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Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei266Required for interaction with IL1RAPBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1521SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1553Phosphocysteine intermediateBy similarity1
Binding sitei1597SubstrateBy similarity1
Active sitei1844Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-8849932 Synaptic adhesion-like molecules

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P23468

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P23468

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000153707.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9668 PTPRD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601598 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P23468

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1265ExtracellularSequence analysisAdd BLAST1245
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1266 – 1290HelicalSequence analysisAdd BLAST25
Topological domaini1291 – 1912CytoplasmicSequence analysisAdd BLAST622

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1178R → A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181. 1 Publication1
Mutagenesisi1181R → A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5789

Open Targets

More...
OpenTargetsi
ENSG00000153707

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34013

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPRD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1709906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002543721 – 1912Receptor-type tyrosine-protein phosphatase deltaAdd BLAST1892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi832N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1181 – 1182CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P23468

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P23468

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23468

PeptideAtlas

More...
PeptideAtlasi
P23468

PRoteomics IDEntifications database

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PRIDEi
P23468

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54101
54102 [P23468-2]
54103 [P23468-3]
54104 [P23468-4]
54105 [P23468-5]
54106 [P23468-6]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
P23468

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P23468

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P23468

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000153707 Expressed in 196 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTPRD

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P23468 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P23468 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054829

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:9624153). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats). Interacts with SLITRK2; induces presynaptic differentiation. Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AURKAO149652EBI-2682990,EBI-448680

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111753, 59 interactors

Database of interacting proteins

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DIPi
DIP-17023N

Protein interaction database and analysis system

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IntActi
P23468, 24 interactors

Molecular INTeraction database

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MINTi
P23468

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348812

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11912
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P23468

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P23468

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P23468

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 114Ig-like C2-type 1Add BLAST91
Domaini126 – 224Ig-like C2-type 2Add BLAST99
Domaini236 – 318Ig-like C2-type 3Add BLAST83
Domaini325 – 415Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini420 – 516Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini518 – 607Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini612 – 709Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini714 – 822Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini823 – 916Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini921 – 1016Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1020 – 1106Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST87
Domaini1357 – 1612Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1644 – 1903Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni180 – 189Interaction with IL1RAPL1By similarity10
Regioni181 – 189Mini-exon peptide A9; sufficient for interaction with IL1RAPL1By similarity9
Regioni227 – 230Mini-exon peptide B; required for interaction with SLITRK2 and in the function in pre-synaptic differentiation; Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP; Modulates affinity for IL1RAPL1 and IL1RAPBy similarity4
Regioni1553 – 1559Substrate bindingBy similarity7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4228 Eukaryota
COG5599 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010250

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053758

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P23468

KEGG Orthology (KO)

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KOi
K06777

Identification of Orthologs from Complete Genome Data

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OMAi
EVWWEPV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G11WG

Database for complete collections of gene phylogenies

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PhylomeDBi
P23468

TreeFam database of animal gene trees

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TreeFami
TF312900

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 11 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23468-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
560 570 580 590 600
YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT
660 670 680 690 700
AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI
960 970 980 990 1000
ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR
1310 1320 1330 1340 1350
KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA
1910
LEYLGSFDHY AT
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:1,912
Mass (Da):214,760
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AE8CBCD32182E26
GO
Isoform 2 (identifier: P23468-2) [UniParc]FASTAAdd to basket
Also known as: Kidney

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     226-229: Missing.
     775-783: Missing.

Show »
Length:1,890
Mass (Da):212,133
Checksum:iF67473E6C295C0D3
GO
Isoform 3 (identifier: P23468-3) [UniParc]FASTAAdd to basket
Also known as: Fetal brain

The sequence of this isoform differs from the canonical sequence as follows:
     609-1137: Missing.

Show »
Length:1,383
Mass (Da):156,088
Checksum:i6FA7F02992F7AEFF
GO
Isoform 4 (identifier: P23468-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     608-608: K → M
     609-1019: Missing.
     1330-1330: G → GSDDSGYPGNLHSSS

Note: No experimental confirmation available.
Show »
Length:1,505
Mass (Da):169,474
Checksum:i737878C2930FBF68
GO
Isoform 5 (identifier: P23468-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSKPD

Note: No experimental confirmation available.
Show »
Length:1,505
Mass (Da):169,606
Checksum:i7F25884835F91CDB
GO
Isoform 6 (identifier: P23468-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSSKPD

Note: No experimental confirmation available.
Show »
Length:1,506
Mass (Da):169,693
Checksum:i136D13489D0BEA56
GO
Isoform 7 (identifier: P23468-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     608-1019: KPSAPPQDIS...QFRTLPVDQV → M
     1291-1291: K → KSKPD

Show »
Length:1,502
Mass (Da):169,277
Checksum:iCDEDB66CFBBE5D0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3KPI9Q3KPI9_HUMAN
PTPRD protein
PTPRD
1,496Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWR7F5GWR7_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
1,505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8S8C9J8S8_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6E4C9J6E4_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU15A0A1B0GU15_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03564528R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1353675904Ensembl.1
Natural variantiVAR_035646276L → P in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024581447Q → E. Corresponds to variant dbSNP:rs10977171Ensembl.1
Natural variantiVAR_035647901V → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061761995R → C. Corresponds to variant dbSNP:rs35929428Ensembl.1
Natural variantiVAR_0517611078E → D. Corresponds to variant dbSNP:rs7869444Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005147181 – 189Missing in isoform 2. Curated9
Alternative sequenceiVSP_054220181 – 183Missing in isoform 7. Curated3
Alternative sequenceiVSP_043384184 – 189Missing in isoform 4. 1 Publication6
Alternative sequenceiVSP_005148226 – 229Missing in isoform 2. Curated4
Alternative sequenceiVSP_043385227 – 230Missing in isoform 4. 1 Publication4
Alternative sequenceiVSP_054221608 – 1019KPSAP…PVDQV → M in isoform 7. CuratedAdd BLAST412
Alternative sequenceiVSP_043386608K → M in isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_005150609 – 1137Missing in isoform 3. CuratedAdd BLAST529
Alternative sequenceiVSP_043387609 – 1019Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST411
Alternative sequenceiVSP_005149775 – 783Missing in isoform 2. Curated9
Alternative sequenceiVSP_0433881291K → KSKPD in isoform 5 and isoform 7. 1 Publication1
Alternative sequenceiVSP_0433891291K → KSSKPD in isoform 6. 1 Publication1
Alternative sequenceiVSP_0433901330G → GSDDSGYPGNLHSSS in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L38929 mRNA Translation: AAC41749.1
AL137125 Genomic DNA No translation available.
AL356584 Genomic DNA No translation available.
AL445926 Genomic DNA No translation available.
AL583805 Genomic DNA No translation available.
AL590397 Genomic DNA No translation available.
AL133479 Genomic DNA No translation available.
AL135790 Genomic DNA No translation available.
AL137069 Genomic DNA No translation available.
AL137851 Genomic DNA No translation available.
AL157826 Genomic DNA No translation available.
AL353638 Genomic DNA No translation available.
AL353733 Genomic DNA No translation available.
AL354722 Genomic DNA No translation available.
AL356054 Genomic DNA No translation available.
AL390723 Genomic DNA No translation available.
AL391864 Genomic DNA No translation available.
AL441884 Genomic DNA No translation available.
AL451130 Genomic DNA No translation available.
AL513422 Genomic DNA No translation available.
AL590307 Genomic DNA No translation available.
AL591133 Genomic DNA No translation available.
AL591622 Genomic DNA No translation available.
AL596451 Genomic DNA No translation available.
AL669908 Genomic DNA No translation available.
BC106713 mRNA Translation: AAI06714.1
BC106714 mRNA Translation: AAI06715.1
BC106715 mRNA Translation: AAI06716.1
X54133 mRNA Translation: CAA38068.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43786.1 [P23468-1]
CCDS55288.1 [P23468-7]
CCDS55289.1 [P23468-4]
CCDS55290.1 [P23468-6]
CCDS6472.2 [P23468-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56178

NCBI Reference Sequences

More...
RefSeqi
NP_001164496.1, NM_001171025.1 [P23468-4]
NP_002830.1, NM_002839.3 [P23468-1]
NP_569075.2, NM_130391.3 [P23468-5]
NP_569076.2, NM_130392.3 [P23468-6]
XP_006716895.1, XM_006716832.3 [P23468-4]
XP_006716896.1, XM_006716833.3 [P23468-5]
XP_006716898.1, XM_006716835.3 [P23468-7]
XP_011516294.1, XM_011517992.2 [P23468-1]
XP_016870480.1, XM_017014991.1 [P23468-6]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.446083

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355233; ENSP00000347373; ENSG00000153707 [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707 [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707 [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707 [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707 [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707 [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707 [P23468-1]
ENST00000634556; ENSP00000489063; ENSG00000282932 [P23468-1]
ENST00000634583; ENSP00000489509; ENSG00000282932 [P23468-5]
ENST00000634608; ENSP00000489257; ENSG00000282932 [P23468-1]
ENST00000635012; ENSP00000489439; ENSG00000282932 [P23468-1]
ENST00000635279; ENSP00000488982; ENSG00000282932 [P23468-4]
ENST00000635611; ENSP00000489155; ENSG00000282932 [P23468-7]
ENST00000635613; ENSP00000489038; ENSG00000282932 [P23468-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5789

UCSC genome browser

More...
UCSCi
uc003zkp.4 human [P23468-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38929 mRNA Translation: AAC41749.1
AL137125 Genomic DNA No translation available.
AL356584 Genomic DNA No translation available.
AL445926 Genomic DNA No translation available.
AL583805 Genomic DNA No translation available.
AL590397 Genomic DNA No translation available.
AL133479 Genomic DNA No translation available.
AL135790 Genomic DNA No translation available.
AL137069 Genomic DNA No translation available.
AL137851 Genomic DNA No translation available.
AL157826 Genomic DNA No translation available.
AL353638 Genomic DNA No translation available.
AL353733 Genomic DNA No translation available.
AL354722 Genomic DNA No translation available.
AL356054 Genomic DNA No translation available.
AL390723 Genomic DNA No translation available.
AL391864 Genomic DNA No translation available.
AL441884 Genomic DNA No translation available.
AL451130 Genomic DNA No translation available.
AL513422 Genomic DNA No translation available.
AL590307 Genomic DNA No translation available.
AL591133 Genomic DNA No translation available.
AL591622 Genomic DNA No translation available.
AL596451 Genomic DNA No translation available.
AL669908 Genomic DNA No translation available.
BC106713 mRNA Translation: AAI06714.1
BC106714 mRNA Translation: AAI06715.1
BC106715 mRNA Translation: AAI06716.1
X54133 mRNA Translation: CAA38068.1
CCDSiCCDS43786.1 [P23468-1]
CCDS55288.1 [P23468-7]
CCDS55289.1 [P23468-4]
CCDS55290.1 [P23468-6]
CCDS6472.2 [P23468-5]
PIRiA56178
RefSeqiNP_001164496.1, NM_001171025.1 [P23468-4]
NP_002830.1, NM_002839.3 [P23468-1]
NP_569075.2, NM_130391.3 [P23468-5]
NP_569076.2, NM_130392.3 [P23468-6]
XP_006716895.1, XM_006716832.3 [P23468-4]
XP_006716896.1, XM_006716833.3 [P23468-5]
XP_006716898.1, XM_006716835.3 [P23468-7]
XP_011516294.1, XM_011517992.2 [P23468-1]
XP_016870480.1, XM_017014991.1 [P23468-6]
UniGeneiHs.446083

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5ZNMR-A506-607[»]
2DLHNMR-A407-514[»]
2YD6X-ray1.35A21-226[»]
2YD7X-ray1.98A/B21-226[»]
4RCAX-ray2.99A21-322[»]
5WY8X-ray3.07A21-318[»]
5XNPX-ray3.73D/E21-320[»]
ProteinModelPortaliP23468
SMRiP23468
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111753, 59 interactors
DIPiDIP-17023N
IntActiP23468, 24 interactors
MINTiP23468
STRINGi9606.ENSP00000348812

PTM databases

DEPODiP23468
iPTMnetiP23468
PhosphoSitePlusiP23468

Polymorphism and mutation databases

BioMutaiPTPRD
DMDMi1709906

Proteomic databases

EPDiP23468
MaxQBiP23468
PaxDbiP23468
PeptideAtlasiP23468
PRIDEiP23468
ProteomicsDBi54101
54102 [P23468-2]
54103 [P23468-3]
54104 [P23468-4]
54105 [P23468-5]
54106 [P23468-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355233; ENSP00000347373; ENSG00000153707 [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707 [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707 [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707 [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707 [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707 [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707 [P23468-1]
ENST00000634556; ENSP00000489063; ENSG00000282932 [P23468-1]
ENST00000634583; ENSP00000489509; ENSG00000282932 [P23468-5]
ENST00000634608; ENSP00000489257; ENSG00000282932 [P23468-1]
ENST00000635012; ENSP00000489439; ENSG00000282932 [P23468-1]
ENST00000635279; ENSP00000488982; ENSG00000282932 [P23468-4]
ENST00000635611; ENSP00000489155; ENSG00000282932 [P23468-7]
ENST00000635613; ENSP00000489038; ENSG00000282932 [P23468-6]
GeneIDi5789
KEGGihsa:5789
UCSCiuc003zkp.4 human [P23468-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5789
DisGeNETi5789
EuPathDBiHostDB:ENSG00000153707.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPRD
HGNCiHGNC:9668 PTPRD
HPAiHPA054829
MIMi601598 gene
neXtProtiNX_P23468
OpenTargetsiENSG00000153707
PharmGKBiPA34013

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000153617
HOGENOMiHOG000010250
HOVERGENiHBG053758
InParanoidiP23468
KOiK06777
OMAiEVWWEPV
OrthoDBiEOG091G11WG
PhylomeDBiP23468
TreeFamiTF312900

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-8849932 Synaptic adhesion-like molecules
SignaLinkiP23468
SIGNORiP23468

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPRD human
EvolutionaryTraceiP23468

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPRD

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5789

Protein Ontology

More...
PROi
PR:P23468

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153707 Expressed in 196 organ(s), highest expression level in forebrain
CleanExiHS_PTPRD
ExpressionAtlasiP23468 baseline and differential
GenevisibleiP23468 HS

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23468
Secondary accession number(s): B1ALA0
, F5GWT7, Q3KPJ0, Q3KPJ1, Q3KPJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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