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Protein

Adenylate cyclase

Gene

CYR1

Organism
Lachancea kluyveri (Yeast) (Saccharomyces kluyveri)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1488MagnesiumBy similarity1
Metal bindingi1531MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:CYR1
OrganismiLachancea kluyveri (Yeast) (Saccharomyces kluyveri)
Taxonomic identifieri4934 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957321 – 1839Adenylate cyclaseAdd BLAST1839

Proteomic databases

PRIDEiP23466

Structurei

3D structure databases

ProteinModelPortaliP23466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini494 – 574Ras-associatingPROSITE-ProRule annotationAdd BLAST81
Repeati632 – 655LRR 1Add BLAST24
Repeati659 – 679LRR 2Add BLAST21
Repeati681 – 702LRR 3Add BLAST22
Repeati704 – 726LRR 4Add BLAST23
Repeati727 – 748LRR 5Add BLAST22
Repeati750 – 771LRR 6Add BLAST22
Repeati773 – 794LRR 7Add BLAST22
Repeati795 – 816LRR 8Add BLAST22
Repeati817 – 834LRR 9Add BLAST18
Repeati835 – 856LRR 10Add BLAST22
Repeati858 – 879LRR 11Add BLAST22
Repeati882 – 903LRR 12Add BLAST22
Repeati905 – 926LRR 13Add BLAST22
Repeati928 – 950LRR 14Add BLAST23
Repeati951 – 971LRR 15Add BLAST21
Repeati982 – 1004LRR 16Add BLAST23
Repeati1006 – 1027LRR 17Add BLAST22
Repeati1028 – 1048LRR 18Add BLAST21
Repeati1051 – 1073LRR 19Add BLAST23
Repeati1074 – 1096LRR 20Add BLAST23
Repeati1103 – 1124LRR 21Add BLAST22
Repeati1135 – 1160LRR 22Add BLAST26
Domaini1173 – 1439PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST267
Domaini1483 – 1620Guanylate cyclasePROSITE-ProRule annotationAdd BLAST138

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR029787 Nucleotide_cyclase
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
IPR000159 RA_dom
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF13855 LRR_8, 3 hits
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SM00369 LRR_TYP, 11 hits
SM00332 PP2Cc, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF55073 SSF55073, 2 hits
SSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS51450 LRR, 18 hits
PS51746 PPM_2, 1 hit
PS50200 RA, 1 hit

Sequencei

Sequence statusi: Complete.

P23466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPTDAERV NMRREKHPQI EETFEEHVHN AMPKFKKHYA LGITTHTNDE
60 70 80 90 100
DDDPRDHRQR GIHNPNFIHS PNDPRPPLSQ PIKPRFSVHG TASNASVFSH
110 120 130 140 150
GDIAPVRKTS RAGSLFKRLA GKKSTTSLLG TEHQQRQQQQ SSNSLVPAAG
160 170 180 190 200
LRRKMSTFIH GGSGSQSNES RGTRSSIFFP STSNSRRGSA TSTMTSGSRS
210 220 230 240 250
SHPPDTPPIT SQQQEQQYDQ QRQQRPETRE QEQKPPTLSD MPIVSRSPSF
260 270 280 290 300
FMLDTDLNNL SDITNIISAT PKNTESDEVR STGANKTLKY PKPPLSSHKS
310 320 330 340 350
TSASDLSHHK AQWTAPESWD IEEDANKLLA TKRKAKHHHH YHHPQHPRPP
360 370 380 390 400
HRKHYSNFSK PIEDKAVVEK EQEPPEKCPQ PISTDSNDAQ GLEIAKPIDE
410 420 430 440 450
SSGIQHSAST QSVSSFSSGA TGASGATGKQ IGGDQETEST ISTVGEDEEV
460 470 480 490 500
TNLRSIDSEQ TDDTSFSKFD EEYDKAEYQL EKYYNDFSDV DLNRRYAIRI
510 520 530 540 550
FNIDDTFTTL SCTPNTTLQD MMPQLKRKFN VGQGSYQVSL KVGKLSKILR
560 570 580 590 600
PTAKPILIQR RLLLLNGYLK SDPLHIMGIE DLSFIFSFVF HPVATSHLNY
610 620 630 640 650
EQEQRLSRGD FVHVDLRNMD LTTPPIILYQ HTSDIESLDV SNNANIFLPL
660 670 680 690 700
DFIESAIKLS SLRMVNIRAS KFPANVTDAY KLVSLDLERN FIKKVPDSIF
710 720 730 740 750
KLNNLTIVNL QCNNLERLPP GFSKLKNLQL LDISSNKFVN YPEVINSCTN
760 770 780 790 800
LLQIDLSYNK IHSLPVSINQ LVKLAKMNLF NNRLTSVGDL SQMKNLRTLN
810 820 830 840 850
LRCNRVTSIE CHAPNLQNLF LTDNRISTFD DDLTRLRTLE LQQNPITSMV
860 870 880 890 900
CGGNYMANMT SLSLNKAKLS SFSAELLSKL PRLEKLELNE NNLTQLPPEI
910 920 930 940 950
NKLTRLIYLS VARNKLESIP DEISDLRSLK SLDLHSNNLR MLMNNLEDLE
960 970 980 990 1000
LTSLNVSSNL LTGFHGSPAK FFASPSPKLA KSLLFLSVAD NNLTDSIWPL
1010 1020 1030 1040 1050
VNTFQNLKTL NLSYNNFVEI SDLKLQNLTE LYLSGNNFTS LPGEAVQHLR
1060 1070 1080 1090 1100
SLKVLMLNGN KLLSLPAELS QLSRLSVLDV GSNQLKYNIS NYHYDWNWRN
1110 1120 1130 1140 1150
NKDLKYLNFS GNKRFEIKSA LDPEGKNDLS DLGILKQLRV LGLMDVTLKT
1160 1170 1180 1190 1200
SKVPDESVSI RLRTTASMIN GMRYGVADTL GQSDSVCSRD VTFERFRGRE
1210 1220 1230 1240 1250
DECLICLYDG KNENASSGHK ISKIIRDIYD KILIRLLEKY GEESDGIKRA
1260 1270 1280 1290 1300
LRYSFLQLNK EINGMLVSVE DGNTDSGLTS ADLLSGSSAT VVYLKGKKIY
1310 1320 1330 1340 1350
TANIGDTMAV LSKNNGDFVT LTKLHVPAER EEYERIRTSG GYVNNQKLDG
1360 1370 1380 1390 1400
VSEVSRAVGF FDLLPHIHAS PDISETVLSY SDEMLIIATH KLWEYLDYET
1410 1420 1430 1440 1450
VCDISRENKS QPMSAAEKMK DYAISYGCSD NITILCVSLD KSVNQQSQFT
1460 1470 1480 1490 1500
LNREDLISRK NTFEDTVLRR LQPEIAPPTG NVAIVFTDIK NSTFLWELFP
1510 1520 1530 1540 1550
DAMRAAIKTH NDIMRRQLRI YGGYEVKTEG DAFMVAFPTP TSALVWCLSV
1560 1570 1580 1590 1600
QLKLLEAEWP EEITSIQDGC LITDNSGTKV YLGLSVRMGV HWGCPVPEID
1610 1620 1630 1640 1650
LVTQRMDYLG PVVNKAARVS GVADGGQITL SSDFCSEFKK IMKFHKRVVE
1660 1670 1680 1690 1700
NQEPLKEVYG EDFIGEVLER EIHMLENVGW VFKDLGEQKL KGLETKEFIT
1710 1720 1730 1740 1750
IAYPKTLASR HDLATKNQNS SVLNDDLLFQ LRTISNKLEN ILSSINGGLI
1760 1770 1780 1790 1800
ESETPGNSSI YMTFDKNTKD AVITKSTESD WISFLDHLVT RVESTVAILQ
1810 1820 1830
LRQKLQGGLE LYTSSDSTMH KSVFELLDEI LKIQTDQKQ
Length:1,839
Mass (Da):206,896
Last modified:November 1, 1991 - v1
Checksum:i86A69BCB1F2733CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56042 Genomic DNA Translation: CAA39513.1
PIRiJQ1145 OYBYK

Similar proteinsi

Entry informationi

Entry nameiCYAA_LACKL
AccessioniPrimary (citable) accession number: P23466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 18, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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