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Protein

Disintegrin CTF-II

Gene
N/A
Organism
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits fibrinogen interaction with platelet receptors, and inhibits aggregation induced by ADP, thrombin, collagen and platelet-activating factor. Acts by binding to the alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface (By similarity).By similarity

Miscellaneous

The disintegrin belongs to the medium disintegrin subfamily.

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin CTF-II
Alternative name(s):
Cytotoxic factor 2
Cleaved into the following chain:
Alternative name(s):
Cytotoxic factor 1
OrganismiProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Taxonomic identifieri88087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000072441 – 75Disintegrin CTF-IIAdd BLAST75
ChainiPRO_00000072454 – 75Disintegrin CTF-IAdd BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 18PROSITE-ProRule annotation
Disulfide bondi11 ↔ 19PROSITE-ProRule annotation
Disulfide bondi24 ↔ 38PROSITE-ProRule annotation
Disulfide bondi32 ↔ 62PROSITE-ProRule annotation
Disulfide bondi37 ↔ 41PROSITE-ProRule annotation
Disulfide bondi50 ↔ 69PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP23323

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer (disintegrin).By similarity

Structurei

3D structure databases

ProteinModelPortaliP23323
SMRiP23323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 75DisintegrinPROSITE-ProRule annotationAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 56Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ELLEEGEDCY CHIPPNPCCD PATCKLTPGS QCAEGLCCDQ CRFKKKGTIC
60 70
RIARGDFPDD RCTGLSDDCP RWNDL
Length:75
Mass (Da):8,328
Last modified:November 1, 1991 - v1
Checksum:i329B00C6F08F62A3
GO

Sequence databases

PIRiJX0169

Similar proteinsi

Entry informationi

Entry nameiVM2C_PROFL
AccessioniPrimary (citable) accession number: P23323
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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