UniProtKB - P23359 (BMP7_MOUSE)
Protein
Bone morphogenetic protein 7
Gene
Bmp7
Organism
Mus musculus (Mouse)
Status
Functioni
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including members of the SOX family of transcription factors (By similarity).By similarity
GO - Molecular functioni
- BMP receptor binding Source: MGI
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- heparin binding Source: MGI
GO - Biological processi
- allantois development Source: BHF-UCL
- anatomical structure formation involved in morphogenesis Source: MGI
- animal organ morphogenesis Source: MGI
- axon guidance Source: MGI
- BMP signaling pathway Source: MGI
- branching involved in salivary gland morphogenesis Source: MGI
- branching morphogenesis of an epithelial tube Source: MGI
- camera-type eye morphogenesis Source: MGI
- cardiac muscle tissue development Source: BHF-UCL
- cardiac septum morphogenesis Source: BHF-UCL
- cartilage development Source: UniProtKB-KW
- cell development Source: MGI
- cellular response to BMP stimulus Source: MGI
- chorio-allantoic fusion Source: BHF-UCL
- embryonic camera-type eye morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- embryonic pattern specification Source: MGI
- embryonic skeletal joint morphogenesis Source: MGI
- endocardial cushion formation Source: BHF-UCL
- epithelial cell differentiation Source: MGI
- eye development Source: UniProtKB
- heart trabecula morphogenesis Source: BHF-UCL
- hindbrain development Source: BHF-UCL
- kidney development Source: UniProtKB
- mesenchymal cell differentiation Source: UniProtKB
- mesenchyme development Source: UniProtKB
- mesoderm formation Source: MGI
- metanephric mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
- metanephric mesenchyme morphogenesis Source: UniProtKB
- monocyte aggregation Source: MGI
- negative regulation of cell cycle Source: MGI
- negative regulation of cell death Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
- negative regulation of MAP kinase activity Source: UniProtKB
- negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Source: MGI
- negative regulation of mitotic nuclear division Source: UniProtKB
- negative regulation of neurogenesis Source: MGI
- negative regulation of neuron differentiation Source: MGI
- negative regulation of Notch signaling pathway Source: MGI
- negative regulation of phosphorylation Source: UniProtKB
- negative regulation of prostatic bud formation Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- nephrogenic mesenchyme morphogenesis Source: UniProtKB
- neural fold elevation formation Source: BHF-UCL
- neuron projection morphogenesis Source: MGI
- odontogenesis of dentin-containing tooth Source: MGI
- ossification Source: UniProtKB-KW
- pattern specification process Source: MGI
- pericardium morphogenesis Source: BHF-UCL
- pharyngeal system development Source: BHF-UCL
- positive regulation of apoptotic process Source: MGI
- positive regulation of bone mineralization Source: MGI
- positive regulation of brown fat cell differentiation Source: UniProtKB
- positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Source: BHF-UCL
- positive regulation of cell death Source: UniProtKB
- positive regulation of cell differentiation Source: MGI
- positive regulation of dendrite development Source: MGI
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of gene expression Source: MGI
- positive regulation of heterotypic cell-cell adhesion Source: MGI
- positive regulation of hyaluranon cable assembly Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of osteoblast differentiation Source: MGI
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of peptidyl-threonine phosphorylation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein localization to nucleus Source: UniProtKB
- regulation of branching involved in prostate gland morphogenesis Source: MGI
- regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- regulation of phosphorylation Source: MGI
- response to estradiol Source: Ensembl
- response to peptide hormone Source: Ensembl
- response to vitamin D Source: Ensembl
- salivary gland morphogenesis Source: MGI
- SMAD protein signal transduction Source: UniProtKB
- steroid hormone mediated signaling pathway Source: MGI
- tube morphogenesis Source: MGI
- ureteric bud development Source: UniProtKB
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein 7Short name: BMP-7 Alternative name(s): Osteogenic protein 1 Short name: OP-1 |
Gene namesi | Name:Bmp7 Synonyms:Bmp-7, Op1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103302, Bmp7 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- collagen-containing extracellular matrix Source: MGI
- vesicle Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
PropeptideiPRO_0000033878 | 30 – 291 | By similarityAdd BLAST | 262 | |
ChainiPRO_0000033879 | 292 – 430 | Bone morphogenetic protein 7Add BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 320 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 329 ↔ 395 | By similarity | ||
Disulfide bondi | 358 ↔ 427 | By similarity | ||
Disulfide bondi | 362 ↔ 429 | By similarity | ||
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 394 | InterchainBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P23359 |
PRIDEi | P23359 |
ProteomicsDBi | 281698 |
PTM databases
GlyGeni | P23359, 4 sites |
iPTMneti | P23359 |
PhosphoSitePlusi | P23359 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000008999, Expressed in internal ear and 315 other tissues |
Genevisiblei | P23359, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- BMP receptor binding Source: MGI
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 198367, 3 interactors |
STRINGi | 10090.ENSMUSP00000009143 |
Miscellaneous databases
RNActi | P23359, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000156490 |
HOGENOMi | CLU_020515_4_1_1 |
InParanoidi | P23359 |
OMAi | LWFDVSK |
OrthoDBi | 1063560at2759 |
PhylomeDBi | P23359 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P23359-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE
60 70 80 90 100
RREMQREILS ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ
110 120 130 140 150
GFSYPYKAVF STQGPPLASL QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY
160 170 180 190 200
HHREFRFDLS KIPEGEAVTA AEFRIYKDYI RERFDNETFQ ITVYQVLQEH
210 220 230 240 250
SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH NLGLQLSVET
260 270 280 290 300
LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ
310 320 330 340 350
NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP
360 370 380 390 400
EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL
410 420 430
NAISVLYFDD SSNVILKKYR NMVVRACGCH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | A → R in CAA40222 (PubMed:1715687).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56906 mRNA Translation: CAA40222.1 BC010771 mRNA Translation: AAH10771.1 |
CCDSi | CCDS17136.1 |
PIRi | JQ1184 |
RefSeqi | NP_031583.2, NM_007557.3 |
Genome annotation databases
Ensembli | ENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999 |
GeneIDi | 12162 |
KEGGi | mmu:12162 |
UCSCi | uc008odb.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56906 mRNA Translation: CAA40222.1 BC010771 mRNA Translation: AAH10771.1 |
CCDSi | CCDS17136.1 |
PIRi | JQ1184 |
RefSeqi | NP_031583.2, NM_007557.3 |
3D structure databases
SMRi | P23359 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198367, 3 interactors |
STRINGi | 10090.ENSMUSP00000009143 |
PTM databases
GlyGeni | P23359, 4 sites |
iPTMneti | P23359 |
PhosphoSitePlusi | P23359 |
Proteomic databases
PaxDbi | P23359 |
PRIDEi | P23359 |
ProteomicsDBi | 281698 |
Protocols and materials databases
Antibodypediai | 14123, 924 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000009143; ENSMUSP00000009143; ENSMUSG00000008999 |
GeneIDi | 12162 |
KEGGi | mmu:12162 |
UCSCi | uc008odb.3, mouse |
Organism-specific databases
CTDi | 655 |
MGIi | MGI:103302, Bmp7 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000156490 |
HOGENOMi | CLU_020515_4_1_1 |
InParanoidi | P23359 |
OMAi | LWFDVSK |
OrthoDBi | 1063560at2759 |
PhylomeDBi | P23359 |
TreeFami | TF316134 |
Enzyme and pathway databases
Reactomei | R-MMU-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
BioGRID-ORCSi | 12162, 0 hits in 52 CRISPR screens |
ChiTaRSi | Bmp7, mouse |
PROi | PR:P23359 |
RNActi | P23359, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000008999, Expressed in internal ear and 315 other tissues |
Genevisiblei | P23359, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMP7_MOUSE | |
Accessioni | P23359Primary (citable) accession number: P23359 Secondary accession number(s): Q91XF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | January 23, 2002 | |
Last modified: | April 7, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families