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UniProtKB - P23497 (SP100_HUMAN)

Entry version 228 (07 Oct 2020)
Sequence version 3 (27 Apr 2001)
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Protein

Nuclear autoantigen Sp-100

Gene

SP100

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.9 Publications

Miscellaneous

The major isoform Sp100-A, has a calculated molecular weight of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent molecular weight of 100 kDa.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi677 – 753HMG box 1PROSITE-ProRule annotationAdd BLAST77
DNA bindingi769 – 837HMG box 2PROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23497

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-877300, Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear autoantigen Sp-100
Alternative name(s):
Nuclear dot-associated Sp100 protein
Speckled 100 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SP100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000067066.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:11206, SP100

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604585, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23497

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi165R → A: Prevents CDC20-mediated degradation; when associated with Ala-168. 1 Publication1
Mutagenesisi168L → A: Prevents CDC20-mediated degradation; when associated with Ala-165. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6672

Open Targets

More...OpenTargetsi		ENSG00000067066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36043

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23497, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SP100

Domain mapping of disease mutations (DMDM)

More...DMDMi		13878931

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000740962 – 879Nuclear autoantigen Sp-100Add BLAST878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki300Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki387Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei394PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.
Sumoylated. Sumoylated with SUMO1. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylation may stabilize the interaction with CBX5.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P23497

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23497

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23497

MaxQB - The MaxQuant DataBase

More...MaxQBi		P23497

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23497

PeptideAtlas

More...PeptideAtlasi		P23497

PRoteomics IDEntifications database

More...PRIDEi		P23497

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		18390
32155
54115 [P23497-1]
54116 [P23497-2]
54117 [P23497-3]
54118 [P23497-4]
54119 [P23497-5]
7363

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23497, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23497

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23497

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by interferon, retinoic acid, TNF-alpha/TNFA and lipopolysaccharide (at protein level). Up-regulated following heat-shock.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000067066, Expressed in small intestine Peyer's patch and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23497, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23497, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000067066, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; isoforms are able to heterodimerize.

Interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif.

Interacts with ETS1; the interaction is direct and modulates ETS1 transcriptional activity.

Interacts with the MRN complex which is composed of two heterodimers RAD50/MRE11 associated with a single NBN; recruits the complex to PML-related bodies.

Interacts with HIPK2; positively regulates TP53-dependent transcription.

Interacts with CASP8AP2; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm.

Interacts with SUMO1P1/SUMO5 (PubMed:27211601).

9 Publications

(Microbial infection) Interacts with Epstein-Barr virus EBNA-LP; this interaction is important for EBNA-LP coactivator activity.

1 Publication

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123; may play a role in infection by the virus.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112555, 67 interactors

Database of interacting proteins

More...DIPi		DIP-5983N

Protein interaction database and analysis system

More...IntActi		P23497, 43 interactors

Molecular INTeraction database

More...MINTi		P23497

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343023

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23497, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1879
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23497

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23497

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 149HSRPROSITE-ProRule annotationAdd BLAST117
Domaini595 – 676SANDPROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni333 – 478Sufficient to mediate interaction with ETS1Add BLAST146

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi165 – 168D-box; recognition signal for CDC20-mediated degradation4
Motifi284 – 297PxVxL motifAdd BLAST14
Motifi536 – 553Nuclear localization signalSequence analysisAdd BLAST18
Motifi568 – 592Nuclear localization signalSequence analysisAdd BLAST25
Motifi717 – 734Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 6Poly-Gly4
Compositional biasi156 – 164Poly-Glu9
Compositional biasi759 – 764Poly-Lys6
Compositional biasi854 – 859Poly-Lys6
Compositional biasi860 – 868Poly-Glu9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HSR domain is important for the nuclear body targeting as well as for the dimerization.1 Publication
Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162212

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23497

KEGG Orthology (KO)

More...KOi		K15413

Identification of Orthologs from Complete Genome Data

More...OMAi		AGMWNNT

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23497

TreeFam database of animal gene trees

More...TreeFami		TF335091

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.30.10, 2 hits
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR004865, HSR_dom
IPR010919, SAND-like_dom_sf
IPR000770, SAND_dom
IPR043563, Sp110/Sp140/Sp140L

The PANTHER Classification System

More...PANTHERi		PTHR46386, PTHR46386, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00505, HMG_box, 1 hit
PF09011, HMG_box_2, 1 hit
PF03172, HSR, 1 hit
PF01342, SAND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00398, HMG, 2 hits
SM00258, SAND, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47095, SSF47095, 2 hits
SSF63763, SSF63763, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50118, HMG_BOX_2, 2 hits
PS51414, HSR, 1 hit
PS50864, SAND, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Sp100-HMG (identifier: P23497-1) [UniParc]FASTAAdd to basket
Also known as: SP100HMG, SpAlt-HMG

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY 
        60         70         80         90        100
DIVFKHFKRN KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV 
       110        120        130        140        150
PVQRVVYNVL SELEKTFNLP VLEALFSDVN MQEYPDLIHI YKGFENVIHD 
       160        170        180        190        200
KLPLQESEEE EREERSGLQL SLEQGTGENS FRSLTWPPSG SPSHAGTTPP 
       210        220        230        240        250
ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ KAEPTESCEQ 
       260        270        280        290        300
IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK 
       310        320        330        340        350
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS 
       360        370        380        390        400
EPVINNDNPL ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI 
       410        420        430        440        450
GQDHDFSESS EEEAPAEASS GALRSKHGEK APMTSRSTST WRIPSRKRRF 
       460        470        480        490        500
SSSDFSDLSN GEELQETCSS SLRRGSGSQP QEPENKKCSC VMCFPKGVPR 
       510        520        530        540        550
SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR SKVNGLQRGR 
       560        570        580        590        600
KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF 
       610        620        630        640        650
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG 
       660        670        680        690        700
ASKNWKLSIR CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE 
       710        720        730        740        750
HKKKNPDASV KFSEFLKKCS ETWKTIFAKE KGKFEDMAKA DKAHYEREMK 
       760        770        780        790        800
TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC SEYRPKIKGE HPGLSIDDVV 
       810        820        830        840        850
KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG KPNSAKKRVV 
       860        870 
KAEKSKKKKE EEEDEEDEQE EENEEDDDK
Length:879
Mass (Da):100,417
Last modified:April 27, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA55547DE21B2A10
GO
Isoform Sp100-A (identifier: P23497-2) [UniParc]FASTAAdd to basket
Also known as: SP100A, SP100

The sequence of this isoform differs from the canonical sequence as follows:
     478-480: SQP → KED
     481-879: Missing.

Note: Major isoform.Curated
Show »
Length:480
Mass (Da):53,768
Checksum:i10351A33BF3A4C12
GO
Isoform Sp100-B (identifier: P23497-3) [UniParc]FASTAAdd to basket
Also known as: SP100B, SpAlt-212

The sequence of this isoform differs from the canonical sequence as follows:
     685-688: RILE → VMIK
     689-879: Missing.

Show »
Length:688
Mass (Da):78,174
Checksum:iC0B470372DA75C96
GO
Isoform Sp100-C (identifier: P23497-4) [UniParc]FASTAAdd to basket
Also known as: SP100C

The sequence of this isoform differs from the canonical sequence as follows:
     699-879: EEHKKKNPDA...EEENEEDDDK → PENSNICEVC...ETSKNIIMFI

Show »
Length:885
Mass (Da):101,575
Checksum:i3D33A477B171D7DE
GO
Isoform SpAlt-C (identifier: P23497-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-472: RFSSSDFSDLSNGEELQETCSSSL → LKKKKKKKQCHPQPQPQRGLLEQS
     473-879: Missing.

Show »
Length:472
Mass (Da):53,113
Checksum:i3FD218C65A00100D
GO
Isoform 6 (identifier: P23497-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-35: Missing.
     428-430: Missing.
     478-480: SQP → KED
     481-879: Missing.

Show »
Length:452
Mass (Da):50,590
Checksum:iC957A23305439EE8
GO
Isoform 7 (identifier: P23497-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQR → M
     478-480: SQP → KED
     481-879: Missing.

Show »
Length:445
Mass (Da):50,032
Checksum:i05DF245B919FAA1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHV6E9PHV6_HUMAN
Nuclear autoantigen Sp-100
SP100
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4R8H0Y4R8_HUMAN
Nuclear autoantigen Sp-100
SP100
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBL0C9JBL0_HUMAN
Nuclear autoantigen Sp-100
SP100
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4B4H7C4B4_HUMAN
Nuclear autoantigen Sp-100
SP100
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1G8H7C1G8_HUMAN
Nuclear autoantigen Sp-100
SP100
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47R → M in BAG56886 (PubMed:14702039).Curated1
Sequence conflicti247S → P in BAG56886 (PubMed:14702039).Curated1
Sequence conflicti402Q → H in BAG56886 (PubMed:14702039).Curated1
Sequence conflicti651A → R in AAL77438 (PubMed:9973607).Curated1
Sequence conflicti651A → R in AAL77439 (PubMed:9973607).Curated1
Isoform Sp100-B (identifier: P23497-3)
Sequence conflicti686M → T in AAC50743 (PubMed:8695863).Curated1
Isoform Sp100-C (identifier: P23497-4)
Sequence conflicti826M → T in AAK51202 (PubMed:11313457).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_005621433M → V. Corresponds to variant dbSNP:rs12724Ensembl.1
Natural variantiVAR_005622471S → P. 1
Natural variantiVAR_034510699E → G. Corresponds to variant dbSNP:rs34700604Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0458681 – 36MAGGG…HDLQR → M in isoform 7. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_04586911 – 35Missing in isoform 6. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_045870428 – 430Missing in isoform 6. 1 Publication3
Alternative sequenceiVSP_005982449 – 472RFSSS…CSSSL → LKKKKKKKQCHPQPQPQRGL LEQS in isoform SpAlt-C. CuratedAdd BLAST24
Alternative sequenceiVSP_005983473 – 879Missing in isoform SpAlt-C. CuratedAdd BLAST407
Alternative sequenceiVSP_005978478 – 480SQP → KED in isoform Sp100-A, isoform 6 and isoform 7. 3 Publications3
Alternative sequenceiVSP_005979481 – 879Missing in isoform Sp100-A, isoform 6 and isoform 7. 3 PublicationsAdd BLAST399
Alternative sequenceiVSP_005980685 – 688RILE → VMIK in isoform Sp100-B. 1 Publication4
Alternative sequenceiVSP_005981689 – 879Missing in isoform Sp100-B. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_005984699 – 879EEHKK…EDDDK → PENSNICEVCNKWGRLFCCD TCPRSFHEHCHIPSVEANKN PWSCIFCRIKTIQERCPESQ SGHQESEVLMRQMLPEEQLK CEFLLLKVYCDSKSCFFASE PYYNREGSQGPQKPMWLNKV KTSLNEQMYTRVEGFVQDMR LIFHNHKEFYREDKFTRLGI QVQDIFEKNFRNIFAIQETS KNIIMFI in isoform Sp100-C. 1 PublicationAdd BLAST181

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M60618 mRNA Translation: AAA35537.1
U36501 mRNA Translation: AAC50743.1
AF056322 mRNA Translation: AAC39790.1
AF255565 mRNA Translation: AAK51202.1
AK293373 mRNA Translation: BAG56886.1
AC009949 Genomic DNA No translation available.
AC010149 Genomic DNA No translation available.
BC011562 mRNA Translation: AAH11562.1
X95472 Genomic DNA Translation: CAA64744.1
L79986 mRNA Translation: AAL77441.1
L79987 mRNA Translation: AAL77439.1
L79988 mRNA Translation: AAL77438.1
AF076675 Genomic DNA Translation: AAF39781.1
AF378670 Genomic DNA Translation: AAK57703.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2477.1 [P23497-1]
CCDS42832.1 [P23497-4]
CCDS56170.1 [P23497-3]
CCDS56171.1 [P23497-2]
CCDS56172.1 [P23497-6]
CCDS56173.1 [P23497-7]

Protein sequence database of the Protein Information Resource

More...PIRi		A37244

NCBI Reference Sequences

More...RefSeqi		NP_001073860.1, NM_001080391.1 [P23497-4]
NP_001193630.1, NM_001206701.1 [P23497-3]
NP_001193631.1, NM_001206702.1 [P23497-2]
NP_001193632.1, NM_001206703.1 [P23497-6]
NP_001193633.1, NM_001206704.1 [P23497-7]
NP_003104.2, NM_003113.3 [P23497-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264052; ENSP00000264052; ENSG00000067066 [P23497-1]
ENST00000340126; ENSP00000343023; ENSG00000067066 [P23497-4]
ENST00000409112; ENSP00000386427; ENSG00000067066 [P23497-3]
ENST00000409341; ENSP00000386404; ENSG00000067066 [P23497-2]
ENST00000409897; ENSP00000386998; ENSG00000067066 [P23497-7]
ENST00000427101; ENSP00000399389; ENSG00000067066 [P23497-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6672

UCSC genome browser

More...UCSCi		uc002vqq.3, human [P23497-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60618 mRNA Translation: AAA35537.1
U36501 mRNA Translation: AAC50743.1
AF056322 mRNA Translation: AAC39790.1
AF255565 mRNA Translation: AAK51202.1
AK293373 mRNA Translation: BAG56886.1
AC009949 Genomic DNA No translation available.
AC010149 Genomic DNA No translation available.
BC011562 mRNA Translation: AAH11562.1
X95472 Genomic DNA Translation: CAA64744.1
L79986 mRNA Translation: AAL77441.1
L79987 mRNA Translation: AAL77439.1
L79988 mRNA Translation: AAL77438.1
AF076675 Genomic DNA Translation: AAF39781.1
AF378670 Genomic DNA Translation: AAK57703.1
CCDSiCCDS2477.1 [P23497-1]
CCDS42832.1 [P23497-4]
CCDS56170.1 [P23497-3]
CCDS56171.1 [P23497-2]
CCDS56172.1 [P23497-6]
CCDS56173.1 [P23497-7]
PIRiA37244
RefSeqiNP_001073860.1, NM_001080391.1 [P23497-4]
NP_001193630.1, NM_001206701.1 [P23497-3]
NP_001193631.1, NM_001206702.1 [P23497-2]
NP_001193632.1, NM_001206703.1 [P23497-6]
NP_001193633.1, NM_001206704.1 [P23497-7]
NP_003104.2, NM_003113.3 [P23497-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H5PNMR-A595-688[»]
4PTBX-ray1.60A/B466-508[»]
5FB0X-ray2.70A/C696-878[»]
5FB1X-ray2.10A696-875[»]
5PWEX-ray1.69A/B466-508[»]
5PWFX-ray1.48A/B466-508[»]
5PWGX-ray1.46A/B466-508[»]
5PWHX-ray1.50A/B466-508[»]
5PWIX-ray1.62A/B466-508[»]
5PWJX-ray1.89A/B466-508[»]
5PWKX-ray1.62A/B466-508[»]
5PWLX-ray1.83A/B466-508[»]
5PWMX-ray1.54A/B466-508[»]
5PWNX-ray1.64A/B466-508[»]
5PWOX-ray1.85A/B466-508[»]
5PWPX-ray1.51A/B466-508[»]
5PWQX-ray1.52A/B466-508[»]
5PWRX-ray1.46A/B466-508[»]
5PWSX-ray1.40A/B466-508[»]
5PWTX-ray1.58A/B466-508[»]
5PWUX-ray1.44A/B466-508[»]
5PWVX-ray1.58A/B466-508[»]
5PWWX-ray1.59A/B466-508[»]
5PWXX-ray1.69A/B466-508[»]
5PWYX-ray1.98A/B466-508[»]
5PWZX-ray1.62A/B466-508[»]
5PX0X-ray1.55A/B466-508[»]
5PX1X-ray1.55A/B466-508[»]
5PX2X-ray1.43A/B466-508[»]
5PX3X-ray1.57A/B466-508[»]
5PX4X-ray1.45A/B466-508[»]
5PX5X-ray1.74A/B466-508[»]
5PX6X-ray1.43A/B466-508[»]
5PX7X-ray1.74A/B466-508[»]
5PX8X-ray1.71A/B466-508[»]
5PX9X-ray1.89A/B466-508[»]
5PXAX-ray1.43A/B466-508[»]
5PXBX-ray1.46A/B466-508[»]
5PXCX-ray1.52A/B466-508[»]
5PXDX-ray1.64A/B466-508[»]
5PXEX-ray1.55A/B466-508[»]
5PXFX-ray1.71A/B466-508[»]
5PXGX-ray1.98A/B466-508[»]
5PXHX-ray2.25A/B466-508[»]
5PXIX-ray1.76A/B466-508[»]
5PXJX-ray1.68A/B466-508[»]
5PXKX-ray1.98A/B466-508[»]
5PXLX-ray1.35A/B466-508[»]
5PXMX-ray1.59A/B466-508[»]
5PXNX-ray1.43A/B466-508[»]
5PXOX-ray1.78A/B466-508[»]
5PXPX-ray1.86A/B466-508[»]
5PXQX-ray1.62A/B466-508[»]
5PXRX-ray1.81A/B466-508[»]
5PXSX-ray1.49A/B466-508[»]
5PXTX-ray1.40A/B466-508[»]
5PXUX-ray1.76A/B466-508[»]
5PXVX-ray1.65A/B466-508[»]
5PXWX-ray2.01A/B466-508[»]
5PXXX-ray1.57A/B466-508[»]
5PXYX-ray2.14A/B466-508[»]
5PXZX-ray1.65A/B466-508[»]
5PY0X-ray1.70A/B466-508[»]
5PY1X-ray1.74A/B466-508[»]
5PY2X-ray1.62A/B466-508[»]
5PY3X-ray1.78A/B466-508[»]
5PY4X-ray1.67A/B466-508[»]
5PY5X-ray1.44A/B466-508[»]
5PY6X-ray1.74A/B466-508[»]
5PY7X-ray1.68A/B466-508[»]
5PY8X-ray1.66A/B466-508[»]
5PY9X-ray1.73A/B466-508[»]
5PYAX-ray1.55A/B466-508[»]
5PYBX-ray1.74A/B466-508[»]
5PYCX-ray1.87A/B466-508[»]
5PYDX-ray2.02A/B466-508[»]
5PYEX-ray1.81A/B466-508[»]
5PYFX-ray1.83A/B466-508[»]
5PYGX-ray1.95A/B466-508[»]
5PYHX-ray1.74A/B466-508[»]
5PYIX-ray2.29A/B466-508[»]
5PYJX-ray1.97A/B466-508[»]
5PYKX-ray1.88A/B466-508[»]
5PYLX-ray1.53A/B466-508[»]
5PYMX-ray1.70A/B466-508[»]
5PYNX-ray1.89A/B466-508[»]
5PYOX-ray1.67A/B466-508[»]
5PYPX-ray1.63A/B466-508[»]
5PYQX-ray1.97A/B466-508[»]
5PYRX-ray1.94A/B466-508[»]
5PYSX-ray2.09A/B466-508[»]
5PYTX-ray2.13A/B466-508[»]
5PYUX-ray1.74A/B466-508[»]
5PYVX-ray1.94A/B466-508[»]
5PYWX-ray1.45A/B466-508[»]
5PYXX-ray1.57A/B466-508[»]
5PYYX-ray1.64A/B466-508[»]
5PYZX-ray1.59A/B466-508[»]
5PZ0X-ray2.13A/B466-508[»]
5PZ1X-ray2.13A/B466-508[»]
5PZ2X-ray1.88A/B466-508[»]
5PZ3X-ray1.93A/B466-508[»]
5PZ4X-ray1.94A/B466-508[»]
5PZ5X-ray2.64A/B466-508[»]
5PZ6X-ray1.87A/B466-508[»]
5PZ7X-ray1.54A/B466-508[»]
5PZ8X-ray1.52A/B466-508[»]
5PZ9X-ray2.01A/B466-508[»]
5PZAX-ray1.59A/B466-508[»]
5PZBX-ray2.05A/B466-508[»]
5PZCX-ray1.61A/B466-508[»]
5PZDX-ray1.74A/B466-508[»]
5PZEX-ray1.82A/B466-508[»]
5PZFX-ray1.84A/B466-508[»]
5PZGX-ray1.88A/B466-508[»]
5PZHX-ray1.63A/B466-508[»]
5PZIX-ray1.62A/B466-508[»]
5PZJX-ray1.72A/B466-508[»]
6G5NX-ray1.76A/B466-508[»]
6G5PX-ray1.35A/B466-508[»]
SMRiP23497
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112555, 67 interactors
DIPiDIP-5983N
IntActiP23497, 43 interactors
MINTiP23497
STRINGi9606.ENSP00000343023

PTM databases

GlyGeniP23497, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP23497
PhosphoSitePlusiP23497

Polymorphism and mutation databases

BioMutaiSP100
DMDMi13878931

Proteomic databases

EPDiP23497
jPOSTiP23497
MassIVEiP23497
MaxQBiP23497
PaxDbiP23497
PeptideAtlasiP23497
PRIDEiP23497
ProteomicsDBi18390
32155
54115 [P23497-1]
54116 [P23497-2]
54117 [P23497-3]
54118 [P23497-4]
54119 [P23497-5]
7363

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20190, 301 antibodies

Genome annotation databases

EnsembliENST00000264052; ENSP00000264052; ENSG00000067066 [P23497-1]
ENST00000340126; ENSP00000343023; ENSG00000067066 [P23497-4]
ENST00000409112; ENSP00000386427; ENSG00000067066 [P23497-3]
ENST00000409341; ENSP00000386404; ENSG00000067066 [P23497-2]
ENST00000409897; ENSP00000386998; ENSG00000067066 [P23497-7]
ENST00000427101; ENSP00000399389; ENSG00000067066 [P23497-6]
GeneIDi6672
KEGGihsa:6672
UCSCiuc002vqq.3, human [P23497-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6672
DisGeNETi6672
EuPathDBiHostDB:ENSG00000067066.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SP100
HGNCiHGNC:11206, SP100
HPAiENSG00000067066, Low tissue specificity
MIMi604585, gene
neXtProtiNX_P23497
OpenTargetsiENSG00000067066
PharmGKBiPA36043

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000162212
HOGENOMiCLU_015844_0_0_1
InParanoidiP23497
KOiK15413
OMAiAGMWNNT
PhylomeDBiP23497
TreeFamiTF335091

Enzyme and pathway databases

PathwayCommonsiP23497
ReactomeiR-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-877300, Interferon gamma signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6672, 1 hit in 895 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SP100, human
EvolutionaryTraceiP23497

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6672
PharosiP23497, Tbio

Protein Ontology

More...PROi		PR:P23497
RNActiP23497, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000067066, Expressed in small intestine Peyer's patch and 230 other tissues
ExpressionAtlasiP23497, baseline and differential
GenevisibleiP23497, HS

Family and domain databases

Gene3Di1.10.30.10, 2 hits
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR004865, HSR_dom
IPR010919, SAND-like_dom_sf
IPR000770, SAND_dom
IPR043563, Sp110/Sp140/Sp140L
PANTHERiPTHR46386, PTHR46386, 1 hit
PfamiView protein in Pfam
PF00505, HMG_box, 1 hit
PF09011, HMG_box_2, 1 hit
PF03172, HSR, 1 hit
PF01342, SAND, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 2 hits
SM00258, SAND, 1 hit
SUPFAMiSSF47095, SSF47095, 2 hits
SSF63763, SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 2 hits
PS51414, HSR, 1 hit
PS50864, SAND, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSP100_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23497
Secondary accession number(s): B4DDX5
, B8ZZD8, E7EUA7, E9PH61, F8WFE2, O75450, Q13343, Q8TE34, Q96F70, Q96T24, Q96T95, Q9NP33, Q9UE32
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 27, 2001
Last modified: October 7, 2020
This is version 228 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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