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UniProtKB - P23348 (B3A3_RAT)
Protein
Anion exchange protein 3
Gene
Slc4a3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Plasma membrane anion exchange protein.
GO - Molecular functioni
- anion:anion antiporter activity Source: RGD
- bicarbonate transmembrane transporter activity Source: RGD
- enzyme binding Source: RGD
- inorganic anion exchanger activity Source: InterPro
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- bicarbonate transport Source: RGD
- cardiac conduction Source: RGD
- ion homeostasis Source: GO_Central
- regulation of intracellular pH Source: RGD
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Anion exchange, Antiport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-425381, Bicarbonate transporters |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange protein 3Short name: AE 3 Short name: Anion exchanger 3 Alternative name(s): Band 3-related protein 3 Short name: B3RP-3 Neuronal band 3-like protein Solute carrier family 4 member 3 |
Gene namesi | Name:Slc4a3 Synonyms:Ae3, B3rp3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3712, Slc4a3 |
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 707 | CytoplasmicAdd BLAST | 707 | |
Transmembranei | 708 – 730 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 736 – 773 | HelicalSequence analysisAdd BLAST | 38 | |
Transmembranei | 793 – 815 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 825 – 846 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 888 – 905 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 906 – 920 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 921 – 941 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 975 – 997 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1023 – 1044 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1078 – 1123 | HelicalSequence analysisAdd BLAST | 46 | |
Transmembranei | 1150 – 1186 | HelicalSequence analysisAdd BLAST | 37 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079222 | 1 – 1227 | Anion exchange protein 3Add BLAST | 1227 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Modified residuei | 175 | PhosphoserineCombined sources | 1 | |
Modified residuei | 198 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | Omega-N-methylarginineBy similarity | 1 | |
Glycosylationi | 868 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1160 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P23348 |
PRIDEi | P23348 |
PTM databases
GlyGeni | P23348, 1 site |
iPTMneti | P23348 |
PhosphoSitePlusi | P23348 |
Expressioni
Tissue specificityi
Neuronal.
Interactioni
GO - Molecular functioni
- enzyme binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 246905, 1 interactor |
STRINGi | 10116.ENSRNOP00000027337 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 255 | DisorderedSequence analysisAdd BLAST | 255 | |
Regioni | 286 – 312 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 428 – 497 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 708 – 1227 | Membrane (anion exchange)Add BLAST | 520 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 23 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 62 – 77 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 98 – 113 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 131 – 151 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 193 – 224 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 435 – 453 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 479 – 497 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1172, Eukaryota |
InParanoidi | P23348 |
PhylomeDBi | P23348 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002979, Anion_exchange_3 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF15, PTHR11453:SF15, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01189, ANIONEXHNGR3 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P23348-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANGVIPPPG GPSPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSARHARRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPPPGP PQKAKFSIGS DEDDSPGLSI KAPCAKALPS VGLPSDQSPQ
210 220 230 240 250
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV
260 270 280 290 300
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL
310 320 330 340 350
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV
360 370 380 390 400
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE
410 420 430 440 450
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG
460 470 480 490 500
NHHPTPSHGP DGAVPTMADD LGEPAPLWPH DPDAKEKPLH MPGGDGHRGK
510 520 530 540 550
SLKLLEKIPE DAEATVVLVG SVPFLEQPAA AFVRLSEAVL LESVLEVPVP
560 570 580 590 600
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI
610 620 630 640 650
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG
660 670 680 690 700
YVAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR
710 720 730 740 750
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG
760 770 780 790 800
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV
810 820 830 840 850
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP
860 870 880 890 900
LLPFYPPEEA LEPGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL
910 920 930 940 950
IAFFLRKFRN SRFLGGKARR VIGDFGIPIS ILVMVLVDYS ITDTYTQKLT
960 970 980 990 1000
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ
1010 1020 1030 1040 1050
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT
1060 1070 1080 1090 1100
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI
1110 1120 1130 1140 1150
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM
1160 1170 1180 1190 1200
HLFTFIQLGC IALLWVVKST VASLAFPFLL LLTVPLRRCL LPRLFQDREL
1210 1220
QALDSEDAEP NFDEDGQDEY NELHMPV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V8P8 | G3V8P8_RAT | Anion exchange protein | Slc4a3 rCG_23720 | 1,227 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05167 mRNA Translation: AAA40798.1 |
PIRi | B34911 |
RefSeqi | NP_058745.1, NM_017049.1 |
Genome annotation databases
GeneIDi | 24781 |
KEGGi | rno:24781 |
UCSCi | RGD:3712, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05167 mRNA Translation: AAA40798.1 |
PIRi | B34911 |
RefSeqi | NP_058745.1, NM_017049.1 |
3D structure databases
SMRi | P23348 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 246905, 1 interactor |
STRINGi | 10116.ENSRNOP00000027337 |
PTM databases
GlyGeni | P23348, 1 site |
iPTMneti | P23348 |
PhosphoSitePlusi | P23348 |
Proteomic databases
PaxDbi | P23348 |
PRIDEi | P23348 |
Genome annotation databases
GeneIDi | 24781 |
KEGGi | rno:24781 |
UCSCi | RGD:3712, rat |
Organism-specific databases
CTDi | 6508 |
RGDi | 3712, Slc4a3 |
Phylogenomic databases
eggNOGi | KOG1172, Eukaryota |
InParanoidi | P23348 |
PhylomeDBi | P23348 |
Enzyme and pathway databases
Reactomei | R-RNO-425381, Bicarbonate transporters |
Miscellaneous databases
PROi | PR:P23348 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002979, Anion_exchange_3 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF15, PTHR11453:SF15, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01189, ANIONEXHNGR3 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B3A3_RAT | |
Accessioni | P23348Primary (citable) accession number: P23348 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | June 2, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families