UniProtKB - P23378 (GCSP_HUMAN)
Protein
Glycine dehydrogenase (decarboxylating), mitochondrial
Gene
GLDC
Organism
Homo sapiens (Human)
Status
Functioni
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).3 Publications
Catalytic activityi
- glycine + H+ + N6-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N6-(S8-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO23 PublicationsEC:1.4.4.23 Publications
Cofactori
pyridoxal 5'-phosphateBy similarity
Activity regulationi
Stimulated by lipoic acid. Inhibited in presence of methylamine (By similarity).By similarity
GO - Molecular functioni
- electron transfer activity Source: UniProtKB
- enzyme binding Source: Ensembl
- glycine binding Source: GO_Central
- glycine dehydrogenase (decarboxylating) activity Source: UniProtKB
- lyase activity Source: InterPro
- protein homodimerization activity Source: UniProtKB
- pyridoxal binding Source: UniProtKB
- pyridoxal phosphate binding Source: GO_Central
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
- glycine catabolic process Source: UniProtKB
- glycine decarboxylation via glycine cleavage system Source: GO_Central
- protein-containing complex assembly Source: Ensembl
- response to lipoic acid Source: UniProtKB
- response to methylamine Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00622-MONOMER |
PathwayCommonsi | P23378 |
Reactomei | R-HSA-6783984, Glycine degradation |
SABIO-RKi | P23378 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycine dehydrogenase (decarboxylating), mitochondrial1 Publication (EC:1.4.4.23 Publications)Alternative name(s): Glycine cleavage system P protein Glycine decarboxylase2 Publications Glycine dehydrogenase (aminomethyl-transferring) |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4313, GLDC |
MIMi | 238300, gene |
neXtProti | NX_P23378 |
VEuPathDBi | HostDB:ENSG00000178445.8 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrial matrix Source: Reactome
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- glycine cleavage complex Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Non-ketotic hyperglycinemia (NKH)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078776 | 146 | T → K in NKH; loss of glycine catabolic process; loss of expression. 1 PublicationCorresponds to variant dbSNP:rs376578742EnsemblClinVar. | 1 | |
Natural variantiVAR_078777 | 173 | L → P in NKH; loss of glycine catabolic process; decreased abundance. 1 Publication | 1 | |
Natural variantiVAR_078778 | 267 | P → A in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs1554648117EnsemblClinVar. | 1 | |
Natural variantiVAR_016849 | 283 | A → P in NKH. 1 PublicationCorresponds to variant dbSNP:rs386833589EnsemblClinVar. | 1 | |
Natural variantiVAR_078779 | 362 | R → C in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs10975674EnsemblClinVar. | 1 | |
Natural variantiVAR_078780 | 373 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs150171524EnsemblClinVar. | 1 | |
Natural variantiVAR_078781 | 376 | K → E in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs774093619Ensembl. | 1 | |
Natural variantiVAR_078782 | 461 | R → W in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs761957837EnsemblClinVar. | 1 | |
Natural variantiVAR_016851 | 515 | R → S in NKH. 1 PublicationCorresponds to variant dbSNP:rs121964976EnsemblClinVar. | 1 | |
Natural variantiVAR_078783 | 548 | L → P in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
Natural variantiVAR_004979 | 564 | S → I in NKH; common mutation in Finland. 1 PublicationCorresponds to variant dbSNP:rs121964974EnsemblClinVar. | 1 | |
Natural variantiVAR_078784 | 580 | H → Y in NKH; loss of glycine catabolic process; loss of expression. 1 Publication | 1 | |
Natural variantiVAR_078785 | 581 | P → R in NKH; loss of glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs772871471EnsemblClinVar. | 1 | |
Natural variantiVAR_078786 | 624 | A → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
Natural variantiVAR_009939 | 756 | Missing in NKH. 1 Publication | 1 | |
Natural variantiVAR_078787 | 763 | G → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 PublicationCorresponds to variant dbSNP:rs1374110692Ensembl. | 1 | |
Natural variantiVAR_078788 | 768 | G → E in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
Natural variantiVAR_078789 | 790 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs386833556EnsemblClinVar. | 1 | |
Natural variantiVAR_079313 | 839 | Y → C in NKH. 1 Publication | 1 | |
Natural variantiVAR_078790 | 866 | D → H in NKH; decreased glycine catabolic process; decreased abundance. 1 Publication | 1 | |
Natural variantiVAR_078791 | 905 | V → G in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 PublicationCorresponds to variant dbSNP:rs188269735EnsemblClinVar. | 1 | |
Natural variantiVAR_078792 | 933 | I → T in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs758029533EnsemblClinVar. | 1 | |
Natural variantiVAR_078793 | 994 | G → R in NKH; loss of glycine catabolic process; loss of expression. 1 PublicationCorresponds to variant dbSNP:rs1406713104EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 2731 |
GeneReviewsi | GLDC |
MalaCardsi | GLDC |
MIMi | 605899, phenotype |
OpenTargetsi | ENSG00000178445 |
Orphaneti | 289863, Atypical glycine encephalopathy 289860, Infantile glycine encephalopathy 289857, Neonatal glycine encephalopathy |
PharmGKBi | PA28716 |
Miscellaneous databases
Pharosi | P23378, Tbio |
Chemistry databases
DrugBanki | DB00145, Glycine DB00114, Pyridoxal phosphate |
Genetic variation databases
BioMutai | GLDC |
DMDMi | 229462870 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | MitochondrionSequence analysisAdd BLAST | 35 | |
ChainiPRO_0000010740 | 36 – 1020 | Glycine dehydrogenase (decarboxylating), mitochondrialAdd BLAST | 985 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 447 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 514 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 648 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 664 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 754 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P23378 |
jPOSTi | P23378 |
MassIVEi | P23378 |
MaxQBi | P23378 |
PaxDbi | P23378 |
PeptideAtlasi | P23378 |
PRIDEi | P23378 |
ProteomicsDBi | 54084 |
PTM databases
iPTMneti | P23378 |
PhosphoSitePlusi | P23378 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178445, Expressed in placenta and 179 other tissues |
ExpressionAtlasi | P23378, baseline and differential |
Genevisiblei | P23378, HS |
Organism-specific databases
HPAi | ENSG00000178445, Group enriched (kidney, liver, placenta) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with GCSH (By similarity). The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).
By similarityGO - Molecular functioni
- enzyme binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108993, 23 interactors |
IntActi | P23378, 17 interactors |
MINTi | P23378 |
STRINGi | 9606.ENSP00000370737 |
Miscellaneous databases
RNActi | P23378, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P23378 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GcvP family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2040, Eukaryota |
GeneTreei | ENSGT00390000017970 |
HOGENOMi | CLU_004620_3_2_1 |
InParanoidi | P23378 |
OMAi | CVPMSEY |
OrthoDBi | 390348at2759 |
PhylomeDBi | P23378 |
TreeFami | TF300678 |
Family and domain databases
CDDi | cd00613, GDC-P, 2 hits |
Gene3Di | 3.40.640.10, 2 hits 3.90.1150.10, 1 hit |
HAMAPi | MF_00711, GcvP, 1 hit |
InterProi | View protein in InterPro IPR001597, ArAA_b-elim_lyase/Thr_aldolase IPR003437, GcvP IPR020581, GDC_P IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR11773, PTHR11773, 1 hit |
Pfami | View protein in Pfam PF01212, Beta_elim_lyase, 1 hit PF02347, GDC-P, 1 hit |
SUPFAMi | SSF53383, SSF53383, 2 hits |
TIGRFAMsi | TIGR00461, gcvP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
P23378-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSCARAWGL RLGRGVGGGR RLAGGSGPCW APRSRDSSSG GGDSAAAGAS
60 70 80 90 100
RLLERLLPRH DDFARRHIGP GDKDQREMLQ TLGLASIDEL IEKTVPANIR
110 120 130 140 150
LKRPLKMEDP VCENEILATL HAISSKNQIW RSYIGMGYYN CSVPQTILRN
160 170 180 190 200
LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ TMVCDITGLD MANASLLDEG
210 220 230 240 250
TAAAEALQLC YRHNKRRKFL VDPRCHPQTI AVVQTRAKYT GVLTELKLPC
260 270 280 290 300
EMDFSGKDVS GVLFQYPDTE GKVEDFTELV ERAHQSGSLA CCATDLLALC
310 320 330 340 350
ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRESL VRMMPGRMVG
360 370 380 390 400
VTRDATGKEV YRLALQTREQ HIRRDKATSN ICTAQALLAN MAAMFAIYHG
410 420 430 440 450
SHGLEHIARR VHNATLILSE GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL
460 470 480 490 500
GRAAQRQINF RLFEDGTLGI SLDETVNEKD LDDLLWIFGC ESSAELVAES
510 520 530 540 550
MGEECRGIPG SVFKRTSPFL THQVFNSYHS ETNIVRYMKK LENKDISLVH
560 570 580 590 600
SMIPLGSCTM KLNSSSELAP ITWKEFANIH PFVPLDQAQG YQQLFRELEK
610 620 630 640 650
DLCELTGYDQ VCFQPNSGAQ GEYAGLATIR AYLNQKGEGH RTVCLIPKSA
660 670 680 690 700
HGTNPASAHM AGMKIQPVEV DKYGNIDAVH LKAMVDKHKE NLAAIMITYP
710 720 730 740 750
STNGVFEENI SDVCDLIHQH GGQVYLDGAN MNAQVGICRP GDFGSDVSHL
760 770 780 790 800
NLHKTFCIPH GGGGPGMGPI GVKKHLAPFL PNHPVISLKR NEDACPVGTV
810 820 830 840 850
SAAPWGSSSI LPISWAYIKM MGGKGLKQAT ETAILNANYM AKRLETHYRI
860 870 880 890 900
LFRGARGYVG HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA
910 920 930 940 950
GTLMVEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH
960 970 980 990 1000
SLTCVTSSHW DRPYSREVAA FPLPFVKPEN KFWPTIARID DIYGDQHLVC
1010 1020
TCPPMEVYES PFSEQKRASS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PP74 | A0A1W2PP74_HUMAN | Glycine dehydrogenase (aminomethyl-... | GLDC | 420 | Annotation score: | ||
A0A1W2PQV3 | A0A1W2PQV3_HUMAN | Glycine dehydrogenase (aminomethyl-... | GLDC | 388 | Annotation score: | ||
A0A1W2PPE1 | A0A1W2PPE1_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 164 | Annotation score: | ||
A0A1W2PPG0 | A0A1W2PPG0_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 55 | Annotation score: | ||
A0A1W2PPH6 | A0A1W2PPH6_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 140 | Annotation score: | ||
A0A1W2PPB1 | A0A1W2PPB1_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 254 | Annotation score: | ||
A0A1W2PQU6 | A0A1W2PQU6_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 106 | Annotation score: | ||
A0A1W2PPK8 | A0A1W2PPK8_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 103 | Annotation score: | ||
A0A1W2PPD7 | A0A1W2PPD7_HUMAN | Glycine dehydrogenase (decarboxylat... | GLDC | 64 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 396 | A → R in AAA36463 (PubMed:1993704).Curated | 1 | |
Sequence conflicti | 396 | A → R in BAA14286 (PubMed:1993704).Curated | 1 | |
Sequence conflicti | 441 | Q → H in AAA36478 (PubMed:1996985).Curated | 1 | |
Sequence conflicti | 441 | Q → H in AAA36463 (PubMed:1993704).Curated | 1 | |
Sequence conflicti | 441 | Q → H in BAA14286 (PubMed:1993704).Curated | 1 | |
Sequence conflicti | 608 | Y → H in AAA36478 (PubMed:1996985).Curated | 1 | |
Sequence conflicti | 976 | V → M in AAA36463 (PubMed:1993704).Curated | 1 | |
Sequence conflicti | 976 | V → M in BAA14286 (PubMed:1993704).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078776 | 146 | T → K in NKH; loss of glycine catabolic process; loss of expression. 1 PublicationCorresponds to variant dbSNP:rs376578742EnsemblClinVar. | 1 | |
Natural variantiVAR_078777 | 173 | L → P in NKH; loss of glycine catabolic process; decreased abundance. 1 Publication | 1 | |
Natural variantiVAR_078778 | 267 | P → A in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs1554648117EnsemblClinVar. | 1 | |
Natural variantiVAR_016849 | 283 | A → P in NKH. 1 PublicationCorresponds to variant dbSNP:rs386833589EnsemblClinVar. | 1 | |
Natural variantiVAR_016850 | 329 | P → T in one non-ketotic hyperglycinemia patient. 1 PublicationCorresponds to variant dbSNP:rs386833593EnsemblClinVar. | 1 | |
Natural variantiVAR_078779 | 362 | R → C in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs10975674EnsemblClinVar. | 1 | |
Natural variantiVAR_078780 | 373 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs150171524EnsemblClinVar. | 1 | |
Natural variantiVAR_078781 | 376 | K → E in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs774093619Ensembl. | 1 | |
Natural variantiVAR_078782 | 461 | R → W in NKH; decreased glycine catabolic process; changed localization to the mitochondria; also expressed diffusely throughout the cytosol; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs761957837EnsemblClinVar. | 1 | |
Natural variantiVAR_016851 | 515 | R → S in NKH. 1 PublicationCorresponds to variant dbSNP:rs121964976EnsemblClinVar. | 1 | |
Natural variantiVAR_078783 | 548 | L → P in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
Natural variantiVAR_004979 | 564 | S → I in NKH; common mutation in Finland. 1 PublicationCorresponds to variant dbSNP:rs121964974EnsemblClinVar. | 1 | |
Natural variantiVAR_078784 | 580 | H → Y in NKH; loss of glycine catabolic process; loss of expression. 1 Publication | 1 | |
Natural variantiVAR_078785 | 581 | P → R in NKH; loss of glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs772871471EnsemblClinVar. | 1 | |
Natural variantiVAR_078786 | 624 | A → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
Natural variantiVAR_009939 | 756 | Missing in NKH. 1 Publication | 1 | |
Natural variantiVAR_078787 | 763 | G → D in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 PublicationCorresponds to variant dbSNP:rs1374110692Ensembl. | 1 | |
Natural variantiVAR_078788 | 768 | G → E in NKH; loss of GCS P-protein glycine exchange activity; no effect on abundance. 1 Publication | 1 | |
Natural variantiVAR_078789 | 790 | R → W in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs386833556EnsemblClinVar. | 1 | |
Natural variantiVAR_079313 | 839 | Y → C in NKH. 1 Publication | 1 | |
Natural variantiVAR_078790 | 866 | D → H in NKH; decreased glycine catabolic process; decreased abundance. 1 Publication | 1 | |
Natural variantiVAR_078791 | 905 | V → G in NKH; decreased GCS P-protein glycine exchange activity; no effect on abundance. 1 PublicationCorresponds to variant dbSNP:rs188269735EnsemblClinVar. | 1 | |
Natural variantiVAR_078792 | 933 | I → T in NKH; decreased glycine catabolic process; decreased abundance. 1 PublicationCorresponds to variant dbSNP:rs758029533EnsemblClinVar. | 1 | |
Natural variantiVAR_078793 | 994 | G → R in NKH; loss of glycine catabolic process; loss of expression. 1 PublicationCorresponds to variant dbSNP:rs1406713104EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63635 mRNA Translation: AAA36478.1 M64590 mRNA Translation: AAA36463.1 D90239 mRNA Translation: BAA14286.1 AK314156 mRNA Translation: BAG36841.1 AL353718 Genomic DNA No translation available. AL162411 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58740.1 BC111993 mRNA Translation: AAI11994.1 BC111995 mRNA Translation: AAI11996.1 |
CCDSi | CCDS34987.1 |
PIRi | JN0124 |
RefSeqi | NP_000161.2, NM_000170.2 |
Genome annotation databases
Ensembli | ENST00000321612; ENSP00000370737; ENSG00000178445 |
GeneIDi | 2731 |
KEGGi | hsa:2731 |
UCSCi | uc003zkc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63635 mRNA Translation: AAA36478.1 M64590 mRNA Translation: AAA36463.1 D90239 mRNA Translation: BAA14286.1 AK314156 mRNA Translation: BAG36841.1 AL353718 Genomic DNA No translation available. AL162411 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58740.1 BC111993 mRNA Translation: AAI11994.1 BC111995 mRNA Translation: AAI11996.1 |
CCDSi | CCDS34987.1 |
PIRi | JN0124 |
RefSeqi | NP_000161.2, NM_000170.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6I33 | X-ray | 2.30 | A/B | 45-1020 | [»] | |
6I34 | X-ray | 2.10 | A/B/C/D | 45-1020 | [»] | |
6I35 | X-ray | 2.00 | A/B/C/D | 45-1020 | [»] | |
SMRi | P23378 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108993, 23 interactors |
IntActi | P23378, 17 interactors |
MINTi | P23378 |
STRINGi | 9606.ENSP00000370737 |
Chemistry databases
DrugBanki | DB00145, Glycine DB00114, Pyridoxal phosphate |
PTM databases
iPTMneti | P23378 |
PhosphoSitePlusi | P23378 |
Genetic variation databases
BioMutai | GLDC |
DMDMi | 229462870 |
Proteomic databases
EPDi | P23378 |
jPOSTi | P23378 |
MassIVEi | P23378 |
MaxQBi | P23378 |
PaxDbi | P23378 |
PeptideAtlasi | P23378 |
PRIDEi | P23378 |
ProteomicsDBi | 54084 |
Protocols and materials databases
Antibodypediai | 9715, 190 antibodies |
Genome annotation databases
Ensembli | ENST00000321612; ENSP00000370737; ENSG00000178445 |
GeneIDi | 2731 |
KEGGi | hsa:2731 |
UCSCi | uc003zkc.4, human |
Organism-specific databases
CTDi | 2731 |
DisGeNETi | 2731 |
GeneCardsi | GLDC |
GeneReviewsi | GLDC |
HGNCi | HGNC:4313, GLDC |
HPAi | ENSG00000178445, Group enriched (kidney, liver, placenta) |
MalaCardsi | GLDC |
MIMi | 238300, gene 605899, phenotype |
neXtProti | NX_P23378 |
OpenTargetsi | ENSG00000178445 |
Orphaneti | 289863, Atypical glycine encephalopathy 289860, Infantile glycine encephalopathy 289857, Neonatal glycine encephalopathy |
PharmGKBi | PA28716 |
VEuPathDBi | HostDB:ENSG00000178445.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2040, Eukaryota |
GeneTreei | ENSGT00390000017970 |
HOGENOMi | CLU_004620_3_2_1 |
InParanoidi | P23378 |
OMAi | CVPMSEY |
OrthoDBi | 390348at2759 |
PhylomeDBi | P23378 |
TreeFami | TF300678 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00622-MONOMER |
PathwayCommonsi | P23378 |
Reactomei | R-HSA-6783984, Glycine degradation |
SABIO-RKi | P23378 |
Miscellaneous databases
BioGRID-ORCSi | 2731, 5 hits in 875 CRISPR screens |
ChiTaRSi | GLDC, human |
GeneWikii | Glycine_dehydrogenase_(decarboxylating) |
GenomeRNAii | 2731 |
Pharosi | P23378, Tbio |
PROi | PR:P23378 |
RNActi | P23378, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178445, Expressed in placenta and 179 other tissues |
ExpressionAtlasi | P23378, baseline and differential |
Genevisiblei | P23378, HS |
Family and domain databases
CDDi | cd00613, GDC-P, 2 hits |
Gene3Di | 3.40.640.10, 2 hits 3.90.1150.10, 1 hit |
HAMAPi | MF_00711, GcvP, 1 hit |
InterProi | View protein in InterPro IPR001597, ArAA_b-elim_lyase/Thr_aldolase IPR003437, GcvP IPR020581, GDC_P IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
PANTHERi | PTHR11773, PTHR11773, 1 hit |
Pfami | View protein in Pfam PF01212, Beta_elim_lyase, 1 hit PF02347, GDC-P, 1 hit |
SUPFAMi | SSF53383, SSF53383, 2 hits |
TIGRFAMsi | TIGR00461, gcvP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GCSP_HUMAN | |
Accessioni | P23378Primary (citable) accession number: P23378 Secondary accession number(s): Q2M2F8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 10, 2021 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants