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Protein

Receptor-type tyrosine-protein phosphatase beta

Gene

PTPRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1870Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1904Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1
Binding sitei1948SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processAngiogenesis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P23467

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P23467

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase beta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase beta
Short name:
R-PTP-beta
Alternative name(s):
Vascular endothelial protein tyrosine phosphatase
Short name:
VE-PTP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRB
Synonyms:PTPB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127329.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9665 PTPRB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176882 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P23467

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 1621ExtracellularSequence analysisAdd BLAST1599
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1622 – 1642HelicalSequence analysisAdd BLAST21
Topological domaini1643 – 1997CytoplasmicSequence analysisAdd BLAST355

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5787

Open Targets

More...
OpenTargetsi
ENSG00000127329

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34010

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2706

Drug and drug target database

More...
DrugBanki
DB08678 (4-ETHYLPHENYL)SULFAMIC ACID
DB06989 {4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1851

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPRB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002543623 – 1997Receptor-type tyrosine-protein phosphatase betaAdd BLAST1975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi652N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi829N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1040N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1096N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1518N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1981PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P23467

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P23467

PeptideAtlas

More...
PeptideAtlasi
P23467

PRoteomics IDEntifications database

More...
PRIDEi
P23467

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54098
54099 [P23467-2]
54100 [P23467-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
P23467

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P23467

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P23467

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by hypoxia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127329 Expressed in 203 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTPRB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P23467 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P23467 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004782
HPA067868

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with TEK (PubMed:19451274). Interacts via fibronectin type-III 17 domain with CDH5. Detected in a complex with CNTN1 and NRCAM (By similarity). Interacts (phosphorylated form) with FYN and GRB2 (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111751, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P23467

Protein interaction database and analysis system

More...
IntActi
P23467, 32 interactors

Molecular INTeraction database

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MINTi
P23467

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334928

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P23467

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11997
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P23467

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P23467

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P23467

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 111Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini112 – 207Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini203 – 288Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST86
Domaini291 – 378Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini379 – 471Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93
Domaini467 – 552Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST86
Domaini556 – 641Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST86
Domaini642 – 729Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST88
Domaini730 – 829Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST100
Domaini819 – 906Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST88
Domaini909 – 1001Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST93
Domaini995 – 1083Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST89
Domaini1087 – 1175Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST89
Domaini1173 – 1260Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST88
Domaini1260 – 1356Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST97
Domaini1357 – 1448Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST92
Domaini1458 – 1554Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST97
Domaini1703 – 1963Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1904 – 1910Substrate bindingBy similarity7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0791 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156088

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060224

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053759

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23467

KEGG Orthology (KO)

More...
KOi
K05694

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHIRVNK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00JF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23467

TreeFam database of animal gene trees

More...
TreeFami
TF351926

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 15 hits
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 15 hits
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 17 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 16 hits
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 12 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23467-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSHGAGLAL WITLSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS
60 70 80 90 100
PCNFSLIYSS DTLGAALCPT FRIDNTTYGC NLQDLQAGTI YNFRIISLDE
110 120 130 140 150
ERTVVLQTDP LPPARFGVSK EKTTSTSLHV WWTPSSGKVT SYEVQLFDEN
160 170 180 190 200
NQKIQGVQIQ ESTSWNEYTF FNLTAGSKYN IAITAVSGGK RSFSVYTNGS
210 220 230 240 250
TVPSPVKDIG ISTKANSLLI SWSHGSGNVE RYRLMLMDKG ILVHGGVVDK
260 270 280 290 300
HATSYAFHGL TPGYLYNLTV MTEAAGLQNY RWKLVRTAPM EVSNLKVTND
310 320 330 340 350
GSLTSLKVKW QRPPGNVDSY NITLSHKGTI KESRVLAPWI TETHFKELVP
360 370 380 390 400
GRLYQVTVSC VSGELSAQKM AVGRTFPDKV ANLEANNNGR MRSLVVSWSP
410 420 430 440 450
PAGDWEQYRI LLFNDSVVLL NITVGKEETQ YVMDDTGLVP GRQYEVEVIV
460 470 480 490 500
ESGNLKNSER CQGRTVPLAV LQLRVKHANE TSLSIMWQTP VAEWEKYIIS
510 520 530 540 550
LADRDLLLIH KSLSKDAKEF TFTDLVPGRK YMATVTSISG DLKNSSSVKG
560 570 580 590 600
RTVPAQVTDL HVANQGMTSS LFTNWTQAQG DVEFYQVLLI HENVVIKNES
610 620 630 640 650
ISSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT
660 670 680 690 700
VNNSGRNDYL SVSWLLAPGD VDNYEVTLSH DGKVVQSLVI AKSVRECSFS
710 720 730 740 750
SLTPGRLYTV TITTRSGKYE NHSFSQERTV PDKVQGVSVS NSARSDYLRV
760 770 780 790 800
SWVHATGDFD HYEVTIKNKN NFIQTKSIPK SENECVFVQL VPGRLYSVTV
810 820 830 840 850
TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR STEDLHVTWS GANGDVDQYE
860 870 880 890 900
IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF
910 920 930 940 950
IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD
960 970 980 990 1000
SQTIPKHVFE HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG
1010 1020 1030 1040 1050
VIADNAYSSY SLIVSWQKAA GVAERYDILL LTENGILLRN TSEPATTKQH
1060 1070 1080 1090 1100
KFEDLTPGKK YKIQILTVSG GLFSKEAQTE GRTVPAAVTD LRITENSTRH
1110 1120 1130 1140 1150
LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPLVQSFS FQNLLQGRMY
1160 1170 1180 1190 1200
KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL WFNWSPASGD
1210 1220 1230 1240 1250
FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS
1260 1270 1280 1290 1300
NKVTAESRTA PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR
1310 1320 1330 1340 1350
DALTVFNPYN NRKSEGRIVY GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS
1360 1370 1380 1390 1400
VRTKPDKIQN LHCRPQNSTA IACSWIPPDS DFDGYSIECR KMDTQEVEFS
1410 1420 1430 1440 1450
RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS TITMIDRPPP
1460 1470 1480 1490 1500
PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE
1510 1520 1530 1540 1550
LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA
1560 1570 1580 1590 1600
EMESLGGKCD PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY
1610 1620 1630 1640 1650
SDTFFSLPIT TESEPLFGAI EGVSAGLFLI GMLVAVVALL ICRQKVSHGR
1660 1670 1680 1690 1700
ERPSARLSIR RDRPLSVHLN LGQKGNRKTS CPIKINQFEG HFMKLQADSN
1710 1720 1730 1740 1750
YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD ATRVKLSNVD
1760 1770 1780 1790 1800
DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM
1810 1820 1830 1840 1850
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG
1860 1870 1880 1890 1900
EEQLDAHRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT
1910 1920 1930 1940 1950
VVHCSAGVGR TGTFIALDRI LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE
1960 1970 1980 1990
CQYVYLHQCV RDVLRARKLR SEQENPLFPI YENVNPEYHR DPVYSRH
Length:1,997
Mass (Da):224,301
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76E67B4A6109AA0F
GO
Isoform 2 (identifier: P23467-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-466: Missing.

Show »
Length:1,907
Mass (Da):214,209
Checksum:iC8A61E610D7ECC31
GO
Isoform 3 (identifier: P23467-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MLSHGAGLALWITLSLLQ → MEAEFYMVIL...TQPFSSTTEE

Show »
Length:2,215
Mass (Da):249,143
Checksum:i605BB45BA4541F02
GO
Isoform 4 (identifier: P23467-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     997-1086: Missing.

Show »
Length:1,907
Mass (Da):214,505
Checksum:i237BC55F05D696E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU56F8VU56_HUMAN
Receptor-type tyrosine-protein phos...
PTPRB
2,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6ZR19Q6ZR19_HUMAN
Receptor-type tyrosine-protein phos...
PTPRB
1,407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSD5F8VSD5_HUMAN
Receptor-type tyrosine-protein phos...
PTPRB
1,583Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHE8H0YHE8_HUMAN
Receptor-type tyrosine-protein phos...
PTPRB
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti261T → S in CAA38066 (PubMed:2170109).Curated1
Sequence conflicti666L → V in CAA38066 (PubMed:2170109).Curated1
Sequence conflicti926V → A in BX648245 (PubMed:17974005).Curated1
Sequence conflicti1559C → R in CAA38066 (PubMed:2170109).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06225194R → K2 PublicationsCorresponds to variant dbSNP:rs2252784Ensembl.1
Natural variantiVAR_062252127S → G1 PublicationCorresponds to variant dbSNP:rs2465811Ensembl.1
Natural variantiVAR_057135395V → A. Corresponds to variant dbSNP:rs36027530Ensembl.1
Natural variantiVAR_057136415D → E. Corresponds to variant dbSNP:rs2165627Ensembl.1
Natural variantiVAR_057137939T → M. Corresponds to variant dbSNP:rs2304821Ensembl.1
Natural variantiVAR_0571381032T → I. Corresponds to variant dbSNP:rs34902691Ensembl.1
Natural variantiVAR_0571391934G → A. Corresponds to variant dbSNP:rs17226367Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0404841 – 18MLSHG…LSLLQ → MEAEFYMVILTCLIFRNSEG FQIVHVQKQQCLFKNEKVVV GSCNRTIQNQQWMWTEDEKL LHVKSALCLAISNSSRGPSR SAILDRCSQAPRWTCYDQEG FLEVENASLFLQKQGSRVVV KKARKYLHSWMKIDVNKEGK LVNESLCLQKAGLGAEVSVR STRNTAPPQILTTFNAVPDG LVFLIRNTTEAFIRNAAENY SQNSSERQHPNLHMTGITDT SWVLSTTQPFSSTTEE in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_038521377 – 466Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_053944997 – 1086Missing in isoform 4. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54131 mRNA Translation: CAA38066.1
BX648245 mRNA No translation available.
AC025569 Genomic DNA No translation available.
AC083809 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97254.1
BC101679 mRNA Translation: AAI01680.1
BC113463 mRNA Translation: AAI13464.1
BC143356 mRNA Translation: AAI43357.1
BC143360 mRNA Translation: AAI43361.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44943.1 [P23467-3]
CCDS44944.1 [P23467-1]
CCDS55845.1 [P23467-2]
CCDS55846.1 [P23467-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
S12050

NCBI Reference Sequences

More...
RefSeqi
NP_001103224.1, NM_001109754.3 [P23467-3]
NP_001193900.1, NM_001206971.2 [P23467-2]
NP_001193901.1, NM_001206972.2 [P23467-4]
NP_001317133.1, NM_001330204.1
NP_002828.3, NM_002837.5 [P23467-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.201030
Hs.434375

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261266; ENSP00000261266; ENSG00000127329 [P23467-1]
ENST00000334414; ENSP00000334928; ENSG00000127329 [P23467-3]
ENST00000538708; ENSP00000438927; ENSG00000127329 [P23467-4]
ENST00000550857; ENSP00000447302; ENSG00000127329 [P23467-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5787

UCSC genome browser

More...
UCSCi
uc001swb.6 human [P23467-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54131 mRNA Translation: CAA38066.1
BX648245 mRNA No translation available.
AC025569 Genomic DNA No translation available.
AC083809 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97254.1
BC101679 mRNA Translation: AAI01680.1
BC113463 mRNA Translation: AAI13464.1
BC143356 mRNA Translation: AAI43357.1
BC143360 mRNA Translation: AAI43361.1
CCDSiCCDS44943.1 [P23467-3]
CCDS44944.1 [P23467-1]
CCDS55845.1 [P23467-2]
CCDS55846.1 [P23467-4]
PIRiS12050
RefSeqiNP_001103224.1, NM_001109754.3 [P23467-3]
NP_001193900.1, NM_001206971.2 [P23467-2]
NP_001193901.1, NM_001206972.2 [P23467-4]
NP_001317133.1, NM_001330204.1
NP_002828.3, NM_002837.5 [P23467-1]
UniGeneiHs.201030
Hs.434375

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AHSX-ray2.10A/B1686-1971[»]
2H02X-ray2.30A/B1662-1973[»]
2H03X-ray1.65A1676-1970[»]
2H04X-ray2.30A1662-1973[»]
2HC1X-ray1.30A1676-1970[»]
2HC2X-ray1.40A1676-1970[»]
2I3RX-ray1.85A/B1662-1973[»]
2I3UX-ray1.85A1662-1973[»]
2I4EX-ray1.75A/B1662-1973[»]
2I4GX-ray1.65A1662-1973[»]
2I4HX-ray2.15A1662-1973[»]
2I5XX-ray1.70A/B1662-1973[»]
ProteinModelPortaliP23467
SMRiP23467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111751, 12 interactors
CORUMiP23467
IntActiP23467, 32 interactors
MINTiP23467
STRINGi9606.ENSP00000334928

Chemistry databases

BindingDBiP23467
ChEMBLiCHEMBL2706
DrugBankiDB08678 (4-ETHYLPHENYL)SULFAMIC ACID
DB06989 {4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID
GuidetoPHARMACOLOGYi1851

PTM databases

DEPODiP23467
iPTMnetiP23467
PhosphoSitePlusiP23467

Polymorphism and mutation databases

BioMutaiPTPRB
DMDMi317373518

Proteomic databases

MaxQBiP23467
PaxDbiP23467
PeptideAtlasiP23467
PRIDEiP23467
ProteomicsDBi54098
54099 [P23467-2]
54100 [P23467-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261266; ENSP00000261266; ENSG00000127329 [P23467-1]
ENST00000334414; ENSP00000334928; ENSG00000127329 [P23467-3]
ENST00000538708; ENSP00000438927; ENSG00000127329 [P23467-4]
ENST00000550857; ENSP00000447302; ENSG00000127329 [P23467-2]
GeneIDi5787
KEGGihsa:5787
UCSCiuc001swb.6 human [P23467-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5787
DisGeNETi5787
EuPathDBiHostDB:ENSG00000127329.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTPRB

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0017674
HIX0037045
HGNCiHGNC:9665 PTPRB
HPAiCAB004782
HPA067868
MIMi176882 gene
neXtProtiNX_P23467
OpenTargetsiENSG00000127329
PharmGKBiPA34010

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000156088
HOGENOMiHOG000060224
HOVERGENiHBG053759
InParanoidiP23467
KOiK05694
OMAiPHIRVNK
OrthoDBiEOG091G00JF
PhylomeDBiP23467
TreeFamiTF351926

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
SignaLinkiP23467
SIGNORiP23467

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTPRB human
EvolutionaryTraceiP23467

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PTPRB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5787

Protein Ontology

More...
PROi
PR:P23467

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127329 Expressed in 203 organ(s), highest expression level in visceral pleura
CleanExiHS_PTPRB
ExpressionAtlasiP23467 baseline and differential
GenevisibleiP23467 HS

Family and domain databases

CDDicd00063 FN3, 14 hits
Gene3Di2.60.40.10, 15 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 15 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 17 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 16 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 12 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23467
Secondary accession number(s): B7ZKS8
, B7ZKT0, C9JX87, F5H3G6, Q14D85, Q3MIV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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