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Protein

Mitochondrial RNA-splicing protein MRS4

Gene

MRS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

MRS4 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). Not essential.

Miscellaneous

Present with 1340 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ferrous iron transmembrane transporter activity Source: Reactome
  • iron ion transmembrane transporter activity Source: SGD

GO - Biological processi

Keywordsi

Biological processmRNA processing, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32022-MONOMER

Protein family/group databases

TCDBi2.A.29.5.2 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial RNA-splicing protein MRS4
Gene namesi
Name:MRS4
Ordered Locus Names:YKR052C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR052C
SGDiS000001760 MRS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 41Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei83 – 102Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei120 – 139Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei175 – 194Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei209 – 228Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei275 – 288Helical; Name=6Sequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906921 – 304Mitochondrial RNA-splicing protein MRS4Add BLAST304

Proteomic databases

MaxQBiP23500
PaxDbiP23500
PRIDEiP23500

Interactioni

Protein-protein interaction databases

BioGridi34183, 79 interactors
DIPiDIP-4751N
IntActiP23500, 23 interactors
STRINGi4932.YKR052C

Structurei

3D structure databases

ProteinModelPortaliP23500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 108Solcar 1Add BLAST88
Repeati118 – 200Solcar 2Add BLAST83
Repeati207 – 300Solcar 3Add BLAST94

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074721
HOGENOMiHOG000038810
InParanoidiP23500
KOiK15113
OMAiNSHFANG
OrthoDBiEOG092C3EFS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P23500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSELSIAE EIDYEALPSH APLHSQLLAG AFAGIMEHSL MFPIDALKTR
60 70 80 90 100
VQAAGLNKAA STGMISQISK ISTMEGSMAL WKGVQSVILG AGPAHAVYFG
110 120 130 140 150
TYEFCKARLI SPEDMQTHQP MKTALSGTIA TIAADALMNP FDTVKQRLQL
160 170 180 190 200
DTNLRVWNVT KQIYQNEGFA AFYYSYPTTL AMNIPFAAFN FMIYESASKF
210 220 230 240 250
FNPQNSYNPL IHCLCGGISG ATCAALTTPL DCIKTVLQVR GSETVSIEIM
260 270 280 290 300
KDANTFGRAS RAILEVHGWK GFWRGLKPRI VANIPATAIS WTAYECAKHF

LMKN
Length:304
Mass (Da):33,307
Last modified:November 1, 1991 - v1
Checksum:i5ABBF9858B547EDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56444 Genomic DNA Translation: CAA39828.1
Z28277 Genomic DNA Translation: CAA82130.1
BK006944 Genomic DNA Translation: DAA09203.1
PIRiS13533
RefSeqiNP_012978.1, NM_001179842.1

Genome annotation databases

EnsemblFungiiYKR052C; YKR052C; YKR052C
GeneIDi853926
KEGGisce:YKR052C

Similar proteinsi

Entry informationi

Entry nameiMRS4_YEAST
AccessioniPrimary (citable) accession number: P23500
Secondary accession number(s): D6VXB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 25, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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