NAR1

Functionⁱ

Essential component of a cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	20	Iron-sulfur 1 (4Fe-4S)Curated	1
Metal bindingⁱ	59	Iron-sulfur 1 (4Fe-4S)Curated	1
Metal bindingⁱ	62	Iron-sulfur 1 (4Fe-4S)Curated	1
Metal bindingⁱ	65	Iron-sulfur 1 (4Fe-4S)Curated	1
Metal bindingⁱ	177	Iron-sulfur 2 (4Fe-4S)Curated	1
Metal bindingⁱ	231	Iron-sulfur 2 (4Fe-4S)Curated	1
Metal bindingⁱ	412	Iron-sulfur 2 (4Fe-4S)Curated	1
Metal bindingⁱ	416	Iron-sulfur 2 (4Fe-4S)Curated	1

GO - Molecular functionⁱ

4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
ferredoxin hydrogenase activity
Source: SGD
Inferred from sequence or structural similarityⁱ
- 10514485
iron-sulfur cluster binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19385603
metal ion binding Source: UniProtKB-KW
NADH dehydrogenase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

iron-sulfur cluster assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19385603

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	4Fe-4S, Iron, Iron-sulfur, Metal-binding

Ligand

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33238-MONOMER
Reactomeⁱ	R-SCE-2564818 Cytosolic iron-sulfur cluster assembly (yeast)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytosolic Fe-S cluster assembly factor NAR1 Alternative name(s): Nuclear architecture-related protein 1
Gene namesⁱ	Name:NAR1 Ordered Locus Names:YNL240C ORF Names:N1114
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL240C
Saccharomyces Genome Database More...SGDⁱ	S000005184 NAR1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	20	C → A: Weakly reduced iron content and impaired maturation of cytosolic Fe/S proteins. Strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-62 or A-65. 1 Publication	1
Mutagenesisⁱ	59	C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins. 1 Publication	1
Mutagenesisⁱ	62	C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins. 1 Publication	1
Mutagenesisⁱ	65	C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins. 1 Publication	1
Mutagenesisⁱ	177	C → A: Impaired maturation of cytosolic Fe/S proteins. Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-416. 1 Publication	1
Mutagenesisⁱ	177	C → S: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with S-412. 1 Publication	1
Mutagenesisⁱ	231	C → A: Impaired maturation of cytosolic Fe/S proteins. Strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-416. 1 Publication	1
Mutagenesisⁱ	412	C → S: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with S-177. 1 Publication	1
Mutagenesisⁱ	416	C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-177 or A-231. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096718	1 – 491	Cytosolic Fe-S cluster assembly factor NAR1Add BLAST		491

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P23503
PaxDbⁱ	P23503
PRIDEⁱ	P23503

PTM databases

iPTMnetⁱ	P23503

iPTMnetⁱ

P23503

Interactionⁱ

Subunit structureⁱ

Interacts with CIA1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CIA1	Q05583	2	EBI-11864,EBI-32145

With

Entry

#Exp.

IntAct

Notes

CIA1

Q05583

2

EBI-11864,EBI-32145

Protein-protein interaction databases

BioGridⁱ	35599, 303 interactors
IntActⁱ	P23503, 5 interactors
STRINGⁱ	4932.YNL240C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23503
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NARF family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017231
HOGENOMⁱ	HOG000191744
InParanoidⁱ	P23503
OMAⁱ	CIKPVET
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C2MTS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009016 Fe_hydrogenase IPR004108 Fe_hydrogenase_lsu_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02906 Fe_hyd_lg_C, 1 hit
SUPFAMⁱ	SSF53920 SSF53920, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P23503-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSALLSESDL NDFISPALAC VKPTQVSGGK KDNVNMNGEY EVSTEPDQLE 
        60         70         80         90        100
KVSITLSDCL ACSGCITSSE EILLSSQSHS VFLKNWGKLS QQQDKFLVVS 
       110        120        130        140        150
VSPQCRLSLA QYYGLTLEAA DLCLMNFFQK HFQCKYMVGT EMGRIISISK 
       160        170        180        190        200
TVEKIIAHKK QKENTGADRK PLLSAVCPGF LIYTEKTKPQ LVPMLLNVKS 
       210        220        230        240        250
PQQITGSLIR ATFESLAIAR ESFYHLSLMP CFDKKLEASR PESLDDGIDC 
       260        270        280        290        300
VITPREIVTM LQELNLDFKS FLTEDTSLYG RLSPPGWDPR VHWASNLGGT 
       310        320        330        340        350
CGGYAYQYVT AVQRLHPGSQ MIVLEGRNSD IVEYRLLHDD RIIAAASELS 
       360        370        380        390        400
GFRNIQNLVR KLTSGSGSER KRNITALRKR RTGPKANSRE MAAATAATAD 
       410        420        430        440        450
PYHSDYIEVN ACPGACMNGG GLLNGEQNSL KRKQLVQTLN KRHGEELAMV 
       460        470        480        490 
DPLTLGPKLE EAAARPLSLE YVFAPVKQAV EKDLVSVGST W

Length:491

Mass (Da):54,151

Last modified:October 1, 1996 - v2

Checksum:ⁱFFEB2A07A881BBC1

GO

Sequence cautionⁱ

The sequence AAA34618 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z69381 Genomic DNA Translation: CAA93358.1 Z71516 Genomic DNA Translation: CAA96145.1 AY692992 Genomic DNA Translation: AAT93011.1 M34709 Genomic DNA Translation: AAA34618.1 Frameshift. BK006947 Genomic DNA Translation: DAA10319.1
PIRⁱ	S63206
NCBI Reference Sequences More...RefSeqⁱ	NP_014159.1, NM_001183078.1

Genome annotation databases

EnsemblFungiⁱ	YNL240C; YNL240C; YNL240C
GeneIDⁱ	855481
KEGGⁱ	sce:YNL240C

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23503	YNL240Cp-like protein		YEAS6		491	UniRef100_P23503
Nar1p		YEAS2		491

Protein	Similar proteins		Species	Score	Length	Source
P23503	Cytosolic Fe-S cluster assembly factor NAR1		YEAS7		491	UniRef90_P23503
YNL240Cp-like protein		YEAS6		491
Nar1p		YEAS2		491
Nar1p		YEASO		493
Protein LET1		YEAS1		491
+9

Protein	Similar proteins		Species	Score	Length	Source
P23503	Cytosolic Fe-S cluster assembly factor NAR1		YEAS7		491	UniRef50_P23503
Cytosolic Fe-S cluster assembly factor NAR1		KLULA		469
YNL240Cp-like protein		YEAS6		491
Nar1p		YEAS2		491
Nar1p		YEASO		493
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z69381 Genomic DNA Translation: CAA93358.1 Z71516 Genomic DNA Translation: CAA96145.1 AY692992 Genomic DNA Translation: AAT93011.1 M34709 Genomic DNA Translation: AAA34618.1 Frameshift. BK006947 Genomic DNA Translation: DAA10319.1
PIRⁱ	S63206
RefSeqⁱ	NP_014159.1, NM_001183078.1

3D structure databases

ProteinModelPortalⁱ	P23503
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35599, 303 interactors
IntActⁱ	P23503, 5 interactors
STRINGⁱ	4932.YNL240C

PTM databases

iPTMnetⁱ	P23503

iPTMnetⁱ

P23503

Proteomic databases

MaxQBⁱ	P23503
PaxDbⁱ	P23503
PRIDEⁱ	P23503

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNL240C; YNL240C; YNL240C
GeneIDⁱ	855481
KEGGⁱ	sce:YNL240C

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL240C
SGDⁱ	S000005184 NAR1

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000017231
HOGENOMⁱ	HOG000191744
InParanoidⁱ	P23503
OMAⁱ	CIKPVET
OrthoDBⁱ	EOG092C2MTS

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33238-MONOMER
Reactomeⁱ	R-SCE-2564818 Cytosolic iron-sulfur cluster assembly (yeast)

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P23503

PROⁱ

PR:P23503

Family and domain databases

InterProⁱ	View protein in InterPro IPR009016 Fe_hydrogenase IPR004108 Fe_hydrogenase_lsu_C
Pfamⁱ	View protein in Pfam PF02906 Fe_hyd_lg_C, 1 hit
SUPFAMⁱ	SSF53920 SSF53920, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAR1_YEAST
Accessionⁱ	P23503Primary (citable) accession number: P23503 Secondary accession number(s): D6W0V3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

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UniProtKB - P23503 (NAR1_YEAST)

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Cytosolic Fe-S cluster assembly factor NAR1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ