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Protein

Homeobox protein Hox-D8

Gene

Hoxd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi195 – 254HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • skeletal system morphogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D8
Alternative name(s):
Homeobox protein Hox-4.3
Homeobox protein Hox-5.4
Gene namesi
Name:Hoxd8
Synonyms:Hox-4.3, Hoxd-8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96209 Hoxd8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002171 – 289Homeobox protein Hox-D8Add BLAST289

Proteomic databases

PaxDbiP23463
PRIDEiP23463

PTM databases

PhosphoSitePlusiP23463

Expressioni

Gene expression databases

BgeeiENSMUSG00000027102 Expressed in 210 organ(s), highest expression level in cortex of kidney
CleanExiMM_HOXD8
ExpressionAtlasiP23463 baseline and differential
GenevisibleiP23463 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019749

Structurei

3D structure databases

ProteinModelPortaliP23463
SMRiP23463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 188Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 28Poly-AlaAdd BLAST14
Compositional biasi62 – 89Gly/Pro-richAdd BLAST28
Compositional biasi108 – 117Poly-Pro10

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP23463
KOiK09308
OMAiQEYFHPG
OrthoDBiEOG091G09XD
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P23463-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNPLY SKYKAAAAAA AAAAAAAAGE AINPTYYDCH FAPEVSGRHA
60 70 80 90 100
AALQLYGNSA AGFPHAHPHP HPHPSPPPGC GGGGGPGPGQ DYFHAGAGSP
110 120 130 140 150
TAAYQAAPPP PHPPPPPPPP PCGGIACHGE PAKFYGYDNL QRQPIFTTQQ
160 170 180 190 200
EAELVQYPDC KSSSGNIGED PDHLNQSSSP SQMFPWMRPQ AAPGRRRGRQ
210 220 230 240 250
TYSRFQTLEL EKEFLFNPYL TRKRRIEVSH TLALTERQVK IWFQNRRMKW
260 270 280
KKENNKDKFP ASRPEAKDGD PKKEVSGLEE DGAEGCPTN
Length:289
Mass (Da):31,363
Last modified:October 3, 2012 - v4
Checksum:iE9996BB134A3A22E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ASN1A2ASN1_MOUSE
Homeobox protein Hox-D8
Hoxd8
288Annotation score:
F6W963F6W963_MOUSE
Homeobox protein Hox-D8
Hoxd8
107Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56561 Genomic DNA Translation: CAA39911.1
AL928644 Genomic DNA Translation: CAM20532.1
M87803 Genomic DNA Translation: AAA37852.1
CCDSiCCDS16143.1
PIRiA43562
S16177 A41605
RefSeqiNP_032302.2, NM_008276.3
UniGeneiMm.280673
Mm.486465

Genome annotation databases

EnsembliENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102
GeneIDi15437
KEGGimmu:15437
UCSCiuc008kea.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56561 Genomic DNA Translation: CAA39911.1
AL928644 Genomic DNA Translation: CAM20532.1
M87803 Genomic DNA Translation: AAA37852.1
CCDSiCCDS16143.1
PIRiA43562
S16177 A41605
RefSeqiNP_032302.2, NM_008276.3
UniGeneiMm.280673
Mm.486465

3D structure databases

ProteinModelPortaliP23463
SMRiP23463
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019749

PTM databases

PhosphoSitePlusiP23463

Proteomic databases

PaxDbiP23463
PRIDEiP23463

Protocols and materials databases

DNASUi15437
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019749; ENSMUSP00000019749; ENSMUSG00000027102
GeneIDi15437
KEGGimmu:15437
UCSCiuc008kea.2 mouse

Organism-specific databases

CTDi3234
MGIiMGI:96209 Hoxd8

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP23463
KOiK09308
OMAiQEYFHPG
OrthoDBiEOG091G09XD
TreeFamiTF316310

Miscellaneous databases

PROiPR:P23463
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027102 Expressed in 210 organ(s), highest expression level in cortex of kidney
CleanExiMM_HOXD8
ExpressionAtlasiP23463 baseline and differential
GenevisibleiP23463 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD8_MOUSE
AccessioniPrimary (citable) accession number: P23463
Secondary accession number(s): A2ASN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 149 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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