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Protein

Nuclear autoantigen Sp-100

Gene

SP100

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.9 Publications

Miscellaneous

The major isoform Sp100-A, has a calculated molecular weight of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent molecular weight of 100 kDa.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi677 – 753HMG box 1PROSITE-ProRule annotationAdd BLAST77
DNA bindingi769 – 837HMG box 2PROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear autoantigen Sp-100
Alternative name(s):
Nuclear dot-associated Sp100 protein
Speckled 100 kDa
Gene namesi
Name:SP100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000067066.16
HGNCiHGNC:11206 SP100
MIMi604585 gene
neXtProtiNX_P23497

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi165R → A: Prevents CDC20-mediated degradation; when associated with Ala-168. 1 Publication1
Mutagenesisi168L → A: Prevents CDC20-mediated degradation; when associated with Ala-165. 1 Publication1

Organism-specific databases

DisGeNETi6672
OpenTargetsiENSG00000067066
PharmGKBiPA36043

Polymorphism and mutation databases

BioMutaiSP100
DMDMi13878931

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000740962 – 879Nuclear autoantigen Sp-100Add BLAST878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Cross-linki241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki300Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki387Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei394PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Cross-linki594Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.
Sumoylated. Sumoylated with SUMO1. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylation may stabilize the interaction with CBX5.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP23497
MaxQBiP23497
PaxDbiP23497
PeptideAtlasiP23497
PRIDEiP23497
ProteomicsDBi54115
54116 [P23497-2]
54117 [P23497-3]
54118 [P23497-4]
54119 [P23497-5]

PTM databases

iPTMnetiP23497
PhosphoSitePlusiP23497

Expressioni

Tissue specificityi

Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.

Inductioni

Up-regulated by interferon, retinoic acid, TNF-alpha/TNFA and lipopolysaccharide (at protein level). Up-regulated following heat-shock.3 Publications

Gene expression databases

BgeeiENSG00000067066 Expressed in 220 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SP100
ExpressionAtlasiP23497 baseline and differential
GenevisibleiP23497 HS

Organism-specific databases

HPAiHPA016707
HPA017384

Interactioni

Subunit structurei

Homodimer; isoforms are able to heterodimerize. Interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif. Interacts with ETS1; the interaction is direct and modulates ETS1 transcriptional activity. Interacts with the MRN complex which is composed of two heterodimers RAD50/MRE11 associated with a single NBN; recruits the complex to PML-related bodies. Interacts with HIPK2; positively regulates TP53-dependent transcription. Interacts with CASP8AP2; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm. Interacts with SUMO1P1/SUMO5 (PubMed:27211601).9 Publications
(Microbial infection) Interacts with Epstein-Barr virus EBNA-LP; this interaction is important for EBNA-LP coactivator activity.1 Publication
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123; may play a role in infection by the virus.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112555, 61 interactors
DIPiDIP-5983N
IntActiP23497, 39 interactors
MINTiP23497
STRINGi9606.ENSP00000343023

Structurei

Secondary structure

1879
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23497
SMRiP23497
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23497

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 149HSRPROSITE-ProRule annotationAdd BLAST117
Domaini595 – 676SANDPROSITE-ProRule annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni333 – 478Sufficient to mediate interaction with ETS1Add BLAST146

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 168D-box; recognition signal for CDC20-mediated degradation4
Motifi284 – 297PxVxL motifAdd BLAST14
Motifi536 – 553Nuclear localization signalSequence analysisAdd BLAST18
Motifi568 – 592Nuclear localization signalSequence analysisAdd BLAST25
Motifi717 – 734Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 6Poly-Gly4
Compositional biasi156 – 164Poly-Glu9
Compositional biasi759 – 764Poly-Lys6
Compositional biasi854 – 859Poly-Lys6
Compositional biasi860 – 868Poly-Glu9

Domaini

The HSR domain is important for the nuclear body targeting as well as for the dimerization.1 Publication
Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00510000046835
HOGENOMiHOG000089984
HOVERGENiHBG057632
InParanoidiP23497
KOiK15413
OMAiAGRETPC
OrthoDBiEOG091G01MN
PhylomeDBiP23497
TreeFamiTF335091

Family and domain databases

Gene3Di1.10.30.10, 2 hits
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR004865 HSR_dom
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF09011 HMG_box_2, 1 hit
PF03172 HSR, 1 hit
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SM00258 SAND, 1 hit
SUPFAMiSSF47095 SSF47095, 2 hits
SSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 2 hits
PS51414 HSR, 1 hit
PS50864 SAND, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Sp100-HMG (identifier: P23497-1) [UniParc]FASTAAdd to basket
Also known as: SP100HMG, SpAlt-HMG

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY
60 70 80 90 100
DIVFKHFKRN KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV
110 120 130 140 150
PVQRVVYNVL SELEKTFNLP VLEALFSDVN MQEYPDLIHI YKGFENVIHD
160 170 180 190 200
KLPLQESEEE EREERSGLQL SLEQGTGENS FRSLTWPPSG SPSHAGTTPP
210 220 230 240 250
ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ KAEPTESCEQ
260 270 280 290 300
IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK
310 320 330 340 350
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS
360 370 380 390 400
EPVINNDNPL ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI
410 420 430 440 450
GQDHDFSESS EEEAPAEASS GALRSKHGEK APMTSRSTST WRIPSRKRRF
460 470 480 490 500
SSSDFSDLSN GEELQETCSS SLRRGSGSQP QEPENKKCSC VMCFPKGVPR
510 520 530 540 550
SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR SKVNGLQRGR
560 570 580 590 600
KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF
610 620 630 640 650
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG
660 670 680 690 700
ASKNWKLSIR CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE
710 720 730 740 750
HKKKNPDASV KFSEFLKKCS ETWKTIFAKE KGKFEDMAKA DKAHYEREMK
760 770 780 790 800
TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC SEYRPKIKGE HPGLSIDDVV
810 820 830 840 850
KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG KPNSAKKRVV
860 870
KAEKSKKKKE EEEDEEDEQE EENEEDDDK
Length:879
Mass (Da):100,417
Last modified:April 27, 2001 - v3
Checksum:iCA55547DE21B2A10
GO
Isoform Sp100-A (identifier: P23497-2) [UniParc]FASTAAdd to basket
Also known as: SP100A, SP100

The sequence of this isoform differs from the canonical sequence as follows:
     478-480: SQP → KED
     481-879: Missing.

Note: Major isoform.
Show »
Length:480
Mass (Da):53,768
Checksum:i10351A33BF3A4C12
GO
Isoform Sp100-B (identifier: P23497-3) [UniParc]FASTAAdd to basket
Also known as: SP100B, SpAlt-212

The sequence of this isoform differs from the canonical sequence as follows:
     685-688: RILE → VMIK
     689-879: Missing.

Show »
Length:688
Mass (Da):78,174
Checksum:iC0B470372DA75C96
GO
Isoform Sp100-C (identifier: P23497-4) [UniParc]FASTAAdd to basket
Also known as: SP100C

The sequence of this isoform differs from the canonical sequence as follows:
     699-879: EEHKKKNPDA...EEENEEDDDK → PENSNICEVC...ETSKNIIMFI

Show »
Length:885
Mass (Da):101,575
Checksum:i3D33A477B171D7DE
GO
Isoform SpAlt-C (identifier: P23497-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-472: RFSSSDFSDLSNGEELQETCSSSL → LKKKKKKKQCHPQPQPQRGLLEQS
     473-879: Missing.

Show »
Length:472
Mass (Da):53,113
Checksum:i3FD218C65A00100D
GO
Isoform 6 (identifier: P23497-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-35: Missing.
     428-430: Missing.
     478-480: SQP → KED
     481-879: Missing.

Note: No experimental confirmation available.
Show »
Length:452
Mass (Da):50,590
Checksum:iC957A23305439EE8
GO
Isoform 7 (identifier: P23497-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQR → M
     478-480: SQP → KED
     481-879: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):50,032
Checksum:i05DF245B919FAA1B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHV6E9PHV6_HUMAN
Nuclear autoantigen Sp-100
SP100
455Annotation score:
H0Y4R8H0Y4R8_HUMAN
Nuclear autoantigen Sp-100
SP100
259Annotation score:
C9JBL0C9JBL0_HUMAN
Nuclear autoantigen Sp-100
SP100
192Annotation score:
H7C4B4H7C4B4_HUMAN
Nuclear autoantigen Sp-100
SP100
193Annotation score:
H7C1G8H7C1G8_HUMAN
Nuclear autoantigen Sp-100
SP100
126Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47R → M in BAG56886 (PubMed:14702039).Curated1
Sequence conflicti247S → P in BAG56886 (PubMed:14702039).Curated1
Sequence conflicti402Q → H in BAG56886 (PubMed:14702039).Curated1
Sequence conflicti651A → R in AAL77438 (PubMed:9973607).Curated1
Sequence conflicti651A → R in AAL77439 (PubMed:9973607).Curated1
Isoform Sp100-B (identifier: P23497-3)
Sequence conflicti686M → T in AAC50743 (PubMed:8695863).Curated1
Isoform Sp100-C (identifier: P23497-4)
Sequence conflicti826M → T in AAK51202 (PubMed:11313457).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_005621433M → V. Corresponds to variant dbSNP:rs12724Ensembl.1
Natural variantiVAR_005622471S → P. 1
Natural variantiVAR_034510699E → G. Corresponds to variant dbSNP:rs34700604Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0458681 – 36MAGGG…HDLQR → M in isoform 7. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_04586911 – 35Missing in isoform 6. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_045870428 – 430Missing in isoform 6. 1 Publication3
Alternative sequenceiVSP_005982449 – 472RFSSS…CSSSL → LKKKKKKKQCHPQPQPQRGL LEQS in isoform SpAlt-C. CuratedAdd BLAST24
Alternative sequenceiVSP_005983473 – 879Missing in isoform SpAlt-C. CuratedAdd BLAST407
Alternative sequenceiVSP_005978478 – 480SQP → KED in isoform Sp100-A, isoform 6 and isoform 7. 3 Publications3
Alternative sequenceiVSP_005979481 – 879Missing in isoform Sp100-A, isoform 6 and isoform 7. 3 PublicationsAdd BLAST399
Alternative sequenceiVSP_005980685 – 688RILE → VMIK in isoform Sp100-B. 1 Publication4
Alternative sequenceiVSP_005981689 – 879Missing in isoform Sp100-B. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_005984699 – 879EEHKK…EDDDK → PENSNICEVCNKWGRLFCCD TCPRSFHEHCHIPSVEANKN PWSCIFCRIKTIQERCPESQ SGHQESEVLMRQMLPEEQLK CEFLLLKVYCDSKSCFFASE PYYNREGSQGPQKPMWLNKV KTSLNEQMYTRVEGFVQDMR LIFHNHKEFYREDKFTRLGI QVQDIFEKNFRNIFAIQETS KNIIMFI in isoform Sp100-C. 1 PublicationAdd BLAST181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60618 mRNA Translation: AAA35537.1
U36501 mRNA Translation: AAC50743.1
AF056322 mRNA Translation: AAC39790.1
AF255565 mRNA Translation: AAK51202.1
AK293373 mRNA Translation: BAG56886.1
AC009949 Genomic DNA No translation available.
AC010149 Genomic DNA No translation available.
BC011562 mRNA Translation: AAH11562.1
X95472 Genomic DNA Translation: CAA64744.1
L79986 mRNA Translation: AAL77441.1
L79987 mRNA Translation: AAL77439.1
L79988 mRNA Translation: AAL77438.1
AF076675 Genomic DNA Translation: AAF39781.1
AF378670 Genomic DNA Translation: AAK57703.1
CCDSiCCDS2477.1 [P23497-1]
CCDS42832.1 [P23497-4]
CCDS56170.1 [P23497-3]
CCDS56171.1 [P23497-2]
CCDS56172.1 [P23497-6]
CCDS56173.1 [P23497-7]
PIRiA37244
RefSeqiNP_001073860.1, NM_001080391.1 [P23497-4]
NP_001193630.1, NM_001206701.1 [P23497-3]
NP_001193631.1, NM_001206702.1 [P23497-2]
NP_001193632.1, NM_001206703.1 [P23497-6]
NP_001193633.1, NM_001206704.1 [P23497-7]
NP_003104.2, NM_003113.3 [P23497-1]
UniGeneiHs.369056

Genome annotation databases

EnsembliENST00000264052; ENSP00000264052; ENSG00000067066 [P23497-1]
ENST00000340126; ENSP00000343023; ENSG00000067066 [P23497-4]
ENST00000409112; ENSP00000386427; ENSG00000067066 [P23497-3]
ENST00000409341; ENSP00000386404; ENSG00000067066 [P23497-2]
ENST00000409897; ENSP00000386998; ENSG00000067066 [P23497-7]
ENST00000427101; ENSP00000399389; ENSG00000067066 [P23497-6]
GeneIDi6672
KEGGihsa:6672
UCSCiuc002vqq.3 human [P23497-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60618 mRNA Translation: AAA35537.1
U36501 mRNA Translation: AAC50743.1
AF056322 mRNA Translation: AAC39790.1
AF255565 mRNA Translation: AAK51202.1
AK293373 mRNA Translation: BAG56886.1
AC009949 Genomic DNA No translation available.
AC010149 Genomic DNA No translation available.
BC011562 mRNA Translation: AAH11562.1
X95472 Genomic DNA Translation: CAA64744.1
L79986 mRNA Translation: AAL77441.1
L79987 mRNA Translation: AAL77439.1
L79988 mRNA Translation: AAL77438.1
AF076675 Genomic DNA Translation: AAF39781.1
AF378670 Genomic DNA Translation: AAK57703.1
CCDSiCCDS2477.1 [P23497-1]
CCDS42832.1 [P23497-4]
CCDS56170.1 [P23497-3]
CCDS56171.1 [P23497-2]
CCDS56172.1 [P23497-6]
CCDS56173.1 [P23497-7]
PIRiA37244
RefSeqiNP_001073860.1, NM_001080391.1 [P23497-4]
NP_001193630.1, NM_001206701.1 [P23497-3]
NP_001193631.1, NM_001206702.1 [P23497-2]
NP_001193632.1, NM_001206703.1 [P23497-6]
NP_001193633.1, NM_001206704.1 [P23497-7]
NP_003104.2, NM_003113.3 [P23497-1]
UniGeneiHs.369056

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H5PNMR-A595-688[»]
4PTBX-ray1.60A/B466-508[»]
5FB0X-ray2.70A/C696-878[»]
5FB1X-ray2.10A696-875[»]
5PWEX-ray1.69A/B466-508[»]
5PWFX-ray1.48A/B466-508[»]
5PWGX-ray1.46A/B466-508[»]
5PWHX-ray1.50A/B466-508[»]
5PWIX-ray1.62A/B466-508[»]
5PWJX-ray1.89A/B466-508[»]
5PWKX-ray1.62A/B466-508[»]
5PWLX-ray1.83A/B466-508[»]
5PWMX-ray1.54A/B466-508[»]
5PWNX-ray1.64A/B466-508[»]
5PWOX-ray1.85A/B466-508[»]
5PWPX-ray1.51A/B466-508[»]
5PWQX-ray1.52A/B466-508[»]
5PWRX-ray1.46A/B466-508[»]
5PWSX-ray1.40A/B466-508[»]
5PWTX-ray1.58A/B466-508[»]
5PWUX-ray1.44A/B466-508[»]
5PWVX-ray1.58A/B466-508[»]
5PWWX-ray1.59A/B466-508[»]
5PWXX-ray1.69A/B466-508[»]
5PWYX-ray1.98A/B466-508[»]
5PWZX-ray1.62A/B466-508[»]
5PX0X-ray1.55A/B466-508[»]
5PX1X-ray1.55A/B466-508[»]
5PX2X-ray1.43A/B466-508[»]
5PX3X-ray1.57A/B466-508[»]
5PX4X-ray1.45A/B466-508[»]
5PX5X-ray1.74A/B466-508[»]
5PX6X-ray1.43A/B466-508[»]
5PX7X-ray1.74A/B466-508[»]
5PX8X-ray1.71A/B466-508[»]
5PX9X-ray1.89A/B466-508[»]
5PXAX-ray1.43A/B466-508[»]
5PXBX-ray1.46A/B466-508[»]
5PXCX-ray1.52A/B466-508[»]
5PXDX-ray1.64A/B466-508[»]
5PXEX-ray1.55A/B466-508[»]
5PXFX-ray1.71A/B466-508[»]
5PXGX-ray1.98A/B466-508[»]
5PXHX-ray2.25A/B466-508[»]
5PXIX-ray1.76A/B466-508[»]
5PXJX-ray1.68A/B466-508[»]
5PXKX-ray1.98A/B466-508[»]
5PXLX-ray1.35A/B466-508[»]
5PXMX-ray1.59A/B466-508[»]
5PXNX-ray1.43A/B466-508[»]
5PXOX-ray1.78A/B466-508[»]
5PXPX-ray1.86A/B466-508[»]
5PXQX-ray1.62A/B466-508[»]
5PXRX-ray1.81A/B466-508[»]
5PXSX-ray1.49A/B466-508[»]
5PXTX-ray1.40A/B466-508[»]
5PXUX-ray1.76A/B466-508[»]
5PXVX-ray1.65A/B466-508[»]
5PXWX-ray2.01A/B466-508[»]
5PXXX-ray1.57A/B466-508[»]
5PXYX-ray2.14A/B466-508[»]
5PXZX-ray1.65A/B466-508[»]
5PY0X-ray1.70A/B466-508[»]
5PY1X-ray1.74A/B466-508[»]
5PY2X-ray1.62A/B466-508[»]
5PY3X-ray1.78A/B466-508[»]
5PY4X-ray1.67A/B466-508[»]
5PY5X-ray1.44A/B466-508[»]
5PY6X-ray1.74A/B466-508[»]
5PY7X-ray1.68A/B466-508[»]
5PY8X-ray1.66A/B466-508[»]
5PY9X-ray1.73A/B466-508[»]
5PYAX-ray1.55A/B466-508[»]
5PYBX-ray1.74A/B466-508[»]
5PYCX-ray1.87A/B466-508[»]
5PYDX-ray2.02A/B466-508[»]
5PYEX-ray1.81A/B466-508[»]
5PYFX-ray1.83A/B466-508[»]
5PYGX-ray1.95A/B466-508[»]
5PYHX-ray1.74A/B466-508[»]
5PYIX-ray2.29A/B466-508[»]
5PYJX-ray1.97A/B466-508[»]
5PYKX-ray1.88A/B466-508[»]
5PYLX-ray1.53A/B466-508[»]
5PYMX-ray1.70A/B466-508[»]
5PYNX-ray1.89A/B466-508[»]
5PYOX-ray1.67A/B466-508[»]
5PYPX-ray1.63A/B466-508[»]
5PYQX-ray1.97A/B466-508[»]
5PYRX-ray1.94A/B466-508[»]
5PYSX-ray2.09A/B466-508[»]
5PYTX-ray2.13A/B466-508[»]
5PYUX-ray1.74A/B466-508[»]
5PYVX-ray1.94A/B466-508[»]
5PYWX-ray1.45A/B466-508[»]
5PYXX-ray1.57A/B466-508[»]
5PYYX-ray1.64A/B466-508[»]
5PYZX-ray1.59A/B466-508[»]
5PZ0X-ray2.13A/B466-508[»]
5PZ1X-ray2.13A/B466-508[»]
5PZ2X-ray1.88A/B466-508[»]
5PZ3X-ray1.93A/B466-508[»]
5PZ4X-ray1.94A/B466-508[»]
5PZ5X-ray2.64A/B466-508[»]
5PZ6X-ray1.87A/B466-508[»]
5PZ7X-ray1.54A/B466-508[»]
5PZ8X-ray1.52A/B466-508[»]
5PZ9X-ray2.01A/B466-508[»]
5PZAX-ray1.59A/B466-508[»]
5PZBX-ray2.05A/B466-508[»]
5PZCX-ray1.61A/B466-508[»]
5PZDX-ray1.74A/B466-508[»]
5PZEX-ray1.82A/B466-508[»]
5PZFX-ray1.84A/B466-508[»]
5PZGX-ray1.88A/B466-508[»]
5PZHX-ray1.63A/B466-508[»]
5PZIX-ray1.62A/B466-508[»]
5PZJX-ray1.72A/B466-508[»]
6G5NX-ray1.76A/B466-508[»]
6G5PX-ray1.35A/B466-508[»]
ProteinModelPortaliP23497
SMRiP23497
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112555, 61 interactors
DIPiDIP-5983N
IntActiP23497, 39 interactors
MINTiP23497
STRINGi9606.ENSP00000343023

PTM databases

iPTMnetiP23497
PhosphoSitePlusiP23497

Polymorphism and mutation databases

BioMutaiSP100
DMDMi13878931

Proteomic databases

EPDiP23497
MaxQBiP23497
PaxDbiP23497
PeptideAtlasiP23497
PRIDEiP23497
ProteomicsDBi54115
54116 [P23497-2]
54117 [P23497-3]
54118 [P23497-4]
54119 [P23497-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264052; ENSP00000264052; ENSG00000067066 [P23497-1]
ENST00000340126; ENSP00000343023; ENSG00000067066 [P23497-4]
ENST00000409112; ENSP00000386427; ENSG00000067066 [P23497-3]
ENST00000409341; ENSP00000386404; ENSG00000067066 [P23497-2]
ENST00000409897; ENSP00000386998; ENSG00000067066 [P23497-7]
ENST00000427101; ENSP00000399389; ENSG00000067066 [P23497-6]
GeneIDi6672
KEGGihsa:6672
UCSCiuc002vqq.3 human [P23497-1]

Organism-specific databases

CTDi6672
DisGeNETi6672
EuPathDBiHostDB:ENSG00000067066.16
GeneCardsiSP100
HGNCiHGNC:11206 SP100
HPAiHPA016707
HPA017384
MIMi604585 gene
neXtProtiNX_P23497
OpenTargetsiENSG00000067066
PharmGKBiPA36043
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00510000046835
HOGENOMiHOG000089984
HOVERGENiHBG057632
InParanoidiP23497
KOiK15413
OMAiAGRETPC
OrthoDBiEOG091G01MN
PhylomeDBiP23497
TreeFamiTF335091

Enzyme and pathway databases

ReactomeiR-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSiSP100 human
EvolutionaryTraceiP23497
GenomeRNAii6672
PROiPR:P23497
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067066 Expressed in 220 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SP100
ExpressionAtlasiP23497 baseline and differential
GenevisibleiP23497 HS

Family and domain databases

Gene3Di1.10.30.10, 2 hits
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR004865 HSR_dom
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF09011 HMG_box_2, 1 hit
PF03172 HSR, 1 hit
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SM00258 SAND, 1 hit
SUPFAMiSSF47095 SSF47095, 2 hits
SSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 2 hits
PS51414 HSR, 1 hit
PS50864 SAND, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSP100_HUMAN
AccessioniPrimary (citable) accession number: P23497
Secondary accession number(s): B4DDX5
, B8ZZD8, E7EUA7, E9PH61, F8WFE2, O75450, Q13343, Q8TE34, Q96F70, Q96T24, Q96T95, Q9NP33, Q9UE32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 27, 2001
Last modified: October 10, 2018
This is version 213 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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