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UniProtKB - P23490 (LORI_HUMAN)

Entry version 164 (29 Sep 2021)
Sequence version 2 (25 Nov 2008)
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Protein

Loricrin

Gene

LORICRIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major keratinocyte cell envelope protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
  • structural constituent of skin epidermis Source: CAFA
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23490

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6809371, Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

More...SIGNORi		P23490

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LoricrinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LORICRINImported
Synonyms:LOR, LRN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6663, LORICRIN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		152445, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23490

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000203782

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Vohwinkel syndrome with ichthyosis (VSI)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA variant form of Vohwinkel syndrome without hearing loss and associated with ichthyosiform dermatosis. Clinical features include palmoplantar keratoderma, pseudoainhum and ichthyosis. Compact hyperkeratosis with round retained nuclei and hypergranulosis is observed on skin biopsies.
Related information in OMIM

Keywords - Diseasei

Ichthyosis, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		4014

MalaCards human disease database

More...MalaCardsi		LORICRIN
MIMi604117, phenotype

Open Targets

More...OpenTargetsi		ENSG00000203782

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79395, Keratoderma hereditarium mutilans with ichthyosis
316, Progressive symmetric erythrokeratodermia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30426

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23490, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LOR

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844581 – 312LoricrinAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki89Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-154); alternate1 Publication
Cross-linki89Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-216); alternate1 Publication
Cross-linki154Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-89)1 Publication
Cross-linki212Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-312)1 Publication
Cross-linki213Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-312)1 Publication
Cross-linki216Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-89)1 Publication
Cross-linki312Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-212); alternate1 Publication
Cross-linki312Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-213); alternate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
Contains inter- or intramolecular disulfide-bonds.Curated

Keywords - PTMi

Disulfide bond, Isopeptide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23490

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23490

PeptideAtlas

More...PeptideAtlasi		P23490

PRoteomics IDEntifications database

More...PRIDEi		P23490

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54114

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23490, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23490

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23490

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000203782, Expressed in upper arm skin and 100 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23490, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000203782, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110198, 18 interactors

Protein interaction database and analysis system

More...IntActi		P23490, 7 interactors

Molecular INTeraction database

More...MINTi		P23490

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357731

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23490, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni276 – 312DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi295 – 312Polar residuesSequence analysisAdd BLAST18

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RU07, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00840000132175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_891260_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23490

Identification of Orthologs from Complete Genome Data

More...OMAi		GGTYDQG

Database of Orthologous Groups

More...OrthoDBi		48717at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031700, Loricrin

The PANTHER Classification System

More...PANTHERi		PTHR39228, PTHR39228, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15847, Loricrin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23490-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYQKKQPTP QPPVDCVKTS GGGGGGGGSG GGGCGFFGGG GSGGGSSGSG 
        60         70         80         90        100
CGYSGGGGYS GGGCGGGSSG GGGGGGIGGC GGGSGGSVKY SGGGGSSGGG 
       110        120        130        140        150
SGCFSSGGGG SGCFSSGGGG SSGGGSGCFS SGGGGSSGGG SGCFSSGGGG 
       160        170        180        190        200
FSGQAVQCQS YGGVSSGGSS GGGSGCFSSG GGGGSVCGYS GGGSGCGGGS 
       210        220        230        240        250
SGGSGSGYVS SQQVTQTSCA PQPSYGGGSS GGGGSGGSGC FSSGGGGGSS 
       260        270        280        290        300
GCGGGSSGIG SGCIISGGGS VCGGGSSGGG GGGSSVGGSG SGKGVPICHQ 
       310 
TQQKQAPTWP SK
Length:312
Mass (Da):25,761
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA64248C3E4FD698E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29S → T in AAA36180 (PubMed:2007607).Curated1
Sequence conflicti29S → T in AAA36181 (PubMed:1355480).Curated1
Sequence conflicti29S → T in AAH34690 (PubMed:15489334).Curated1
Sequence conflicti29S → T in AAI08291 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04771229S → G1 PublicationCorresponds to variant dbSNP:rs6661601Ensembl.1
Natural variantiVAR_065891189Y → YSGGG2 PublicationsCorresponds to variant dbSNP:rs11275959Ensembl.1
Natural variantiVAR_061676285S → F. Corresponds to variant dbSNP:rs56816110EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M61120 mRNA Translation: AAA36180.1
M94077 Genomic DNA Translation: AAA36181.1
AL161636 Genomic DNA No translation available.
BC034690 mRNA Translation: AAH34690.1
BC108290 mRNA Translation: AAI08291.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30870.1

Protein sequence database of the Protein Information Resource

More...PIRi		A38743

NCBI Reference Sequences

More...RefSeqi		NP_000418.2, NM_000427.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368742; ENSP00000357731; ENSG00000203782

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4014

UCSC genome browser

More...UCSCi		uc001fbm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61120 mRNA Translation: AAA36180.1
M94077 Genomic DNA Translation: AAA36181.1
AL161636 Genomic DNA No translation available.
BC034690 mRNA Translation: AAH34690.1
BC108290 mRNA Translation: AAI08291.1
CCDSiCCDS30870.1
PIRiA38743
RefSeqiNP_000418.2, NM_000427.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110198, 18 interactors
IntActiP23490, 7 interactors
MINTiP23490
STRINGi9606.ENSP00000357731

PTM databases

GlyGeniP23490, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP23490
PhosphoSitePlusiP23490

Genetic variation databases

BioMutaiLOR
DMDMi215274015

Proteomic databases

MassIVEiP23490
PaxDbiP23490
PeptideAtlasiP23490
PRIDEiP23490
ProteomicsDBi54114

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20374, 78 antibodies

The DNASU plasmid repository

More...DNASUi		4014

Genome annotation databases

EnsembliENST00000368742; ENSP00000357731; ENSG00000203782
GeneIDi4014
KEGGihsa:4014
UCSCiuc001fbm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4014
DisGeNETi4014

GeneCards: human genes, protein and diseases

More...GeneCardsi		LORICRIN
HGNCiHGNC:6663, LORICRIN
HPAiENSG00000203782, Tissue enriched (skin)
MalaCardsiLORICRIN
MIMi152445, gene
604117, phenotype
neXtProtiNX_P23490
OpenTargetsiENSG00000203782
Orphaneti79395, Keratoderma hereditarium mutilans with ichthyosis
316, Progressive symmetric erythrokeratodermia
PharmGKBiPA30426
VEuPathDBiHostDB:ENSG00000203782

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RU07, Eukaryota
GeneTreeiENSGT00840000132175
HOGENOMiCLU_891260_0_0_1
InParanoidiP23490
OMAiGGTYDQG
OrthoDBi48717at2759

Enzyme and pathway databases

PathwayCommonsiP23490
ReactomeiR-HSA-6809371, Formation of the cornified envelope
SIGNORiP23490

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4014, 10 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LOR, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Loricrin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4014
PharosiP23490, Tbio

Protein Ontology

More...PROi		PR:P23490
RNActiP23490, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000203782, Expressed in upper arm skin and 100 other tissues
GenevisibleiP23490, HS

Family and domain databases

InterProiView protein in InterPro
IPR031700, Loricrin
PANTHERiPTHR39228, PTHR39228, 2 hits
PfamiView protein in Pfam
PF15847, Loricrin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLORI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23490
Secondary accession number(s): Q5T869, Q5XKF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 25, 2008
Last modified: September 29, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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