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Entry version 188 (08 May 2019)
Sequence version 1 (01 Nov 1991)
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Protein

Glycine receptor subunit alpha-2

Gene

GLRA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).5 Publications

Miscellaneous

The alpha subunit binds strychnine.1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by strychnine (PubMed:2155780, PubMed:15302677). Inhibited by picrotoxin (PubMed:15302677). Channel activity is potentiated by 10-100 µM Zn2+ (PubMed:15302677, PubMed:16144831, PubMed:23895467). Channel activity is marginally increased by 50 mM ethanol; it is strongly increased by a combination of 0.5 µM Zn2+ and 50 mM ethanol (PubMed:23895467). Channel activity is inhibited by 100-1000 µM Zn2+ (PubMed:15302677).4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

For isoform Alpha-2* homopentamers, a concentration of about 66 µM glycine results in half-maximal channel conductance. For isoform Alpha-2B homopentamers, a concentration of about 34 µM glycine results in half-maximal channel conductance.

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi226ZincBy similarity1
      Metal bindingi228ZincBy similarity1
      Metal bindingi249ZincBy similarity1
      <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei295Important for obstruction of the ion pore in the closed conformationBy similarity1

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
      Biological processIon transport, Transport
      LigandChloride, Metal-binding, Zinc

      Enzyme and pathway databases

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

      Protein family/group databases

      Transport Classification Database

      More...
      TCDBi
      1.A.9.3.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Glycine receptor subunit alpha-2
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:GLRA2
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

      Organism-specific databases

      Human Gene Nomenclature Database

      More...
      HGNCi
      HGNC:4327 GLRA2

      Online Mendelian Inheritance in Man (OMIM)

      More...
      MIMi
      305990 gene

      neXtProt; the human protein knowledge platform

      More...
      neXtProti
      NX_P23416

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Topology

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 256ExtracellularBy similarityAdd BLAST229
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei257 – 278Helical; Name=1By similarityAdd BLAST22
      Topological domaini279 – 283CytoplasmicBy similarity5
      Transmembranei284 – 304Helical; Name=2By similarityAdd BLAST21
      Topological domaini305 – 315ExtracellularBy similarityAdd BLAST11
      Transmembranei316 – 336Helical; Name=3By similarityAdd BLAST21
      Topological domaini337 – 420CytoplasmicBy similarityAdd BLAST84
      Transmembranei421 – 441Helical; Name=4By similarityAdd BLAST21
      Topological domaini442 – 452ExtracellularBy similarityAdd BLAST11

      Keywords - Cellular componenti

      Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Organism-specific databases

      DisGeNET

      More...
      DisGeNETi
      2742

      Open Targets

      More...
      OpenTargetsi
      ENSG00000101958

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...
      PharmGKBi
      PA28728

      Chemistry databases

      ChEMBL database of bioactive drug-like small molecules

      More...
      ChEMBLi
      CHEMBL5871

      Drug and drug target database

      More...
      DrugBanki
      DB00898 Ethanol
      DB00145 Glycine
      DB00431 Lindane
      DB00466 Picrotoxin

      IUPHAR/BPS Guide to PHARMACOLOGY

      More...
      GuidetoPHARMACOLOGYi
      424

      Polymorphism and mutation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...
      BioMutai
      GLRA2

      Domain mapping of disease mutations (DMDM)

      More...
      DMDMi
      121578

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
      <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000041628 – 452Glycine receptor subunit alpha-2Add BLAST425

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
      Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
      <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi172 ↔ 186By similarity
      Disulfide bondi232 ↔ 243By similarity

      Keywords - PTMi

      Disulfide bond, Glycoprotein

      Proteomic databases

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      P23416

      PeptideAtlas

      More...
      PeptideAtlasi
      P23416

      PRoteomics IDEntifications database

      More...
      PRIDEi
      P23416

      ProteomicsDB human proteome resource

      More...
      ProteomicsDBi
      54091
      54092 [P23416-2]

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      P23416

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      P23416

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSG00000101958 Expressed in 50 organ(s), highest expression level in frontal cortex

      ExpressionAtlas, Differential and Baseline Expression

      More...
      ExpressionAtlasi
      P23416 baseline and differential

      Genevisible search portal to normalized and curated expression data from Genevestigator

      More...
      Genevisiblei
      P23416 HS

      Organism-specific databases

      Human Protein Atlas

      More...
      HPAi
      CAB070422

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homopentamer (in vitro). Interacts with GLRB (PubMed:16144831). Heteropentamer composed of GLRA2 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:15302677).1 Publication1 Publication

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGrid)

      More...
      BioGridi
      109004, 27 interactors

      Protein interaction database and analysis system

      More...
      IntActi
      P23416, 6 interactors

      STRING: functional protein association networks

      More...
      STRINGi
      9606.ENSP00000218075

      Chemistry databases

      BindingDB database of measured binding affinities

      More...
      BindingDBi
      P23416

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      P23416

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Region

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni236 – 241Strychnine-bindingBy similarity6

      <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Keywords - Domaini

      Signal, Transmembrane, Transmembrane helix

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      KOG3643 Eukaryota
      ENOG410XPWH LUCA

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000158730

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      HOG000231336

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      P23416

      KEGG Orthology (KO)

      More...
      KOi
      K05194

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      AFFNLAY

      Database of Orthologous Groups

      More...
      OrthoDBi
      614790at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      P23416

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF315453

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      2.70.170.10, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR006028 GABAA/Glycine_rcpt
      IPR008127 Glycine_rcpt_A
      IPR008129 Glycine_rcpt_A2
      IPR006202 Neur_chan_lig-bd
      IPR036734 Neur_chan_lig-bd_sf
      IPR006201 Neur_channel
      IPR036719 Neuro-gated_channel_TM_sf
      IPR006029 Neurotrans-gated_channel_TM
      IPR018000 Neurotransmitter_ion_chnl_CS

      The PANTHER Classification System

      More...
      PANTHERi
      PTHR18945 PTHR18945, 1 hit
      PTHR18945:SF28 PTHR18945:SF28, 1 hit

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF02931 Neur_chan_LBD, 1 hit
      PF02932 Neur_chan_memb, 1 hit

      Protein Motif fingerprint database; a protein domain database

      More...
      PRINTSi
      PR00253 GABAARECEPTR
      PR01673 GLYRALPHA
      PR01675 GLYRALPHA2
      PR00252 NRIONCHANNEL

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF63712 SSF63712, 1 hit
      SSF90112 SSF90112, 1 hit

      TIGRFAMs; a protein family database

      More...
      TIGRFAMsi
      TIGR00860 LIC, 1 hit

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS00236 NEUROTR_ION_CHANNEL, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

      This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

      This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

      Isoform Alpha-2* (identifier: P23416-1) [UniParc]FASTAAdd to basket

      This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

      « Hide
              10         20         30         40         50
      MNRQLVNILT ALFAFFLETN HFRTAFCKDH DSRSGKQPSQ TLSPSDFLDK
      60 70 80 90 100
      LMGRTSGYDA RIRPNFKGPP VNVTCNIFIN SFGSVTETTM DYRVNIFLRQ
      110 120 130 140 150
      QWNDSRLAYS EYPDDSLDLD PSMLDSIWKP DLFFANEKGA NFHDVTTDNK
      160 170 180 190 200
      LLRISKNGKV LYSIRLTLTL SCPMDLKNFP MDVQTCTMQL ESFGYTMNDL
      210 220 230 240 250
      IFEWLSDGPV QVAEGLTLPQ FILKEEKELG YCTKHYNTGK FTCIEVKFHL
      260 270 280 290 300
      ERQMGYYLIQ MYIPSLLIVI LSWVSFWINM DAAPARVALG ITTVLTMTTQ
      310 320 330 340 350
      SSGSRASLPK VSYVKAIDIW MAVCLLFVFA ALLEYAAVNF VSRQHKEFLR
      360 370 380 390 400
      LRRRQKRQNK EEDVTRESRF NFSGYGMGHC LQVKDGTAVK ATPANPLPQP
      410 420 430 440 450
      PKDGDAIKKK FVDRAKRIDT ISRAAFPLAF LIFNIFYWIT YKIIRHEDVH

      KK
      Length:452
      Mass (Da):52,002
      Last modified:November 1, 1991 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EE74B3F49A555EA
      GO
      Isoform Alpha-2B (identifier: P23416-2) [UniParc]FASTAAdd to basket

      The sequence of this isoform differs from the canonical sequence as follows:
           85-86: VT → IA

      Show »
      Length:452
      Mass (Da):51,986
      Checksum:i949E968DD0D8C722
      GO
      Isoform 3 (identifier: P23416-3) [UniParc]FASTAAdd to basket

      The sequence of this isoform differs from the canonical sequence as follows:
           1-89: Missing.

      Note: No experimental confirmation available.
      Show »
      Length:363
      Mass (Da):42,002
      Checksum:i0990033F04610697
      GO

      <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

      There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      Gene namesLengthAnnotation
      C9JBL4C9JBL4_HUMAN
      Glycine receptor subunit alpha-2
      GLRA2
      215Annotation score:

      Annotation score:2 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389V → A in BAH12541 (PubMed:14702039).Curated1

      Alternative sequence

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454651 – 89Missing in isoform 3. 1 PublicationAdd BLAST89
      Alternative sequenceiVSP_00008285 – 86VT → IA in isoform Alpha-2B. 3 Publications2

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      X52008 mRNA Translation: CAA36257.1
      AF053495
      , AF053487, AF053488, AF053489, AF053490, AF053491, AF053492, AF053493, AF053494 Genomic DNA Translation: AAC35290.1
      AY437083 mRNA Translation: AAR87842.1
      AY437084 mRNA Translation: AAR87843.1
      CR450343 mRNA Translation: CAG29339.1
      AK289561 mRNA Translation: BAF82250.1
      AK297304 mRNA Translation: BAH12541.1
      AK312591 mRNA Translation: BAG35485.1
      AC003658 Genomic DNA No translation available.
      AC003683 Genomic DNA No translation available.
      CH471074 Genomic DNA Translation: EAW98859.1
      CH471074 Genomic DNA Translation: EAW98860.1
      BC032864 mRNA Translation: AAH32864.1
      U77731
      , U77724, U77725, U77726, U77727, U77728, U77729, U77730 Genomic DNA Translation: AAB38272.1
      U77731
      , U77724, U77725, U77726, U77727, U77728, U77729, U77730 Genomic DNA Translation: AAB38273.1

      The Consensus CDS (CCDS) project

      More...
      CCDSi
      CCDS14160.1 [P23416-1]
      CCDS48085.1 [P23416-2]
      CCDS55371.1 [P23416-3]

      Protein sequence database of the Protein Information Resource

      More...
      PIRi
      S12381

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_001112357.1, NM_001118885.1 [P23416-1]
      NP_001112358.1, NM_001118886.1 [P23416-2]
      NP_001165413.1, NM_001171942.1 [P23416-3]
      NP_002054.1, NM_002063.3 [P23416-1]
      XP_016884916.1, XM_017029427.1 [P23416-2]
      XP_016884917.1, XM_017029428.1 [P23416-3]
      XP_016884918.1, XM_017029429.1 [P23416-3]

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENST00000218075; ENSP00000218075; ENSG00000101958 [P23416-1]
      ENST00000355020; ENSP00000347123; ENSG00000101958 [P23416-2]
      ENST00000443437; ENSP00000387756; ENSG00000101958 [P23416-3]

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      2742

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      hsa:2742

      UCSC genome browser

      More...
      UCSCi
      uc004cwe.5 human [P23416-1]

      Keywords - Coding sequence diversityi

      Alternative splicing

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      X52008 mRNA Translation: CAA36257.1
      AF053495
      , AF053487, AF053488, AF053489, AF053490, AF053491, AF053492, AF053493, AF053494 Genomic DNA Translation: AAC35290.1
      AY437083 mRNA Translation: AAR87842.1
      AY437084 mRNA Translation: AAR87843.1
      CR450343 mRNA Translation: CAG29339.1
      AK289561 mRNA Translation: BAF82250.1
      AK297304 mRNA Translation: BAH12541.1
      AK312591 mRNA Translation: BAG35485.1
      AC003658 Genomic DNA No translation available.
      AC003683 Genomic DNA No translation available.
      CH471074 Genomic DNA Translation: EAW98859.1
      CH471074 Genomic DNA Translation: EAW98860.1
      BC032864 mRNA Translation: AAH32864.1
      U77731
      , U77724, U77725, U77726, U77727, U77728, U77729, U77730 Genomic DNA Translation: AAB38272.1
      U77731
      , U77724, U77725, U77726, U77727, U77728, U77729, U77730 Genomic DNA Translation: AAB38273.1
      CCDSiCCDS14160.1 [P23416-1]
      CCDS48085.1 [P23416-2]
      CCDS55371.1 [P23416-3]
      PIRiS12381
      RefSeqiNP_001112357.1, NM_001118885.1 [P23416-1]
      NP_001112358.1, NM_001118886.1 [P23416-2]
      NP_001165413.1, NM_001171942.1 [P23416-3]
      NP_002054.1, NM_002063.3 [P23416-1]
      XP_016884916.1, XM_017029427.1 [P23416-2]
      XP_016884917.1, XM_017029428.1 [P23416-3]
      XP_016884918.1, XM_017029429.1 [P23416-3]

      3D structure databases

      SMRiP23416
      ModBaseiSearch...
      MobiDBiSearch...

      Protein-protein interaction databases

      BioGridi109004, 27 interactors
      IntActiP23416, 6 interactors
      STRINGi9606.ENSP00000218075

      Chemistry databases

      BindingDBiP23416
      ChEMBLiCHEMBL5871
      DrugBankiDB00898 Ethanol
      DB00145 Glycine
      DB00431 Lindane
      DB00466 Picrotoxin
      GuidetoPHARMACOLOGYi424

      Protein family/group databases

      TCDBi1.A.9.3.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

      PTM databases

      iPTMnetiP23416
      PhosphoSitePlusiP23416

      Polymorphism and mutation databases

      BioMutaiGLRA2
      DMDMi121578

      Proteomic databases

      PaxDbiP23416
      PeptideAtlasiP23416
      PRIDEiP23416
      ProteomicsDBi54091
      54092 [P23416-2]

      Protocols and materials databases

      The DNASU plasmid repository

      More...
      DNASUi
      2742
      Structural Biology KnowledgebaseSearch...

      Genome annotation databases

      EnsembliENST00000218075; ENSP00000218075; ENSG00000101958 [P23416-1]
      ENST00000355020; ENSP00000347123; ENSG00000101958 [P23416-2]
      ENST00000443437; ENSP00000387756; ENSG00000101958 [P23416-3]
      GeneIDi2742
      KEGGihsa:2742
      UCSCiuc004cwe.5 human [P23416-1]

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      2742
      DisGeNETi2742

      GeneCards: human genes, protein and diseases

      More...
      GeneCardsi
      GLRA2

      H-Invitational Database, human transcriptome db

      More...
      H-InvDBi
      HIX0016955
      HGNCiHGNC:4327 GLRA2
      HPAiCAB070422
      MIMi305990 gene
      neXtProtiNX_P23416
      OpenTargetsiENSG00000101958
      PharmGKBiPA28728

      GenAtlas: human gene database

      More...
      GenAtlasi
      Search...

      Phylogenomic databases

      eggNOGiKOG3643 Eukaryota
      ENOG410XPWH LUCA
      GeneTreeiENSGT00940000158730
      HOGENOMiHOG000231336
      InParanoidiP23416
      KOiK05194
      OMAiAFFNLAY
      OrthoDBi614790at2759
      PhylomeDBiP23416
      TreeFamiTF315453

      Enzyme and pathway databases

      ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

      Miscellaneous databases

      ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

      More...
      ChiTaRSi
      GLRA2 human

      The Gene Wiki collection of pages on human genes and proteins

      More...
      GeneWikii
      GLRA2

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...
      GenomeRNAii
      2742

      Protein Ontology

      More...
      PROi
      PR:P23416

      The Stanford Online Universal Resource for Clones and ESTs

      More...
      SOURCEi
      Search...

      Gene expression databases

      BgeeiENSG00000101958 Expressed in 50 organ(s), highest expression level in frontal cortex
      ExpressionAtlasiP23416 baseline and differential
      GenevisibleiP23416 HS

      Family and domain databases

      Gene3Di2.70.170.10, 1 hit
      InterProiView protein in InterPro
      IPR006028 GABAA/Glycine_rcpt
      IPR008127 Glycine_rcpt_A
      IPR008129 Glycine_rcpt_A2
      IPR006202 Neur_chan_lig-bd
      IPR036734 Neur_chan_lig-bd_sf
      IPR006201 Neur_channel
      IPR036719 Neuro-gated_channel_TM_sf
      IPR006029 Neurotrans-gated_channel_TM
      IPR018000 Neurotransmitter_ion_chnl_CS
      PANTHERiPTHR18945 PTHR18945, 1 hit
      PTHR18945:SF28 PTHR18945:SF28, 1 hit
      PfamiView protein in Pfam
      PF02931 Neur_chan_LBD, 1 hit
      PF02932 Neur_chan_memb, 1 hit
      PRINTSiPR00253 GABAARECEPTR
      PR01673 GLYRALPHA
      PR01675 GLYRALPHA2
      PR00252 NRIONCHANNEL
      SUPFAMiSSF63712 SSF63712, 1 hit
      SSF90112 SSF90112, 1 hit
      TIGRFAMsiTIGR00860 LIC, 1 hit
      PROSITEiView protein in PROSITE
      PS00236 NEUROTR_ION_CHANNEL, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLRA2_HUMAN
      <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23416
      Secondary accession number(s): A8K0J6
      , B2R6I8, B7Z4F5, J3KQ59, Q53YX7, Q6ICQ0, Q99862
      <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
      Last sequence update: November 1, 1991
      Last modified: May 8, 2019
      This is version 188 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Reference proteome

      Documents

      1. Human chromosome X
        Human chromosome X: entries, gene names and cross-references to MIM
      2. SIMILARITY comments
        Index of protein domains and families
      3. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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