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Protein

Glycine receptor subunit alpha-1

Gene

GLRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).By similarity1 Publication12 Publications

Miscellaneous

The alpha subunit binds strychnine.1 Publication

Activity regulationi

Channel activity is potentiated by nanomolar concentrations of Zn2+; half-maximal activation is observed with 37 nM Zn2+ (PubMed:16144831). Inhibited by higher Zn2+ levels; haf-maximal inhibition occurs at 20 µM Zn2+ (PubMed:16144831). Inhibited by strychnine (PubMed:2155780, PubMed:16144831, PubMed:25445488). Inhibited by lindane (PubMed:25445488). Inhibited by picrotoxin (PubMed:22715885, PubMed:23994010, PubMed:25730860). Strychnine binding locks the channel in a closed conformation and prevents channel opening in response to extracellular glycine (By similarity).By similarity6 Publications

Kineticsi

A concentration of about 0.02 mM glycine results in half-maximal channel conductance for homopentamers. A concentration of 0.018 mM glycine results in half-maximal channel conductance for homopentamers upon heterologous expression in cultured human embryonic kidney cells (PubMed:9009272). A concentration of 0.027 mM glycine results in half-maximal channel conductance for homopentamers upon heterologous expression in cultured human embryonic kidney cells (PubMed:7920629).2 Publications

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Metal bindingi220Zinc1 Publication1
      Metal bindingi222Zinc1 Publication1
      Metal bindingi243Zinc1 Publication1
      Sitei289Important for obstruction of the ion pore in the closed conformation1 Publication1

      GO - Molecular functioni

      GO - Biological processi

      Keywordsi

      Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
      Biological processIon transport, Transport
      LigandChloride, Metal-binding, Zinc

      Enzyme and pathway databases

      ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

      Protein family/group databases

      TCDBi1.A.9.3.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

      Names & Taxonomyi

      Protein namesi
      Recommended name:
      Glycine receptor subunit alpha-1
      Alternative name(s):
      Glycine receptor 48 kDa subunit
      Glycine receptor strychnine-binding subunit
      Gene namesi
      Name:GLRA1
      OrganismiHomo sapiens (Human)
      Taxonomic identifieri9606 [NCBI]
      Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      Proteomesi
      • UP000005640 Componenti: Chromosome 5

      Organism-specific databases

      EuPathDBiHostDB:ENSG00000145888.10
      HGNCiHGNC:4326 GLRA1
      MIMi138491 gene
      neXtProtiNX_P23415

      Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

      Topology

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Topological domaini29 – 250ExtracellularCuratedAdd BLAST222
      Transmembranei251 – 272Helical; Name=12 PublicationsAdd BLAST22
      Topological domaini273 – 277Cytoplasmic2 Publications5
      Transmembranei278 – 298Helical; Name=22 PublicationsAdd BLAST21
      Topological domaini299 – 309Extracellular2 PublicationsAdd BLAST11
      Transmembranei310 – 330Helical; Name=32 PublicationsAdd BLAST21
      Topological domaini331 – 425Cytoplasmic1 PublicationAdd BLAST95
      Transmembranei426 – 446Helical; Name=41 PublicationAdd BLAST21
      Topological domaini447 – 457ExtracellularCuratedAdd BLAST11

      Keywords - Cellular componenti

      Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

      Pathology & Biotechi

      Involvement in diseasei

      Hyperekplexia 1 (HKPX1)14 Publications
      The disease is caused by mutations affecting the gene represented in this entry.
      Disease descriptionA neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
      See also OMIM:149400
      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Natural variantiVAR_07541893R → W in HKPX1; impairs expression at the cell membrane; requires much higher glycine levels for channel activation; compound heterozygote with S-258. 1 PublicationCorresponds to variant dbSNP:rs199547699EnsemblClinVar.1
      Natural variantiVAR_075419100R → C in HKPX1; abolishes expression at the cell membrane; requires much higher glycine levels for channel activation. 1 Publication1
      Natural variantiVAR_075420246R → W in HKPX1; abolishes expression at the cell membrane; requires much higher glycine levels for channel activation. 1 PublicationCorresponds to variant dbSNP:rs751659671Ensembl.1
      Natural variantiVAR_075421254Q → E in HKPX1; strongly increases sensitivity to extracellular glycine; high leak currents in the absence of glycine due to spontaneous channel opening. 2 Publications1
      Natural variantiVAR_075422258P → S in HKPX1; impairs expression at the cell membrane; requires much higher glycine levels for channel activation; compound heterozygote with W-93. 1 Publication1
      Natural variantiVAR_000296272I → N in HKPX1; requires much higher glycine levels for channel activation. 2 PublicationsCorresponds to variant dbSNP:rs121918409EnsemblClinVar.1
      Natural variantiVAR_010112278P → T in HKPX1; requires much higher glycine levels for channel activation and displays an increased rate of desensitization. 2 PublicationsCorresponds to variant dbSNP:rs121918413EnsemblClinVar.1
      Natural variantiVAR_010113280R → H in HKPX1. 1 PublicationCorresponds to variant dbSNP:rs281864918EnsemblClinVar.1
      Natural variantiVAR_000297294Q → H in HKPX1. 1 PublicationCorresponds to variant dbSNP:rs121918411EnsemblClinVar.1
      Natural variantiVAR_000298299R → L in HKPX1; requires much higher glycine levels for channel activation. 4 PublicationsCorresponds to variant dbSNP:rs121918408EnsemblClinVar.1
      Natural variantiVAR_000299299R → Q in HKPX1; decreases unitary channel conductance and requires much higher glycine concentrations for activation. 4 PublicationsCorresponds to variant dbSNP:rs121918408EnsemblClinVar.1
      Natural variantiVAR_000300304K → E in HKPX1; requires much higher glycine levels for channel activation. 3 PublicationsCorresponds to variant dbSNP:rs121918412EnsemblClinVar.1
      Natural variantiVAR_000301307Y → C in HKPX1; requires much higher glycine levels for channel activation. 3 PublicationsCorresponds to variant dbSNP:rs121918410EnsemblClinVar.1
      Natural variantiVAR_075423308V → M in HKPX1; high leak currents in the absence of glycine due to spontaneous channel opening. 2 Publications1
      Natural variantiVAR_075424319L → P in HKPX1; impairs expression at the cell membrane; requires much higher glycine levels for channel activation; compound heterozygote with A-424. 1 Publication1
      Natural variantiVAR_075425424D → A in HKPX1; abolishes expression at the cell membrane; compound heterozygote with P-319. 1 Publication1
      Natural variantiVAR_010114428R → H in HKPX1. 1 PublicationCorresponds to variant dbSNP:rs281864919Ensembl.1
      Natural variantiVAR_075426450R → H in HKPX1; displays leak currents in the absence of glycine due to spontaneous channel opening. 1 PublicationCorresponds to variant dbSNP:rs200130685Ensembl.1

      Mutagenesis

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Mutagenesisi80A → S: The mutant channel requires much higher glycine concentrations for activation. 1 Publication1
      Mutagenesisi137H → F: Abolishes sensitivity of channel activity to potentiation or inhibition by Zn(2+); when associated with K-222. 1 Publication1
      Mutagenesisi137H → N: Strongly decreases sensitivity to inhibition by Zn(2+). 1 Publication1
      Mutagenesisi220E → A: Abolishes potentiation of channel activity by Zn(2+). 1 Publication1
      Mutagenesisi222D → A: Abolishes potentiation of channel activity by Zn(2+). 1 Publication1
      Mutagenesisi222D → K: Abolishes sensitivity of channel activity to potentiation or inhibition by Zn(2+); when associated with F-137. 1 Publication1
      Mutagenesisi243H → A: Strongly decreases potentiation of channel activity by Zn(2+). 1 Publication1
      Mutagenesisi282G → A: Increased single-channel conductance. No effect on glycine sensitivity, but decreased rate of activation. 1 Publication1
      Mutagenesisi304K → C: Decreases channel conductance; the mutant channel requires much higher glycine concentrations for activation. 1 Publication1

      Keywords - Diseasei

      Disease mutation

      Organism-specific databases

      DisGeNETi2741
      GeneReviewsiGLRA1
      MalaCardsiGLRA1
      MIMi149400 phenotype
      OpenTargetsiENSG00000145888
      Orphaneti3197 Hereditary hyperekplexia
      PharmGKBiPA28727

      Chemistry databases

      ChEMBLiCHEMBL5845
      DrugBankiDB03929 D-Serine
      DB01189 Desflurane
      DB00228 Enflurane
      DB00898 Ethanol
      DB01381 Ginkgo biloba
      DB00145 Glycine
      DB05417 GW 468816
      DB01159 Halothane
      DB00753 Isoflurane
      DB00431 Lindane
      DB01028 Methoxyflurane
      DB01236 Sevoflurane
      DB11582 Thiocolchicoside
      GuidetoPHARMACOLOGYi423

      Polymorphism and mutation databases

      BioMutaiGLRA1
      DMDMi116242495

      PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Signal peptidei1 – 28Sequence analysisBy similarityAdd BLAST28
      ChainiPRO_000000041229 – 457Glycine receptor subunit alpha-1Add BLAST429

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Glycosylationi66N-linked (GlcNAc...) asparagineCurated1
      Disulfide bondi166 ↔ 1801 Publication
      Disulfide bondi226 ↔ 2371 Publication

      Keywords - PTMi

      Disulfide bond, Glycoprotein

      Proteomic databases

      PaxDbiP23415
      PeptideAtlasiP23415
      PRIDEiP23415
      ProteomicsDBi54089
      54090 [P23415-2]

      PTM databases

      iPTMnetiP23415
      PhosphoSitePlusiP23415

      Expressioni

      Gene expression databases

      BgeeiENSG00000145888 Expressed in 21 organ(s), highest expression level in hypothalamus
      CleanExiHS_GLRA1
      ExpressionAtlasiP23415 baseline and differential
      GenevisibleiP23415 HS

      Organism-specific databases

      HPAiCAB079042
      HPA016502

      Interactioni

      Subunit structurei

      Homopentamer (in vitro) (PubMed:22715885, PubMed:22973015, PubMed:23994010, PubMed:25730860). Interacts with GLRB to form heteropentameric channels; this is probably the predominant form in vivo (PubMed:22715885, PubMed:22973015, PubMed:25445488). Heteropentamer composed of two GLRA1 and three GLRB (PubMed:22715885). Heteropentamer composed of three GLRA1 and two GLRB (PubMed:22973015). Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:14551753, PubMed:22715885, PubMed:22973015, PubMed:25445488, PubMed:23994010, PubMed:25730860).6 Publications

      GO - Molecular functioni

      Protein-protein interaction databases

      DIPiDIP-48768N
      IntActiP23415, 2 interactors
      STRINGi9606.ENSP00000411593

      Structurei

      Secondary structure

      1457
      Legend: HelixTurnBeta strandPDB Structure known for this area
      Show more details

      3D structure databases

      ProteinModelPortaliP23415
      SMRiP23415
      ModBaseiSearch...
      MobiDBiSearch...

      Miscellaneous databases

      EvolutionaryTraceiP23415

      Family & Domainsi

      Region

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Regioni230 – 235Strychnine-bindingBy similarity6

      Domaini

      The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits. In the absence of the extracellular domain, the channel is in a constitutively open conformation (PubMed:23994010). Channel opening is effected by an outward rotation of the transmembrane domains that increases the diameter of the pore (By similarity).By similarity1 Publication

      Sequence similaritiesi

      Keywords - Domaini

      Signal, Transmembrane, Transmembrane helix

      Phylogenomic databases

      eggNOGiKOG3643 Eukaryota
      ENOG410XPWH LUCA
      GeneTreeiENSGT00760000118821
      HOGENOMiHOG000231336
      HOVERGENiHBG051707
      InParanoidiP23415
      KOiK05193
      OMAiHGFRNNT
      OrthoDBiEOG091G0805
      PhylomeDBiP23415
      TreeFamiTF315453

      Family and domain databases

      Gene3Di2.70.170.10, 1 hit
      InterProiView protein in InterPro
      IPR006028 GABAA/Glycine_rcpt
      IPR008127 Glycine_rcpt_A
      IPR008128 Glycine_rcpt_A1
      IPR006202 Neur_chan_lig-bd
      IPR036734 Neur_chan_lig-bd_sf
      IPR006201 Neur_channel
      IPR036719 Neuro-gated_channel_TM_sf
      IPR006029 Neurotrans-gated_channel_TM
      IPR018000 Neurotransmitter_ion_chnl_CS
      PANTHERiPTHR18945 PTHR18945, 1 hit
      PfamiView protein in Pfam
      PF02931 Neur_chan_LBD, 1 hit
      PF02932 Neur_chan_memb, 1 hit
      PRINTSiPR00253 GABAARECEPTR
      PR01673 GLYRALPHA
      PR01674 GLYRALPHA1
      PR00252 NRIONCHANNEL
      SUPFAMiSSF63712 SSF63712, 1 hit
      SSF90112 SSF90112, 1 hit
      TIGRFAMsiTIGR00860 LIC, 1 hit
      PROSITEiView protein in PROSITE
      PS00236 NEUROTR_ION_CHANNEL, 1 hit

      Sequences (2+)i

      Sequence statusi: Complete.

      Sequence processingi: The displayed sequence is further processed into a mature form.

      This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

      This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

      Isoform a (identifier: P23415-1) [UniParc]FASTAAdd to basket

      This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

      « Hide
              10         20         30         40         50
      MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS
      60 70 80 90 100
      GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR
      110 120 130 140 150
      LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR
      160 170 180 190 200
      NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE
      210 220 230 240 250
      QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY
      260 270 280 290 300
      YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA
      310 320 330 340 350
      SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR
      360 370 380 390 400
      HHKSPMLNLF QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN
      410 420 430 440 450
      PPPAPSKSPE EMRKLFIQRA KKIDKISRIG FPMAFLIFNM FYWIIYKIVR

      REDVHNQ
      Length:457
      Mass (Da):52,624
      Last modified:October 17, 2006 - v2
      Checksum:i5ED80AF62B06A3AA
      GO
      Isoform b (identifier: P23415-2) [UniParc]FASTAAdd to basket

      The sequence of this isoform differs from the canonical sequence as follows:
           354-361: Missing.

      Show »
      Length:449
      Mass (Da):51,693
      Checksum:i8F6EEB28634E2A94
      GO

      Computationally mapped potential isoform sequencesi

      There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      Gene namesLengthAnnotation
      E5RJ70E5RJ70_HUMAN
      Glycine receptor subunit alpha-1
      GLRA1
      37Annotation score:

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Sequence conflicti12 – 14WET → SGA in CAA36258 (PubMed:2155780).Curated3
      Sequence conflicti33P → T in CAA36258 (PubMed:2155780).Curated1

      Natural variant

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Natural variantiVAR_07541893R → W in HKPX1; impairs expression at the cell membrane; requires much higher glycine levels for channel activation; compound heterozygote with S-258. 1 PublicationCorresponds to variant dbSNP:rs199547699EnsemblClinVar.1
      Natural variantiVAR_075419100R → C in HKPX1; abolishes expression at the cell membrane; requires much higher glycine levels for channel activation. 1 Publication1
      Natural variantiVAR_075420246R → W in HKPX1; abolishes expression at the cell membrane; requires much higher glycine levels for channel activation. 1 PublicationCorresponds to variant dbSNP:rs751659671Ensembl.1
      Natural variantiVAR_075421254Q → E in HKPX1; strongly increases sensitivity to extracellular glycine; high leak currents in the absence of glycine due to spontaneous channel opening. 2 Publications1
      Natural variantiVAR_075422258P → S in HKPX1; impairs expression at the cell membrane; requires much higher glycine levels for channel activation; compound heterozygote with W-93. 1 Publication1
      Natural variantiVAR_000296272I → N in HKPX1; requires much higher glycine levels for channel activation. 2 PublicationsCorresponds to variant dbSNP:rs121918409EnsemblClinVar.1
      Natural variantiVAR_010112278P → T in HKPX1; requires much higher glycine levels for channel activation and displays an increased rate of desensitization. 2 PublicationsCorresponds to variant dbSNP:rs121918413EnsemblClinVar.1
      Natural variantiVAR_010113280R → H in HKPX1. 1 PublicationCorresponds to variant dbSNP:rs281864918EnsemblClinVar.1
      Natural variantiVAR_000297294Q → H in HKPX1. 1 PublicationCorresponds to variant dbSNP:rs121918411EnsemblClinVar.1
      Natural variantiVAR_000298299R → L in HKPX1; requires much higher glycine levels for channel activation. 4 PublicationsCorresponds to variant dbSNP:rs121918408EnsemblClinVar.1
      Natural variantiVAR_000299299R → Q in HKPX1; decreases unitary channel conductance and requires much higher glycine concentrations for activation. 4 PublicationsCorresponds to variant dbSNP:rs121918408EnsemblClinVar.1
      Natural variantiVAR_000300304K → E in HKPX1; requires much higher glycine levels for channel activation. 3 PublicationsCorresponds to variant dbSNP:rs121918412EnsemblClinVar.1
      Natural variantiVAR_000301307Y → C in HKPX1; requires much higher glycine levels for channel activation. 3 PublicationsCorresponds to variant dbSNP:rs121918410EnsemblClinVar.1
      Natural variantiVAR_075423308V → M in HKPX1; high leak currents in the absence of glycine due to spontaneous channel opening. 2 Publications1
      Natural variantiVAR_075424319L → P in HKPX1; impairs expression at the cell membrane; requires much higher glycine levels for channel activation; compound heterozygote with A-424. 1 Publication1
      Natural variantiVAR_075425424D → A in HKPX1; abolishes expression at the cell membrane; compound heterozygote with P-319. 1 Publication1
      Natural variantiVAR_010114428R → H in HKPX1. 1 PublicationCorresponds to variant dbSNP:rs281864919Ensembl.1
      Natural variantiVAR_075426450R → H in HKPX1; displays leak currents in the absence of glycine due to spontaneous channel opening. 1 PublicationCorresponds to variant dbSNP:rs200130685Ensembl.1

      Alternative sequence

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      Alternative sequenceiVSP_021142354 – 361Missing in isoform b. 3 Publications8

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      X52009 mRNA Translation: CAA36258.1
      AK312702 mRNA Translation: BAG35580.1
      CH471062 Genomic DNA Translation: EAW61657.1
      BC074980 mRNA Translation: AAH74980.1
      BC114947 mRNA Translation: AAI14948.1
      CCDSiCCDS4320.1 [P23415-2]
      CCDS54942.1 [P23415-1]
      PIRiS12382
      RefSeqiNP_000162.2, NM_000171.3 [P23415-2]
      NP_001139512.1, NM_001146040.1 [P23415-1]
      UniGeneiHs.121490

      Genome annotation databases

      EnsembliENST00000274576; ENSP00000274576; ENSG00000145888 [P23415-2]
      ENST00000455880; ENSP00000411593; ENSG00000145888 [P23415-1]
      GeneIDi2741
      KEGGihsa:2741
      UCSCiuc003lur.4 human [P23415-1]

      Keywords - Coding sequence diversityi

      Alternative splicing

      Similar proteinsi

      Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      X52009 mRNA Translation: CAA36258.1
      AK312702 mRNA Translation: BAG35580.1
      CH471062 Genomic DNA Translation: EAW61657.1
      BC074980 mRNA Translation: AAH74980.1
      BC114947 mRNA Translation: AAI14948.1
      CCDSiCCDS4320.1 [P23415-2]
      CCDS54942.1 [P23415-1]
      PIRiS12382
      RefSeqiNP_000162.2, NM_000171.3 [P23415-2]
      NP_001139512.1, NM_001146040.1 [P23415-1]
      UniGeneiHs.121490

      3D structure databases

      Select the link destinations:
      PDBei
      RCSB PDBi
      PDBji
      Links Updated
      PDB entryMethodResolution (Å)ChainPositionsPDBsum
      1MOTNMR-A277-304[»]
      1VRYNMR-A278-337[»]
      2M6BNMR-A244-453[»]
      2M6INMR-A/B/C/D/E244-453[»]
      4X5TX-ray3.50A/B/C/D/E246-338[»]
      A/B/C/D/E418-446[»]
      ProteinModelPortaliP23415
      SMRiP23415
      ModBaseiSearch...
      MobiDBiSearch...

      Protein-protein interaction databases

      DIPiDIP-48768N
      IntActiP23415, 2 interactors
      STRINGi9606.ENSP00000411593

      Chemistry databases

      ChEMBLiCHEMBL5845
      DrugBankiDB03929 D-Serine
      DB01189 Desflurane
      DB00228 Enflurane
      DB00898 Ethanol
      DB01381 Ginkgo biloba
      DB00145 Glycine
      DB05417 GW 468816
      DB01159 Halothane
      DB00753 Isoflurane
      DB00431 Lindane
      DB01028 Methoxyflurane
      DB01236 Sevoflurane
      DB11582 Thiocolchicoside
      GuidetoPHARMACOLOGYi423

      Protein family/group databases

      TCDBi1.A.9.3.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

      PTM databases

      iPTMnetiP23415
      PhosphoSitePlusiP23415

      Polymorphism and mutation databases

      BioMutaiGLRA1
      DMDMi116242495

      Proteomic databases

      PaxDbiP23415
      PeptideAtlasiP23415
      PRIDEiP23415
      ProteomicsDBi54089
      54090 [P23415-2]

      Protocols and materials databases

      Structural Biology KnowledgebaseSearch...

      Genome annotation databases

      EnsembliENST00000274576; ENSP00000274576; ENSG00000145888 [P23415-2]
      ENST00000455880; ENSP00000411593; ENSG00000145888 [P23415-1]
      GeneIDi2741
      KEGGihsa:2741
      UCSCiuc003lur.4 human [P23415-1]

      Organism-specific databases

      CTDi2741
      DisGeNETi2741
      EuPathDBiHostDB:ENSG00000145888.10
      GeneCardsiGLRA1
      GeneReviewsiGLRA1
      HGNCiHGNC:4326 GLRA1
      HPAiCAB079042
      HPA016502
      MalaCardsiGLRA1
      MIMi138491 gene
      149400 phenotype
      neXtProtiNX_P23415
      OpenTargetsiENSG00000145888
      Orphaneti3197 Hereditary hyperekplexia
      PharmGKBiPA28727
      GenAtlasiSearch...

      Phylogenomic databases

      eggNOGiKOG3643 Eukaryota
      ENOG410XPWH LUCA
      GeneTreeiENSGT00760000118821
      HOGENOMiHOG000231336
      HOVERGENiHBG051707
      InParanoidiP23415
      KOiK05193
      OMAiHGFRNNT
      OrthoDBiEOG091G0805
      PhylomeDBiP23415
      TreeFamiTF315453

      Enzyme and pathway databases

      ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

      Miscellaneous databases

      ChiTaRSiGLRA1 human
      EvolutionaryTraceiP23415
      GeneWikiiGlycine_receptor,_alpha_1
      GenomeRNAii2741
      PROiPR:P23415
      SOURCEiSearch...

      Gene expression databases

      BgeeiENSG00000145888 Expressed in 21 organ(s), highest expression level in hypothalamus
      CleanExiHS_GLRA1
      ExpressionAtlasiP23415 baseline and differential
      GenevisibleiP23415 HS

      Family and domain databases

      Gene3Di2.70.170.10, 1 hit
      InterProiView protein in InterPro
      IPR006028 GABAA/Glycine_rcpt
      IPR008127 Glycine_rcpt_A
      IPR008128 Glycine_rcpt_A1
      IPR006202 Neur_chan_lig-bd
      IPR036734 Neur_chan_lig-bd_sf
      IPR006201 Neur_channel
      IPR036719 Neuro-gated_channel_TM_sf
      IPR006029 Neurotrans-gated_channel_TM
      IPR018000 Neurotransmitter_ion_chnl_CS
      PANTHERiPTHR18945 PTHR18945, 1 hit
      PfamiView protein in Pfam
      PF02931 Neur_chan_LBD, 1 hit
      PF02932 Neur_chan_memb, 1 hit
      PRINTSiPR00253 GABAARECEPTR
      PR01673 GLYRALPHA
      PR01674 GLYRALPHA1
      PR00252 NRIONCHANNEL
      SUPFAMiSSF63712 SSF63712, 1 hit
      SSF90112 SSF90112, 1 hit
      TIGRFAMsiTIGR00860 LIC, 1 hit
      PROSITEiView protein in PROSITE
      PS00236 NEUROTR_ION_CHANNEL, 1 hit
      ProtoNetiSearch...

      Entry informationi

      Entry nameiGLRA1_HUMAN
      AccessioniPrimary (citable) accession number: P23415
      Secondary accession number(s): B2R6T3, Q14C77, Q6DJV9
      Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
      Last sequence update: October 17, 2006
      Last modified: November 7, 2018
      This is version 199 of the entry and version 2 of the sequence. See complete history.
      Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      Miscellaneousi

      Keywords - Technical termi

      3D-structure, Complete proteome, Reference proteome

      Documents

      1. SIMILARITY comments
        Index of protein domains and families
      2. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
      3. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      4. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      5. PDB cross-references
        Index of Protein Data Bank (PDB) cross-references
      6. Human chromosome 5
        Human chromosome 5: entries, gene names and cross-references to MIM
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