UniProtKB - P23443 (KS6B1_HUMAN)
Ribosomal protein S6 kinase beta-1
RPS6KB1
Functioni
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 123 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 218 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 97 – 105 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- kinase activity Source: Reactome
- PDZ domain binding Source: Ensembl
- peptide binding Source: Ensembl
- protein kinase activity Source: UniProtKB
- protein phosphatase 2A binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: MGI
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- ribosomal protein S6 kinase activity Source: Ensembl
GO - Biological processi
- aging Source: Ensembl
- apoptotic process Source: UniProtKB-KW
- behavioral fear response Source: Ensembl
- cell migration Source: Ensembl
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to growth factor stimulus Source: UniProtKB
- cellular response to insulin stimulus Source: GO_Central
- cellular response to interferon-gamma Source: Ensembl
- G1/S transition of mitotic cell cycle Source: UniProtKB
- germ cell development Source: Ensembl
- intracellular signal transduction Source: GO_Central
- long-chain fatty acid import into cell Source: UniProtKB
- long-term memory Source: Ensembl
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of insulin receptor signaling pathway Source: UniProtKB
- peptidyl-serine phosphorylation Source: UniProtKB
- phosphatidylinositol-mediated signaling Source: UniProtKB
- positive regulation of mitotic cell cycle Source: UniProtKB
- positive regulation of skeletal muscle tissue growth Source: Ensembl
- positive regulation of smooth muscle cell migration Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of translation Source: UniProtKB
- positive regulation of translational initiation Source: UniProtKB
- protein kinase B signaling Source: Ensembl
- protein phosphorylation Source: GO_Central
- regulation of glucose import Source: Ensembl
- response to drug Source: Ensembl
- response to electrical stimulus involved in regulation of muscle adaptation Source: Ensembl
- response to ethanol Source: Ensembl
- response to glucagon Source: Ensembl
- response to glucose Source: Ensembl
- response to heat Source: Ensembl
- response to leucine Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to nutrient Source: Ensembl
- response to nutrient levels Source: UniProtKB
- response to testosterone Source: Ensembl
- response to toxic substance Source: Ensembl
- response to tumor necrosis factor Source: Ensembl
- response to wounding Source: Ensembl
- signal transduction Source: ProtInc
- skeletal muscle atrophy Source: Ensembl
- skeletal muscle contraction Source: Ensembl
- TOR signaling Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle, Translation regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P23443 |
Reactomei | R-HSA-166208, mTORC1-mediated signalling |
SABIO-RKi | P23443 |
SignaLinki | P23443 |
SIGNORi | P23443 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase beta-1 (EC:2.7.11.14 Publications)Short name: S6K-beta-1 Short name: S6K1 Alternative name(s): 70 kDa ribosomal protein S6 kinase 1 Short name: P70S6K1 Short name: p70-S6K 1 Ribosomal protein S6 kinase I Serine/threonine-protein kinase 14A p70 ribosomal S6 kinase alpha Short name: p70 S6 kinase alpha Short name: p70 S6K-alpha Short name: p70 S6KA |
Gene namesi | Name:RPS6KB1 Synonyms:STK14A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10436, RPS6KB1 |
MIMi | 608938, gene |
neXtProti | NX_P23443 |
VEuPathDBi | HostDB:ENSG00000108443.13 |
Subcellular locationi
Mitochondrion
Other locations
- synaptosome By similarity
Note: Colocalizes with URI1 at mitochondrion.
Other locations
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cell surface Source: Ensembl
- cytoplasm Source: UniProtKB
- neuron projection Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: Ensembl
- synapse Source: UniProtKB-KW
Keywords - Cellular componenti
Cell junction, Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus, Synapse, SynaptosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 167 | K → N: Greatly reduces activity. Greatly reduces phosphorylation at T-412 and moderately reduces phosphorylation at T-252. 1 Publication | 1 | |
Mutagenesisi | 394 | S → A: Loss of activity. Loss of phosphorylation at T-412. 1 Publication | 1 | |
Mutagenesisi | 412 | T → E: Mimics phosphorylation. Facilitates phosphorylation of T-252 by PDPK1; when associated with E-434; E-441; E-444 and E-447. Mimics phosphorylation. No effect on interaction with PDPK1 and phosphorylation of T-252. Impairs association with the eIF3 complex. 3 Publications | 1 | |
Mutagenesisi | 434 | S → E: Facilitates phosphorylation of T-252 by PDPK1; when associated with E-412; E-441; E-444 and E-447. 1 Publication | 1 | |
Mutagenesisi | 441 | S → E: Facilitates phosphorylation of T-252 by PDPK1; when associated with E-412; E-434; E-444 and E-447. 1 Publication | 1 | |
Mutagenesisi | 444 | T → E: Facilitates phosphorylation of T-252 by PDPK1; when associated with E-412; E-434; E-441 and E-447. 1 Publication | 1 | |
Mutagenesisi | 447 | S → E: Facilitates phosphorylation of T-252 by PDPK1; when associated with E-412; E-434; E-441 and E-444. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6198 |
OpenTargetsi | ENSG00000108443 |
PharmGKBi | PA34851 |
Miscellaneous databases
Pharosi | P23443, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4501 |
DrugCentrali | P23443 |
GuidetoPHARMACOLOGYi | 1525 |
Genetic variation databases
BioMutai | RPS6KB1 |
DMDMi | 54041234 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000024342 | 1 – 525 | Ribosomal protein S6 kinase beta-1Add BLAST | 525 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 252 | Phosphothreonine; by PDPK12 Publications | 1 | |
Modified residuei | 394 | Phosphoserine1 Publication | 1 | |
Modified residuei | 412 | Phosphothreonine; by MTOR, NEK6 and NEK71 Publication | 1 | |
Modified residuei | 434 | PhosphoserineBy similarity | 1 | |
Modified residuei | 441 | PhosphoserineCombined sources | 1 | |
Modified residuei | 444 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 447 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Modified residuei | 516 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P23443 |
jPOSTi | P23443 |
MassIVEi | P23443 |
MaxQBi | P23443 |
PaxDbi | P23443 |
PeptideAtlasi | P23443 |
PRIDEi | P23443 |
ProteomicsDBi | 28050 4559 54095 [P23443-1] 54096 [P23443-2] 69478 |
PTM databases
iPTMneti | P23443 |
PhosphoSitePlusi | P23443 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000108443, Expressed in cerebellar vermis and 223 other tissues |
ExpressionAtlasi | P23443, baseline and differential |
Genevisiblei | P23443, HS |
Organism-specific databases
HPAi | ENSG00000108443, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PPP1R9A/neurabin-1 (By similarity).
Interacts with RPTOR (PubMed:12150926).
Interacts with IRS1 (PubMed:18952604).
Interacts with EIF3B and EIF3C (PubMed:16286006).
Interacts with TRAF4 (PubMed:12801526).
Interacts with POLDIP3 (PubMed:15341740).
Interacts (via N-terminus) with IER5 (PubMed:26496226).
By similarity6 PublicationsBinary interactionsi
Hide detailsP23443
Isoform Alpha II [P23443-2]
With | #Exp. | IntAct |
---|---|---|
GLI1 [P08151] | 2 | EBI-6093204,EBI-308084 |
Isoform 3 [P23443-4]
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-25882353,EBI-77613 |
PIK3R1 - isoform 2 [P27986-2] | 3 | EBI-25882353,EBI-9090282 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- PDZ domain binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112112, 82 interactors |
DIPi | DIP-29986N |
ELMi | P23443 |
IntActi | P23443, 34 interactors |
MINTi | P23443 |
STRINGi | 9606.ENSP00000225577 |
Chemistry databases
BindingDBi | P23443 |
Miscellaneous databases
RNActi | P23443, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P23443 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23443 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 91 – 352 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 353 – 423 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 424 – 525 | Autoinhibitory domainAdd BLAST | 102 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 28 – 32 | TOS motif | 5 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000154203 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | P23443 |
OMAi | WELAENF |
OrthoDBi | 1132245at2759 |
PhylomeDBi | P23443 |
TreeFami | TF313438 |
Family and domain databases
DisProti | DP01554 |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016238, Ribosomal_S6_kinase IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000605, Ribsml_S6_kin_1, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL
60 70 80 90 100
NESMDHGGVG PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG
110 120 130 140 150
GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV
160 170 180 190 200
KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA
210 220 230 240 250
EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT
260 270 280 290 300
HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
310 320 330 340 350
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP
360 370 380 390 400
FFRHINWEEL LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL
410 420 430 440 450
SESANQVFLG FTYVAPSVLE SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK
460 470 480 490 500
FSPGDFWGRG ASASTANPQT PVEYPMETSG IEQMDVTMSG EASAPLPIRQ
510 520
PNSGPYKKQA FPMISKRPEH LRMNL
The sequence of this isoform differs from the canonical sequence as follows:
1-23: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ER06 | K7ER06_HUMAN | Ribosomal protein S6 kinase beta-1 | RPS6KB1 | 140 | Annotation score: | ||
K7EMM2 | K7EMM2_HUMAN | Ribosomal protein S6 kinase beta-1 | RPS6KB1 | 52 | Annotation score: | ||
K7EIM2 | K7EIM2_HUMAN | Ribosomal protein S6 kinase beta-1 | RPS6KB1 | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 222 | E → V in BAG61973 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 428 | F → L in BAG35726 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040639 | 225 | M → I1 Publication | 1 | |
Natural variantiVAR_040640 | 272 | R → C1 PublicationCorresponds to variant dbSNP:rs766645749Ensembl. | 1 | |
Natural variantiVAR_040641 | 276 | W → C1 Publication | 1 | |
Natural variantiVAR_035628 | 289 | G → E in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040642 | 398 | S → A1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054613 | 1 – 53 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_018839 | 1 – 23 | Missing in isoform Alpha II. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_055026 | 104 – 126 | Missing in isoform 4. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_054614 | 448 – 525 | PVKFS…LRMNL → TAMC in isoform 3. 1 PublicationAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60724 mRNA Translation: AAA36410.1 M60725 mRNA Translation: AAA36411.1 AK297147 mRNA Translation: BAG59646.1 AK300202 mRNA Translation: BAG61973.1 AK312875 mRNA Translation: BAG35726.1 AC004686 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94384.1 BC053365 mRNA Translation: AAH53365.1 |
CCDSi | CCDS11621.1 [P23443-1] CCDS62271.1 [P23443-4] CCDS62272.1 [P23443-5] CCDS62273.1 [P23443-3] |
PIRi | A41687 |
RefSeqi | NP_001258971.1, NM_001272042.1 [P23443-5] NP_001258972.1, NM_001272043.1 [P23443-4] NP_001258973.1, NM_001272044.1 [P23443-3] NP_001258989.1, NM_001272060.1 [P23443-2] NP_003152.1, NM_003161.3 [P23443-1] |
Genome annotation databases
Ensembli | ENST00000225577; ENSP00000225577; ENSG00000108443 [P23443-1] ENST00000393021; ENSP00000376744; ENSG00000108443 [P23443-3] ENST00000406116; ENSP00000384335; ENSG00000108443 [P23443-4] ENST00000443572; ENSP00000441993; ENSG00000108443 [P23443-5] |
GeneIDi | 6198 |
KEGGi | hsa:6198 |
UCSCi | uc002ixy.5, human [P23443-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60724 mRNA Translation: AAA36410.1 M60725 mRNA Translation: AAA36411.1 AK297147 mRNA Translation: BAG59646.1 AK300202 mRNA Translation: BAG61973.1 AK312875 mRNA Translation: BAG35726.1 AC004686 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94384.1 BC053365 mRNA Translation: AAH53365.1 |
CCDSi | CCDS11621.1 [P23443-1] CCDS62271.1 [P23443-4] CCDS62272.1 [P23443-5] CCDS62273.1 [P23443-3] |
PIRi | A41687 |
RefSeqi | NP_001258971.1, NM_001272042.1 [P23443-5] NP_001258972.1, NM_001272043.1 [P23443-4] NP_001258973.1, NM_001272044.1 [P23443-3] NP_001258989.1, NM_001272060.1 [P23443-2] NP_003152.1, NM_003161.3 [P23443-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3A60 | X-ray | 2.80 | A/B | 75-399 | [»] | |
3A61 | X-ray | 3.43 | A | 75-399 | [»] | |
3A62 | X-ray | 2.35 | A | 75-399 | [»] | |
3WE4 | X-ray | 2.00 | A | 78-399 | [»] | |
3WF5 | X-ray | 2.10 | A | 78-399 | [»] | |
3WF6 | X-ray | 2.03 | A | 78-399 | [»] | |
3WF7 | X-ray | 1.85 | A | 78-399 | [»] | |
3WF8 | X-ray | 1.98 | A | 78-399 | [»] | |
3WF9 | X-ray | 2.04 | A | 78-399 | [»] | |
4L3J | X-ray | 2.10 | A | 75-375 | [»] | |
4L3L | X-ray | 2.10 | A | 75-375 | [»] | |
4L42 | X-ray | 2.80 | A | 75-417 | [»] | |
4L43 | X-ray | 3.00 | A | 75-417 | [»] | |
4L44 | X-ray | 2.90 | A | 75-417 | [»] | |
4L45 | X-ray | 2.90 | A | 75-417 | [»] | |
4L46 | X-ray | 3.01 | A | 75-417 | [»] | |
4RLO | X-ray | 2.53 | A/B | 85-372 | [»] | |
4RLP | X-ray | 2.79 | A | 85-372 | [»] | |
5WBH | X-ray | 1.75 | W | 412-437 | [»] | |
5WBK | X-ray | 3.11 | T | 24-37 | [»] | |
SMRi | P23443 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112112, 82 interactors |
DIPi | DIP-29986N |
ELMi | P23443 |
IntActi | P23443, 34 interactors |
MINTi | P23443 |
STRINGi | 9606.ENSP00000225577 |
Chemistry databases
BindingDBi | P23443 |
ChEMBLi | CHEMBL4501 |
DrugCentrali | P23443 |
GuidetoPHARMACOLOGYi | 1525 |
PTM databases
iPTMneti | P23443 |
PhosphoSitePlusi | P23443 |
Genetic variation databases
BioMutai | RPS6KB1 |
DMDMi | 54041234 |
Proteomic databases
EPDi | P23443 |
jPOSTi | P23443 |
MassIVEi | P23443 |
MaxQBi | P23443 |
PaxDbi | P23443 |
PeptideAtlasi | P23443 |
PRIDEi | P23443 |
ProteomicsDBi | 28050 4559 54095 [P23443-1] 54096 [P23443-2] 69478 |
Protocols and materials databases
Antibodypediai | 3544, 2548 antibodies |
DNASUi | 6198 |
Genome annotation databases
Ensembli | ENST00000225577; ENSP00000225577; ENSG00000108443 [P23443-1] ENST00000393021; ENSP00000376744; ENSG00000108443 [P23443-3] ENST00000406116; ENSP00000384335; ENSG00000108443 [P23443-4] ENST00000443572; ENSP00000441993; ENSG00000108443 [P23443-5] |
GeneIDi | 6198 |
KEGGi | hsa:6198 |
UCSCi | uc002ixy.5, human [P23443-1] |
Organism-specific databases
CTDi | 6198 |
DisGeNETi | 6198 |
GeneCardsi | RPS6KB1 |
HGNCi | HGNC:10436, RPS6KB1 |
HPAi | ENSG00000108443, Low tissue specificity |
MIMi | 608938, gene |
neXtProti | NX_P23443 |
OpenTargetsi | ENSG00000108443 |
PharmGKBi | PA34851 |
VEuPathDBi | HostDB:ENSG00000108443.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000154203 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | P23443 |
OMAi | WELAENF |
OrthoDBi | 1132245at2759 |
PhylomeDBi | P23443 |
TreeFami | TF313438 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P23443 |
Reactomei | R-HSA-166208, mTORC1-mediated signalling |
SABIO-RKi | P23443 |
SignaLinki | P23443 |
SIGNORi | P23443 |
Miscellaneous databases
BioGRID-ORCSi | 6198, 33 hits in 906 CRISPR screens |
ChiTaRSi | RPS6KB1, human |
EvolutionaryTracei | P23443 |
GeneWikii | P70-S6_Kinase_1 |
GenomeRNAii | 6198 |
Pharosi | P23443, Tchem |
PROi | PR:P23443 |
RNActi | P23443, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108443, Expressed in cerebellar vermis and 223 other tissues |
ExpressionAtlasi | P23443, baseline and differential |
Genevisiblei | P23443, HS |
Family and domain databases
DisProti | DP01554 |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016238, Ribosomal_S6_kinase IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000605, Ribsml_S6_kin_1, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KS6B1_HUMAN | |
Accessioni | P23443Primary (citable) accession number: P23443 Secondary accession number(s): B2R779 Q7Z721 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 10, 2021 | |
This is version 214 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families