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Entry version 140 (10 Feb 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Secretogranin-1

Gene

CHGB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites.
Secretolytin has antibacterial activity.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secretogranin-1
Alternative name(s):
Chromogranin-B
Short name:
CgB
Secretogranin I
Short name:
SgI
Cleaved into the following 5 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHGB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 202 PublicationsAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000543421 – 646Secretogranin-1Add BLAST626
ChainiPRO_0000326263476 – 566Secretogranin-1(476-566)Add BLAST91
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000432729544 – 554PE-11By similarityAdd BLAST11
PeptideiPRO_0000005436567 – 580Peptide BAM-1745Add BLAST14
PeptideiPRO_0000411987584 – 646CCB peptideAdd BLAST63
PeptideiPRO_0000005437634 – 646SecretolytinAdd BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 57By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei74PhosphoserineSequence analysis1
Modified residuei79PhosphothreonineCurated1
Modified residuei92PhosphothreonineSequence analysis1
Modified residuei93PhosphoserineBy similarity1
Modified residuei99PhosphoserineSequence analysis1
Modified residuei100PhosphoserineSequence analysis1
Modified residuei104PhosphoserineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi113O-linked (GalNAc...) threonine1 Publication1
Modified residuei123PhosphoserineBy similarity1
Modified residuei146PhosphoserineCurated1
Modified residuei168Phosphoserine1 Publication1
Glycosylationi190O-linked (GalNAc...) threonine1 Publication1
Modified residuei205PhosphoserineBy similarity1
Modified residuei276PhosphoserineSequence analysis1
Modified residuei277PhosphoserineSequence analysis1
Modified residuei295PhosphoserineSequence analysis1
Modified residuei315SulfotyrosineBy similarity1
Modified residuei351Phosphoserine1 Publication1
Modified residuei354Phosphoserine1 Publication1
Modified residuei374PhosphotyrosineBy similarity1
Modified residuei375PhosphoserineSequence analysis1
Modified residuei378PhosphoserineSequence analysisBy similarity1
Modified residuei441Sulfotyrosine1 Publication1
Modified residuei476Pyrrolidone carboxylic acid; in secretogranin-1(476-566)1 Publication1
Modified residuei502PhosphoserineSequence analysis1
Modified residuei503PhosphoserineSequence analysis1
Modified residuei514PhosphoserineSequence analysis1
Modified residuei535Sulfotyrosine1 Publication1
Modified residuei567Pyrrolidone carboxylic acid; in peptide BAM-17452 Publications1
Modified residuei584Phosphoserine1 Publication1
Modified residuei591SulfotyrosineBy similarity1
Modified residuei593Phosphoserine1 Publication1
Modified residuei598Phosphoserine1 Publication1
Modified residuei634Pyrrolidone carboxylic acid; in Secretolytin; partial1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated by the trisaccharide, GalNAc-Gal-NeuAc, on 2 sites in the N-terminal. May be glycated.1 Publication
Extensively phosphorylated.1 Publication
Differentially processed on numerous sites throughout the sequence depending on tissue type.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei161 – 162Cleavage; major site2
Sitei275 – 276Cleavage; major site2
Sitei278 – 279Cleavage; major site2
Sitei324 – 325Cleavage; major site2
Sitei629 – 630Cleavage; major site2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23389

PRoteomics IDEntifications database

More...
PRIDEi
P23389

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P23389

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
P23389

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000015645

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi617 – 624Poly-Glu8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRBF, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026095_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23389

Database of Orthologous Groups

More...
OrthoDBi
670416at2759

TreeFam database of animal gene trees

More...
TreeFami
TF336596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001819, Chromogranin_AB
IPR018054, Chromogranin_CS
IPR001990, Granin

The PANTHER Classification System

More...
PANTHERi
PTHR10583, PTHR10583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01271, Granin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00659, CHROMOGRANIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00422, GRANINS_1, 1 hit
PS00423, GRANINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P23389-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPAALLGLL GATVVAAVSS MPVDIRNHNE EVVTHCIIEV LSNALLKSSA
60 70 80 90 100
PPITPECRQV LKKNGKELKN EEKSENENTR FEVRLLRDPA DTSEAPGLSS
110 120 130 140 150
REDSGEGDAQ VPTVADTESG GHSRERAGEP PGSQVAKEAK TRYSKSEGQN
160 170 180 190 200
REEEMVKYQK RERGEVGSEE RLSEGPGKAQ TAFLNQRNQT PAKKEELVSR
210 220 230 240 250
YDTQSARGLE KSHSRERSSQ ESGEETKSQE NWPQELQRHP EGQEAPGESE
260 270 280 290 300
EDASPEVDKR HSRPRHHHGR SRPDRSSQEG NPPLEEESHV GTGNSDEEKA
310 320 330 340 350
RHPAHFRALE EGAEYGEEVR RHSAAQAPGD LQGARFGGRG RGEHQALRRP
360 370 380 390 400
SEESLEQENK RHGLSPDLNM AQGYSEESEE ERGPAPGPSY RARGGEAAAY
410 420 430 440 450
STLGQTDEKR FLGETHHRVQ ESQRDKARRR LPGELRNYLD YGEEKGEEAA
460 470 480 490 500
RGKWQPQGDP RDADENREEA RLRGKQYAPH HITEKRLGEL LNPFYDPSQW
510 520 530 540 550
KSSRFERKDP MDDSFLEGEE ENGLTLNEKN FFPEYNYDWW EKKPFEEDVN
560 570 580 590 600
WGYEKRNPVP KLDLKRQYDR VAELDQLLHY RKKSAEFPDF YDSEEQMSPQ
610 620 630 640
HTAENEEEKA GQGVLTEEEE KELENLAAMD LELQKIAEKF SGTRRG
Length:646
Mass (Da):73,340
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i420DB1178FD9E415
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64N → S in CAA38846 (PubMed:2025642).Curated1
Sequence conflicti70N → D in AAC48720 (PubMed:9136897).Curated1
Sequence conflicti93 – 98SEAPGL → FRSPRAS in CAA39109 (PubMed:1350945).Curated6
Sequence conflicti181T → M in AAC48720 (PubMed:9136897).Curated1
Sequence conflicti261H → R in AAC48720 (PubMed:9136897).Curated1
Sequence conflicti386P → R in AAC48720 (PubMed:9136897).Curated1
Sequence conflicti481H → L in CAA39109 (PubMed:1350945).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 1746 Da. Determined by MALDI. Pyroglutamate.1 Publication
Molecular mass is 1746 Da. Determined by FAB. Pyroglutamate.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti597M → V2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X55027 mRNA Translation: CAA38846.1
U88551 mRNA Translation: AAC48720.1
X55489 mRNA Translation: CAA39109.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S15901

NCBI Reference Sequences

More...
RefSeqi
NP_851349.1, NM_181006.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
281071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281071

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55027 mRNA Translation: CAA38846.1
U88551 mRNA Translation: AAC48720.1
X55489 mRNA Translation: CAA39109.1
PIRiS15901
RefSeqiNP_851349.1, NM_181006.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

MINTiP23389
STRINGi9913.ENSBTAP00000015645

PTM databases

iPTMnetiP23389

Proteomic databases

PaxDbiP23389
PRIDEiP23389

Genome annotation databases

GeneIDi281071
KEGGibta:281071

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1114

Phylogenomic databases

eggNOGiENOG502QRBF, Eukaryota
HOGENOMiCLU_026095_0_0_1
InParanoidiP23389
OrthoDBi670416at2759
TreeFamiTF336596

Family and domain databases

InterProiView protein in InterPro
IPR001819, Chromogranin_AB
IPR018054, Chromogranin_CS
IPR001990, Granin
PANTHERiPTHR10583, PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271, Granin, 1 hit
PRINTSiPR00659, CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422, GRANINS_1, 1 hit
PS00423, GRANINS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCG1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23389
Secondary accession number(s): O02707
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 2000
Last modified: February 10, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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