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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA.

GO - Molecular functioni

  • ATPase activity Source: EcoliWiki
  • ATP binding Source: EcoliWiki
  • DNA binding Source: EcoliWiki
  • identical protein binding Source: IntAct
  • mismatched DNA binding Source: InterPro
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

  • mismatch repair Source: EcoliWiki
  • regulation of DNA recombination Source: EcoliWiki

Keywordsi

Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11281-MONOMER
MetaCyc:EG11281-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutL
Gene namesi
Name:mutL
Ordered Locus Names:b4170, JW4128
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11281 mutL

Subcellular locationi

GO - Cellular componenti

  • mismatch repair complex Source: EcoliWiki

Pathology & Biotechi

Chemistry databases

DrugBankiDB04077 Glycerol
DB02325 Isopropyl Alcohol
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779431 – 615DNA mismatch repair protein MutLAdd BLAST615

Proteomic databases

PaxDbiP23367
PRIDEiP23367

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4263476, 52 interactors
852983, 1 interactor
DIPiDIP-10285N
IntActiP23367, 14 interactors
STRINGi316385.ECDH10B_4365

Structurei

Secondary structure

1615
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23367
SMRiP23367
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23367

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DC6 Bacteria
COG0323 LUCA
HOGENOMiHOG000256551
InParanoidiP23367
KOiK03572
OMAiKVIRQYR
PhylomeDBiP23367

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00149 DNA_mis_repair, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR020667 DNA_mismatch_repair_MutL
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF08676 MutL_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit
SUPFAMiSSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

P23367-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG
60 70 80 90 100
AKLIRIRDNG CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA
110 120 130 140 150
SISSVSRLTL TSRTAEQQEA WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL
160 170 180 190 200
FYNTPARRKF LRTEKTEFNH IDEIIRRIAL ARFDVTINLS HNGKIVRQYR
210 220 230 240 250
AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV ADPNHTTPAL
260 270 280 290 300
AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD
310 320 330 340 350
VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS
360 370 380 390 400
IPENRVAAGR NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ
410 420 430 440 450
QGEVYRQLLQ TPAPMQKLKA PEPQEPALAA NSQSFGRVLT IVHSDCALLE
460 470 480 490 500
RDGNISLLSL PVAERWLRQA QLTPGEAPVC AQPLLIPLRL KVSAEEKSAL
510 520 530 540 550
EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP ELIGYLAKQS
560 570 580 590 600
VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL
610
QSVDLHPAIK ALKDE
Length:615
Mass (Da):67,924
Last modified:May 1, 1992 - v2
Checksum:iC69D2735BF5FA165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11831 Genomic DNA Translation: CAA77850.1
U14003 Genomic DNA Translation: AAA97066.1
U00096 Genomic DNA Translation: AAC77127.1
AP009048 Genomic DNA Translation: BAE78171.1
M63655 Genomic DNA Translation: AAA24173.1
L19346 Unassigned DNA Translation: AAA20098.1
PIRiPH0853
RefSeqiNP_418591.1, NC_000913.3
WP_001122505.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77127; AAC77127; b4170
BAE78171; BAE78171; BAE78171
GeneIDi948691
KEGGiecj:JW4128
eco:b4170
PATRICifig|1411691.4.peg.2531

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11831 Genomic DNA Translation: CAA77850.1
U14003 Genomic DNA Translation: AAA97066.1
U00096 Genomic DNA Translation: AAC77127.1
AP009048 Genomic DNA Translation: BAE78171.1
M63655 Genomic DNA Translation: AAA24173.1
L19346 Unassigned DNA Translation: AAA20098.1
PIRiPH0853
RefSeqiNP_418591.1, NC_000913.3
WP_001122505.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B62X-ray2.10A1-349[»]
1B63X-ray1.90A1-331[»]
1BKNX-ray2.90A/B1-349[»]
1NHHX-ray2.40A1-331[»]
1NHIX-ray2.00A1-331[»]
1NHJX-ray2.30A1-331[»]
1X9ZX-ray2.10A/B432-615[»]
5AKBX-ray4.71C/D/F1-349[»]
5AKCX-ray6.60C/D/G/H/K/L1-349[»]
5AKDX-ray7.60C/D/G/H/K/L1-349[»]
ProteinModelPortaliP23367
SMRiP23367
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263476, 52 interactors
852983, 1 interactor
DIPiDIP-10285N
IntActiP23367, 14 interactors
STRINGi316385.ECDH10B_4365

Chemistry databases

DrugBankiDB04077 Glycerol
DB02325 Isopropyl Alcohol
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester

Proteomic databases

PaxDbiP23367
PRIDEiP23367

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77127; AAC77127; b4170
BAE78171; BAE78171; BAE78171
GeneIDi948691
KEGGiecj:JW4128
eco:b4170
PATRICifig|1411691.4.peg.2531

Organism-specific databases

EchoBASEiEB1258
EcoGeneiEG11281 mutL

Phylogenomic databases

eggNOGiENOG4105DC6 Bacteria
COG0323 LUCA
HOGENOMiHOG000256551
InParanoidiP23367
KOiK03572
OMAiKVIRQYR
PhylomeDBiP23367

Enzyme and pathway databases

BioCyciEcoCyc:EG11281-MONOMER
MetaCyc:EG11281-MONOMER

Miscellaneous databases

EvolutionaryTraceiP23367
PROiPR:P23367

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00149 DNA_mis_repair, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR020667 DNA_mismatch_repair_MutL
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF08676 MutL_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit
SUPFAMiSSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMUTL_ECOLI
AccessioniPrimary (citable) accession number: P23367
Secondary accession number(s): Q2M6D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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