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UniProtKB - P23381 (SYWC_HUMAN)

Entry version 207 (02 Dec 2020)
Sequence version 2 (01 Dec 1992)
Previous versions | rss
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Protein

Tryptophan--tRNA ligase, cytoplasmic

Gene

WARS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processAngiogenesis, Protein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.1.1.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23381

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-379716, Cytosolic tRNA aminoacylation

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		P23381

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tryptophan--tRNA ligase, cytoplasmicCurated (EC:6.1.1.22 Publications)
Alternative name(s):
Interferon-induced protein 53
Short name:
IFP53
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Short name:
hWRS
Cleaved into the following 2 chains:
T1-TrpRS
T2-TrpRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WARS1Imported
Synonyms:IFI53, WARS, WRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000140105.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:12729, WARS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		191050, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23381

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neuronopathy, distal hereditary motor, 9 (HMN9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurologic disorder characterized by juvenile onset of slowly progressive distal muscle weakness and atrophy affecting both the lower and upper limbs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080407257H → R in HMN9; decreased tryptophan-tRNA ligase activity; dominant negative effect; decreased general protein synthesis; decreased cell viability; no effect on homodimerization. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		7453

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		WARS

MalaCards human disease database

More...MalaCardsi		WARS1
MIMi617721, phenotype

Open Targets

More...OpenTargetsi		ENSG00000140105

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37340

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23381, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00150, Tryptophan
DB04537, Tryptophanamide
DB01831, Tryptophanyl-5'amp

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WARS

Domain mapping of disease mutations (DMDM)

More...DMDMi		135191

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001367382 – 471Tryptophan--tRNA ligase, cytoplasmicAdd BLAST470
ChainiPRO_000038646171 – 471T1-TrpRSAdd BLAST401
ChainiPRO_000038646294 – 471T2-TrpRSAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei154N6-succinyllysineBy similarity1
Modified residuei351PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage generates 2 forms; T1-TrpRS and T2-TrpRS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P23381

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23381

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23381

MaxQB - The MaxQuant DataBase

More...MaxQBi		P23381

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23381

PeptideAtlas

More...PeptideAtlasi		P23381

PRoteomics IDEntifications database

More...PRIDEi		P23381

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54085 [P23381-1]
54086 [P23381-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P23381

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23381

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P23381

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23381

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P23381

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140105, Expressed in epithelium of bronchus and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23381, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23381, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140105, Tissue enhanced (blood, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:28369220). Isoform 1 and isoform 2 interact with an oxidized form of GAPDH. GAPDH stimulates the aminoacylation activity of isoform 2 (PubMed:15628863).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113292, 80 interactors

Database of interacting proteins

More...DIPi		DIP-29493N

Protein interaction database and analysis system

More...IntActi		P23381, 17 interactors

Molecular INTeraction database

More...MINTi		P23381

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347495

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23381, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23381

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23381

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 64WHEP-TRSPROSITE-ProRule annotationAdd BLAST57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi164 – 173'HIGH' region10
Motifi349 – 353'KMSKS' region5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2145, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032621_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23381

Identification of Orthologs from Complete Genome Data

More...OMAi		SIYHRFM

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23381

TreeFam database of animal gene trees

More...TreeFami		TF105669

Family and domain databases

Conserved Domains Database

More...CDDi		cd00806, TrpRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR002305, aa-tRNA-synth_Ic
IPR014729, Rossmann-like_a/b/a_fold
IPR009068, S15_NS1_RNA-bd
IPR002306, Trp-tRNA-ligase
IPR000738, WHEP-TRS_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00579, tRNA-synt_1b, 1 hit
PF00458, WHEP-TRS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01039, TRNASYNTHTRP

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00991, WHEP-TRS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47060, SSF47060, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00233, trpS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit
PS00762, WHEP_TRS_1, 1 hit
PS51185, WHEP_TRS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 26 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23381-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY 
        60         70         80         90        100
KAAAGEDYKA DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY 
       110        120        130        140        150
DKLIVRFGSS KIDKELINRI ERATGQRPHH FLRRGIFFSH RDMNQVLDAY 
       160        170        180        190        200
ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT KWLQDVFNVP LVIQMTDDEK 
       210        220        230        240        250
YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY MGMSSGFYKN 
       260        270        280        290        300
VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR 
       310        320        330        340        350
TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM 
       360        370        380        390        400
SASDPNSSIF LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF 
       410        420        430        440        450
MYLTFFLEDD DKLEQIRKDY TSGAMLTGEL KKALIEVLQP LIAEHQARRK 
       460        470 
EVTDEIVKEF MTPRKLSFDF Q
Length:471
Mass (Da):53,165
Last modified:December 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE96344449053A0D0
GO
Isoform 2 (identifier: P23381-2) [UniParc]FASTAAdd to basket
Also known as: mini TrpRS

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:430
Mass (Da):48,852
Checksum:i5FE1254E781221DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 26 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3H8G3V3H8_HUMAN
Tryptophanyl-tRNA synthetase
WARS1
223Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3Y5G3V3Y5_HUMAN
Tryptophanyl-tRNA synthetase
WARS1
226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJP3H0YJP3_HUMAN
Tryptophanyl-tRNA synthetase
WARS1
185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V277G3V277_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V456G3V456_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5U1G3V5U1_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2Y7G3V2Y7_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V227G3V227_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3P2G3V3P2_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3S7G3V3S7_HUMAN
Tryptophan--tRNA ligase, cytoplasmi...
WARS1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213 – 214SY → GD in AAA61298 (PubMed:1765274).Curated2
Sequence conflicti310A → V in AAH95453 (PubMed:15489334).Curated1
Sequence conflicti424A → R in CAA44450 (PubMed:1537332).Curated1
Sequence conflicti439Q → L in AAH95453 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05240654A → S. Corresponds to variant dbSNP:rs2234521Ensembl.1
Natural variantiVAR_080407257H → R in HMN9; decreased tryptophan-tRNA ligase activity; dominant negative effect; decreased general protein synthesis; decreased cell viability; no effect on homodimerization. 1 Publication1
Natural variantiVAR_080408443A → S1 PublicationCorresponds to variant dbSNP:rs139914390Ensembl.1
Natural variantiVAR_036466455E → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0382211 – 41Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M77804 mRNA Translation: AAA67324.1
X59892 mRNA Translation: CAA42545.1
M61715 mRNA Translation: AAA61298.1
X62570 mRNA Translation: CAA44450.1
BX248006 mRNA Translation: CAD62335.1
AK056100 mRNA Translation: BAG51626.1
AK291141 mRNA Translation: BAF83830.1
AL157871 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81700.1
BC017489 mRNA Translation: AAH17489.1
BC095453 mRNA Translation: AAH95453.1
S82905 Genomic DNA Translation: AAB39381.1
X67920, X67921, X67922 Genomic DNA Translation: CAB94198.1
X67923 X67928 Genomic DNA Translation: CAB94199.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9960.1 [P23381-1]
CCDS9961.1 [P23381-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A41633, A41706

NCBI Reference Sequences

More...RefSeqi		NP_004175.2, NM_004184.3 [P23381-1]
NP_776049.1, NM_173701.1 [P23381-1]
NP_998810.1, NM_213645.1 [P23381-2]
NP_998811.1, NM_213646.1 [P23381-2]
XP_005268101.1, XM_005268044.3 [P23381-1]
XP_006720312.1, XM_006720249.3 [P23381-1]
XP_011535435.1, XM_011537133.2 [P23381-1]
XP_011535437.1, XM_011537135.2
XP_011535438.1, XM_011537136.2 [P23381-2]
XP_016877116.1, XM_017021627.1 [P23381-1]
XP_016877117.1, XM_017021628.1
XP_016877118.1, XM_017021629.1 [P23381-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344102; ENSP00000339485; ENSG00000140105 [P23381-2]
ENST00000355338; ENSP00000347495; ENSG00000140105 [P23381-1]
ENST00000358655; ENSP00000351481; ENSG00000140105 [P23381-2]
ENST00000392882; ENSP00000376620; ENSG00000140105 [P23381-1]
ENST00000556645; ENSP00000451887; ENSG00000140105 [P23381-2]
ENST00000557135; ENSP00000451460; ENSG00000140105 [P23381-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7453

UCSC genome browser

More...UCSCi		uc001yhg.3, human [P23381-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77804 mRNA Translation: AAA67324.1
X59892 mRNA Translation: CAA42545.1
M61715 mRNA Translation: AAA61298.1
X62570 mRNA Translation: CAA44450.1
BX248006 mRNA Translation: CAD62335.1
AK056100 mRNA Translation: BAG51626.1
AK291141 mRNA Translation: BAF83830.1
AL157871 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81700.1
BC017489 mRNA Translation: AAH17489.1
BC095453 mRNA Translation: AAH95453.1
S82905 Genomic DNA Translation: AAB39381.1
X67920, X67921, X67922 Genomic DNA Translation: CAB94198.1
X67923 X67928 Genomic DNA Translation: CAB94199.1
CCDSiCCDS9960.1 [P23381-1]
CCDS9961.1 [P23381-2]
PIRiA41633, A41706
RefSeqiNP_004175.2, NM_004184.3 [P23381-1]
NP_776049.1, NM_173701.1 [P23381-1]
NP_998810.1, NM_213645.1 [P23381-2]
NP_998811.1, NM_213646.1 [P23381-2]
XP_005268101.1, XM_005268044.3 [P23381-1]
XP_006720312.1, XM_006720249.3 [P23381-1]
XP_011535435.1, XM_011537133.2 [P23381-1]
XP_011535437.1, XM_011537135.2
XP_011535438.1, XM_011537136.2 [P23381-2]
XP_016877116.1, XM_017021627.1 [P23381-1]
XP_016877117.1, XM_017021628.1
XP_016877118.1, XM_017021629.1 [P23381-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O5TX-ray2.50A94-471[»]
1R6TX-ray2.10A/B1-466[»]
1R6UX-ray2.00A/B48-471[»]
1ULHX-ray2.31A/B82-471[»]
2AKEX-ray3.10A94-471[»]
2AZXX-ray2.80A/B1-471[»]
2DR2X-ray3.00A94-471[»]
2QUHX-ray2.40A/B1-471[»]
2QUIX-ray2.40A/B1-471[»]
2QUJX-ray2.42A/B1-471[»]
2QUKX-ray2.80A1-471[»]
5UJIX-ray2.79A/B97-471[»]
5UJJX-ray2.10A/B1-471[»]
SMRiP23381
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113292, 80 interactors
DIPiDIP-29493N
IntActiP23381, 17 interactors
MINTiP23381
STRINGi9606.ENSP00000347495

Chemistry databases

DrugBankiDB00150, Tryptophan
DB04537, Tryptophanamide
DB01831, Tryptophanyl-5'amp

Protein family/group databases

MoonProtiP23381

PTM databases

iPTMnetiP23381
MetOSiteiP23381
PhosphoSitePlusiP23381
SwissPalmiP23381

Polymorphism and mutation databases

BioMutaiWARS
DMDMi135191

2D gel databases

OGPiP23381

Proteomic databases

EPDiP23381
jPOSTiP23381
MassIVEiP23381
MaxQBiP23381
PaxDbiP23381
PeptideAtlasiP23381
PRIDEiP23381
ProteomicsDBi54085 [P23381-1]
54086 [P23381-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P23381, 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27522, 242 antibodies

Genome annotation databases

EnsembliENST00000344102; ENSP00000339485; ENSG00000140105 [P23381-2]
ENST00000355338; ENSP00000347495; ENSG00000140105 [P23381-1]
ENST00000358655; ENSP00000351481; ENSG00000140105 [P23381-2]
ENST00000392882; ENSP00000376620; ENSG00000140105 [P23381-1]
ENST00000556645; ENSP00000451887; ENSG00000140105 [P23381-2]
ENST00000557135; ENSP00000451460; ENSG00000140105 [P23381-1]
GeneIDi7453
KEGGihsa:7453
UCSCiuc001yhg.3, human [P23381-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7453
DisGeNETi7453
EuPathDBiHostDB:ENSG00000140105.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		WARS1
GeneReviewsiWARS
HGNCiHGNC:12729, WARS1
HPAiENSG00000140105, Tissue enhanced (blood, thyroid gland)
MalaCardsiWARS1
MIMi191050, gene
617721, phenotype
neXtProtiNX_P23381
OpenTargetsiENSG00000140105
PharmGKBiPA37340

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2145, Eukaryota
GeneTreeiENSGT00940000153724
HOGENOMiCLU_032621_0_1_1
InParanoidiP23381
OMAiSIYHRFM
PhylomeDBiP23381
TreeFamiTF105669

Enzyme and pathway databases

BRENDAi6.1.1.2, 2681
PathwayCommonsiP23381
ReactomeiR-HSA-379716, Cytosolic tRNA aminoacylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7453, 725 hits in 852 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WARS, human
EvolutionaryTraceiP23381

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WARS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7453
PharosiP23381, Tbio

Protein Ontology

More...PROi		PR:P23381
RNActiP23381, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140105, Expressed in epithelium of bronchus and 248 other tissues
ExpressionAtlasiP23381, baseline and differential
GenevisibleiP23381, HS

Family and domain databases

CDDicd00806, TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR002305, aa-tRNA-synth_Ic
IPR014729, Rossmann-like_a/b/a_fold
IPR009068, S15_NS1_RNA-bd
IPR002306, Trp-tRNA-ligase
IPR000738, WHEP-TRS_dom
PfamiView protein in Pfam
PF00579, tRNA-synt_1b, 1 hit
PF00458, WHEP-TRS, 1 hit
PRINTSiPR01039, TRNASYNTHTRP
SMARTiView protein in SMART
SM00991, WHEP-TRS, 1 hit
SUPFAMiSSF47060, SSF47060, 1 hit
TIGRFAMsiTIGR00233, trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit
PS00762, WHEP_TRS_1, 1 hit
PS51185, WHEP_TRS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYWC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23381
Secondary accession number(s): A6NGN1
, A6NID3, P78535, Q502Y0, Q53XB6, Q9UDI5, Q9UDL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 1992
Last modified: December 2, 2020
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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