UniProtKB - P23396 (RS3_HUMAN)
40S ribosomal protein S3
RPS3
Functioni
Catalytic activityi
- The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.1 Publication EC:4.2.99.18
Activity regulationi
pH dependencei
GO - Molecular functioni
- class I DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB-EC
- damaged DNA binding Source: UniProtKB
- DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB
- DNA binding Source: UniProtKB
- endodeoxyribonuclease activity Source: UniProtKB
- enzyme binding Source: UniProtKB
- Hsp70 protein binding Source: UniProtKB
- Hsp90 protein binding Source: UniProtKB
- iron-sulfur cluster binding Source: UniProtKB
- kinase binding Source: UniProtKB
- microtubule binding Source: UniProtKB
- mRNA binding Source: UniProtKB
- oxidized purine DNA binding Source: UniProtKB
- oxidized pyrimidine DNA binding Source: UniProtKB
- protein-containing complex binding Source: CAFA
- protein kinase A binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- RNA binding Source: UniProtKB
- small ribosomal subunit rRNA binding Source: UniProtKB
- structural constituent of ribosome Source: UniProtKB
- supercoiled DNA binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- tubulin binding Source: UniProtKB
- ubiquitin-like protein conjugating enzyme binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to hydrogen peroxide Source: UniProtKB
- cellular response to reactive oxygen species Source: UniProtKB
- cellular response to tumor necrosis factor Source: CAFA
- chromosome segregation Source: UniProtKB
- DNA damage response, detection of DNA damage Source: UniProtKB
- DNA repair Source: UniProtKB-KW
- negative regulation of DNA repair Source: UniProtKB
- negative regulation of protein ubiquitination Source: UniProtKB
- negative regulation of translation Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- positive regulation of activated T cell proliferation Source: CAFA
- positive regulation of apoptotic signaling pathway Source: UniProtKB
- positive regulation of base-excision repair Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: UniProtKB
- positive regulation of DNA N-glycosylase activity Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- positive regulation of endodeoxyribonuclease activity Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of interleukin-2 production Source: CAFA
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
- positive regulation of JUN kinase activity Source: UniProtKB
- positive regulation of microtubule polymerization Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: CAFA
- positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: CAFA
- positive regulation of T cell receptor signaling pathway Source: CAFA
- regulation of apoptotic process Source: UniProtKB
- response to TNF agonist Source: UniProtKB
- spindle assembly Source: UniProtKB
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | DNA-binding, Lyase, Ribonucleoprotein, Ribosomal protein, RNA-binding |
Biological process | Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | P23396 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P23396 |
Protein family/group databases
MoonProti | P23396 |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S3 (EC:4.2.99.181 Publication)Alternative name(s): Small ribosomal subunit protein uS31 Publication |
Gene namesi | Name:RPS3 ORF Names:OK/SW-cl.26 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149273.14 |
HGNCi | HGNC:10420, RPS3 |
MIMi | 600454, gene |
neXtProti | NX_P23396 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoskeleton
- spindle 1 Publication
Nucleus
Other locations
- Cytoplasm 6 Publications
Note: In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661).By similarity4 Publications
Cytoskeleton
- mitotic spindle Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
- cytosolic small ribosomal subunit Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial matrix Source: UniProtKB
Nucleus
- nucleolus Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
- ruffle membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- NF-kappaB complex Source: CAFA
- polysome Source: UniProtKB
- postsynaptic density Source: SynGO
- ribonucleoprotein complex Source: UniProtKB
- ribosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 6 | S → A: No effect on phosphorylation by CDK1. Greatly reduced phosphorylation by PRKCD. Abolishes phosphorylation by PRKCD; when associated with A-221. 2 Publications | 1 | |
Mutagenesisi | 18 | K → R: No effect on sumoylation. Abolishes sumoylation; when associated with R-214 and R-230. 1 Publication | 1 | |
Mutagenesisi | 35 | S → A: No effect on phosphorylation by PRKCD. 1 Publication | 1 | |
Mutagenesisi | 42 | T → A: Abolishes phosphorylation by MAPK and translocation to the nucleus following exposure of cells to hydrogen peroxide. No effect on phosphorylation by CDK1 or PRKCD. 4 Publications | 1 | |
Mutagenesisi | 42 | T → D: Phosphomimetic mutant which is detected exclusively in the nucleus. 1 Publication | 1 | |
Mutagenesisi | 70 | T → A: No effect on phosphorylation by PRKCD. Abolishes phosphorylation by PKB. 2 Publications | 1 | |
Mutagenesisi | 70 | T → D, E or R: Abolishes phosphorylation by PKB. 1 Publication | 1 | |
Mutagenesisi | 132 | K → A: Does not affect ability to cleave DNA but abolishes binding to 8-oxoG. 1 Publication | 1 | |
Mutagenesisi | 139 | S → A: No effect on phosphorylation by PRKCD. 1 Publication | 1 | |
Mutagenesisi | 149 | S → A: No effect on phosphorylation by PRKCD. 1 Publication | 1 | |
Mutagenesisi | 195 | T → A: No effect on phosphorylation by PRKCD. 1 Publication | 1 | |
Mutagenesisi | 209 | S → A: Reduced phosphorylation by IKKB. 1 Publication | 1 | |
Mutagenesisi | 214 | K → R: No effect on sumoylation. Abolishes sumoylation; when associated with R-18 and R-230. 1 Publication | 1 | |
Mutagenesisi | 221 | T → A: No effect on phosphorylation by MAPK. Significantly reduces phosphorylation by CDK1 and nuclear accumulation. Greatly reduced phosphorylation by PRKCD. Abolishes phosphorylation by PRKCD; when associated with A-6. 3 Publications | 1 | |
Mutagenesisi | 230 | K → R: No effect on sumoylation. Abolishes sumoylation; when associated with R-18 and R-214. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6188 |
OpenTargetsi | ENSG00000149273 |
PharmGKBi | PA34829 |
Miscellaneous databases
Pharosi | P23396, Tbio |
Polymorphism and mutation databases
BioMutai | RPS3 |
DMDMi | 417719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000130320 | 2 – 243 | 40S ribosomal protein S3Add BLAST | 242 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 6 | Phosphoserine; by PKC/PRKCD1 Publication | 1 | |
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Modified residuei | 42 | Phosphothreonine; by MAPK1 Publication | 1 | |
Modified residuei | 62 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 64 | Asymmetric dimethylarginine; by PRMT11 Publication | 1 | |
Modified residuei | 65 | Asymmetric dimethylarginine; by PRMT11 Publication | 1 | |
Modified residuei | 67 | Asymmetric dimethylarginine; by PRMT11 Publication | 1 | |
Modified residuei | 70 | Phosphothreonine; by PKB1 Publication | 1 | |
Cross-linki | 90 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 104 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | N6-succinyllysineBy similarity | 1 | |
Cross-linki | 202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 209 | Phosphoserine; by IKKB1 Publication | 1 | |
Cross-linki | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications | ||
Modified residuei | 220 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 221 | Phosphothreonine; by CDK1 and PKC/PRKCDCombined sources3 Publications | 1 | |
Modified residuei | 224 | PhosphoserineCombined sources | 1 | |
Cross-linki | 230 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 242 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P23396 |
jPOSTi | P23396 |
MassIVEi | P23396 |
MaxQBi | P23396 |
PaxDbi | P23396 |
PeptideAtlasi | P23396 |
PRIDEi | P23396 |
ProteomicsDBi | 54087 [P23396-1] |
PTM databases
iPTMneti | P23396 |
MetOSitei | P23396 |
PhosphoSitePlusi | P23396 |
SwissPalmi | P23396 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149273, Expressed in female gonad and 240 other tissues |
ExpressionAtlasi | P23396, baseline and differential |
Genevisiblei | P23396, HS |
Organism-specific databases
HPAi | ENSG00000149273, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 40S small ribosomal subunit (PubMed:8706699).
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).
Interacts with HNRPD (PubMed:24423872).
Interacts with PRMT1; the interaction methylates RPS3 (PubMed:19460357).
Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed:21968017).
Interacts with UBC9 (PubMed:21968017).
Interacts with CDK1; the interaction phosphorylates RPS3 (PubMed:21871177).
Interacts with PRKCD; the interaction phosphorylates RPS3 (PubMed:19059439).
Interacts with PKB/AKT; the interaction phosphorylates RPS3 (PubMed:20605787).
Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787).
Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity (PubMed:15518571).
Interacts with UNG; the interaction increases the uracil excision activity of UNG1 (PubMed:18973764).
Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels (PubMed:16314389).
Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion (PubMed:23911537).
Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex (PubMed:18045535).
Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA (PubMed:24457201).
Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus (PubMed:21399639).
Interacts (via KH domain) with MDM2 and TP53 (PubMed:19656744).
Interacts with TRADD (PubMed:22510408).
Interacts (via N-terminus) with E.coli O157:H7 (strain EDL933) nleH1 and nleH2; the interaction with nleH1 inhibits phosphorylation by IKKB, reduces RPS3 nuclear abundance and inhibits transcriptional activation by the NF-kappa-B p65-p50 complex (PubMed:20041225, PubMed:21399639).
Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon (PubMed:19541769).
Interacts with CRY1 (By similarity).
1 PublicationBy similarity19 PublicationsBinary interactionsi
Hide detailsP23396
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- Hsp70 protein binding Source: UniProtKB
- Hsp90 protein binding Source: UniProtKB
- kinase binding Source: UniProtKB
- microtubule binding Source: UniProtKB
- protein kinase A binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- tubulin binding Source: UniProtKB
- ubiquitin-like protein conjugating enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112102, 375 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P23396 |
DIPi | DIP-33177N |
ELMi | P23396 |
IntActi | P23396, 124 interactors |
MINTi | P23396 |
STRINGi | 9606.ENSP00000278572 |
Miscellaneous databases
RNActi | P23396, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P23396 |
SMRi | P23396 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23396 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 92 | KH type-2PROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3181, Eukaryota |
GeneTreei | ENSGT00390000008610 |
HOGENOMi | CLU_058591_2_1_1 |
InParanoidi | P23396 |
OMAi | MLPHDPE |
OrthoDBi | 1135751at2759 |
PhylomeDBi | P23396 |
TreeFami | TF300901 |
Family and domain databases
Gene3Di | 3.30.1140.32, 1 hit 3.30.300.20, 1 hit |
InterProi | View protein in InterPro IPR015946, KH_dom-like_a/b IPR004044, KH_dom_type_2 IPR009019, KH_sf_prok-type IPR001351, Ribosomal_S3_C IPR036419, Ribosomal_S3_C_sf IPR018280, Ribosomal_S3_CS IPR005703, Ribosomal_S3_euk/arc |
Pfami | View protein in Pfam PF07650, KH_2, 1 hit PF00189, Ribosomal_S3_C, 1 hit |
SUPFAMi | SSF54814, SSF54814, 1 hit SSF54821, SSF54821, 1 hit |
TIGRFAMsi | TIGR01008, uS3_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS50823, KH_TYPE_2, 1 hit PS00548, RIBOSOMAL_S3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII
60 70 80 90 100
LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA
110 120 130 140 150
QAESLRYKLL GGLAVRRACY GVLRFIMESG AKGCEVVVSG KLRGQRAKSM
160 170 180 190 200
KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG VLGIKVKIML PWDPTGKIGP
210 220 230 240
KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV PTA
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PL09 | E9PL09_HUMAN | 40S ribosomal protein S3 | RPS3 | 231 | Annotation score: | ||
E9PPU1 | E9PPU1_HUMAN | 40S ribosomal protein S3 | RPS3 | 158 | Annotation score: | ||
H0YEU2 | H0YEU2_HUMAN | 40S ribosomal protein S3 | RPS3 | 171 | Annotation score: | ||
E9PSF4 | E9PSF4_HUMAN | 40S ribosomal protein S3 | RPS3 | 103 | Annotation score: | ||
F2Z2S8 | F2Z2S8_HUMAN | 40S ribosomal protein S3 | RPS3 | 117 | Annotation score: | ||
H0YCJ7 | H0YCJ7_HUMAN | 40S ribosomal protein S3 | RPS3 | 135 | Annotation score: | ||
H0YF32 | H0YF32_HUMAN | 40S ribosomal protein S3 | RPS3 | 123 | Annotation score: | ||
E9PJN9 | E9PJN9_HUMAN | 40S ribosomal protein S3 | RPS3 | 36 | Annotation score: | ||
E9PK82 | E9PK82_HUMAN | 40S ribosomal protein S3 | RPS3 | 128 | Annotation score: | ||
E9PJH4 | E9PJH4_HUMAN | 40S ribosomal protein S3 | RPS3 | 115 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | K → R in AAB19349 (PubMed:1712897).Curated | 1 | |
Sequence conflicti | 104 | S → C in CAA39248 (PubMed:2129557).Curated | 1 | |
Sequence conflicti | 233 | P → L in CAA39248 (PubMed:2129557).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046667 | 85 | E → ELKIMVMVTGYPLLPLK in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14990 mRNA Translation: AAB60336.1 U14991 mRNA Translation: AAB60337.1 U14992 mRNA Translation: AAB60338.1 X55715 mRNA Translation: CAA39248.1 S42658 mRNA Translation: AAB19349.2 AB061838 Genomic DNA Translation: BAB79476.1 AY791291 Genomic DNA Translation: AAV40835.1 AK313051 mRNA Translation: BAG35882.1 AP000744 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74963.1 BC003137 mRNA Translation: AAH03137.1 BC003577 mRNA Translation: AAH03577.1 BC013196 mRNA Translation: AAH13196.1 BC034149 mRNA Translation: AAH34149.1 BC071917 mRNA Translation: AAH71917.1 BC100284 mRNA Translation: AAI00285.1 L16016 Genomic DNA Translation: AAA18095.1 AB062288 mRNA Translation: BAB93471.1 Different initiation. |
CCDSi | CCDS58161.1 [P23396-2] CCDS8236.1 [P23396-1] |
PIRi | A41247, R3HUS3 |
RefSeqi | NP_000996.2, NM_001005.4 [P23396-1] NP_001243731.1, NM_001256802.1 [P23396-1] NP_001247435.1, NM_001260506.1 [P23396-2] NP_001247436.1, NM_001260507.1 |
Genome annotation databases
Ensembli | ENST00000278572; ENSP00000278572; ENSG00000149273 [P23396-2] ENST00000524851; ENSP00000433821; ENSG00000149273 [P23396-1] ENST00000527446; ENSP00000436971; ENSG00000149273 [P23396-1] ENST00000531188; ENSP00000434643; ENSG00000149273 [P23396-1] |
GeneIDi | 6188 |
KEGGi | hsa:6188 |
UCSCi | uc001owh.5, human [P23396-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14990 mRNA Translation: AAB60336.1 U14991 mRNA Translation: AAB60337.1 U14992 mRNA Translation: AAB60338.1 X55715 mRNA Translation: CAA39248.1 S42658 mRNA Translation: AAB19349.2 AB061838 Genomic DNA Translation: BAB79476.1 AY791291 Genomic DNA Translation: AAV40835.1 AK313051 mRNA Translation: BAG35882.1 AP000744 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74963.1 BC003137 mRNA Translation: AAH03137.1 BC003577 mRNA Translation: AAH03577.1 BC013196 mRNA Translation: AAH13196.1 BC034149 mRNA Translation: AAH34149.1 BC071917 mRNA Translation: AAH71917.1 BC100284 mRNA Translation: AAI00285.1 L16016 Genomic DNA Translation: AAA18095.1 AB062288 mRNA Translation: BAB93471.1 Different initiation. |
CCDSi | CCDS58161.1 [P23396-2] CCDS8236.1 [P23396-1] |
PIRi | A41247, R3HUS3 |
RefSeqi | NP_000996.2, NM_001005.4 [P23396-1] NP_001243731.1, NM_001256802.1 [P23396-1] NP_001247435.1, NM_001260506.1 [P23396-2] NP_001247436.1, NM_001260507.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WH9 | NMR | - | A | 17-95 | [»] | |
4UG0 | electron microscopy | - | SD | 1-243 | [»] | |
4V6X | electron microscopy | 5.00 | AD | 1-243 | [»] | |
5A2Q | electron microscopy | 3.90 | D | 1-243 | [»] | |
5AJ0 | electron microscopy | 3.50 | BD | 1-243 | [»] | |
5FLX | electron microscopy | 3.90 | D | 1-243 | [»] | |
5LKS | electron microscopy | 3.60 | SD | 1-243 | [»] | |
5OA3 | electron microscopy | 4.30 | D | 1-243 | [»] | |
5T2C | electron microscopy | 3.60 | Aq | 1-243 | [»] | |
5VYC | X-ray | 6.00 | D1/D2/D3/D4/D5/D6 | 1-243 | [»] | |
6EK0 | electron microscopy | 2.90 | SD | 1-243 | [»] | |
6FEC | electron microscopy | 6.30 | g | 1-227 | [»] | |
6G51 | electron microscopy | 4.10 | D | 1-243 | [»] | |
6G53 | electron microscopy | 4.50 | D | 1-243 | [»] | |
6G5H | electron microscopy | 3.60 | D | 1-243 | [»] | |
6G5I | electron microscopy | 3.50 | D | 1-243 | [»] | |
6IP5 | electron microscopy | 3.90 | 2p | 1-243 | [»] | |
6IP6 | electron microscopy | 4.50 | 2p | 1-243 | [»] | |
6IP8 | electron microscopy | 3.90 | 2p | 1-243 | [»] | |
6OLE | electron microscopy | 3.10 | SD | 2-227 | [»] | |
6OLF | electron microscopy | 3.90 | SD | 2-227 | [»] | |
6OLG | electron microscopy | 3.40 | BD | 2-221 | [»] | |
6OLI | electron microscopy | 3.50 | SD | 2-227 | [»] | |
6OLZ | electron microscopy | 3.90 | BD | 2-221 | [»] | |
6OM0 | electron microscopy | 3.10 | SD | 2-227 | [»] | |
6OM7 | electron microscopy | 3.70 | SD | 2-227 | [»] | |
6QZP | electron microscopy | 2.90 | SD | 1-227 | [»] | |
6Y0G | electron microscopy | 3.20 | SD | 1-243 | [»] | |
6Y2L | electron microscopy | 3.00 | SD | 1-243 | [»] | |
6Y57 | electron microscopy | 3.50 | SD | 1-243 | [»] | |
6Z6L | electron microscopy | 3.00 | SD | 1-243 | [»] | |
6Z6M | electron microscopy | 3.10 | SD | 1-243 | [»] | |
6Z6N | electron microscopy | 2.90 | SD | 1-243 | [»] | |
6ZLW | electron microscopy | 2.60 | F | 1-243 | [»] | |
6ZM7 | electron microscopy | 2.70 | SD | 1-243 | [»] | |
6ZME | electron microscopy | 3.00 | SD | 1-243 | [»] | |
6ZMI | electron microscopy | 2.60 | SD | 1-243 | [»] | |
6ZMO | electron microscopy | 3.10 | SD | 1-243 | [»] | |
6ZMT | electron microscopy | 3.00 | F | 1-243 | [»] | |
6ZN5 | electron microscopy | 3.20 | F | 3-227 | [»] | |
6ZOJ | electron microscopy | 2.80 | D | 1-243 | [»] | |
6ZOL | electron microscopy | 2.80 | D | 1-243 | [»] | |
6ZON | electron microscopy | 3.00 | b | 1-243 | [»] | |
6ZP4 | electron microscopy | 2.90 | b | 1-243 | [»] | |
6ZVH | electron microscopy | 2.90 | D | 1-227 | [»] | |
BMRBi | P23396 | |||||
SMRi | P23396 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112102, 375 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P23396 |
DIPi | DIP-33177N |
ELMi | P23396 |
IntActi | P23396, 124 interactors |
MINTi | P23396 |
STRINGi | 9606.ENSP00000278572 |
Protein family/group databases
MoonProti | P23396 |
PTM databases
iPTMneti | P23396 |
MetOSitei | P23396 |
PhosphoSitePlusi | P23396 |
SwissPalmi | P23396 |
Polymorphism and mutation databases
BioMutai | RPS3 |
DMDMi | 417719 |
Proteomic databases
EPDi | P23396 |
jPOSTi | P23396 |
MassIVEi | P23396 |
MaxQBi | P23396 |
PaxDbi | P23396 |
PeptideAtlasi | P23396 |
PRIDEi | P23396 |
ProteomicsDBi | 54087 [P23396-1] |
Protocols and materials databases
Antibodypediai | 31150, 328 antibodies |
DNASUi | 6188 |
Genome annotation databases
Ensembli | ENST00000278572; ENSP00000278572; ENSG00000149273 [P23396-2] ENST00000524851; ENSP00000433821; ENSG00000149273 [P23396-1] ENST00000527446; ENSP00000436971; ENSG00000149273 [P23396-1] ENST00000531188; ENSP00000434643; ENSG00000149273 [P23396-1] |
GeneIDi | 6188 |
KEGGi | hsa:6188 |
UCSCi | uc001owh.5, human [P23396-1] |
Organism-specific databases
CTDi | 6188 |
DisGeNETi | 6188 |
EuPathDBi | HostDB:ENSG00000149273.14 |
GeneCardsi | RPS3 |
HGNCi | HGNC:10420, RPS3 |
HPAi | ENSG00000149273, Low tissue specificity |
MIMi | 600454, gene |
neXtProti | NX_P23396 |
OpenTargetsi | ENSG00000149273 |
PharmGKBi | PA34829 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3181, Eukaryota |
GeneTreei | ENSGT00390000008610 |
HOGENOMi | CLU_058591_2_1_1 |
InParanoidi | P23396 |
OMAi | MLPHDPE |
OrthoDBi | 1135751at2759 |
PhylomeDBi | P23396 |
TreeFami | TF300901 |
Enzyme and pathway databases
PathwayCommonsi | P23396 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P23396 |
Miscellaneous databases
BioGRID-ORCSi | 6188, 751 hits in 828 CRISPR screens |
ChiTaRSi | RPS3, human |
EvolutionaryTracei | P23396 |
GeneWikii | RPS3 |
GenomeRNAii | 6188 |
Pharosi | P23396, Tbio |
PROi | PR:P23396 |
RNActi | P23396, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149273, Expressed in female gonad and 240 other tissues |
ExpressionAtlasi | P23396, baseline and differential |
Genevisiblei | P23396, HS |
Family and domain databases
Gene3Di | 3.30.1140.32, 1 hit 3.30.300.20, 1 hit |
InterProi | View protein in InterPro IPR015946, KH_dom-like_a/b IPR004044, KH_dom_type_2 IPR009019, KH_sf_prok-type IPR001351, Ribosomal_S3_C IPR036419, Ribosomal_S3_C_sf IPR018280, Ribosomal_S3_CS IPR005703, Ribosomal_S3_euk/arc |
Pfami | View protein in Pfam PF07650, KH_2, 1 hit PF00189, Ribosomal_S3_C, 1 hit |
SUPFAMi | SSF54814, SSF54814, 1 hit SSF54821, SSF54821, 1 hit |
TIGRFAMsi | TIGR01008, uS3_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS50823, KH_TYPE_2, 1 hit PS00548, RIBOSOMAL_S3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS3_HUMAN | |
Accessioni | P23396Primary (citable) accession number: P23396 Secondary accession number(s): B2R7N5 Q8NI95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | October 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 231 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries