PTPRE

Functionⁱ

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).By similarity

Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).By similarity

Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca²⁺.By similarity

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	303	SubstrateBy similarity	1
Active siteⁱ	335	Phosphocysteine intermediateBy similarity	1
Binding siteⁱ	379	SubstrateBy similarity	1
Active siteⁱ	630	Phosphocysteine intermediateBy similarity	1

GO - Molecular functionⁱ

transmembrane receptor protein tyrosine phosphatase activity
Source: ProtInc
Traceable author statementⁱ
- 2170109

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of insulin receptor signaling pathway Source: UniProtKB
protein dephosphorylation
Source: ProtInc
Traceable author statementⁱ
- 2170109

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
SignaLinkⁱ	P23469
SIGNORⁱ	P23469

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein phosphatase epsilon (EC:3.1.3.48) Short name: Protein-tyrosine phosphatase epsilon Short name: R-PTP-epsilon
Gene namesⁱ	Name:PTPRE
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132334.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9669 PTPRE
MIMⁱ	600926 gene
neXtProtⁱ	NX_P23469

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 46	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	47 – 69	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	70 – 700	CytoplasmicSequence analysisAdd BLAST	631

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5791
Open Targets More...OpenTargetsⁱ	ENSG00000132334
PharmGKBⁱ	PA34014

Chemistry databases

ChEMBLⁱ	CHEMBL4850
Drug and drug target database More...DrugBankⁱ	DB00630 Alendronic acid

Polymorphism and mutation databases

BioMutaⁱ	PTPRE
DMDMⁱ	126471

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000025439	20 – 700	Receptor-type tyrosine-protein phosphatase epsilonAdd BLAST		681

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	23	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	30	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	696	PhosphotyrosineCombined sources	1

Post-translational modificationⁱ

A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.1 Publication

Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.1 Publication

Isoform 1 is glycosylated.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P23469
PaxDbⁱ	P23469
PeptideAtlas More...PeptideAtlasⁱ	P23469
PRIDEⁱ	P23469
ProteomicsDBⁱ	54107 54108 [P23469-2] 54109 [P23469-3]

PTM databases

DEPODⁱ	P23469
iPTMnetⁱ	P23469
PhosphoSitePlusⁱ	P23469

Expressionⁱ

Tissue specificityⁱ

Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).1 Publication

Inductionⁱ

Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in HL-60 cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000132334 Expressed in 213 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_PTPRE
ExpressionAtlasⁱ	P23469 baseline and differential
Genevisibleⁱ	P23469 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015870 HPA021872

HPAⁱ

HPA015870
HPA021872

Interactionⁱ

Subunit structureⁱ

Monomer. Isoform 2: Homodimer. Can form oligomers. Dimerization is increased by oxidative stress and decreased by EGFR. Isoform 2 interacts with GRB2 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	111755, 38 interactors
IntActⁱ	P23469, 10 interactors
Molecular INTeraction database More...MINTⁱ	P23469
STRINGⁱ	9606.ENSP00000254667

Chemistry databases

BindingDBⁱ

P23469

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	117 – 119	Combined sources	3
Helixⁱ	120 – 126	Combined sources	7
Helixⁱ	139 – 141	Combined sources	3
Turnⁱ	152 – 155	Combined sources	4
Helixⁱ	157 – 162	Combined sources	6
Beta strandⁱ	172 – 177	Combined sources	6
Turnⁱ	185 – 188	Combined sources	4
Beta strandⁱ	189 – 197	Combined sources	9
Beta strandⁱ	200 – 207	Combined sources	8
Helixⁱ	212 – 214	Combined sources	3
Helixⁱ	215 – 224	Combined sources	10
Beta strandⁱ	229 – 232	Combined sources	4
Beta strandⁱ	236 – 238	Combined sources	3
Beta strandⁱ	250 – 256	Combined sources	7
Beta strandⁱ	259 – 268	Combined sources	10
Beta strandⁱ	270 – 280	Combined sources	11
Beta strandⁱ	291 – 298	Combined sources	8
Beta strandⁱ	303 – 305	Combined sources	3
Helixⁱ	311 – 323	Combined sources	13
Beta strandⁱ	331 – 334	Combined sources	4
Beta strandⁱ	336 – 340	Combined sources	5
Helixⁱ	341 – 358	Combined sources	18
Beta strandⁱ	359 – 361	Combined sources	3
Helixⁱ	363 – 371	Combined sources	9
Helixⁱ	381 – 396	Combined sources	16
Helixⁱ	426 – 434	Combined sources	9
Helixⁱ	444 – 447	Combined sources	4
Helixⁱ	449 – 452	Combined sources	4
Beta strandⁱ	464 – 469	Combined sources	6
Beta strandⁱ	481 – 487	Combined sources	7
Beta strandⁱ	490 – 492	Combined sources	3
Beta strandⁱ	496 – 499	Combined sources	4
Turnⁱ	504 – 506	Combined sources	3
Helixⁱ	507 – 516	Combined sources	10
Beta strandⁱ	521 – 524	Combined sources	4
Beta strandⁱ	528 – 530	Combined sources	3
Beta strandⁱ	542 – 548	Combined sources	7
Beta strandⁱ	551 – 560	Combined sources	10
Beta strandⁱ	562 – 573	Combined sources	12
Beta strandⁱ	584 – 592	Combined sources	9
Beta strandⁱ	597 – 599	Combined sources	3
Helixⁱ	605 – 620	Combined sources	16
Beta strandⁱ	626 – 629	Combined sources	4
Beta strandⁱ	631 – 635	Combined sources	5
Helixⁱ	636 – 653	Combined sources	18
Beta strandⁱ	654 – 656	Combined sources	3
Helixⁱ	658 – 666	Combined sources	9
Helixⁱ	676 – 690	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P23469
SMRⁱ	P23469
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P23469

EvolutionaryTraceⁱ

P23469

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	135 – 394	Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST		260
Domainⁱ	426 – 689	Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST		264

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	335 – 341	Substrate bindingBy similarity		7

Domainⁱ

The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118900
HOGENOMⁱ	HOG000231465
HOVERGENⁱ	HBG053758
InParanoidⁱ	P23469
KEGG Orthology (KO) More...KOⁱ	K18033
OMAⁱ	TPCSDYI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02ID
PhylomeDBⁱ	P23469
TreeFamⁱ	TF351829

Family and domain databases

Gene3Dⁱ	3.90.190.10, 2 hits
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR016336 Tyr_Pase_rcpt_a/e-type IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 2 hits
PIRSFⁱ	PIRSF002006 PTPR_alpha_epsilon, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative promoter usage and alternative initiation. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P23469-1) [UniParc]FASTA Add to basket

Also known as: PTPeM, RPTPe, tm-PTPe

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPLCPLLLV GFSLPLARAL RGNETTADSN ETTTTSGPPD PGASQPLLAW 
        60         70         80         90        100
LLLPLLLLLL VLLLAAYFFR FRKQRKAVVS TSDKKMPNGI LEEQEQQRVM 
       110        120        130        140        150
LLSRSPSGPK KYFPIPVEHL EEEIRIRSAD DCKQFREEFN SLPSGHIQGT 
       160        170        180        190        200
FELANKEENR EKNRYPNILP NDHSRVILSQ LDGIPCSDYI NASYIDGYKE 
       210        220        230        240        250
KNKFIAAQGP KQETVNDFWR MVWEQKSATI VMLTNLKERK EEKCHQYWPD 
       260        270        280        290        300
QGCWTYGNIR VCVEDCVVLV DYTIRKFCIQ PQLPDGCKAP RLVSQLHFTS 
       310        320        330        340        350
WPDFGVPFTP IGMLKFLKKV KTLNPVHAGP IVVHCSAGVG RTGTFIVIDA 
       360        370        380        390        400
MMAMMHAEQK VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT 
       410        420        430        440        450
ELDVSSLEKH LQTMHGTTTH FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA 
       460        470        480        490        500
NMKKARVIQI IPYDFNRVIL SMKRGQEYTD YINASFIDGY RQKDYFIATQ 
       510        520        530        540        550
GPLAHTVEDF WRMIWEWKSH TIVMLTEVQE REQDKCYQYW PTEGSVTHGE 
       560        570        580        590        600
ITIEIKNDTL SEAISIRDFL VTLNQPQARQ EEQVRVVRQF HFHGWPEIGI 
       610        620        630        640        650
PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV 
       660        670        680        690        700
KAEGLLDVFQ AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK

Note: Produced by alternative promoter usage.

Length:700

Mass (Da):80,642

Last modified:November 1, 1991 - v1

Checksum:ⁱD096BCADCEA65708

GO

Isoform 2 (identifier: P23469-2) [UniParc]FASTA Add to basket

Also known as: PTPeC, cyt-PTPe

The sequence of this isoform differs from the canonical sequence as follows:
1-70: MEPLCPLLLV...VLLLAAYFFR → MSNRSSFSRLTW

« Hide

        10         20         30         40         50
MSNRSSFSRL TWFRKQRKAV VSTSDKKMPN GILEEQEQQR VMLLSRSPSG 
        60         70         80         90        100
PKKYFPIPVE HLEEEIRIRS ADDCKQFREE FNSLPSGHIQ GTFELANKEE 
       110        120        130        140        150
NREKNRYPNI LPNDHSRVIL SQLDGIPCSD YINASYIDGY KEKNKFIAAQ 
       160        170        180        190        200
GPKQETVNDF WRMVWEQKSA TIVMLTNLKE RKEEKCHQYW PDQGCWTYGN 
       210        220        230        240        250
IRVCVEDCVV LVDYTIRKFC IQPQLPDGCK APRLVSQLHF TSWPDFGVPF 
       260        270        280        290        300
TPIGMLKFLK KVKTLNPVHA GPIVVHCSAG VGRTGTFIVI DAMMAMMHAE 
       310        320        330        340        350
QKVDVFEFVS RIRNQRPQMV QTDMQYTFIY QALLEYYLYG DTELDVSSLE 
       360        370        380        390        400
KHLQTMHGTT THFDKIGLEE EFRKLTNVRI MKENMRTGNL PANMKKARVI 
       410        420        430        440        450
QIIPYDFNRV ILSMKRGQEY TDYINASFID GYRQKDYFIA TQGPLAHTVE 
       460        470        480        490        500
DFWRMIWEWK SHTIVMLTEV QEREQDKCYQ YWPTEGSVTH GEITIEIKND 
       510        520        530        540        550
TLSEAISIRD FLVTLNQPQA RQEEQVRVVR QFHFHGWPEI GIPAEGKGMI 
       560        570        580        590        600
DLIAAVQKQQ QQTGNHPITV HCSAGAGRTG TFIALSNILE RVKAEGLLDV 
       610        620        630        640 
FQAVKSLRLQ RPHMVQTLEQ YEFCYKVVQD FIDIFSDYAN FK

Note: Produced by alternative promoter usage.

Show »

Length:642

Mass (Da):74,595

Checksum:ⁱD39B2835A8D7D949

GO

Isoform 3 (identifier: P23469-3) [UniParc]FASTA Add to basket

Also known as: p67

The sequence of this isoform differs from the canonical sequence as follows:
1-85: Missing.

« Hide

        10         20         30         40         50
MPNGILEEQE QQRVMLLSRS PSGPKKYFPI PVEHLEEEIR IRSADDCKQF 
        60         70         80         90        100
REEFNSLPSG HIQGTFELAN KEENREKNRY PNILPNDHSR VILSQLDGIP 
       110        120        130        140        150
CSDYINASYI DGYKEKNKFI AAQGPKQETV NDFWRMVWEQ KSATIVMLTN 
       160        170        180        190        200
LKERKEEKCH QYWPDQGCWT YGNIRVCVED CVVLVDYTIR KFCIQPQLPD 
       210        220        230        240        250
GCKAPRLVSQ LHFTSWPDFG VPFTPIGMLK FLKKVKTLNP VHAGPIVVHC 
       260        270        280        290        300
SAGVGRTGTF IVIDAMMAMM HAEQKVDVFE FVSRIRNQRP QMVQTDMQYT 
       310        320        330        340        350
FIYQALLEYY LYGDTELDVS SLEKHLQTMH GTTTHFDKIG LEEEFRKLTN 
       360        370        380        390        400
VRIMKENMRT GNLPANMKKA RVIQIIPYDF NRVILSMKRG QEYTDYINAS 
       410        420        430        440        450
FIDGYRQKDY FIATQGPLAH TVEDFWRMIW EWKSHTIVML TEVQEREQDK 
       460        470        480        490        500
CYQYWPTEGS VTHGEITIEI KNDTLSEAIS IRDFLVTLNQ PQARQEEQVR 
       510        520        530        540        550
VVRQFHFHGW PEIGIPAEGK GMIDLIAAVQ KQQQQTGNHP ITVHCSAGAG 
       560        570        580        590        600
RTGTFIALSN ILERVKAEGL LDVFQAVKSL RLQRPHMVQT LEQYEFCYKV 
       610 
VQDFIDIFSD YANFK

Note: Produced by alternative initiation at Met-86 of isoform 1.

Show »

Length:615

Mass (Da):71,382

Checksum:ⁱF4FD48DDAAA0B302

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5VWH5	Q5VWH5_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase epsilon	PTPRE	153	Annotation score:
Q5VWH6	Q5VWH6_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase epsilon	PTPRE	140	Annotation score:
S4R3B0	S4R3B0_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase epsilon	PTPRE	149	Annotation score:
S4R2Y5	S4R2Y5_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase epsilon	PTPRE	536	Annotation score:
S4R448	S4R448_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase epsilon	PTPRE	118	Annotation score:
S4R3X3	S4R3X3_HUMAN	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase epsilon	PTPRE	107	Annotation score:

Sequence cautionⁱ

The sequence AAC50324 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	516	E → D in CAC86583 (PubMed:12121439).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038490	1 – 85	Missing in isoform 3. CuratedAdd BLAST		85
Alternative sequenceⁱVSP_007778	1 – 70	MEPLC…AYFFR → MSNRSSFSRLTW in isoform 2. 2 PublicationsAdd BLAST		70

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54134 mRNA Translation: CAA38069.1 AJ315969 mRNA Translation: CAC86583.1 AK291828 mRNA Translation: BAF84517.1 AL390236 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49180.1 CH471066 Genomic DNA Translation: EAW49181.1 CH471066 Genomic DNA Translation: EAW49182.1 CH471066 Genomic DNA Translation: EAW49184.1 BC050062 mRNA Translation: AAH50062.1 U36623 mRNA Translation: AAC50324.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7657.1 [P23469-1] CCDS7658.1 [P23469-2]
PIRⁱ	S12053
NCBI Reference Sequences More...RefSeqⁱ	NP_001303605.1, NM_001316676.1 NP_001303606.1, NM_001316677.1 [P23469-1] NP_001310283.1, NM_001323354.1 [P23469-1] NP_006495.1, NM_006504.5 [P23469-1] NP_569119.1, NM_130435.4 [P23469-2] XP_005252748.1, XM_005252691.2 [P23469-1] XP_016871957.1, XM_017016468.1 [P23469-1]
UniGeneⁱ	Hs.127022

Genome annotation databases

Ensemblⁱ	ENST00000254667; ENSP00000254667; ENSG00000132334 [P23469-1] ENST00000306042; ENSP00000303350; ENSG00000132334 [P23469-2]
GeneIDⁱ	5791
KEGGⁱ	hsa:5791
UCSC genome browser More...UCSCⁱ	uc001lkb.4 human [P23469-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative promoter usage

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23469	PTPRE (Fragment)		HUMAN		155	UniRef100_P23469
Receptor-type tyrosine-protein phosphatase epsilon (Fragment)		HUMAN		140
Receptor-type tyrosine-protein phosphatase epsilon (Fragment)		HUMAN		153
Isoform 3 of Receptor-type tyrosine-protein phosphatase epsilon		HUMAN		615
UPI000D0C8B95		HUMAN		731

Protein	Similar proteins		Species	Score	Length	Source
P23469	Receptor-type tyrosine-protein phosphatase epsilon		MOUSE		699	UniRef90_P49446
Receptor-type tyrosine-protein phosphatase epsilon		RAT		699
Receptor-type tyrosine-protein phosphatase		CANLF		757
Receptor-type tyrosine-protein phosphatase		PAPAN		733
Receptor-type tyrosine-protein phosphatase		RHIBE		728
+184
P23469-2	Isoform 2 of Receptor-type tyrosine-protein phosphatase epsilon		MOUSE		642	UniRef90_P49446-2
Receptor-type tyrosine-protein phosphatase		BOVIN		713
Receptor-type tyrosine-protein phosphatase		SHEEP		705
Receptor-type tyrosine-protein phosphatase		DELLE		703
Receptor-type tyrosine-protein phosphatase		ODORO		701
+109

Protein	Similar proteins		Species	Score	Length	Source
P23469	Receptor-type tyrosine-protein phosphatase epsilon		MOUSE		699	UniRef50_P49446
Receptor-type tyrosine-protein phosphatase epsilon		RAT		699
Receptor-type tyrosine-protein phosphatase		CANLF		757
Receptor-type tyrosine-protein phosphatase		PAPAN		733
Receptor-type tyrosine-protein phosphatase		RHIBE		728
+834

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54134 mRNA Translation: CAA38069.1 AJ315969 mRNA Translation: CAC86583.1 AK291828 mRNA Translation: BAF84517.1 AL390236 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49180.1 CH471066 Genomic DNA Translation: EAW49181.1 CH471066 Genomic DNA Translation: EAW49182.1 CH471066 Genomic DNA Translation: EAW49184.1 BC050062 mRNA Translation: AAH50062.1 U36623 mRNA Translation: AAC50324.1 Sequence problems.
CCDSⁱ	CCDS7657.1 [P23469-1] CCDS7658.1 [P23469-2]
PIRⁱ	S12053
RefSeqⁱ	NP_001303605.1, NM_001316676.1 NP_001303606.1, NM_001316677.1 [P23469-1] NP_001310283.1, NM_001323354.1 [P23469-1] NP_006495.1, NM_006504.5 [P23469-1] NP_569119.1, NM_130435.4 [P23469-2] XP_005252748.1, XM_005252691.2 [P23469-1] XP_016871957.1, XM_017016468.1 [P23469-1]
UniGeneⁱ	Hs.127022

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JJD	X-ray	3.20	A/B/C/D/E/F	107-697	[»]
ProteinModelPortalⁱ	P23469
SMRⁱ	P23469
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111755, 38 interactors
IntActⁱ	P23469, 10 interactors
MINTⁱ	P23469
STRINGⁱ	9606.ENSP00000254667

Chemistry databases

BindingDBⁱ	P23469
ChEMBLⁱ	CHEMBL4850
DrugBankⁱ	DB00630 Alendronic acid

PTM databases

DEPODⁱ	P23469
iPTMnetⁱ	P23469
PhosphoSitePlusⁱ	P23469

Polymorphism and mutation databases

BioMutaⁱ	PTPRE
DMDMⁱ	126471

Proteomic databases

EPDⁱ	P23469
PaxDbⁱ	P23469
PeptideAtlasⁱ	P23469
PRIDEⁱ	P23469
ProteomicsDBⁱ	54107 54108 [P23469-2] 54109 [P23469-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000254667; ENSP00000254667; ENSG00000132334 [P23469-1] ENST00000306042; ENSP00000303350; ENSG00000132334 [P23469-2]
GeneIDⁱ	5791
KEGGⁱ	hsa:5791
UCSCⁱ	uc001lkb.4 human [P23469-1]

Organism-specific databases

CTDⁱ	5791
DisGeNETⁱ	5791
EuPathDBⁱ	HostDB:ENSG00000132334.16
GeneCardsⁱ	PTPRE
HGNCⁱ	HGNC:9669 PTPRE
HPAⁱ	HPA015870 HPA021872
MIMⁱ	600926 gene
neXtProtⁱ	NX_P23469
OpenTargetsⁱ	ENSG00000132334
PharmGKBⁱ	PA34014
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
GeneTreeⁱ	ENSGT00760000118900
HOGENOMⁱ	HOG000231465
HOVERGENⁱ	HBG053758
InParanoidⁱ	P23469
KOⁱ	K18033
OMAⁱ	TPCSDYI
OrthoDBⁱ	EOG091G02ID
PhylomeDBⁱ	P23469
TreeFamⁱ	TF351829

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
SignaLinkⁱ	P23469
SIGNORⁱ	P23469

Miscellaneous databases

ChiTaRSⁱ	PTPRE human
EvolutionaryTraceⁱ	P23469
GeneWikiⁱ	PTPRE
GenomeRNAiⁱ	5791
Protein Ontology More...PROⁱ	PR:P23469
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132334 Expressed in 213 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_PTPRE
ExpressionAtlasⁱ	P23469 baseline and differential
Genevisibleⁱ	P23469 HS

Family and domain databases

Gene3Dⁱ	3.90.190.10, 2 hits
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR016336 Tyr_Pase_rcpt_a/e-type IPR000387 TYR_PHOSPHATASE_dom
Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 2 hits
PIRSFⁱ	PIRSF002006 PTPR_alpha_epsilon, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTPRE_HUMAN
Accessionⁱ	P23469Primary (citable) accession number: P23469 Secondary accession number(s): Q13345 , Q5VWH3, Q5VWH4, Q96KQ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	November 1, 1991
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P23469 (PTPRE_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Receptor-type tyrosine-protein phosphatase epsilon

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Other locations

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ