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Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

PTPRD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei266Required for interaction with IL1RAPBy similarity1
Binding sitei1521SubstrateBy similarity1
Active sitei1553Phosphocysteine intermediateBy similarity1
Binding sitei1597SubstrateBy similarity1
Active sitei1844Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-8849932 Synaptic adhesion-like molecules
SignaLinkiP23468
SIGNORiP23468

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
Gene namesi
Name:PTPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000153707.15
HGNCiHGNC:9668 PTPRD
MIMi601598 gene
neXtProtiNX_P23468

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 1265ExtracellularSequence analysisAdd BLAST1245
Transmembranei1266 – 1290HelicalSequence analysisAdd BLAST25
Topological domaini1291 – 1912CytoplasmicSequence analysisAdd BLAST622

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1178R → A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181. 1 Publication1
Mutagenesisi1181R → A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178. 1 Publication1

Organism-specific databases

DisGeNETi5789
OpenTargetsiENSG00000153707
PharmGKBiPA34013

Polymorphism and mutation databases

BioMutaiPTPRD
DMDMi1709906

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002543721 – 1912Receptor-type tyrosine-protein phosphatase deltaAdd BLAST1892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi832N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1181 – 1182CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP23468
MaxQBiP23468
PaxDbiP23468
PeptideAtlasiP23468
PRIDEiP23468
ProteomicsDBi54101
54102 [P23468-2]
54103 [P23468-3]
54104 [P23468-4]
54105 [P23468-5]
54106 [P23468-6]

PTM databases

DEPODiP23468
iPTMnetiP23468
PhosphoSitePlusiP23468

Expressioni

Gene expression databases

BgeeiENSG00000153707 Expressed in 196 organ(s), highest expression level in forebrain
CleanExiHS_PTPRD
ExpressionAtlasiP23468 baseline and differential
GenevisibleiP23468 HS

Organism-specific databases

HPAiHPA054829

Interactioni

Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:9624153). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats). Interacts with SLITRK2; induces presynaptic differentiation. Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AURKAO149652EBI-2682990,EBI-448680

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111753, 59 interactors
DIPiDIP-17023N
IntActiP23468, 24 interactors
MINTiP23468
STRINGi9606.ENSP00000348812

Structurei

Secondary structure

11912
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23468
SMRiP23468
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23468

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 114Ig-like C2-type 1Add BLAST91
Domaini126 – 224Ig-like C2-type 2Add BLAST99
Domaini236 – 318Ig-like C2-type 3Add BLAST83
Domaini325 – 415Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini420 – 516Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini518 – 607Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini612 – 709Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini714 – 822Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini823 – 916Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini921 – 1016Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1020 – 1106Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST87
Domaini1357 – 1612Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1644 – 1903Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 189Interaction with IL1RAPL1By similarity10
Regioni181 – 189Mini-exon peptide A9; sufficient for interaction with IL1RAPL1By similarity9
Regioni227 – 230Mini-exon peptide B; required for interaction with SLITRK2 and in the function in pre-synaptic differentiation; Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP; Modulates affinity for IL1RAPL1 and IL1RAPBy similarity4
Regioni1553 – 1559Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000010250
HOVERGENiHBG053758
InParanoidiP23468
KOiK06777
OMAiEVWWEPV
OrthoDBiEOG091G11WG
PhylomeDBiP23468
TreeFamiTF312900

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 6 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P23468-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
560 570 580 590 600
YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT
660 670 680 690 700
AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI
960 970 980 990 1000
ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR
1310 1320 1330 1340 1350
KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA
1910
LEYLGSFDHY AT
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:1,912
Mass (Da):214,760
Last modified:October 1, 1996 - v2
Checksum:i3AE8CBCD32182E26
GO
Isoform 2 (identifier: P23468-2) [UniParc]FASTAAdd to basket
Also known as: Kidney

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     226-229: Missing.
     775-783: Missing.

Show »
Length:1,890
Mass (Da):212,133
Checksum:iF67473E6C295C0D3
GO
Isoform 3 (identifier: P23468-3) [UniParc]FASTAAdd to basket
Also known as: Fetal brain

The sequence of this isoform differs from the canonical sequence as follows:
     609-1137: Missing.

Show »
Length:1,383
Mass (Da):156,088
Checksum:i6FA7F02992F7AEFF
GO
Isoform 4 (identifier: P23468-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     608-608: K → M
     609-1019: Missing.
     1330-1330: G → GSDDSGYPGNLHSSS

Note: No experimental confirmation available.
Show »
Length:1,505
Mass (Da):169,474
Checksum:i737878C2930FBF68
GO
Isoform 5 (identifier: P23468-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSKPD

Note: No experimental confirmation available.
Show »
Length:1,505
Mass (Da):169,606
Checksum:i7F25884835F91CDB
GO
Isoform 6 (identifier: P23468-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-608: K → M
     609-1019: Missing.
     1291-1291: K → KSSKPD

Note: No experimental confirmation available.
Show »
Length:1,506
Mass (Da):169,693
Checksum:i136D13489D0BEA56
GO
Isoform 7 (identifier: P23468-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     608-1019: KPSAPPQDIS...QFRTLPVDQV → M
     1291-1291: K → KSKPD

Show »
Length:1,502
Mass (Da):169,277
Checksum:iCDEDB66CFBBE5D0D
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3KPI9Q3KPI9_HUMAN
PTPRD protein
PTPRD
1,496Annotation score:
F5GWR7F5GWR7_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
1,505Annotation score:
C9J8S8C9J8S8_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
202Annotation score:
C9J6E4C9J6E4_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
93Annotation score:
A0A1B0GU15A0A1B0GU15_HUMAN
Receptor-type tyrosine-protein phos...
PTPRD
297Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03564528R → Q in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035646276L → P in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024581447Q → E. Corresponds to variant dbSNP:rs10977171Ensembl.1
Natural variantiVAR_035647901V → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061761995R → C. Corresponds to variant dbSNP:rs35929428Ensembl.1
Natural variantiVAR_0517611078E → D. Corresponds to variant dbSNP:rs7869444Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005147181 – 189Missing in isoform 2. Curated9
Alternative sequenceiVSP_054220181 – 183Missing in isoform 7. Curated3
Alternative sequenceiVSP_043384184 – 189Missing in isoform 4. 1 Publication6
Alternative sequenceiVSP_005148226 – 229Missing in isoform 2. Curated4
Alternative sequenceiVSP_043385227 – 230Missing in isoform 4. 1 Publication4
Alternative sequenceiVSP_054221608 – 1019KPSAP…PVDQV → M in isoform 7. CuratedAdd BLAST412
Alternative sequenceiVSP_043386608K → M in isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_005150609 – 1137Missing in isoform 3. CuratedAdd BLAST529
Alternative sequenceiVSP_043387609 – 1019Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST411
Alternative sequenceiVSP_005149775 – 783Missing in isoform 2. Curated9
Alternative sequenceiVSP_0433881291K → KSKPD in isoform 5 and isoform 7. 1 Publication1
Alternative sequenceiVSP_0433891291K → KSSKPD in isoform 6. 1 Publication1
Alternative sequenceiVSP_0433901330G → GSDDSGYPGNLHSSS in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38929 mRNA Translation: AAC41749.1
AL137125 Genomic DNA No translation available.
AL356584 Genomic DNA No translation available.
AL445926 Genomic DNA No translation available.
AL583805 Genomic DNA No translation available.
AL590397 Genomic DNA No translation available.
AL133479 Genomic DNA No translation available.
AL135790 Genomic DNA No translation available.
AL137069 Genomic DNA No translation available.
AL137851 Genomic DNA No translation available.
AL157826 Genomic DNA No translation available.
AL353638 Genomic DNA No translation available.
AL353733 Genomic DNA No translation available.
AL354722 Genomic DNA No translation available.
AL356054 Genomic DNA No translation available.
AL390723 Genomic DNA No translation available.
AL391864 Genomic DNA No translation available.
AL441884 Genomic DNA No translation available.
AL451130 Genomic DNA No translation available.
AL513422 Genomic DNA No translation available.
AL590307 Genomic DNA No translation available.
AL591133 Genomic DNA No translation available.
AL591622 Genomic DNA No translation available.
AL596451 Genomic DNA No translation available.
AL669908 Genomic DNA No translation available.
BC106713 mRNA Translation: AAI06714.1
BC106714 mRNA Translation: AAI06715.1
BC106715 mRNA Translation: AAI06716.1
X54133 mRNA Translation: CAA38068.1
CCDSiCCDS43786.1 [P23468-1]
CCDS55288.1 [P23468-7]
CCDS55289.1 [P23468-4]
CCDS55290.1 [P23468-6]
CCDS6472.2 [P23468-5]
PIRiA56178
RefSeqiNP_001164496.1, NM_001171025.1 [P23468-4]
NP_002830.1, NM_002839.3 [P23468-1]
NP_569075.2, NM_130391.3 [P23468-5]
NP_569076.2, NM_130392.3 [P23468-6]
XP_006716895.1, XM_006716832.3 [P23468-4]
XP_006716896.1, XM_006716833.3 [P23468-5]
XP_006716898.1, XM_006716835.3 [P23468-7]
XP_011516294.1, XM_011517992.2 [P23468-1]
XP_016870480.1, XM_017014991.1 [P23468-6]
UniGeneiHs.446083

Genome annotation databases

EnsembliENST00000355233; ENSP00000347373; ENSG00000153707 [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707 [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707 [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707 [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707 [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707 [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707 [P23468-1]
ENST00000634556; ENSP00000489063; ENSG00000282932 [P23468-1]
ENST00000634583; ENSP00000489509; ENSG00000282932 [P23468-5]
ENST00000634608; ENSP00000489257; ENSG00000282932 [P23468-1]
ENST00000635012; ENSP00000489439; ENSG00000282932 [P23468-1]
ENST00000635279; ENSP00000488982; ENSG00000282932 [P23468-4]
ENST00000635611; ENSP00000489155; ENSG00000282932 [P23468-7]
ENST00000635613; ENSP00000489038; ENSG00000282932 [P23468-6]
GeneIDi5789
KEGGihsa:5789
UCSCiuc003zkp.4 human [P23468-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38929 mRNA Translation: AAC41749.1
AL137125 Genomic DNA No translation available.
AL356584 Genomic DNA No translation available.
AL445926 Genomic DNA No translation available.
AL583805 Genomic DNA No translation available.
AL590397 Genomic DNA No translation available.
AL133479 Genomic DNA No translation available.
AL135790 Genomic DNA No translation available.
AL137069 Genomic DNA No translation available.
AL137851 Genomic DNA No translation available.
AL157826 Genomic DNA No translation available.
AL353638 Genomic DNA No translation available.
AL353733 Genomic DNA No translation available.
AL354722 Genomic DNA No translation available.
AL356054 Genomic DNA No translation available.
AL390723 Genomic DNA No translation available.
AL391864 Genomic DNA No translation available.
AL441884 Genomic DNA No translation available.
AL451130 Genomic DNA No translation available.
AL513422 Genomic DNA No translation available.
AL590307 Genomic DNA No translation available.
AL591133 Genomic DNA No translation available.
AL591622 Genomic DNA No translation available.
AL596451 Genomic DNA No translation available.
AL669908 Genomic DNA No translation available.
BC106713 mRNA Translation: AAI06714.1
BC106714 mRNA Translation: AAI06715.1
BC106715 mRNA Translation: AAI06716.1
X54133 mRNA Translation: CAA38068.1
CCDSiCCDS43786.1 [P23468-1]
CCDS55288.1 [P23468-7]
CCDS55289.1 [P23468-4]
CCDS55290.1 [P23468-6]
CCDS6472.2 [P23468-5]
PIRiA56178
RefSeqiNP_001164496.1, NM_001171025.1 [P23468-4]
NP_002830.1, NM_002839.3 [P23468-1]
NP_569075.2, NM_130391.3 [P23468-5]
NP_569076.2, NM_130392.3 [P23468-6]
XP_006716895.1, XM_006716832.3 [P23468-4]
XP_006716896.1, XM_006716833.3 [P23468-5]
XP_006716898.1, XM_006716835.3 [P23468-7]
XP_011516294.1, XM_011517992.2 [P23468-1]
XP_016870480.1, XM_017014991.1 [P23468-6]
UniGeneiHs.446083

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5ZNMR-A506-607[»]
2DLHNMR-A407-514[»]
2YD6X-ray1.35A21-226[»]
2YD7X-ray1.98A/B21-226[»]
4RCAX-ray2.99A21-322[»]
5WY8X-ray3.07A21-318[»]
5XNPX-ray3.73D/E21-320[»]
ProteinModelPortaliP23468
SMRiP23468
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111753, 59 interactors
DIPiDIP-17023N
IntActiP23468, 24 interactors
MINTiP23468
STRINGi9606.ENSP00000348812

PTM databases

DEPODiP23468
iPTMnetiP23468
PhosphoSitePlusiP23468

Polymorphism and mutation databases

BioMutaiPTPRD
DMDMi1709906

Proteomic databases

EPDiP23468
MaxQBiP23468
PaxDbiP23468
PeptideAtlasiP23468
PRIDEiP23468
ProteomicsDBi54101
54102 [P23468-2]
54103 [P23468-3]
54104 [P23468-4]
54105 [P23468-5]
54106 [P23468-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355233; ENSP00000347373; ENSG00000153707 [P23468-6]
ENST00000356435; ENSP00000348812; ENSG00000153707 [P23468-1]
ENST00000381196; ENSP00000370593; ENSG00000153707 [P23468-1]
ENST00000397606; ENSP00000380731; ENSG00000153707 [P23468-4]
ENST00000397611; ENSP00000380735; ENSG00000153707 [P23468-7]
ENST00000486161; ENSP00000417093; ENSG00000153707 [P23468-5]
ENST00000540109; ENSP00000438164; ENSG00000153707 [P23468-1]
ENST00000634556; ENSP00000489063; ENSG00000282932 [P23468-1]
ENST00000634583; ENSP00000489509; ENSG00000282932 [P23468-5]
ENST00000634608; ENSP00000489257; ENSG00000282932 [P23468-1]
ENST00000635012; ENSP00000489439; ENSG00000282932 [P23468-1]
ENST00000635279; ENSP00000488982; ENSG00000282932 [P23468-4]
ENST00000635611; ENSP00000489155; ENSG00000282932 [P23468-7]
ENST00000635613; ENSP00000489038; ENSG00000282932 [P23468-6]
GeneIDi5789
KEGGihsa:5789
UCSCiuc003zkp.4 human [P23468-1]

Organism-specific databases

CTDi5789
DisGeNETi5789
EuPathDBiHostDB:ENSG00000153707.15
GeneCardsiPTPRD
HGNCiHGNC:9668 PTPRD
HPAiHPA054829
MIMi601598 gene
neXtProtiNX_P23468
OpenTargetsiENSG00000153707
PharmGKBiPA34013
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000010250
HOVERGENiHBG053758
InParanoidiP23468
KOiK06777
OMAiEVWWEPV
OrthoDBiEOG091G11WG
PhylomeDBiP23468
TreeFamiTF312900

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-8849932 Synaptic adhesion-like molecules
SignaLinkiP23468
SIGNORiP23468

Miscellaneous databases

ChiTaRSiPTPRD human
EvolutionaryTraceiP23468
GeneWikiiPTPRD
GenomeRNAii5789
PROiPR:P23468
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153707 Expressed in 196 organ(s), highest expression level in forebrain
CleanExiHS_PTPRD
ExpressionAtlasiP23468 baseline and differential
GenevisibleiP23468 HS

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 6 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRD_HUMAN
AccessioniPrimary (citable) accession number: P23468
Secondary accession number(s): B1ALA0
, F5GWT7, Q3KPJ0, Q3KPJ1, Q3KPJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 196 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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