UniProtKB - P23497 (SP100_HUMAN)
Nuclear autoantigen Sp-100
SP100
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 677 – 753 | HMG box 1PROSITE-ProRule annotationAdd BLAST | 77 | |
DNA bindingi | 769 – 837 | HMG box 2PROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromo shadow domain binding Source: BHF-UCL
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- identical protein binding Source: IntAct
- kinase binding Source: BHF-UCL
- protein dimerization activity Source: BHF-UCL
- protein domain specific binding Source: UniProtKB
- protein homodimerization activity Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
GO - Biological processi
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: BHF-UCL
- interferon-gamma-mediated signaling pathway Source: Reactome
- maintenance of protein location Source: BHF-UCL
- negative regulation of cellular component movement Source: BHF-UCL
- negative regulation of DNA binding Source: BHF-UCL
- negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
- negative regulation of endothelial cell migration Source: UniProtKB
- negative regulation of protein export from nucleus Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of viral transcription Source: BHF-UCL
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- regulation of angiogenesis Source: UniProtKB
- regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
- regulation of Fas signaling pathway Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cytokine Source: BHF-UCL
- response to interferon-gamma Source: BHF-UCL
- response to retinoic acid Source: BHF-UCL
- response to type I interferon Source: BHF-UCL
- retinoic acid receptor signaling pathway Source: BHF-UCL
- telomere maintenance Source: UniProtKB
- type I interferon signaling pathway Source: BHF-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P23497 |
Reactomei | R-HSA-3108214, SUMOylation of DNA damage response and repair proteins R-HSA-877300, Interferon gamma signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear autoantigen Sp-100Alternative name(s): Nuclear dot-associated Sp100 protein Speckled 100 kDa |
Gene namesi | Name:SP100 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11206, SP100 |
MIMi | 604585, gene |
neXtProti | NX_P23497 |
VEuPathDBi | HostDB:ENSG00000067066.16 |
Subcellular locationi
Nucleus
- nuclear body Source: HPA
- nuclear periphery Source: BHF-UCL
- nucleolus Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
- PML body Source: BHF-UCL
Other locations
- chromosome, telomeric region Source: BHF-UCL
- cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 165 | R → A: Prevents CDC20-mediated degradation; when associated with Ala-168. 1 Publication | 1 | |
Mutagenesisi | 168 | L → A: Prevents CDC20-mediated degradation; when associated with Ala-165. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6672 |
OpenTargetsi | ENSG00000067066 |
PharmGKBi | PA36043 |
Miscellaneous databases
Pharosi | P23497, Tbio |
Genetic variation databases
BioMutai | SP100 |
DMDMi | 13878931 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000074096 | 2 – 879 | Nuclear autoantigen Sp-100Add BLAST | 878 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 157 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphoserineCombined sources | 1 | |
Modified residuei | 180 | PhosphoserineCombined sources | 1 | |
Modified residuei | 228 | PhosphoserineCombined sources | 1 | |
Cross-linki | 241 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 300 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 306 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphoserineCombined sources | 1 | |
Cross-linki | 366 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 387 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 394 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 409 | PhosphoserineCombined sources | 1 | |
Modified residuei | 410 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphoserineCombined sources | 1 | |
Cross-linki | 594 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P23497 |
jPOSTi | P23497 |
MassIVEi | P23497 |
MaxQBi | P23497 |
PaxDbi | P23497 |
PeptideAtlasi | P23497 |
PRIDEi | P23497 |
ProteomicsDBi | 18390 32155 54115 [P23497-1] 54116 [P23497-2] 54117 [P23497-3] 54118 [P23497-4] 54119 [P23497-5] 7363 |
PTM databases
GlyGeni | P23497, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P23497 |
PhosphoSitePlusi | P23497 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000067066, Expressed in small intestine Peyer's patch and 230 other tissues |
ExpressionAtlasi | P23497, baseline and differential |
Genevisiblei | P23497, HS |
Organism-specific databases
HPAi | ENSG00000067066, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; isoforms are able to heterodimerize.
Interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif.
Interacts with ETS1; the interaction is direct and modulates ETS1 transcriptional activity.
Interacts with the MRN complex which is composed of two heterodimers RAD50/MRE11 associated with a single NBN; recruits the complex to PML-related bodies.
Interacts with HIPK2; positively regulates TP53-dependent transcription.
Interacts with CASP8AP2; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm.
Interacts with SUMO1P1/SUMO5 (PubMed:27211601).
9 Publications(Microbial infection) Interacts with Epstein-Barr virus EBNA-LP; this interaction is important for EBNA-LP coactivator activity.
1 Publication(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123; may play a role in infection by the virus.
1 PublicationBinary interactionsi
Hide detailsP23497
SP100 - isoform Sp100-A [P23497-2]
GO - Molecular functioni
- chromo shadow domain binding Source: BHF-UCL
- identical protein binding Source: IntAct
- kinase binding Source: BHF-UCL
- protein dimerization activity Source: BHF-UCL
- protein domain specific binding Source: UniProtKB
- protein homodimerization activity Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112555, 155 interactors |
DIPi | DIP-5983N |
IntActi | P23497, 89 interactors |
MINTi | P23497 |
STRINGi | 9606.ENSP00000343023 |
Miscellaneous databases
RNActi | P23497, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P23497 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23497 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 149 | HSRPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 595 – 676 | SANDPROSITE-ProRule annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 333 – 478 | Sufficient to mediate interaction with ETS1Add BLAST | 146 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 165 – 168 | D-box; recognition signal for CDC20-mediated degradation | 4 | |
Motifi | 284 – 297 | PxVxL motifAdd BLAST | 14 | |
Motifi | 536 – 553 | Nuclear localization signalSequence analysisAdd BLAST | 18 | |
Motifi | 568 – 592 | Nuclear localization signalSequence analysisAdd BLAST | 25 | |
Motifi | 717 – 734 | Nuclear localization signalSequence analysisAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3 – 6 | Poly-Gly | 4 | |
Compositional biasi | 156 – 164 | Poly-Glu | 9 | |
Compositional biasi | 759 – 764 | Poly-Lys | 6 | |
Compositional biasi | 854 – 859 | Poly-Lys | 6 | |
Compositional biasi | 860 – 868 | Poly-Glu | 9 |
Domaini
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000162212 |
HOGENOMi | CLU_015844_0_0_1 |
InParanoidi | P23497 |
OMAi | AGMWNNT |
PhylomeDBi | P23497 |
TreeFami | TF335091 |
Family and domain databases
Gene3Di | 1.10.30.10, 2 hits 3.10.390.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR004865, HSR_dom IPR010919, SAND-like_dom_sf IPR000770, SAND_dom IPR043563, Sp110/Sp140/Sp140L |
PANTHERi | PTHR46386, PTHR46386, 2 hits |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF09011, HMG_box_2, 1 hit PF03172, HSR, 1 hit PF01342, SAND, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 2 hits SM00258, SAND, 1 hit |
SUPFAMi | SSF47095, SSF47095, 2 hits SSF63763, SSF63763, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 2 hits PS51414, HSR, 1 hit PS50864, SAND, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY
60 70 80 90 100
DIVFKHFKRN KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV
110 120 130 140 150
PVQRVVYNVL SELEKTFNLP VLEALFSDVN MQEYPDLIHI YKGFENVIHD
160 170 180 190 200
KLPLQESEEE EREERSGLQL SLEQGTGENS FRSLTWPPSG SPSHAGTTPP
210 220 230 240 250
ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ KAEPTESCEQ
260 270 280 290 300
IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
310 320 330 340 350
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS
360 370 380 390 400
EPVINNDNPL ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI
410 420 430 440 450
GQDHDFSESS EEEAPAEASS GALRSKHGEK APMTSRSTST WRIPSRKRRF
460 470 480 490 500
SSSDFSDLSN GEELQETCSS SLRRGSGSQP QEPENKKCSC VMCFPKGVPR
510 520 530 540 550
SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR SKVNGLQRGR
560 570 580 590 600
KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
610 620 630 640 650
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG
660 670 680 690 700
ASKNWKLSIR CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE
710 720 730 740 750
HKKKNPDASV KFSEFLKKCS ETWKTIFAKE KGKFEDMAKA DKAHYEREMK
760 770 780 790 800
TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC SEYRPKIKGE HPGLSIDDVV
810 820 830 840 850
KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG KPNSAKKRVV
860 870
KAEKSKKKKE EEEDEEDEQE EENEEDDDK
The sequence of this isoform differs from the canonical sequence as follows:
478-480: SQP → KED
481-879: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
685-688: RILE → VMIK
689-879: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
699-879: EEHKKKNPDA...EEENEEDDDK → PENSNICEVC...ETSKNIIMFI
The sequence of this isoform differs from the canonical sequence as follows:
449-472: RFSSSDFSDLSNGEELQETCSSSL → LKKKKKKKQCHPQPQPQRGLLEQS
473-879: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PHV6 | E9PHV6_HUMAN | Nuclear autoantigen Sp-100 | SP100 | 455 | Annotation score: | ||
H0Y4R8 | H0Y4R8_HUMAN | Nuclear autoantigen Sp-100 | SP100 | 259 | Annotation score: | ||
C9JBL0 | C9JBL0_HUMAN | Nuclear autoantigen Sp-100 | SP100 | 192 | Annotation score: | ||
H7C1G8 | H7C1G8_HUMAN | Nuclear autoantigen Sp-100 | SP100 | 126 | Annotation score: | ||
H7C4B4 | H7C4B4_HUMAN | Nuclear autoantigen Sp-100 | SP100 | 193 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 47 | R → M in BAG56886 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 247 | S → P in BAG56886 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 402 | Q → H in BAG56886 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 651 | A → R in AAL77438 (PubMed:9973607).Curated | 1 | ||
Sequence conflicti | 651 | A → R in AAL77439 (PubMed:9973607).Curated | 1 | ||
Isoform Sp100-B (identifier: P23497-3) | |||||
Sequence conflicti | 686 | M → T in AAC50743 (PubMed:8695863).Curated | 1 | ||
Isoform Sp100-C (identifier: P23497-4) | |||||
Sequence conflicti | 826 | M → T in AAK51202 (PubMed:11313457).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_005621 | 433 | M → V. Corresponds to variant dbSNP:rs12724Ensembl. | 1 | |
Natural variantiVAR_005622 | 471 | S → P. | 1 | |
Natural variantiVAR_034510 | 699 | E → G. Corresponds to variant dbSNP:rs34700604Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045868 | 1 – 36 | MAGGG…HDLQR → M in isoform 7. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_045869 | 11 – 35 | Missing in isoform 6. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_045870 | 428 – 430 | Missing in isoform 6. 1 Publication | 3 | |
Alternative sequenceiVSP_005982 | 449 – 472 | RFSSS…CSSSL → LKKKKKKKQCHPQPQPQRGL LEQS in isoform SpAlt-C. CuratedAdd BLAST | 24 | |
Alternative sequenceiVSP_005983 | 473 – 879 | Missing in isoform SpAlt-C. CuratedAdd BLAST | 407 | |
Alternative sequenceiVSP_005978 | 478 – 480 | SQP → KED in isoform Sp100-A, isoform 6 and isoform 7. 3 Publications | 3 | |
Alternative sequenceiVSP_005979 | 481 – 879 | Missing in isoform Sp100-A, isoform 6 and isoform 7. 3 PublicationsAdd BLAST | 399 | |
Alternative sequenceiVSP_005980 | 685 – 688 | RILE → VMIK in isoform Sp100-B. 1 Publication | 4 | |
Alternative sequenceiVSP_005981 | 689 – 879 | Missing in isoform Sp100-B. 1 PublicationAdd BLAST | 191 | |
Alternative sequenceiVSP_005984 | 699 – 879 | EEHKK…EDDDK → PENSNICEVCNKWGRLFCCD TCPRSFHEHCHIPSVEANKN PWSCIFCRIKTIQERCPESQ SGHQESEVLMRQMLPEEQLK CEFLLLKVYCDSKSCFFASE PYYNREGSQGPQKPMWLNKV KTSLNEQMYTRVEGFVQDMR LIFHNHKEFYREDKFTRLGI QVQDIFEKNFRNIFAIQETS KNIIMFI in isoform Sp100-C. 1 PublicationAdd BLAST | 181 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000264052; ENSP00000264052; ENSG00000067066 [P23497-1] ENST00000340126; ENSP00000343023; ENSG00000067066 [P23497-4] ENST00000409112; ENSP00000386427; ENSG00000067066 [P23497-3] ENST00000409341; ENSP00000386404; ENSG00000067066 [P23497-2] ENST00000409897; ENSP00000386998; ENSG00000067066 [P23497-7] ENST00000427101; ENSP00000399389; ENSG00000067066 [P23497-6] |
GeneIDi | 6672 |
KEGGi | hsa:6672 |
UCSCi | uc002vqq.3, human [P23497-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H5P | NMR | - | A | 595-688 | [»] | |
4PTB | X-ray | 1.60 | A/B | 466-508 | [»] | |
5FB0 | X-ray | 2.70 | A/C | 696-878 | [»] | |
5FB1 | X-ray | 2.10 | A | 696-875 | [»] | |
5PWE | X-ray | 1.69 | A/B | 466-508 | [»] | |
5PWF | X-ray | 1.48 | A/B | 466-508 | [»] | |
5PWG | X-ray | 1.46 | A/B | 466-508 | [»] | |
5PWH | X-ray | 1.50 | A/B | 466-508 | [»] | |
5PWI | X-ray | 1.62 | A/B | 466-508 | [»] | |
5PWJ | X-ray | 1.89 | A/B | 466-508 | [»] | |
5PWK | X-ray | 1.62 | A/B | 466-508 | [»] | |
5PWL | X-ray | 1.83 | A/B | 466-508 | [»] | |
5PWM | X-ray | 1.54 | A/B | 466-508 | [»] | |
5PWN | X-ray | 1.64 | A/B | 466-508 | [»] | |
5PWO | X-ray | 1.85 | A/B | 466-508 | [»] | |
5PWP | X-ray | 1.51 | A/B | 466-508 | [»] | |
5PWQ | X-ray | 1.52 | A/B | 466-508 | [»] | |
5PWR | X-ray | 1.46 | A/B | 466-508 | [»] | |
5PWS | X-ray | 1.40 | A/B | 466-508 | [»] | |
5PWT | X-ray | 1.58 | A/B | 466-508 | [»] | |
5PWU | X-ray | 1.44 | A/B | 466-508 | [»] | |
5PWV | X-ray | 1.58 | A/B | 466-508 | [»] | |
5PWW | X-ray | 1.59 | A/B | 466-508 | [»] | |
5PWX | X-ray | 1.69 | A/B | 466-508 | [»] | |
5PWY | X-ray | 1.98 | A/B | 466-508 | [»] | |
5PWZ | X-ray | 1.62 | A/B | 466-508 | [»] | |
5PX0 | X-ray | 1.55 | A/B | 466-508 | [»] | |
5PX1 | X-ray | 1.55 | A/B | 466-508 | [»] | |
5PX2 | X-ray | 1.43 | A/B | 466-508 | [»] | |
5PX3 | X-ray | 1.57 | A/B | 466-508 | [»] | |
5PX4 | X-ray | 1.45 | A/B | 466-508 | [»] | |
5PX5 | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PX6 | X-ray | 1.43 | A/B | 466-508 | [»] | |
5PX7 | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PX8 | X-ray | 1.71 | A/B | 466-508 | [»] | |
5PX9 | X-ray | 1.89 | A/B | 466-508 | [»] | |
5PXA | X-ray | 1.43 | A/B | 466-508 | [»] | |
5PXB | X-ray | 1.46 | A/B | 466-508 | [»] | |
5PXC | X-ray | 1.52 | A/B | 466-508 | [»] | |
5PXD | X-ray | 1.64 | A/B | 466-508 | [»] | |
5PXE | X-ray | 1.55 | A/B | 466-508 | [»] | |
5PXF | X-ray | 1.71 | A/B | 466-508 | [»] | |
5PXG | X-ray | 1.98 | A/B | 466-508 | [»] | |
5PXH | X-ray | 2.25 | A/B | 466-508 | [»] | |
5PXI | X-ray | 1.76 | A/B | 466-508 | [»] | |
5PXJ | X-ray | 1.68 | A/B | 466-508 | [»] | |
5PXK | X-ray | 1.98 | A/B | 466-508 | [»] | |
5PXL | X-ray | 1.35 | A/B | 466-508 | [»] | |
5PXM | X-ray | 1.59 | A/B | 466-508 | [»] | |
5PXN | X-ray | 1.43 | A/B | 466-508 | [»] | |
5PXO | X-ray | 1.78 | A/B | 466-508 | [»] | |
5PXP | X-ray | 1.86 | A/B | 466-508 | [»] | |
5PXQ | X-ray | 1.62 | A/B | 466-508 | [»] | |
5PXR | X-ray | 1.81 | A/B | 466-508 | [»] | |
5PXS | X-ray | 1.49 | A/B | 466-508 | [»] | |
5PXT | X-ray | 1.40 | A/B | 466-508 | [»] | |
5PXU | X-ray | 1.76 | A/B | 466-508 | [»] | |
5PXV | X-ray | 1.65 | A/B | 466-508 | [»] | |
5PXW | X-ray | 2.01 | A/B | 466-508 | [»] | |
5PXX | X-ray | 1.57 | A/B | 466-508 | [»] | |
5PXY | X-ray | 2.14 | A/B | 466-508 | [»] | |
5PXZ | X-ray | 1.65 | A/B | 466-508 | [»] | |
5PY0 | X-ray | 1.70 | A/B | 466-508 | [»] | |
5PY1 | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PY2 | X-ray | 1.62 | A/B | 466-508 | [»] | |
5PY3 | X-ray | 1.78 | A/B | 466-508 | [»] | |
5PY4 | X-ray | 1.67 | A/B | 466-508 | [»] | |
5PY5 | X-ray | 1.44 | A/B | 466-508 | [»] | |
5PY6 | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PY7 | X-ray | 1.68 | A/B | 466-508 | [»] | |
5PY8 | X-ray | 1.66 | A/B | 466-508 | [»] | |
5PY9 | X-ray | 1.73 | A/B | 466-508 | [»] | |
5PYA | X-ray | 1.55 | A/B | 466-508 | [»] | |
5PYB | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PYC | X-ray | 1.87 | A/B | 466-508 | [»] | |
5PYD | X-ray | 2.02 | A/B | 466-508 | [»] | |
5PYE | X-ray | 1.81 | A/B | 466-508 | [»] | |
5PYF | X-ray | 1.83 | A/B | 466-508 | [»] | |
5PYG | X-ray | 1.95 | A/B | 466-508 | [»] | |
5PYH | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PYI | X-ray | 2.29 | A/B | 466-508 | [»] | |
5PYJ | X-ray | 1.97 | A/B | 466-508 | [»] | |
5PYK | X-ray | 1.88 | A/B | 466-508 | [»] | |
5PYL | X-ray | 1.53 | A/B | 466-508 | [»] | |
5PYM | X-ray | 1.70 | A/B | 466-508 | [»] | |
5PYN | X-ray | 1.89 | A/B | 466-508 | [»] | |
5PYO | X-ray | 1.67 | A/B | 466-508 | [»] | |
5PYP | X-ray | 1.63 | A/B | 466-508 | [»] | |
5PYQ | X-ray | 1.97 | A/B | 466-508 | [»] | |
5PYR | X-ray | 1.94 | A/B | 466-508 | [»] | |
5PYS | X-ray | 2.09 | A/B | 466-508 | [»] | |
5PYT | X-ray | 2.13 | A/B | 466-508 | [»] | |
5PYU | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PYV | X-ray | 1.94 | A/B | 466-508 | [»] | |
5PYW | X-ray | 1.45 | A/B | 466-508 | [»] | |
5PYX | X-ray | 1.57 | A/B | 466-508 | [»] | |
5PYY | X-ray | 1.64 | A/B | 466-508 | [»] | |
5PYZ | X-ray | 1.59 | A/B | 466-508 | [»] | |
5PZ0 | X-ray | 2.13 | A/B | 466-508 | [»] | |
5PZ1 | X-ray | 2.13 | A/B | 466-508 | [»] | |
5PZ2 | X-ray | 1.88 | A/B | 466-508 | [»] | |
5PZ3 | X-ray | 1.93 | A/B | 466-508 | [»] | |
5PZ4 | X-ray | 1.94 | A/B | 466-508 | [»] | |
5PZ5 | X-ray | 2.64 | A/B | 466-508 | [»] | |
5PZ6 | X-ray | 1.87 | A/B | 466-508 | [»] | |
5PZ7 | X-ray | 1.54 | A/B | 466-508 | [»] | |
5PZ8 | X-ray | 1.52 | A/B | 466-508 | [»] | |
5PZ9 | X-ray | 2.01 | A/B | 466-508 | [»] | |
5PZA | X-ray | 1.59 | A/B | 466-508 | [»] | |
5PZB | X-ray | 2.05 | A/B | 466-508 | [»] | |
5PZC | X-ray | 1.61 | A/B | 466-508 | [»] | |
5PZD | X-ray | 1.74 | A/B | 466-508 | [»] | |
5PZE | X-ray | 1.82 | A/B | 466-508 | [»] | |
5PZF | X-ray | 1.84 | A/B | 466-508 | [»] | |
5PZG | X-ray | 1.88 | A/B | 466-508 | [»] | |
5PZH | X-ray | 1.63 | A/B | 466-508 | [»] | |
5PZI | X-ray | 1.62 | A/B | 466-508 | [»] | |
5PZJ | X-ray | 1.72 | A/B | 466-508 | [»] | |
6G5N | X-ray | 1.76 | A/B | 466-508 | [»] | |
6G5P | X-ray | 1.35 | A/B | 466-508 | [»] | |
SMRi | P23497 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112555, 155 interactors |
DIPi | DIP-5983N |
IntActi | P23497, 89 interactors |
MINTi | P23497 |
STRINGi | 9606.ENSP00000343023 |
PTM databases
GlyGeni | P23497, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P23497 |
PhosphoSitePlusi | P23497 |
Genetic variation databases
BioMutai | SP100 |
DMDMi | 13878931 |
Proteomic databases
EPDi | P23497 |
jPOSTi | P23497 |
MassIVEi | P23497 |
MaxQBi | P23497 |
PaxDbi | P23497 |
PeptideAtlasi | P23497 |
PRIDEi | P23497 |
ProteomicsDBi | 18390 32155 54115 [P23497-1] 54116 [P23497-2] 54117 [P23497-3] 54118 [P23497-4] 54119 [P23497-5] 7363 |
Protocols and materials databases
Antibodypediai | 20190, 306 antibodies |
Genome annotation databases
Ensembli | ENST00000264052; ENSP00000264052; ENSG00000067066 [P23497-1] ENST00000340126; ENSP00000343023; ENSG00000067066 [P23497-4] ENST00000409112; ENSP00000386427; ENSG00000067066 [P23497-3] ENST00000409341; ENSP00000386404; ENSG00000067066 [P23497-2] ENST00000409897; ENSP00000386998; ENSG00000067066 [P23497-7] ENST00000427101; ENSP00000399389; ENSG00000067066 [P23497-6] |
GeneIDi | 6672 |
KEGGi | hsa:6672 |
UCSCi | uc002vqq.3, human [P23497-1] |
Organism-specific databases
CTDi | 6672 |
DisGeNETi | 6672 |
GeneCardsi | SP100 |
HGNCi | HGNC:11206, SP100 |
HPAi | ENSG00000067066, Low tissue specificity |
MIMi | 604585, gene |
neXtProti | NX_P23497 |
OpenTargetsi | ENSG00000067066 |
PharmGKBi | PA36043 |
VEuPathDBi | HostDB:ENSG00000067066.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000162212 |
HOGENOMi | CLU_015844_0_0_1 |
InParanoidi | P23497 |
OMAi | AGMWNNT |
PhylomeDBi | P23497 |
TreeFami | TF335091 |
Enzyme and pathway databases
PathwayCommonsi | P23497 |
Reactomei | R-HSA-3108214, SUMOylation of DNA damage response and repair proteins R-HSA-877300, Interferon gamma signaling |
Miscellaneous databases
BioGRID-ORCSi | 6672, 3 hits in 1018 CRISPR screens |
ChiTaRSi | SP100, human |
EvolutionaryTracei | P23497 |
GenomeRNAii | 6672 |
Pharosi | P23497, Tbio |
PROi | PR:P23497 |
RNActi | P23497, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000067066, Expressed in small intestine Peyer's patch and 230 other tissues |
ExpressionAtlasi | P23497, baseline and differential |
Genevisiblei | P23497, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 2 hits 3.10.390.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR004865, HSR_dom IPR010919, SAND-like_dom_sf IPR000770, SAND_dom IPR043563, Sp110/Sp140/Sp140L |
PANTHERi | PTHR46386, PTHR46386, 2 hits |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF09011, HMG_box_2, 1 hit PF03172, HSR, 1 hit PF01342, SAND, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 2 hits SM00258, SAND, 1 hit |
SUPFAMi | SSF47095, SSF47095, 2 hits SSF63763, SSF63763, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 2 hits PS51414, HSR, 1 hit PS50864, SAND, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SP100_HUMAN | |
Accessioni | P23497Primary (citable) accession number: P23497 Secondary accession number(s): B4DDX5 Q9UE32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | April 27, 2001 | |
Last modified: | April 7, 2021 | |
This is version 231 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references