UniProtKB - P23378 (GCSP_HUMAN)
Protein
Glycine dehydrogenase (decarboxylating), mitochondrial
Gene
GLDC
Organism
Homo sapiens (Human)
Status
Functioni
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).3 Publications
Catalytic activityi
Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.3 Publications
Cofactori
pyridoxal 5'-phosphateBy similarity
Activity regulationi
Stimulated by lipoic acid. Inhibited in presence of methylamine (By similarity).By similarity
GO - Molecular functioni
- electron transfer activity Source: UniProtKB
- enzyme binding Source: Ensembl
- glycine binding Source: GO_Central
- glycine dehydrogenase (decarboxylating) activity Source: UniProtKB
- lyase activity Source: InterPro
- protein homodimerization activity Source: UniProtKB
- pyridoxal binding Source: UniProtKB
- pyridoxal phosphate binding Source: Ensembl
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- glycine catabolic process Source: UniProtKB
- glycine decarboxylation via glycine cleavage system Source: GO_Central
- response to lipoic acid Source: UniProtKB
- response to methylamine Source: UniProtKB
Keywordsi
| Molecular function | Oxidoreductase |
| Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
| BioCyci | MetaCyc:HS00622-MONOMER |
| Reactomei | R-HSA-6783984 Glycine degradation |
| SABIO-RKi | P23378 |
Names & Taxonomyi
| Protein namesi | Recommended name: Glycine dehydrogenase (decarboxylating), mitochondrial1 Publication (EC:1.4.4.23 Publications)Alternative name(s): Glycine cleavage system P protein Glycine decarboxylase2 Publications Glycine dehydrogenase (aminomethyl-transferring) |
| Gene namesi | |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000178445.8 |
| HGNCi | HGNC:4313 GLDC |
| MIMi | 238300 gene |
| neXtProti | NX_P23378 |
Pathology & Biotechi
Involvement in diseasei
Non-ketotic hyperglycinemia (NKH)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.
See also OMIM:605899| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_078776 | 146 | T → K in NKH; loss of glycine catabolic process; loss of expression. 1 PublicationCorresponds to variant dbSNP:rs376578742EnsemblClinVar. | 1 | |
| Natural variantiVAR_078777 | 173 | L → P in NKH; loss of glycine catabolic process; decreased abundance. 1 Publication | 1 | |
| Natural variantiVAR_078778 | 267 | P → A in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 Publication | 1 | |
| Natural variantiVAR_016849 | 283 | A → P in NKH. 1 PublicationCorresponds to variant dbSNP:rs386833589EnsemblClinVar. | 1 | |
| Natural variantiVAR_078779 | 362 | R → C in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs10975674EnsemblClinVar. | 1 | |
| Natural variantiVAR_078780 | 373 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs150171524EnsemblClinVar. | 1 | |
| Natural variantiVAR_078781 | 376 | K → E in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs774093619Ensembl. | 1 | |
| Natural variantiVAR_078782 | 461 | R → W in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs761957837EnsemblClinVar. | 1 | |
| Natural variantiVAR_016851 | 515 | R → S in NKH. 1 PublicationCorresponds to variant dbSNP:rs121964976EnsemblClinVar. | 1 | |
| Natural variantiVAR_078783 | 548 | L → P in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_004979 | 564 | S → I in NKH; common mutation in Finland. 1 PublicationCorresponds to variant dbSNP:rs121964974EnsemblClinVar. | 1 | |
| Natural variantiVAR_078784 | 580 | H → Y in NKH; loss of glycine catabolic process; loss of expression. 1 Publication | 1 | |
| Natural variantiVAR_078785 | 581 | P → R in NKH; loss of glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs772871471EnsemblClinVar. | 1 | |
| Natural variantiVAR_078786 | 624 | A → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_009939 | 756 | Missing in NKH. 1 Publication | 1 | |
| Natural variantiVAR_078787 | 763 | G → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_078788 | 768 | G → E in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_078789 | 790 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs386833556EnsemblClinVar. | 1 | |
| Natural variantiVAR_079313 | 839 | Y → C in NKH. 1 Publication | 1 | |
| Natural variantiVAR_078790 | 866 | D → H in NKH; decreased glycine catabolic process; decreased abundance. 1 Publication | 1 | |
| Natural variantiVAR_078791 | 905 | V → G in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 PublicationCorresponds to variant dbSNP:rs188269735Ensembl. | 1 | |
| Natural variantiVAR_078792 | 933 | I → T in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs758029533EnsemblClinVar. | 1 | |
| Natural variantiVAR_078793 | 994 | G → R in NKH; loss of glycine catabolic process; loss of expression. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
| DisGeNETi | 2731 |
| GeneReviewsi | GLDC |
| MalaCardsi | GLDC |
| MIMi | 605899 phenotype |
| OpenTargetsi | ENSG00000178445 |
| Orphaneti | 289863 Atypical glycine encephalopathy 289860 Infantile glycine encephalopathy 289857 Neonatal glycine encephalopathy |
| PharmGKBi | PA28716 |
Chemistry databases
| DrugBanki | DB00145 Glycine DB00114 Pyridoxal Phosphate |
Polymorphism and mutation databases
| BioMutai | GLDC |
| DMDMi | 229462870 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Transit peptidei | 1 – 35 | MitochondrionSequence analysisAdd BLAST | 35 | |
| ChainiPRO_0000010740 | 36 – 1020 | Glycine dehydrogenase (decarboxylating), mitochondrialAdd BLAST | 985 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 447 | N6-acetyllysineBy similarity | 1 | |
| Modified residuei | 514 | N6-acetyllysineBy similarity | 1 | |
| Modified residuei | 648 | N6-acetyllysineBy similarity | 1 | |
| Modified residuei | 664 | N6-acetyllysineBy similarity | 1 | |
| Modified residuei | 754 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
| EPDi | P23378 |
| MaxQBi | P23378 |
| PaxDbi | P23378 |
| PeptideAtlasi | P23378 |
| PRIDEi | P23378 |
| ProteomicsDBi | 54084 |
PTM databases
| iPTMneti | P23378 |
| PhosphoSitePlusi | P23378 |
Expressioni
Gene expression databases
| Bgeei | ENSG00000178445 Expressed in 163 organ(s), highest expression level in placenta |
| CleanExi | HS_GLDC |
| ExpressionAtlasi | P23378 baseline and differential |
| Genevisiblei | P23378 HS |
Organism-specific databases
| HPAi | HPA002318 HPA052887 |
Interactioni
Subunit structurei
Homodimer (By similarity). Interacts with GCSH (By similarity). The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).By similarity
GO - Molecular functioni
- enzyme binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
| BioGridi | 108993, 21 interactors |
| IntActi | P23378, 10 interactors |
| MINTi | P23378 |
| STRINGi | 9606.ENSP00000370737 |
Structurei
3D structure databases
| ProteinModelPortali | P23378 |
| SMRi | P23378 |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GcvP family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
| eggNOGi | KOG2040 Eukaryota COG0403 LUCA COG1003 LUCA |
| GeneTreei | ENSGT00390000017970 |
| HOGENOMi | HOG000239369 |
| HOVERGENi | HBG005820 |
| InParanoidi | P23378 |
| KOi | K00281 |
| OMAi | QTMVCDL |
| OrthoDBi | EOG091G019V |
| PhylomeDBi | P23378 |
| TreeFami | TF300678 |
Family and domain databases
| CDDi | cd00613 GDC-P, 2 hits |
| Gene3Di | 3.40.640.10, 2 hits 3.90.1150.10, 1 hit |
| HAMAPi | MF_00711 GcvP, 1 hit |
| InterProi | View protein in InterPro IPR001597 ArAA_b-elim_lyase/Thr_aldolase IPR003437 GcvP IPR020581 GDC_P IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major |
| PANTHERi | PTHR11773 PTHR11773, 1 hit |
| Pfami | View protein in Pfam PF01212 Beta_elim_lyase, 1 hit PF02347 GDC-P, 1 hit |
| SUPFAMi | SSF53383 SSF53383, 2 hits |
| TIGRFAMsi | TIGR00461 gcvP, 1 hit |
Sequence (1+)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
P23378-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSCARAWGL RLGRGVGGGR RLAGGSGPCW APRSRDSSSG GGDSAAAGAS
60 70 80 90 100
RLLERLLPRH DDFARRHIGP GDKDQREMLQ TLGLASIDEL IEKTVPANIR
110 120 130 140 150
LKRPLKMEDP VCENEILATL HAISSKNQIW RSYIGMGYYN CSVPQTILRN
160 170 180 190 200
LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ TMVCDITGLD MANASLLDEG
210 220 230 240 250
TAAAEALQLC YRHNKRRKFL VDPRCHPQTI AVVQTRAKYT GVLTELKLPC
260 270 280 290 300
EMDFSGKDVS GVLFQYPDTE GKVEDFTELV ERAHQSGSLA CCATDLLALC
310 320 330 340 350
ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRESL VRMMPGRMVG
360 370 380 390 400
VTRDATGKEV YRLALQTREQ HIRRDKATSN ICTAQALLAN MAAMFAIYHG
410 420 430 440 450
SHGLEHIARR VHNATLILSE GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL
460 470 480 490 500
GRAAQRQINF RLFEDGTLGI SLDETVNEKD LDDLLWIFGC ESSAELVAES
510 520 530 540 550
MGEECRGIPG SVFKRTSPFL THQVFNSYHS ETNIVRYMKK LENKDISLVH
560 570 580 590 600
SMIPLGSCTM KLNSSSELAP ITWKEFANIH PFVPLDQAQG YQQLFRELEK
610 620 630 640 650
DLCELTGYDQ VCFQPNSGAQ GEYAGLATIR AYLNQKGEGH RTVCLIPKSA
660 670 680 690 700
HGTNPASAHM AGMKIQPVEV DKYGNIDAVH LKAMVDKHKE NLAAIMITYP
710 720 730 740 750
STNGVFEENI SDVCDLIHQH GGQVYLDGAN MNAQVGICRP GDFGSDVSHL
760 770 780 790 800
NLHKTFCIPH GGGGPGMGPI GVKKHLAPFL PNHPVISLKR NEDACPVGTV
810 820 830 840 850
SAAPWGSSSI LPISWAYIKM MGGKGLKQAT ETAILNANYM AKRLETHYRI
860 870 880 890 900
LFRGARGYVG HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA
910 920 930 940 950
GTLMVEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH
960 970 980 990 1000
SLTCVTSSHW DRPYSREVAA FPLPFVKPEN KFWPTIARID DIYGDQHLVC
1010 1020
TCPPMEVYES PFSEQKRASS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| A0A1W2PPH6 | A0A1W2PPH6_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 140 | Annotation score: | ||
| A0A1W2PPG0 | A0A1W2PPG0_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 55 | Annotation score: | ||
| A0A1W2PQV3 | A0A1W2PQV3_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 388 | Annotation score: | ||
| A0A1W2PPE1 | A0A1W2PPE1_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 164 | Annotation score: | ||
| A0A1W2PP74 | A0A1W2PP74_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 420 | Annotation score: | ||
| A0A1W2PQU6 | A0A1W2PQU6_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 106 | Annotation score: | ||
| A0A1W2PPB1 | A0A1W2PPB1_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 254 | Annotation score: | ||
| A0A1W2PPK8 | A0A1W2PPK8_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 103 | Annotation score: | ||
| A0A1W2PPD7 | A0A1W2PPD7_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 64 | Annotation score: |
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 396 | A → R in AAA36463 (PubMed:1993704).Curated | 1 | |
| Sequence conflicti | 396 | A → R in BAA14286 (PubMed:1993704).Curated | 1 | |
| Sequence conflicti | 441 | Q → H in AAA36478 (PubMed:1996985).Curated | 1 | |
| Sequence conflicti | 441 | Q → H in AAA36463 (PubMed:1993704).Curated | 1 | |
| Sequence conflicti | 441 | Q → H in BAA14286 (PubMed:1993704).Curated | 1 | |
| Sequence conflicti | 608 | Y → H in AAA36478 (PubMed:1996985).Curated | 1 | |
| Sequence conflicti | 976 | V → M in AAA36463 (PubMed:1993704).Curated | 1 | |
| Sequence conflicti | 976 | V → M in BAA14286 (PubMed:1993704).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_078776 | 146 | T → K in NKH; loss of glycine catabolic process; loss of expression. 1 PublicationCorresponds to variant dbSNP:rs376578742EnsemblClinVar. | 1 | |
| Natural variantiVAR_078777 | 173 | L → P in NKH; loss of glycine catabolic process; decreased abundance. 1 Publication | 1 | |
| Natural variantiVAR_078778 | 267 | P → A in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 Publication | 1 | |
| Natural variantiVAR_016849 | 283 | A → P in NKH. 1 PublicationCorresponds to variant dbSNP:rs386833589EnsemblClinVar. | 1 | |
| Natural variantiVAR_016850 | 329 | P → T in one non-ketotic hyperglycinemia patient. 1 PublicationCorresponds to variant dbSNP:rs386833593EnsemblClinVar. | 1 | |
| Natural variantiVAR_078779 | 362 | R → C in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs10975674EnsemblClinVar. | 1 | |
| Natural variantiVAR_078780 | 373 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs150171524EnsemblClinVar. | 1 | |
| Natural variantiVAR_078781 | 376 | K → E in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs774093619Ensembl. | 1 | |
| Natural variantiVAR_078782 | 461 | R → W in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs761957837EnsemblClinVar. | 1 | |
| Natural variantiVAR_016851 | 515 | R → S in NKH. 1 PublicationCorresponds to variant dbSNP:rs121964976EnsemblClinVar. | 1 | |
| Natural variantiVAR_078783 | 548 | L → P in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_004979 | 564 | S → I in NKH; common mutation in Finland. 1 PublicationCorresponds to variant dbSNP:rs121964974EnsemblClinVar. | 1 | |
| Natural variantiVAR_078784 | 580 | H → Y in NKH; loss of glycine catabolic process; loss of expression. 1 Publication | 1 | |
| Natural variantiVAR_078785 | 581 | P → R in NKH; loss of glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs772871471EnsemblClinVar. | 1 | |
| Natural variantiVAR_078786 | 624 | A → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_009939 | 756 | Missing in NKH. 1 Publication | 1 | |
| Natural variantiVAR_078787 | 763 | G → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_078788 | 768 | G → E in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
| Natural variantiVAR_078789 | 790 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs386833556EnsemblClinVar. | 1 | |
| Natural variantiVAR_079313 | 839 | Y → C in NKH. 1 Publication | 1 | |
| Natural variantiVAR_078790 | 866 | D → H in NKH; decreased glycine catabolic process; decreased abundance. 1 Publication | 1 | |
| Natural variantiVAR_078791 | 905 | V → G in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 PublicationCorresponds to variant dbSNP:rs188269735Ensembl. | 1 | |
| Natural variantiVAR_078792 | 933 | I → T in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs758029533EnsemblClinVar. | 1 | |
| Natural variantiVAR_078793 | 994 | G → R in NKH; loss of glycine catabolic process; loss of expression. 1 Publication | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63635 mRNA Translation: AAA36478.1 M64590 mRNA Translation: AAA36463.1 D90239 mRNA Translation: BAA14286.1 AK314156 mRNA Translation: BAG36841.1 AL353718 Genomic DNA No translation available. AL162411 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58740.1 BC111993 mRNA Translation: AAI11994.1 BC111995 mRNA Translation: AAI11996.1 |
| CCDSi | CCDS34987.1 |
| PIRi | JN0124 |
| RefSeqi | NP_000161.2, NM_000170.2 |
| UniGenei | Hs.584238 |
Genome annotation databases
| Ensembli | ENST00000321612; ENSP00000370737; ENSG00000178445 |
| GeneIDi | 2731 |
| KEGGi | hsa:2731 |
| UCSCi | uc003zkc.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63635 mRNA Translation: AAA36478.1 M64590 mRNA Translation: AAA36463.1 D90239 mRNA Translation: BAA14286.1 AK314156 mRNA Translation: BAG36841.1 AL353718 Genomic DNA No translation available. AL162411 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58740.1 BC111993 mRNA Translation: AAI11994.1 BC111995 mRNA Translation: AAI11996.1 |
| CCDSi | CCDS34987.1 |
| PIRi | JN0124 |
| RefSeqi | NP_000161.2, NM_000170.2 |
| UniGenei | Hs.584238 |
3D structure databases
| ProteinModelPortali | P23378 |
| SMRi | P23378 |
| ModBasei | Search... |
| MobiDBi | Search... |
Protein-protein interaction databases
| BioGridi | 108993, 21 interactors |
| IntActi | P23378, 10 interactors |
| MINTi | P23378 |
| STRINGi | 9606.ENSP00000370737 |
Chemistry databases
| DrugBanki | DB00145 Glycine DB00114 Pyridoxal Phosphate |
PTM databases
| iPTMneti | P23378 |
| PhosphoSitePlusi | P23378 |
Polymorphism and mutation databases
| BioMutai | GLDC |
| DMDMi | 229462870 |
Proteomic databases
| EPDi | P23378 |
| MaxQBi | P23378 |
| PaxDbi | P23378 |
| PeptideAtlasi | P23378 |
| PRIDEi | P23378 |
| ProteomicsDBi | 54084 |
Protocols and materials databases
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| Ensembli | ENST00000321612; ENSP00000370737; ENSG00000178445 |
| GeneIDi | 2731 |
| KEGGi | hsa:2731 |
| UCSCi | uc003zkc.4 human |
Organism-specific databases
| CTDi | 2731 |
| DisGeNETi | 2731 |
| EuPathDBi | HostDB:ENSG00000178445.8 |
| GeneCardsi | GLDC |
| GeneReviewsi | GLDC |
| H-InvDBi | HIX0034882 |
| HGNCi | HGNC:4313 GLDC |
| HPAi | HPA002318 HPA052887 |
| MalaCardsi | GLDC |
| MIMi | 238300 gene 605899 phenotype |
| neXtProti | NX_P23378 |
| OpenTargetsi | ENSG00000178445 |
| Orphaneti | 289863 Atypical glycine encephalopathy 289860 Infantile glycine encephalopathy 289857 Neonatal glycine encephalopathy |
| PharmGKBi | PA28716 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG2040 Eukaryota COG0403 LUCA COG1003 LUCA |
| GeneTreei | ENSGT00390000017970 |
| HOGENOMi | HOG000239369 |
| HOVERGENi | HBG005820 |
| InParanoidi | P23378 |
| KOi | K00281 |
| OMAi | QTMVCDL |
| OrthoDBi | EOG091G019V |
| PhylomeDBi | P23378 |
| TreeFami | TF300678 |
Enzyme and pathway databases
| BioCyci | MetaCyc:HS00622-MONOMER |
| Reactomei | R-HSA-6783984 Glycine degradation |
| SABIO-RKi | P23378 |
Miscellaneous databases
| GeneWikii | Glycine_dehydrogenase_(decarboxylating) |
| GenomeRNAii | 2731 |
| PROi | PR:P23378 |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000178445 Expressed in 163 organ(s), highest expression level in placenta |
| CleanExi | HS_GLDC |
| ExpressionAtlasi | P23378 baseline and differential |
| Genevisiblei | P23378 HS |
Family and domain databases
| CDDi | cd00613 GDC-P, 2 hits |
| Gene3Di | 3.40.640.10, 2 hits 3.90.1150.10, 1 hit |
| HAMAPi | MF_00711 GcvP, 1 hit |
| InterProi | View protein in InterPro IPR001597 ArAA_b-elim_lyase/Thr_aldolase IPR003437 GcvP IPR020581 GDC_P IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major |
| PANTHERi | PTHR11773 PTHR11773, 1 hit |
| Pfami | View protein in Pfam PF01212 Beta_elim_lyase, 1 hit PF02347 GDC-P, 1 hit |
| SUPFAMi | SSF53383 SSF53383, 2 hits |
| TIGRFAMsi | TIGR00461 gcvP, 1 hit |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | GCSP_HUMAN | |
| Accessioni | P23378Primary (citable) accession number: P23378 Secondary accession number(s): Q2M2F8 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
| Last sequence update: | May 5, 2009 | |
| Last modified: | November 7, 2018 | |
| This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
