UniProtKB - P23469 (PTPRE_HUMAN)
Receptor-type tyrosine-protein phosphatase epsilon
PTPRE
Functioni
Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).
By similarityIsoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).
By similarityIsoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca2+.
By similarityCatalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 303 | SubstrateBy similarity | 1 | |
Active sitei | 335 | Phosphocysteine intermediateBy similarity | 1 | |
Binding sitei | 379 | SubstrateBy similarity | 1 | |
Active sitei | 630 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: GO_Central
- transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc
GO - Biological processi
- negative regulation of insulin receptor signaling pathway Source: UniProtKB
- protein dephosphorylation Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | P23469 |
SignaLinki | P23469 |
SIGNORi | P23469 |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase epsilon (EC:3.1.3.48)Short name: Protein-tyrosine phosphatase epsilon Short name: R-PTP-epsilon |
Gene namesi | Name:PTPRE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9669, PTPRE |
MIMi | 600926, gene |
neXtProti | NX_P23469 |
VEuPathDBi | HostDB:ENSG00000132334 |
Subcellular locationi
Plasma membrane
Cytoplasm and Cytosol
Note: Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity).By similarity
Cytoplasm and Cytosol
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 46 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 47 – 69 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 70 – 700 | CytoplasmicSequence analysisAdd BLAST | 631 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5791 |
OpenTargetsi | ENSG00000132334 |
PharmGKBi | PA34014 |
Miscellaneous databases
Pharosi | P23469, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4850 |
DrugBanki | DB00630, Alendronic acid DB01133, Tiludronic acid |
Genetic variation databases
BioMutai | PTPRE |
DMDMi | 126471 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000025439 | 20 – 700 | Receptor-type tyrosine-protein phosphatase epsilonAdd BLAST | 681 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 696 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-1569 |
EPDi | P23469 |
jPOSTi | P23469 |
MassIVEi | P23469 |
MaxQBi | P23469 |
PaxDbi | P23469 |
PeptideAtlasi | P23469 |
PRIDEi | P23469 |
ProteomicsDBi | 54107 [P23469-1] 54108 [P23469-2] 54109 [P23469-3] |
PTM databases
DEPODi | PTPRE |
GlyGeni | P23469, 2 sites |
iPTMneti | P23469 |
PhosphoSitePlusi | P23469 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000132334, Expressed in bone marrow and 224 other tissues |
ExpressionAtlasi | P23469, baseline and differential |
Genevisiblei | P23469, HS |
Organism-specific databases
HPAi | ENSG00000132334, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR.
Isoform 2 interacts with GRB2 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 111755, 55 interactors |
IntActi | P23469, 25 interactors |
MINTi | P23469 |
STRINGi | 9606.ENSP00000254667 |
Chemistry databases
BindingDBi | P23469 |
Miscellaneous databases
RNActi | P23469, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P23469 |
SASBDBi | P23469 |
SMRi | P23469 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23469 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 394 | Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 426 – 689 | Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST | 264 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 341 | Substrate bindingBy similarity | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000156570 |
HOGENOMi | CLU_001645_8_2_1 |
InParanoidi | P23469 |
OMAi | RKFCVHS |
OrthoDBi | 411281at2759 |
PhylomeDBi | P23469 |
TreeFami | TF351829 |
Family and domain databases
Gene3Di | 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom IPR016336, Tyr_Pase_rcpt_a/e-type |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 2 hits |
PIRSFi | PIRSF002006, PTPR_alpha_epsilon, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative promoter usage and alternative initiation. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPLCPLLLV GFSLPLARAL RGNETTADSN ETTTTSGPPD PGASQPLLAW
60 70 80 90 100
LLLPLLLLLL VLLLAAYFFR FRKQRKAVVS TSDKKMPNGI LEEQEQQRVM
110 120 130 140 150
LLSRSPSGPK KYFPIPVEHL EEEIRIRSAD DCKQFREEFN SLPSGHIQGT
160 170 180 190 200
FELANKEENR EKNRYPNILP NDHSRVILSQ LDGIPCSDYI NASYIDGYKE
210 220 230 240 250
KNKFIAAQGP KQETVNDFWR MVWEQKSATI VMLTNLKERK EEKCHQYWPD
260 270 280 290 300
QGCWTYGNIR VCVEDCVVLV DYTIRKFCIQ PQLPDGCKAP RLVSQLHFTS
310 320 330 340 350
WPDFGVPFTP IGMLKFLKKV KTLNPVHAGP IVVHCSAGVG RTGTFIVIDA
360 370 380 390 400
MMAMMHAEQK VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT
410 420 430 440 450
ELDVSSLEKH LQTMHGTTTH FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA
460 470 480 490 500
NMKKARVIQI IPYDFNRVIL SMKRGQEYTD YINASFIDGY RQKDYFIATQ
510 520 530 540 550
GPLAHTVEDF WRMIWEWKSH TIVMLTEVQE REQDKCYQYW PTEGSVTHGE
560 570 580 590 600
ITIEIKNDTL SEAISIRDFL VTLNQPQARQ EEQVRVVRQF HFHGWPEIGI
610 620 630 640 650
PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV
660 670 680 690 700
KAEGLLDVFQ AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VWH6 | Q5VWH6_HUMAN | Receptor-type tyrosine-protein phos... | PTPRE | 140 | Annotation score: | ||
Q5VWH5 | Q5VWH5_HUMAN | Receptor-type tyrosine-protein phos... | PTPRE | 153 | Annotation score: | ||
S4R3B0 | S4R3B0_HUMAN | Receptor-type tyrosine-protein phos... | PTPRE | 149 | Annotation score: | ||
S4R448 | S4R448_HUMAN | Receptor-type tyrosine-protein phos... | PTPRE | 118 | Annotation score: | ||
S4R2Y5 | S4R2Y5_HUMAN | Receptor-type tyrosine-protein phos... | PTPRE | 536 | Annotation score: | ||
S4R3X3 | S4R3X3_HUMAN | Receptor-type tyrosine-protein phos... | PTPRE | 107 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 516 | E → D in CAC86583 (PubMed:12121439).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038490 | 1 – 85 | Missing in isoform 3. CuratedAdd BLAST | 85 | |
Alternative sequenceiVSP_007778 | 1 – 70 | MEPLC…AYFFR → MSNRSSFSRLTW in isoform 2. 2 PublicationsAdd BLAST | 70 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54134 mRNA Translation: CAA38069.1 AJ315969 mRNA Translation: CAC86583.1 AK291828 mRNA Translation: BAF84517.1 AL390236 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49180.1 CH471066 Genomic DNA Translation: EAW49181.1 CH471066 Genomic DNA Translation: EAW49182.1 CH471066 Genomic DNA Translation: EAW49184.1 BC050062 mRNA Translation: AAH50062.1 U36623 mRNA Translation: AAC50324.1 Sequence problems. |
CCDSi | CCDS7657.1 [P23469-1] CCDS7658.1 [P23469-2] |
PIRi | S12053 |
RefSeqi | NP_001303605.1, NM_001316676.1 NP_001303606.1, NM_001316677.1 [P23469-1] NP_001310283.1, NM_001323354.1 [P23469-1] NP_006495.1, NM_006504.5 [P23469-1] NP_569119.1, NM_130435.4 [P23469-2] XP_005252748.1, XM_005252691.2 [P23469-1] XP_016871957.1, XM_017016468.1 [P23469-1] |
Genome annotation databases
Ensembli | ENST00000254667.8; ENSP00000254667.3; ENSG00000132334.17 ENST00000306042.9; ENSP00000303350.5; ENSG00000132334.17 [P23469-2] |
GeneIDi | 5791 |
KEGGi | hsa:5791 |
MANE-Selecti | ENST00000254667.8; ENSP00000254667.3; NM_006504.6; NP_006495.1 |
UCSCi | uc001lkb.4, human [P23469-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative promoter usageSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54134 mRNA Translation: CAA38069.1 AJ315969 mRNA Translation: CAC86583.1 AK291828 mRNA Translation: BAF84517.1 AL390236 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49180.1 CH471066 Genomic DNA Translation: EAW49181.1 CH471066 Genomic DNA Translation: EAW49182.1 CH471066 Genomic DNA Translation: EAW49184.1 BC050062 mRNA Translation: AAH50062.1 U36623 mRNA Translation: AAC50324.1 Sequence problems. |
CCDSi | CCDS7657.1 [P23469-1] CCDS7658.1 [P23469-2] |
PIRi | S12053 |
RefSeqi | NP_001303605.1, NM_001316676.1 NP_001303606.1, NM_001316677.1 [P23469-1] NP_001310283.1, NM_001323354.1 [P23469-1] NP_006495.1, NM_006504.5 [P23469-1] NP_569119.1, NM_130435.4 [P23469-2] XP_005252748.1, XM_005252691.2 [P23469-1] XP_016871957.1, XM_017016468.1 [P23469-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JJD | X-ray | 3.20 | A/B/C/D/E/F | 107-697 | [»] | |
6D3F | X-ray | 2.27 | A/B | 425-700 | [»] | |
6D4D | X-ray | 1.76 | A/B | 107-398 | [»] | |
6D4F | X-ray | 1.91 | A | 425-700 | [»] | |
AlphaFoldDBi | P23469 | |||||
SASBDBi | P23469 | |||||
SMRi | P23469 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111755, 55 interactors |
IntActi | P23469, 25 interactors |
MINTi | P23469 |
STRINGi | 9606.ENSP00000254667 |
Chemistry databases
BindingDBi | P23469 |
ChEMBLi | CHEMBL4850 |
DrugBanki | DB00630, Alendronic acid DB01133, Tiludronic acid |
PTM databases
DEPODi | PTPRE |
GlyGeni | P23469, 2 sites |
iPTMneti | P23469 |
PhosphoSitePlusi | P23469 |
Genetic variation databases
BioMutai | PTPRE |
DMDMi | 126471 |
Proteomic databases
CPTACi | CPTAC-1569 |
EPDi | P23469 |
jPOSTi | P23469 |
MassIVEi | P23469 |
MaxQBi | P23469 |
PaxDbi | P23469 |
PeptideAtlasi | P23469 |
PRIDEi | P23469 |
ProteomicsDBi | 54107 [P23469-1] 54108 [P23469-2] 54109 [P23469-3] |
Protocols and materials databases
Antibodypediai | 3004, 509 antibodies from 31 providers |
DNASUi | 5791 |
Genome annotation databases
Ensembli | ENST00000254667.8; ENSP00000254667.3; ENSG00000132334.17 ENST00000306042.9; ENSP00000303350.5; ENSG00000132334.17 [P23469-2] |
GeneIDi | 5791 |
KEGGi | hsa:5791 |
MANE-Selecti | ENST00000254667.8; ENSP00000254667.3; NM_006504.6; NP_006495.1 |
UCSCi | uc001lkb.4, human [P23469-1] |
Organism-specific databases
CTDi | 5791 |
DisGeNETi | 5791 |
GeneCardsi | PTPRE |
HGNCi | HGNC:9669, PTPRE |
HPAi | ENSG00000132334, Tissue enhanced (bone) |
MIMi | 600926, gene |
neXtProti | NX_P23469 |
OpenTargetsi | ENSG00000132334 |
PharmGKBi | PA34014 |
VEuPathDBi | HostDB:ENSG00000132334 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000156570 |
HOGENOMi | CLU_001645_8_2_1 |
InParanoidi | P23469 |
OMAi | RKFCVHS |
OrthoDBi | 411281at2759 |
PhylomeDBi | P23469 |
TreeFami | TF351829 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | P23469 |
SignaLinki | P23469 |
SIGNORi | P23469 |
Miscellaneous databases
BioGRID-ORCSi | 5791, 13 hits in 1072 CRISPR screens |
ChiTaRSi | PTPRE, human |
EvolutionaryTracei | P23469 |
GeneWikii | PTPRE |
GenomeRNAii | 5791 |
Pharosi | P23469, Tbio |
PROi | PR:P23469 |
RNActi | P23469, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132334, Expressed in bone marrow and 224 other tissues |
ExpressionAtlasi | P23469, baseline and differential |
Genevisiblei | P23469, HS |
Family and domain databases
Gene3Di | 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom IPR016336, Tyr_Pase_rcpt_a/e-type |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 2 hits |
PIRSFi | PIRSF002006, PTPR_alpha_epsilon, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 2 hits PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPRE_HUMAN | |
Accessioni | P23469Primary (citable) accession number: P23469 Secondary accession number(s): Q13345 Q96KQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families