LOR

Functionⁱ

Major keratinocyte cell envelope protein.

GO - Molecular functionⁱ

protein binding, bridging
Source: UniProtKB
Inferred from direct assayⁱ
- 10908733
structural constituent of cytoskeleton
Source: ProtInc
Traceable author statementⁱ
- 2007607
structural constituent of epidermis
Source: CAFA
Inferred from direct assayⁱ
- 7543090
structural molecule activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10908733

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
keratinocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 10908733
peptide cross-linking
Source: UniProtKB
Inferred from direct assayⁱ
- 10908733

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Keratinization

Biological process

Keratinization

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6809371 Formation of the cornified envelope
SIGNORⁱ	P23490

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Loricrin
Gene namesⁱ	Name:LOR Synonyms:LRN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000203782.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6663 LOR
MIMⁱ	152445 gene
neXtProtⁱ	NX_P23490

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Vohwinkel syndrome with ichthyosis (VSI)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA variant form of Vohwinkel syndrome without hearing loss and associated with ichthyosiform dermatosis. Clinical features include palmoplantar keratoderma, pseudoainhum and ichthyosis. Compact hyperkeratosis with round retained nuclei and hypergranulosis is observed on skin biopsies.

Keywords - Diseaseⁱ

Ichthyosis, Palmoplantar keratoderma

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4014
MalaCards human disease database More...MalaCardsⁱ	LOR
MIMⁱ	604117 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000203782
Orphanetⁱ	79395 Keratoderma hereditarium mutilans with ichthyosis 316 Progressive symmetric erythrokeratodermia
PharmGKBⁱ	PA30426

Polymorphism and mutation databases

BioMutaⁱ	LOR
DMDMⁱ	215274015

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084458	1 – 312	LoricrinAdd BLAST		312

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	89	Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-154); alternate1 Publication
Cross-linkⁱ	89	Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-216); alternate1 Publication
Cross-linkⁱ	154	Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-89)1 Publication
Cross-linkⁱ	212	Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-312)1 Publication
Cross-linkⁱ	213	Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-312)1 Publication
Cross-linkⁱ	216	Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-89)1 Publication
Cross-linkⁱ	312	Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-212); alternate1 Publication
Cross-linkⁱ	312	Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-213); alternate1 Publication

Post-translational modificationⁱ

Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.

Contains inter- or intramolecular disulfide-bonds.Curated

Keywords - PTMⁱ

Disulfide bond, Isopeptide bond

Proteomic databases

PaxDbⁱ	P23490
PeptideAtlas More...PeptideAtlasⁱ	P23490
PRIDEⁱ	P23490
ProteomicsDBⁱ	54114

PTM databases

iPTMnetⁱ	P23490
PhosphoSitePlusⁱ	P23490

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000203782
CleanExⁱ	HS_LOR
Genevisibleⁱ	P23490 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA076123 HPA077266

HPAⁱ

HPA076123
HPA077266

Interactionⁱ

GO - Molecular functionⁱ

protein binding, bridging
Source: UniProtKB
Inferred from direct assayⁱ
- 10908733

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110198, 14 interactors
IntActⁱ	P23490, 2 interactors
STRINGⁱ	9606.ENSP00000357731

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23490
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Repeat

Phylogenomic databases

InParanoidⁱ	P23490
KEGG Orthology (KO) More...KOⁱ	K10385
OMAⁱ	SSGTVCY

Family and domain databases

InterProⁱ	View protein in InterPro IPR031700 Loricrin
PANTHERⁱ	PTHR39228 PTHR39228, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15847 Loricrin, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P23490-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSYQKKQPTP QPPVDCVKTS GGGGGGGGSG GGGCGFFGGG GSGGGSSGSG 
        60         70         80         90        100
CGYSGGGGYS GGGCGGGSSG GGGGGGIGGC GGGSGGSVKY SGGGGSSGGG 
       110        120        130        140        150
SGCFSSGGGG SGCFSSGGGG SSGGGSGCFS SGGGGSSGGG SGCFSSGGGG 
       160        170        180        190        200
FSGQAVQCQS YGGVSSGGSS GGGSGCFSSG GGGGSVCGYS GGGSGCGGGS 
       210        220        230        240        250
SGGSGSGYVS SQQVTQTSCA PQPSYGGGSS GGGGSGGSGC FSSGGGGGSS 
       260        270        280        290        300
GCGGGSSGIG SGCIISGGGS VCGGGSSGGG GGGSSVGGSG SGKGVPICHQ 
       310 
TQQKQAPTWP SK

Length:312

Mass (Da):25,761

Last modified:November 25, 2008 - v2

Checksum:ⁱA64248C3E4FD698E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	29	S → T in AAA36180 (PubMed:2007607).Curated	1
Sequence conflictⁱ	29	S → T in AAA36181 (PubMed:1355480).Curated	1
Sequence conflictⁱ	29	S → T in AAH34690 (PubMed:15489334).Curated	1
Sequence conflictⁱ	29	S → T in AAI08291 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047712	29	S → G1 PublicationCorresponds to variant dbSNP:rs6661601Ensembl.	1
Natural variantⁱVAR_065891	189	Y → YSGGG2 PublicationsCorresponds to variant dbSNP:rs11275959Ensembl.	1
Natural variantⁱVAR_061676	285	S → F. Corresponds to variant dbSNP:rs56816110Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M61120 mRNA Translation: AAA36180.1 M94077 Genomic DNA Translation: AAA36181.1 AL161636 Genomic DNA No translation available. BC034690 mRNA Translation: AAH34690.1 BC108290 mRNA Translation: AAI08291.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30870.1
PIRⁱ	A38743
NCBI Reference Sequences More...RefSeqⁱ	NP_000418.2, NM_000427.2
UniGeneⁱ	Hs.251680

Genome annotation databases

Ensemblⁱ	ENST00000368742; ENSP00000357731; ENSG00000203782
GeneIDⁱ	4014
KEGGⁱ	hsa:4014
UCSC genome browser More...UCSCⁱ	uc001fbm.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P23490	UPI0004F20A5C		PAPAN		338
Uncharacterized protein		CHLSB		324
Loricrin		MACMU		307
UPI00045DEE60		CHLSB		339
Uncharacterized protein		PAPAN		317

Protein	Similar proteins		Species	Score	Length
P23490	UPI0004F20A5C		PAPAN		338
Uncharacterized protein		CHLSB		324
Loricrin		MACMU		307
UPI000A1BE438		Odocoileus virginianus texanus		357
UPI000C2FDD7E		FELCA		339
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M61120 mRNA Translation: AAA36180.1 M94077 Genomic DNA Translation: AAA36181.1 AL161636 Genomic DNA No translation available. BC034690 mRNA Translation: AAH34690.1 BC108290 mRNA Translation: AAI08291.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30870.1
PIRⁱ	A38743
NCBI Reference Sequences More...RefSeqⁱ	NP_000418.2, NM_000427.2
UniGeneⁱ	Hs.251680

3D structure databases

ProteinModelPortalⁱ	P23490
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110198, 14 interactors
IntActⁱ	P23490, 2 interactors
STRINGⁱ	9606.ENSP00000357731

PTM databases

iPTMnetⁱ	P23490
PhosphoSitePlusⁱ	P23490

Polymorphism and mutation databases

BioMutaⁱ	LOR
DMDMⁱ	215274015

Proteomic databases

PaxDbⁱ	P23490
PeptideAtlas More...PeptideAtlasⁱ	P23490
PRIDEⁱ	P23490
ProteomicsDBⁱ	54114

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000368742; ENSP00000357731; ENSG00000203782
GeneIDⁱ	4014
KEGGⁱ	hsa:4014
UCSC genome browser More...UCSCⁱ	uc001fbm.4 human

Organism-specific databases

CTDⁱ	4014
DisGeNET More...DisGeNETⁱ	4014
EuPathDBⁱ	HostDB:ENSG00000203782.5
GeneCardsⁱ	LOR
H-InvDBⁱ	HIX0028739 HIX0160003
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6663 LOR
Human Protein Atlas More...HPAⁱ	HPA076123 HPA077266
MalaCards human disease database More...MalaCardsⁱ	LOR
MIMⁱ	152445 gene 604117 phenotype
neXtProtⁱ	NX_P23490
Open Targets More...OpenTargetsⁱ	ENSG00000203782
Orphanetⁱ	79395 Keratoderma hereditarium mutilans with ichthyosis 316 Progressive symmetric erythrokeratodermia
PharmGKBⁱ	PA30426
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

InParanoidⁱ	P23490
KEGG Orthology (KO) More...KOⁱ	K10385
OMAⁱ	SSGTVCY

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6809371 Formation of the cornified envelope
SIGNORⁱ	P23490

Miscellaneous databases

GeneWikiⁱ	Loricrin
GenomeRNAiⁱ	4014
Protein Ontology More...PROⁱ	PR:P23490
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000203782
CleanExⁱ	HS_LOR
Genevisibleⁱ	P23490 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031700 Loricrin
PANTHERⁱ	PTHR39228 PTHR39228, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15847 Loricrin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LORI_HUMAN
Accessionⁱ	P23490Primary (citable) accession number: P23490 Secondary accession number(s): Q5T869, Q5XKF8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	November 25, 2008
	Last modified:	June 20, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P23490 (LORI_HUMAN)

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Loricrin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ