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Entry version 156 (02 Dec 2020)
Sequence version 1 (01 Nov 1991)
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Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).By similarity
Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-9026527, Activated NTRK2 signals through PLCG1
R-RNO-9028731, Activated NTRK2 signals through FRS2 and FRS3
R-RNO-9032759, NTRK2 activates RAC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Cleaved into the following chain:
BDNF precursor formCurated
Short name:
ProBDNFCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bdnf
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
2202, Bdnf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044754019 – 249BDNF precursor formCuratedAdd BLAST231
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001964319 – 130By similarityAdd BLAST112
ChainiPRO_0000019644131 – 249Brain-derived neurotrophic factorAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi143 ↔ 210By similarity
Disulfide bondi188 ↔ 239By similarity
Disulfide bondi198 ↔ 241By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and glycosulfated, contrary to mature BDNF.By similarity
Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei59 – 60Cleavage; by MBTPS1By similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23363

PRoteomics IDEntifications database

More...
PRIDEi
P23363

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P23363, 1 site

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000047466, Expressed in brain and 17 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P23363, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P23363, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
246413, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P23363, 3 interactors

Molecular INTeraction database

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MINTi
P23363

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000064356

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRU8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007725

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23363

Database of Orthologous Groups

More...
OrthoDBi
1156054at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23363

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020430, Brain-der_neurotrophic_factor
IPR029034, Cystine-knot_cytokine
IPR020408, Nerve_growth_factor-like
IPR002072, Nerve_growth_factor-rel
IPR019846, Nerve_growth_factor_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11589, PTHR11589, 1 hit
PTHR11589:SF3, PTHR11589:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00243, NGF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001789, NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01912, BDNFACTOR
PR00268, NGF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00140, NGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00248, NGF_1, 1 hit
PS50270, NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P23363-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR
60 70 80 90 100
AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS
110 120 130 140 150
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV
160 170 180 190 200
TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG
210 220 230 240
IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Length:249
Mass (Da):28,109
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9CAAA5DEF9A78B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UI28A0A0H2UI28_RAT
Brain-derived neurotrophic factor
Bdnf rCG_26305
362Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K624A0A0G2K624_RAT
Brain-derived neurotrophic factor
Bdnf rCG_26305
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M61175 mRNA Translation: AAA16841.1
M61178 Genomic DNA Translation: AAA63483.1
D10938 Genomic DNA Translation: BAA01732.1
AY559248 mRNA Translation: AAS67380.1
AY559249 mRNA Translation: AAS67381.1
AY559250 mRNA Translation: AAS67382.1
EF125675 mRNA Translation: ABM30161.1
EF125676 mRNA Translation: ABM30162.1
EF125677 mRNA Translation: ABM30163.1
EF125678 mRNA Translation: ABM30164.1
EF125679 mRNA Translation: ABM30165.1
EF125680 mRNA Translation: ABM30166.1
EF125686 mRNA Translation: ABM30172.1
EF125687 mRNA Translation: ABM30173.1
EF125688 mRNA Translation: ABM30174.1
EF125689 mRNA Translation: ABM30175.1
EF125690 mRNA Translation: ABM30176.1
AY176065 mRNA Translation: AAO17828.1
BC087634 mRNA Translation: AAH87634.1
X67108 mRNA Translation: CAA47481.1

Protein sequence database of the Protein Information Resource

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PIRi
B60536, B40304

NCBI Reference Sequences

More...
RefSeqi
NP_001257559.1, NM_001270630.1
NP_001257560.1, NM_001270631.1
NP_001257561.1, NM_001270632.1
NP_001257562.1, NM_001270633.1
NP_001257563.1, NM_001270634.1
NP_001257564.1, NM_001270635.1
NP_001257565.1, NM_001270636.1
NP_001257566.1, NM_001270637.1
NP_001257567.1, NM_001270638.1
NP_036645.2, NM_012513.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000077703; ENSRNOP00000072849; ENSRNOG00000047466
ENSRNOT00000078543; ENSRNOP00000072315; ENSRNOG00000047466
ENSRNOT00000080190; ENSRNOP00000073265; ENSRNOG00000047466
ENSRNOT00000083289; ENSRNOP00000074338; ENSRNOG00000047466
ENSRNOT00000089233; ENSRNOP00000075479; ENSRNOG00000047466
ENSRNOT00000090445; ENSRNOP00000073685; ENSRNOG00000047466

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24225

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61175 mRNA Translation: AAA16841.1
M61178 Genomic DNA Translation: AAA63483.1
D10938 Genomic DNA Translation: BAA01732.1
AY559248 mRNA Translation: AAS67380.1
AY559249 mRNA Translation: AAS67381.1
AY559250 mRNA Translation: AAS67382.1
EF125675 mRNA Translation: ABM30161.1
EF125676 mRNA Translation: ABM30162.1
EF125677 mRNA Translation: ABM30163.1
EF125678 mRNA Translation: ABM30164.1
EF125679 mRNA Translation: ABM30165.1
EF125680 mRNA Translation: ABM30166.1
EF125686 mRNA Translation: ABM30172.1
EF125687 mRNA Translation: ABM30173.1
EF125688 mRNA Translation: ABM30174.1
EF125689 mRNA Translation: ABM30175.1
EF125690 mRNA Translation: ABM30176.1
AY176065 mRNA Translation: AAO17828.1
BC087634 mRNA Translation: AAH87634.1
X67108 mRNA Translation: CAA47481.1
PIRiB60536, B40304
RefSeqiNP_001257559.1, NM_001270630.1
NP_001257560.1, NM_001270631.1
NP_001257561.1, NM_001270632.1
NP_001257562.1, NM_001270633.1
NP_001257563.1, NM_001270634.1
NP_001257564.1, NM_001270635.1
NP_001257565.1, NM_001270636.1
NP_001257566.1, NM_001270637.1
NP_001257567.1, NM_001270638.1
NP_036645.2, NM_012513.4

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi246413, 1 interactor
IntActiP23363, 3 interactors
MINTiP23363
STRINGi10116.ENSRNOP00000064356

PTM databases

GlyGeniP23363, 1 site

Proteomic databases

PaxDbiP23363
PRIDEiP23363

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P23363, 2 sequenced antibodies

Genome annotation databases

EnsembliENSRNOT00000077703; ENSRNOP00000072849; ENSRNOG00000047466
ENSRNOT00000078543; ENSRNOP00000072315; ENSRNOG00000047466
ENSRNOT00000080190; ENSRNOP00000073265; ENSRNOG00000047466
ENSRNOT00000083289; ENSRNOP00000074338; ENSRNOG00000047466
ENSRNOT00000089233; ENSRNOP00000075479; ENSRNOG00000047466
ENSRNOT00000090445; ENSRNOP00000073685; ENSRNOG00000047466
GeneIDi24225
KEGGirno:24225

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
627
RGDi2202, Bdnf

Phylogenomic databases

eggNOGiENOG502QRU8, Eukaryota
GeneTreeiENSGT00390000007725
InParanoidiP23363
OrthoDBi1156054at2759
PhylomeDBiP23363

Enzyme and pathway databases

ReactomeiR-RNO-9026527, Activated NTRK2 signals through PLCG1
R-RNO-9028731, Activated NTRK2 signals through FRS2 and FRS3
R-RNO-9032759, NTRK2 activates RAC1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23363

Gene expression databases

BgeeiENSRNOG00000047466, Expressed in brain and 17 other tissues
ExpressionAtlasiP23363, baseline and differential
GenevisibleiP23363, RN

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430, Brain-der_neurotrophic_factor
IPR029034, Cystine-knot_cytokine
IPR020408, Nerve_growth_factor-like
IPR002072, Nerve_growth_factor-rel
IPR019846, Nerve_growth_factor_CS
PANTHERiPTHR11589, PTHR11589, 1 hit
PTHR11589:SF3, PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243, NGF, 1 hit
PIRSFiPIRSF001789, NGF, 1 hit
PRINTSiPR01912, BDNFACTOR
PR00268, NGF
SMARTiView protein in SMART
SM00140, NGF, 1 hit
SUPFAMiSSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248, NGF_1, 1 hit
PS50270, NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBDNF_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23363
Secondary accession number(s): Q53YL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: December 2, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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