant cancer protein
Short name:
Protein MCC
Gene namesi
Name:MCC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000171444.17
HGNCiHGNC:6935 MCC
MIMi159350 gene
neXtProtiNX_P23508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi828S → A: Reduced binding to SCRIB. 1 Publication1
Mutagenesisi828S → D: Higher membrane localization, reduced formation of lamellipodia, accumulation of MYH10 at the cell cortex. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi4163
MalaCardsiMCC
OpenTargetsiENSG00000171444
PharmGKBiPA30679

Polymorphism and mutation databases

BioMutaiMCC
DMDMi317373352

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793331 – 829Colorectal mutant cancer proteinAdd BLAST829

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei828Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP23508
MaxQBiP23508
PaxDbiP23508
PeptideAtlasiP23508
PRIDEiP23508
ProteomicsDBi54120
54121 [P23508-2]

PTM databases

iPTMnetiP23508
PhosphoSitePlusiP23508

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

BgeeiENSG00000171444 Expressed in 208 organ(s), highest expression level in female gonad
CleanExiHS_MCC
ExpressionAtlasiP23508 baseline and differential
GenevisibleiP23508 HS

Organism-specific databases

HPAiHPA037390
HPA037391

Interactioni

Subunit structurei

Interacts with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation. Interacts with MYH10. Interacts with CCAR2.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi110333, 58 interactors
CORUMiP23508
DIPiDIP-27599N
IntActiP23508, 88 interactors
MINTiP23508
STRINGi9606.ENSP00000386227

Structurei

3D structure databases

ProteinModelPortaliP23508
SMRiP23508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi766 – 782Nuclear localization signal1 PublicationAdd BLAST17
Motifi826 – 829PDZ-binding4

Sequence similaritiesi

Belongs to the MCC family.Curated

Phylogenomic databases

eggNOGiENOG410IESN Eukaryota
ENOG410XQHM LUCA
GeneTreeiENSGT00530000063974
HOGENOMiHOG000111967
HOVERGENiHBG004762
InParanoidiP23508
OMAiTGCSVQP
OrthoDBiEOG091G0GQZ
PhylomeDBiP23508
TreeFamiTF333056

Family and domain databases

InterProiView protein in InterPro
IPR019536 USH1C-bd_PDZ_domain
PfamiView protein in Pfam
PF10506 MCC-bdg_PDZ, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSGVAMKYG NDSSAELSEL HSAALASLKG DIVELNKRLQ QTERERDLLE
60 70 80 90 100
KKLAKAQCEQ SHLMREHEDV QERTTLRYEE RITELHSVIA ELNKKIDRLQ
110 120 130 140 150
GTTIREEDEY SELRSELSQS QHEVNEDSRS MDQDQTSVSI PENQSTMVTA
160 170 180 190 200
DMDNCSDLNS ELQRVLTGLE NVVCGRKKSS CSLSVAEVDK HIEQLTTASE
210 220 230 240 250
HCDLAIKTVE EIEGVLGRDL YPNLAEERSR WEKELAGLRE ENESLTAMLC
260 270 280 290 300
SKEEELNRTK ATMNAIREER DRLRRRVREL QTRLQSVQAT GPSSPGRLTS
310 320 330 340 350
TNRPINPSTG ELSTSSSSND IPIAKIAERV KLSKTRSESS SSDRPVLGSE
360 370 380 390 400
ISSIGVSSSV AEHLAHSLQD CSNIQEIFQT LYSHGSAISE SKIREFEVET
410 420 430 440 450
ERLNSRIEHL KSQNDLLTIT LEECKSNAER MSMLVGKYES NATALRLALQ
460 470 480 490 500
YSEQCIEAYE LLLALAESEQ SLILGQFRAA GVGSSPGDQS GDENITQMLK
510 520 530 540 550
RAHDCRKTAE NAAKALLMKL DGSCGGAFAV AGCSVQPWES LSSNSHTSTT
560 570 580 590 600
SSTASSCDTE FTKEDEQRLK DYIQQLKNDR AAVKLTMLEL ESIHIDPLSY
610 620 630 640 650
DVKPRGDSQR LDLENAVLMQ ELMAMKEEMA ELKAQLYLLE KEKKALELKL
660 670 680 690 700
STREAQEQAY LVHIEHLKSE VEEQKEQRMR SLSSTSSGSK DKPGKECADA
710 720 730 740 750
ASPALSLAEL RTTCSENELA AEFTNAIRRE KKLKARVQEL VSALERLTKS
760 770 780 790 800
SEIRHQQSAE FVNDLKRANS NLVAAYEKAK KKHQNKLKKL ESQMMAMVER
810 820
HETQVRMLKQ RIALLEEENS RPHTNETSL
Length:829
Mass (Da):93,027
Last modified:January 11, 2011 - v2
Checksum:iC90611B2E91A7F60
GO
Isoform 2 (identifier: P23508-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MNSGVAMKYGNDSSAELSE → MMAAAAAAAA...GGSYLELANT

Show »
Length:1,019
Mass (Da):113,279
Checksum:i09C330B8B43832F1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REY2D6REY2_HUMAN
Colorectal mutant cancer protein
MCC
766Annotation score:
A0A096LNU0A0A096LNU0_HUMAN
Colorectal mutant cancer protein
MCC
715Annotation score:
A0A096LPB3A0A096LPB3_HUMAN
Colorectal mutant cancer protein
MCC
169Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353S → G in BAC87521 (PubMed:14702039).Curated1
Isoform 2 (identifier: P23508-2)
Sequence conflicti25S → GSSSG in BAC87521 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079267142E → K1 PublicationCorresponds to variant dbSNP:rs185322500Ensembl.1
Natural variantiVAR_050905190K → R3 PublicationsCorresponds to variant dbSNP:rs6594681Ensembl.1
Natural variantiVAR_005141267R → L in a colorectal cancer sample. 1 Publication1
Natural variantiVAR_005142486P → L in a colorectal cancer sample. 1 PublicationCorresponds to variant dbSNP:rs35269015Ensembl.1
Natural variantiVAR_005143490S → L in a colorectal cancer sample. 1 PublicationCorresponds to variant dbSNP:rs760495893Ensembl.1
Natural variantiVAR_005144506R → Q in colorectal cancer samples; somatic mutation; decreased binding to CCAR2; significant decrease in its ability to induce the relocalization of CCAR2 to the cytoplasm; loss of its ability to repress the beta-catenin pathway; loss of its ability to induce the SIRT1-mediated deacetylation of beta-catenin. 3 PublicationsCorresponds to variant dbSNP:rs121917732Ensembl.1
Natural variantiVAR_005145698A → V in colorectal cancer samples; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121917731Ensembl.1
Natural variantiVAR_033753751S → C. Corresponds to variant dbSNP:rs17313892Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0376601 – 19MNSGV…AELSE → MMAAAAAAAAGSSSSGGGGG GSGSSSSSSDTSSTGEEERM RRLFQTCDGDGDGYISRNDL LMVCRQLNMEESVAEIMNQL GADENGKISFQDFTRCRMQL VREIRKEEVDLSAKSDNSCT KKLRDRIASWPTSSDNSLGA LSAARESWEYDSGARDLQSP DVQSQSALQKLLEYGGSSLH QQAALHKLLTQSPHIGNSVG GSYLELANT in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62397 mRNA Translation: AAA52069.1
AC008536 Genomic DNA No translation available.
AC010431 Genomic DNA No translation available.
AC079465 Genomic DNA No translation available.
AC093208 Genomic DNA No translation available.
AC106750 Genomic DNA No translation available.
AC126917 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48984.1
CH471086 Genomic DNA Translation: EAW48986.1
BC009279 mRNA Translation: AAH09279.1
BC018919 mRNA Translation: AAH18919.1
AK128596 mRNA Translation: BAC87521.1
CCDSiCCDS4111.1 [P23508-1]
CCDS43351.1 [P23508-2]
PIRiA38434 A33166
RefSeqiNP_001078846.1, NM_001085377.1
NP_002378.1, NM_002387.2
UniGeneiHs.593171

Genome annotation databases

EnsembliENST00000302475; ENSP00000305617; ENSG00000171444 [P23508-1]
ENST00000408903; ENSP00000386227; ENSG00000171444 [P23508-2]
GeneIDi4163
KEGGihsa:4163
UCSCiuc003kqj.5 human [P23508-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62397 mRNA Translation: AAA52069.1
AC008536 Genomic DNA No translation available.
AC010431 Genomic DNA No translation available.
AC079465 Genomic DNA No translation available.
AC093208 Genomic DNA No translation available.
AC106750 Genomic DNA No translation available.
AC126917 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48984.1
CH471086 Genomic DNA Translation: EAW48986.1
BC009279 mRNA Translation: AAH09279.1
BC018919 mRNA Translation: AAH18919.1
AK128596 mRNA Translation: BAC87521.1
CCDSiCCDS4111.1 [P23508-1]
CCDS43351.1 [P23508-2]
PIRiA38434 A33166
RefSeqiNP_001078846.1, NM_001085377.1
NP_002378.1, NM_002387.2
UniGeneiHs.593171

3D structure databases

ProteinModelPortaliP23508
SMRiP23508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110333, 58 interactors
CORUMiP23508
DIPiDIP-27599N
IntActiP23508, 88 interactors
MINTiP23508
STRINGi9606.ENSP00000386227

PTM databases

iPTMnetiP23508
PhosphoSitePlusiP23508

Polymorphism and mutation databases

BioMutaiMCC
DMDMi317373352

Proteomic databases

EPDiP23508
MaxQBiP23508
PaxDbiP23508
PeptideAtlasiP23508
PRIDEiP23508
ProteomicsDBi54120
54121 [P23508-2]

Protocols and materials databases

DNASUi4163
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302475; ENSP00000305617; ENSG00000171444 [P23508-1]
ENST00000408903; ENSP00000386227; ENSG00000171444 [P23508-2]
GeneIDi4163
KEGGihsa:4163
UCSCiuc003kqj.5 human [P23508-1]

Organism-specific databases

CTDi4163
DisGeNETi4163
EuPathDBiHostDB:ENSG00000171444.17
GeneCardsiMCC
HGNCiHGNC:6935 MCC
HPAiHPA037390
HPA037391
MalaCardsiMCC
MIMi159350 gene
neXtProtiNX_P23508
OpenTargetsiENSG00000171444
PharmGKBiPA30679
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IESN Eukaryota
ENOG410XQHM LUCA
GeneTreeiENSGT00530000063974
HOGENOMiHOG000111967
HOVERGENiHBG004762
InParanoidiP23508
OMAiTGCSVQP
OrthoDBiEOG091G0GQZ
PhylomeDBiP23508
TreeFamiTF333056

Enzyme and pathway databases

SignaLinkiP23508

Miscellaneous databases

ChiTaRSiMCC human
GeneWikiiMCC_(gene)
GenomeRNAii4163
PROiPR:P23508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171444 Expressed in 208 organ(s), highest expression level in female gonad
CleanExiHS_MCC
ExpressionAtlasiP23508 baseline and differential
GenevisibleiP23508 HS

Family and domain databases

InterProiView protein in InterPro
IPR019536 USH1C-bd_PDZ_domain
PfamiView protein in Pfam
PF10506 MCC-bdg_PDZ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRCM_HUMAN
AccessioniPrimary (citable) accession number: P23508
Secondary accession number(s): D3DT05, Q6ZR04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again