UniProtKB - P23484 (FECI_ECOLI)
Protein
Probable RNA polymerase sigma factor FecI
Gene
fecI
Organism
Escherichia coli (strain K12)
Status
Functioni
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 139 – 158 | H-T-H motifBy similarityAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
- sigma factor activity Source: UniProtKB-KW
GO - Biological processi
- DNA-templated transcription, initiation Source: InterPro
- ion transport Source: UniProtKB-KW
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Sigma factor |
Biological process | Ion transport, Iron transport, Transcription, Transcription regulation, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00440 MetaCyc:PD00440 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable RNA polymerase sigma factor FecI |
Gene namesi | Name:fecI Ordered Locus Names:b4293, JW4253 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000094011 | 2 – 173 | Probable RNA polymerase sigma factor FecIAdd BLAST | 172 |
Proteomic databases
PaxDbi | P23484 |
PRIDEi | P23484 |
Expressioni
Inductioni
Induced 2.1-fold by hydroxyurea.1 Publication
Interactioni
Protein-protein interaction databases
ComplexPortali | CPX-4888, DNA-directed RNA polymerase holoenzyme complex, Sigma fecI variant |
DIPi | DIP-9588N |
IntActi | P23484, 8 interactors |
STRINGi | 511145.b4293 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 52 | Polymerase core bindingAdd BLAST | 13 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1595, Bacteria |
HOGENOMi | CLU_047691_12_1_6 |
InParanoidi | P23484 |
PhylomeDBi | P23484 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR039425, RNA_pol_sigma-70-like IPR014284, RNA_pol_sigma-70_dom IPR000838, RNA_pol_sigma70_ECF_CS IPR007627, RNA_pol_sigma70_r2 IPR013249, RNA_pol_sigma70_r4_t2 IPR013325, RNA_pol_sigma_r2 IPR013324, RNA_pol_sigma_r3/r4-like IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR43133, PTHR43133, 1 hit |
Pfami | View protein in Pfam PF04542, Sigma70_r2, 1 hit PF08281, Sigma70_r4_2, 1 hit |
SUPFAMi | SSF88659, SSF88659, 1 hit SSF88946, SSF88946, 1 hit |
TIGRFAMsi | TIGR02937, sigma70-ECF, 1 hit |
PROSITEi | View protein in PROSITE PS01063, SIGMA70_ECF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P23484-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDRATTTAS LTFESLYGTH HGWLKSWLTR KLQSAFDADD IAQDTFLRVM
60 70 80 90 100
VSETLSTIRD PRSFLCTIAK RVMVDLFRRN ALEKAYLEML ALMPEGGAPS
110 120 130 140 150
PEERESQLET LQLLDSMLDG LNGKTREAFL LSQLDGLTYS EIAHKLGVSI
160 170
SSVKKYVAKA VEHCLLFRLE YGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63115 Genomic DNA Translation: AAA23766.1 U14003 Genomic DNA Translation: AAA97189.1 U00096 Genomic DNA Translation: AAC77249.1 AP009048 Genomic DNA Translation: BAE78284.1 |
PIRi | JV0111 |
RefSeqi | NP_418713.1, NC_000913.3 WP_001283626.1, NZ_STEB01000013.1 |
Genome annotation databases
EnsemblBacteriai | AAC77249; AAC77249; b4293 BAE78284; BAE78284; BAE78284 |
GeneIDi | 58462728 946839 |
KEGGi | ecj:JW4253 eco:b4293 |
PATRICi | fig|1411691.4.peg.2406 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63115 Genomic DNA Translation: AAA23766.1 U14003 Genomic DNA Translation: AAA97189.1 U00096 Genomic DNA Translation: AAC77249.1 AP009048 Genomic DNA Translation: BAE78284.1 |
PIRi | JV0111 |
RefSeqi | NP_418713.1, NC_000913.3 WP_001283626.1, NZ_STEB01000013.1 |
3D structure databases
SMRi | P23484 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-4888, DNA-directed RNA polymerase holoenzyme complex, Sigma fecI variant |
DIPi | DIP-9588N |
IntActi | P23484, 8 interactors |
STRINGi | 511145.b4293 |
Proteomic databases
PaxDbi | P23484 |
PRIDEi | P23484 |
Genome annotation databases
EnsemblBacteriai | AAC77249; AAC77249; b4293 BAE78284; BAE78284; BAE78284 |
GeneIDi | 58462728 946839 |
KEGGi | ecj:JW4253 eco:b4293 |
PATRICi | fig|1411691.4.peg.2406 |
Organism-specific databases
EchoBASEi | EB0287 |
Phylogenomic databases
eggNOGi | COG1595, Bacteria |
HOGENOMi | CLU_047691_12_1_6 |
InParanoidi | P23484 |
PhylomeDBi | P23484 |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00440 MetaCyc:PD00440 |
Miscellaneous databases
PHI-basei | PHI:8004 |
PROi | PR:P23484 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR039425, RNA_pol_sigma-70-like IPR014284, RNA_pol_sigma-70_dom IPR000838, RNA_pol_sigma70_ECF_CS IPR007627, RNA_pol_sigma70_r2 IPR013249, RNA_pol_sigma70_r4_t2 IPR013325, RNA_pol_sigma_r2 IPR013324, RNA_pol_sigma_r3/r4-like IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR43133, PTHR43133, 1 hit |
Pfami | View protein in Pfam PF04542, Sigma70_r2, 1 hit PF08281, Sigma70_r4_2, 1 hit |
SUPFAMi | SSF88659, SSF88659, 1 hit SSF88946, SSF88946, 1 hit |
TIGRFAMsi | TIGR02937, sigma70-ECF, 1 hit |
PROSITEi | View protein in PROSITE PS01063, SIGMA70_ECF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FECI_ECOLI | |
Accessioni | P23484Primary (citable) accession number: P23484 Secondary accession number(s): Q2M622 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families