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Entry version 160 (23 Feb 2022)
Sequence version 2 (01 Oct 1996)
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Protein

Cytosolic Fe-S cluster assembly factor NAR1

Gene

NAR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of a cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.

3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi20Iron-sulfur (4Fe-4S) 1Curated1
Metal bindingi59Iron-sulfur (4Fe-4S) 1Curated1
Metal bindingi62Iron-sulfur (4Fe-4S) 1Curated1
Metal bindingi65Iron-sulfur (4Fe-4S) 1Curated1
Metal bindingi177Iron-sulfur (4Fe-4S) 2Curated1
Metal bindingi231Iron-sulfur (4Fe-4S) 2Curated1
Metal bindingi412Iron-sulfur (4Fe-4S) 2Curated1
Metal bindingi416Iron-sulfur (4Fe-4S) 2Curated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: GO_Central
  • ferredoxin hydrogenase activity Source: SGD
  • iron-sulfur cluster binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • iron-sulfur cluster assembly Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic Fe-S cluster assembly factor NAR1
Alternative name(s):
Nuclear architecture-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAR1
Ordered Locus Names:YNL240C
ORF Names:N1114
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005184, NAR1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL240C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20C → A: Weakly reduced iron content and impaired maturation of cytosolic Fe/S proteins. Strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-62 or A-65. 1 Publication1
Mutagenesisi59C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins. 1 Publication1
Mutagenesisi62C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins. 1 Publication1
Mutagenesisi65C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins. 1 Publication1
Mutagenesisi177C → A: Impaired maturation of cytosolic Fe/S proteins. Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-416. 1 Publication1
Mutagenesisi177C → S: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with S-412. 1 Publication1
Mutagenesisi231C → A: Impaired maturation of cytosolic Fe/S proteins. Strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-416. 1 Publication1
Mutagenesisi412C → S: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with S-177. 1 Publication1
Mutagenesisi416C → A: Reduced iron content and strongly impaired maturation of cytosolic Fe/S proteins; when associated with A-177 or A-231. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967181 – 491Cytosolic Fe-S cluster assembly factor NAR1Add BLAST491

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P23503

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23503

PRoteomics IDEntifications database

More...
PRIDEi
P23503

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P23503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CIA1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35599, 305 interactors

Protein interaction database and analysis system

More...
IntActi
P23503, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YNL240C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P23503, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P23503

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NARF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2439, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153514

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018240_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23503

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTWVVDT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009016, Fe_hydrogenase
IPR004108, Fe_hydrogenase_lsu_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02906, Fe_hyd_lg_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53920, SSF53920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23503-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALLSESDL NDFISPALAC VKPTQVSGGK KDNVNMNGEY EVSTEPDQLE
60 70 80 90 100
KVSITLSDCL ACSGCITSSE EILLSSQSHS VFLKNWGKLS QQQDKFLVVS
110 120 130 140 150
VSPQCRLSLA QYYGLTLEAA DLCLMNFFQK HFQCKYMVGT EMGRIISISK
160 170 180 190 200
TVEKIIAHKK QKENTGADRK PLLSAVCPGF LIYTEKTKPQ LVPMLLNVKS
210 220 230 240 250
PQQITGSLIR ATFESLAIAR ESFYHLSLMP CFDKKLEASR PESLDDGIDC
260 270 280 290 300
VITPREIVTM LQELNLDFKS FLTEDTSLYG RLSPPGWDPR VHWASNLGGT
310 320 330 340 350
CGGYAYQYVT AVQRLHPGSQ MIVLEGRNSD IVEYRLLHDD RIIAAASELS
360 370 380 390 400
GFRNIQNLVR KLTSGSGSER KRNITALRKR RTGPKANSRE MAAATAATAD
410 420 430 440 450
PYHSDYIEVN ACPGACMNGG GLLNGEQNSL KRKQLVQTLN KRHGEELAMV
460 470 480 490
DPLTLGPKLE EAAARPLSLE YVFAPVKQAV EKDLVSVGST W
Length:491
Mass (Da):54,151
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFEB2A07A881BBC1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA34618 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z69381 Genomic DNA Translation: CAA93358.1
Z71516 Genomic DNA Translation: CAA96145.1
AY692992 Genomic DNA Translation: AAT93011.1
M34709 Genomic DNA Translation: AAA34618.1 Frameshift.
BK006947 Genomic DNA Translation: DAA10319.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S63206

NCBI Reference Sequences

More...
RefSeqi
NP_014159.1, NM_001183078.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL240C_mRNA; YNL240C; YNL240C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855481

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL240C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA Translation: CAA93358.1
Z71516 Genomic DNA Translation: CAA96145.1
AY692992 Genomic DNA Translation: AAT93011.1
M34709 Genomic DNA Translation: AAA34618.1 Frameshift.
BK006947 Genomic DNA Translation: DAA10319.1
PIRiS63206
RefSeqiNP_014159.1, NM_001183078.1

3D structure databases

SMRiP23503
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35599, 305 interactors
IntActiP23503, 5 interactors
STRINGi4932.YNL240C

PTM databases

iPTMnetiP23503

Proteomic databases

MaxQBiP23503
PaxDbiP23503
PRIDEiP23503

Genome annotation databases

EnsemblFungiiYNL240C_mRNA; YNL240C; YNL240C
GeneIDi855481
KEGGisce:YNL240C

Organism-specific databases

SGDiS000005184, NAR1
VEuPathDBiFungiDB:YNL240C

Phylogenomic databases

eggNOGiKOG2439, Eukaryota
GeneTreeiENSGT00940000153514
HOGENOMiCLU_018240_0_1_1
InParanoidiP23503
OMAiFTWVVDT

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23503
RNActiP23503, protein

Family and domain databases

InterProiView protein in InterPro
IPR009016, Fe_hydrogenase
IPR004108, Fe_hydrogenase_lsu_C
PfamiView protein in Pfam
PF02906, Fe_hyd_lg_C, 1 hit
SUPFAMiSSF53920, SSF53920, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAR1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23503
Secondary accession number(s): D6W0V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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