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Protein

Metabotropic glutamate receptor 1

Gene

Grm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.4 Publications

Miscellaneous

Activated by quisqualate > glutamate > ibotenate > trans-1- aminocyclopentyl-1,3-dicarboxylate; inhibited by 2-amino-3-phosphonopropionate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74Glutamate2 Publications1
Binding sitei165Glutamate2 Publications1
Binding sitei236Glutamate2 Publications1
Binding sitei318Glutamate2 Publications1
Binding sitei409Glutamate2 Publications1

GO - Molecular functioni

  • estrogen receptor binding Source: RGD
  • glutamate receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: RGD
  • G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential Source: SynGO
  • identical protein binding Source: IntAct
  • PLC activating G-protein coupled glutamate receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events
R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-RNO-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 1
Short name:
mGluR1
Gene namesi
Name:Grm1
Synonyms:Gprc1a, Mglur1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2742 Grm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 592ExtracellularBy similarityAdd BLAST574
Transmembranei593 – 615Helical; Name=1By similarityAdd BLAST23
Topological domaini616 – 629CytoplasmicBy similarityAdd BLAST14
Transmembranei630 – 650Helical; Name=2By similarityAdd BLAST21
Topological domaini651 – 658ExtracellularBy similarity8
Transmembranei659 – 680Helical; Name=3By similarityAdd BLAST22
Topological domaini681 – 703CytoplasmicBy similarityAdd BLAST23
Transmembranei704 – 727Helical; Name=4By similarityAdd BLAST24
Topological domaini728 – 750ExtracellularBy similarityAdd BLAST23
Transmembranei751 – 772Helical; Name=5By similarityAdd BLAST22
Topological domaini773 – 785CytoplasmicBy similarityAdd BLAST13
Transmembranei786 – 807Helical; Name=6By similarityAdd BLAST22
Topological domaini808 – 815ExtracellularBy similarity8
Transmembranei816 – 840Helical; Name=7By similarityAdd BLAST25
Topological domaini841 – 1199CytoplasmicBy similarityAdd BLAST359

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67C → S: Impairs protein folding and abolishes location at the cell surface. 1 Publication1
Mutagenesisi109C → S: Impairs protein folding and abolishes location at the cell surface. 1 Publication1
Mutagenesisi140C → S: Impairs homodimerization. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL4477
GuidetoPHARMACOLOGYi289

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001292419 – 1199Metabotropic glutamate receptor 1Add BLAST1181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 109
Glycosylationi98N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi140Interchain
Glycosylationi223N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi289 ↔ 291
Disulfide bondi378 ↔ 394
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi432 ↔ 439
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi657 ↔ 746By similarity
Modified residuei853PhosphoserineBy similarity1
Modified residuei871PhosphothreonineBy similarity1
Modified residuei894PhosphoserineCombined sources1
Modified residuei969PhosphoserineBy similarity1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1151PhosphothreonineCombined sources1
Modified residuei1154PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP23385
PRIDEiP23385

PTM databases

iPTMnetiP23385
PhosphoSitePlusiP23385

Miscellaneous databases

PMAP-CutDBiP23385

Expressioni

Tissue specificityi

Predominantly expressed in cerebellar Purkinje cells, CA2-CA3 pyramidal cells of the hippocampus, and mitral and tufted cells of the olfactory bulb.2 Publications

Gene expression databases

BgeeiENSRNOG00000014290 Expressed in 2 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiP23385 baseline and differential

Interactioni

Subunit structurei

The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3 (By similarity). Interacts with SIAH1 and GRASP. Homodimer; disulfide-linked.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246579, 9 interactors
CORUMiP23385
DIPiDIP-44897N
ELMiP23385
IntActiP23385, 5 interactors
MINTiP23385
STRINGi10116.ENSRNOP00000019319

Chemistry databases

BindingDBiP23385

Structurei

Secondary structure

11199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23385
SMRiP23385
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23385

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 188Glutamate binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1014 – 1034Gln/Pro-richAdd BLAST21
Compositional biasi1074 – 1080Gln/Pro-rich7
Compositional biasi1126 – 1135Asp/Glu-rich (acidic)10
Compositional biasi1140 – 1199Ser-richAdd BLAST60

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218636
HOVERGENiHBG107965
InParanoidiP23385
KOiK04603
PhylomeDBiP23385

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001256 GPCR_3_mtglu_rcpt_1
IPR019588 Metabotropic_Glu_rcpt_Homer-bd
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF10606 GluR_Homer-bdg, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01051 MTABOTROPC1R
PR00593 MTABOTROPICR
SMARTiView protein in SMART
SM01229 GluR_Homer-bdg, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1A (identifier: P23385-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRLLLIFFP MIFLEMSILP RMPDRKVLLA GASSQRSVAR MDGDVIIGAL
60 70 80 90 100
FSVHHQPPAE KVPERKCGEI REQYGIQRVE AMFHTLDKIN ADPVLLPNIT
110 120 130 140 150
LGSEIRDSCW HSSVALEQSI EFIRDSLISI RDEKDGLNRC LPDGQTLPPG
160 170 180 190 200
RTKKPIAGVI GPGSSSVAIQ VQNLLQLFDI PQIAYSATSI DLSDKTLYKY
210 220 230 240 250
FLRVVPSDTL QARAMLDIVK RYNWTYVSAV HTEGNYGESG MDAFKELAAQ
260 270 280 290 300
EGLCIAHSDK IYSNAGEKSF DRLLRKLRER LPKARVVVCF CEGMTVRGLL
310 320 330 340 350
SAMRRLGVVG EFSLIGSDGW ADRDEVIEGY EVEANGGITI KLQSPEVRSF
360 370 380 390 400
DDYFLKLRLD TNTRNPWFPE FWQHRFQCRL PGHLLENPNF KKVCTGNESL
410 420 430 440 450
EENYVQDSKM GFVINAIYAM AHGLQNMHHA LCPGHVGLCD AMKPIDGRKL
460 470 480 490 500
LDFLIKSSFV GVSGEEVWFD EKGDAPGRYD IMNLQYTEAN RYDYVHVGTW
510 520 530 540 550
HEGVLNIDDY KIQMNKSGMV RSVCSEPCLK GQIKVIRKGE VSCCWICTAC
560 570 580 590 600
KENEFVQDEF TCRACDLGWW PNAELTGCEP IPVRYLEWSD IESIIAIAFS
610 620 630 640 650
CLGILVTLFV TLIFVLYRDT PVVKSSSREL CYIILAGIFL GYVCPFTLIA
660 670 680 690 700
KPTTTSCYLQ RLLVGLSSAM CYSALVTKTN RIARILAGSK KKICTRKPRF
710 720 730 740 750
MSAWAQVIIA SILISVQLTL VVTLIIMEPP MPILSYPSIK EVYLICNTSN
760 770 780 790 800
LGVVAPVGYN GLLIMSCTYY AFKTRNVPAN FNEAKYIAFT MYTTCIIWLA
810 820 830 840 850
FVPIYFGSNY KIITTCFAVS LSVTVALGCM FTPKMYIIIA KPERNVRSAF
860 870 880 890 900
TTSDVVRMHV GDGKLPCRSN TFLNIFRRKK PGAGNANSNG KSVSWSEPGG
910 920 930 940 950
RQAPKGQHVW QRLSVHVKTN ETACNQTAVI KPLTKSYQGS GKSLTFSDAS
960 970 980 990 1000
TKTLYNVEEE DNTPSAHFSP PSSPSMVVHR RGPPVATTPP LPPHLTAEET
1010 1020 1030 1040 1050
PLFLADSVIP KGLPPPLPQQ QPQQPPPQQP PQQPKSLMDQ LQGVVTNFGS
1060 1070 1080 1090 1100
GIPDFHAVLA GPGTPGNSLR SLYPPPPPPQ HLQMLPLHLS TFQEESISPP
1110 1120 1130 1140 1150
GEDIDDDSER FKLLQEFVYE REGNTEEDEL EEEEDLPTAS KLTPEDSPAL
1160 1170 1180 1190
TPPSPFRDSV ASGSSVPSSP VSESVLCTPP NVTYASVILR DYKQSSSTL
Length:1,199
Mass (Da):133,236
Last modified:November 1, 1991 - v1
Checksum:iEEE5A04C50694B9F
GO
Isoform 1B (identifier: P23385-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-906: NSNGKSVSWSEPGGRQAPKG → KKRQPEFSPSSQCPSAHAQL
     907-1199: Missing.

Note: C-terminally truncated forms of isoform 1A.
Show »
Length:906
Mass (Da):101,638
Checksum:i93201A86AD366DB3
GO
Isoform 1C (identifier: P23385-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     888-897: SNGKSVSWSE → FALDRQNTVY
     898-1199: Missing.

Note: C-terminally truncated forms of isoform 1A.
Show »
Length:897
Mass (Da):100,752
Checksum:i6F1E809C2AC521B9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7U1G3V7U1_RAT
Glutamate receptor, metabotropic 1,...
Grm1 rCG_57330
1,199Annotation score:
M0R476M0R476_RAT
Leucine-rich repeat-containing prot...
Lrrc15 Grm1, rCG_36691
578Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002026887 – 906NSNGK…QAPKG → KKRQPEFSPSSQCPSAHAQL in isoform 1B. CuratedAdd BLAST20
Alternative sequenceiVSP_002028888 – 897SNGKSVSWSE → FALDRQNTVY in isoform 1C. Curated10
Alternative sequenceiVSP_002029898 – 1199Missing in isoform 1C. CuratedAdd BLAST302
Alternative sequenceiVSP_002027907 – 1199Missing in isoform 1B. CuratedAdd BLAST293

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57569 mRNA Translation: CAA40799.1
M61099 mRNA Translation: AAA19497.1
S48085 mRNA Translation: AAB24138.1
PIRiA41939
RefSeqiNP_001107802.1, NM_001114330.1 [P23385-2]
NP_058707.1, NM_017011.1 [P23385-1]
UniGeneiRn.87787

Genome annotation databases

EnsembliENSRNOT00000044325; ENSRNOP00000047790; ENSRNOG00000014290 [P23385-2]
GeneIDi24414
KEGGirno:24414
UCSCiRGD:2742 rat [P23385-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57569 mRNA Translation: CAA40799.1
M61099 mRNA Translation: AAA19497.1
S48085 mRNA Translation: AAB24138.1
PIRiA41939
RefSeqiNP_001107802.1, NM_001114330.1 [P23385-2]
NP_058707.1, NM_017011.1 [P23385-1]
UniGeneiRn.87787

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EWKX-ray2.20A/B33-522[»]
1EWTX-ray3.70A/B33-522[»]
1EWVX-ray4.00A/B33-522[»]
1ISRX-ray4.00A33-522[»]
1ISSX-ray3.30A/B33-522[»]
ProteinModelPortaliP23385
SMRiP23385
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246579, 9 interactors
CORUMiP23385
DIPiDIP-44897N
ELMiP23385
IntActiP23385, 5 interactors
MINTiP23385
STRINGi10116.ENSRNOP00000019319

Chemistry databases

BindingDBiP23385
ChEMBLiCHEMBL4477
GuidetoPHARMACOLOGYi289

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP23385
PhosphoSitePlusiP23385

Proteomic databases

PaxDbiP23385
PRIDEiP23385

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044325; ENSRNOP00000047790; ENSRNOG00000014290 [P23385-2]
GeneIDi24414
KEGGirno:24414
UCSCiRGD:2742 rat [P23385-1]

Organism-specific databases

CTDi2911
RGDi2742 Grm1

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118884
HOGENOMiHOG000218636
HOVERGENiHBG107965
InParanoidiP23385
KOiK04603
PhylomeDBiP23385

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events
R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-RNO-6794361 Neurexins and neuroligins

Miscellaneous databases

EvolutionaryTraceiP23385
PMAP-CutDBiP23385
PROiPR:P23385

Gene expression databases

BgeeiENSRNOG00000014290 Expressed in 2 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiP23385 baseline and differential

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR000162 GPCR_3_mtglu_rcpt
IPR001256 GPCR_3_mtglu_rcpt_1
IPR019588 Metabotropic_Glu_rcpt_Homer-bd
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF10606 GluR_Homer-bdg, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
PR01051 MTABOTROPC1R
PR00593 MTABOTROPICR
SMARTiView protein in SMART
SM01229 GluR_Homer-bdg, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRM1_RAT
AccessioniPrimary (citable) accession number: P23385
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 12, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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