Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • neurotrophin TRKB receptor binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to norepinephrine stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • chronic inflammatory response Source: RGD
  • cognition Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • learning Source: RGD
  • mitochondrial electron transport, NADH to ubiquinone Source: RGD
  • negative regulation of myotube differentiation Source: BHF-UCL
  • negative regulation of neuron apoptotic process Source: GO_Central
  • negative regulation of neuron death Source: RGD
  • negative regulation of striated muscle tissue development Source: RGD
  • nervous system development Source: RGD
  • neuron differentiation Source: RGD
  • neuron projection extension Source: RGD
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of glucocorticoid receptor signaling pathway Source: MGI
  • positive regulation of long-term neuronal synaptic plasticity Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of receptor binding Source: ParkinsonsUK-UCL
  • regeneration Source: RGD
  • regulation of axon extension Source: RGD
  • regulation of long-term neuronal synaptic plasticity Source: RGD
  • regulation of short-term neuronal synaptic plasticity Source: RGD
  • response to activity Source: RGD
  • response to anesthetic Source: RGD
  • response to auditory stimulus Source: RGD
  • response to drug Source: RGD
  • response to electrical stimulus Source: RGD
  • response to food Source: RGD
  • response to hormone Source: RGD
  • response to hyperoxia Source: RGD
  • response to hypoxia Source: RGD
  • response to L-glutamate Source: RGD
  • response to light intensity Source: RGD
  • response to light stimulus Source: RGD
  • response to nerve growth factor Source: RGD
  • response to nutrient levels Source: RGD
  • response to potassium ion Source: RGD
  • response to tumor necrosis factor Source: RGD
  • response to vitamin A Source: RGD
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-RNO-9026527 Activated NTRK2 signals through PLCG1
R-RNO-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Gene namesi
Name:Bdnf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2202 Bdnf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001964319 – 130Add BLAST112
ChainiPRO_0000019644131 – 249Brain-derived neurotrophic factorAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 210By similarity
Disulfide bondi188 ↔ 239By similarity
Disulfide bondi198 ↔ 241By similarity

Post-translational modificationi

Converted into mature BDNF by plasmin (PLG).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57 – 58Cleavage; by S1PBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP23363
PRIDEiP23363

Miscellaneous databases

PMAP-CutDBiP23363

Expressioni

Gene expression databases

BgeeiENSRNOG00000047466
ExpressionAtlasiP23363 baseline and differential
GenevisibleiP23363 RN

Interactioni

Subunit structurei

Monomers and homodimers. Binds to NTRK2/TRKB (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • neurotrophin TRKB receptor binding Source: RGD

Protein-protein interaction databases

IntActiP23363, 3 interactors
MINTiP23363
STRINGi10116.ENSRNOP00000064356

Structurei

3D structure databases

ProteinModelPortaliP23363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH7X Eukaryota
ENOG410XRPH LUCA
GeneTreeiENSGT00390000007725
HOVERGENiHBG006494
InParanoidiP23363
KOiK04355
OrthoDBiEOG091G0GHL
PhylomeDBiP23363

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01912 BDNFACTOR
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR
60 70 80 90 100
AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS
110 120 130 140 150
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV
160 170 180 190 200
TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG
210 220 230 240
IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Length:249
Mass (Da):28,109
Last modified:November 1, 1991 - v1
Checksum:iF9CAAA5DEF9A78B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61175 mRNA Translation: AAA16841.1
M61178 Genomic DNA Translation: AAA63483.1
D10938 Genomic DNA Translation: BAA01732.1
AY559248 mRNA Translation: AAS67380.1
AY559249 mRNA Translation: AAS67381.1
AY559250 mRNA Translation: AAS67382.1
EF125675 mRNA Translation: ABM30161.1
EF125676 mRNA Translation: ABM30162.1
EF125677 mRNA Translation: ABM30163.1
EF125678 mRNA Translation: ABM30164.1
EF125679 mRNA Translation: ABM30165.1
EF125680 mRNA Translation: ABM30166.1
EF125686 mRNA Translation: ABM30172.1
EF125687 mRNA Translation: ABM30173.1
EF125688 mRNA Translation: ABM30174.1
EF125689 mRNA Translation: ABM30175.1
EF125690 mRNA Translation: ABM30176.1
AY176065 mRNA Translation: AAO17828.1
BC087634 mRNA Translation: AAH87634.1
X67108 mRNA Translation: CAA47481.1
PIRiB60536 B40304
RefSeqiNP_001257559.1, NM_001270630.1
NP_001257560.1, NM_001270631.1
NP_001257561.1, NM_001270632.1
NP_001257562.1, NM_001270633.1
NP_001257563.1, NM_001270634.1
NP_001257564.1, NM_001270635.1
NP_001257565.1, NM_001270636.1
NP_001257566.1, NM_001270637.1
NP_001257567.1, NM_001270638.1
NP_036645.2, NM_012513.4
UniGeneiRn.11266

Genome annotation databases

EnsembliENSRNOT00000077703; ENSRNOP00000072849; ENSRNOG00000047466
ENSRNOT00000078543; ENSRNOP00000072315; ENSRNOG00000047466
ENSRNOT00000080190; ENSRNOP00000073265; ENSRNOG00000047466
ENSRNOT00000083289; ENSRNOP00000074338; ENSRNOG00000047466
ENSRNOT00000089233; ENSRNOP00000075479; ENSRNOG00000047466
ENSRNOT00000090445; ENSRNOP00000073685; ENSRNOG00000047466
GeneIDi24225
KEGGirno:24225

Similar proteinsi

Entry informationi

Entry nameiBDNF_RAT
AccessioniPrimary (citable) accession number: P23363
Secondary accession number(s): Q53YL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health