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Protein

Protein S100-A1

Gene

S100A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a Ca2+ signal transducer (PubMed:22399290). In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).2 Publications

Miscellaneous

Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinity1 PublicationAdd BLAST14
Calcium bindingi63 – 742; high affinity1 PublicationAdd BLAST12

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: ProtInc
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-5686938 Regulation of TLR by endogenous ligand

Protein family/group databases

TCDBi8.A.81.1.1 the s100 calcium-binding protein (s100) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100A1
Synonyms:S100A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160678.11
HGNCiHGNC:10486 S100A1
MIMi176940 gene
neXtProtiNX_P23297

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6271
OpenTargetsiENSG00000160678
PharmGKBiPA34898

Chemistry databases

DrugBankiDB00768 Olopatadine

Polymorphism and mutation databases

BioMutaiS100A1
DMDMi134136

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439611 – 94Protein S100-A1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86S-nitrosocysteine1 Publication1

Keywords - PTMi

S-nitrosylation

Proteomic databases

MaxQBiP23297
PaxDbiP23297
PeptideAtlasiP23297
PRIDEiP23297
ProteomicsDBi54079

PTM databases

iPTMnetiP23297
PhosphoSitePlusiP23297

Expressioni

Tissue specificityi

Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.1 Publication

Gene expression databases

BgeeiENSG00000160678 Expressed in 176 organ(s), highest expression level in apex of heart
CleanExiHS_S100A1
ExpressionAtlasiP23297 baseline and differential
GenevisibleiP23297 HS

Organism-specific databases

HPAiCAB002599
HPA006462

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (PubMed:21296671). Also forms heterodimers with S100P (PubMed:15171681). Interacts with AGER (By similarity). Intreacts with CAPZA1 (By similarity). Interacts with FKBP4 (PubMed:20188096). Interacts with RYR1 and RYR2 (PubMed:18650434). Interacts with CACYBP in a calcium-dependent manner (PubMed:12042313). Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (PubMed:22399290).By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112179, 20 interactors
IntActiP23297, 13 interactors
MINTiP23297
STRINGi9606.ENSP00000292169

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23297
SMRiP23297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXZ2 Eukaryota
ENOG4111987 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP23297
PhylomeDBiP23297
TreeFamiTF332727

Family and domain databases

CDDicd05025 S-100A1, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028486 S100-A1
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF66 PTHR11639:SF66, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P23297-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKELLQT ELSGFLDAQK
60 70 80 90
DVDAVDKVMK ELDENGDGEV DFQEYVVLVA ALTVACNNFF WENS
Length:94
Mass (Da):10,546
Last modified:January 23, 2007 - v2
Checksum:iAD5E53AF326B25D2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T7Y6Q5T7Y6_HUMAN
Protein S100
S100A1 hCG_15470
147Annotation score:
Q5T7Y4Q5T7Y4_HUMAN
Protein S100-A1
S100A1
53Annotation score:
Q5T7Y5Q5T7Y5_HUMAN
Protein S100-A1
S100A1
34Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58079 mRNA Translation: CAA41107.1
AK312152 mRNA Translation: BAG35086.1
BT006938 mRNA Translation: AAP35584.1
AB451316 mRNA Translation: BAG70130.1
AB451446 mRNA Translation: BAG70260.1
AL162258 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53302.1
BC014392 mRNA Translation: AAH14392.1
CCDSiCCDS1047.1
PIRiA44470 BCHUIA
RefSeqiNP_006262.1, NM_006271.1
UniGeneiHs.515715

Genome annotation databases

EnsembliENST00000292169; ENSP00000292169; ENSG00000160678
GeneIDi6271
KEGGihsa:6271
UCSCiuc001fck.1 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58079 mRNA Translation: CAA41107.1
AK312152 mRNA Translation: BAG35086.1
BT006938 mRNA Translation: AAP35584.1
AB451316 mRNA Translation: BAG70130.1
AB451446 mRNA Translation: BAG70260.1
AL162258 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53302.1
BC014392 mRNA Translation: AAH14392.1
CCDSiCCDS1047.1
PIRiA44470 BCHUIA
RefSeqiNP_006262.1, NM_006271.1
UniGeneiHs.515715

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L0PNMR-A/B1-94[»]
2LHLNMR-A/B2-94[»]
2LLSNMR-A/B2-94[»]
2LLTNMR-A/B2-94[»]
2LLUNMR-A/B2-94[»]
2LP2NMR-A/B2-94[»]
2LP3NMR-A/B2-94[»]
2LUXNMR-A/B2-94[»]
2M3WNMR-A/B2-94[»]
5K89X-ray2.25A/C/H1-94[»]
ProteinModelPortaliP23297
SMRiP23297
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112179, 20 interactors
IntActiP23297, 13 interactors
MINTiP23297
STRINGi9606.ENSP00000292169

Chemistry databases

DrugBankiDB00768 Olopatadine

Protein family/group databases

TCDBi8.A.81.1.1 the s100 calcium-binding protein (s100) family

PTM databases

iPTMnetiP23297
PhosphoSitePlusiP23297

Polymorphism and mutation databases

BioMutaiS100A1
DMDMi134136

Proteomic databases

MaxQBiP23297
PaxDbiP23297
PeptideAtlasiP23297
PRIDEiP23297
ProteomicsDBi54079

Protocols and materials databases

DNASUi6271
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292169; ENSP00000292169; ENSG00000160678
GeneIDi6271
KEGGihsa:6271
UCSCiuc001fck.1 human

Organism-specific databases

CTDi6271
DisGeNETi6271
EuPathDBiHostDB:ENSG00000160678.11
GeneCardsiS100A1
HGNCiHGNC:10486 S100A1
HPAiCAB002599
HPA006462
MIMi176940 gene
neXtProtiNX_P23297
OpenTargetsiENSG00000160678
PharmGKBiPA34898
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXZ2 Eukaryota
ENOG4111987 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP23297
PhylomeDBiP23297
TreeFamiTF332727

Enzyme and pathway databases

ReactomeiR-HSA-5686938 Regulation of TLR by endogenous ligand

Miscellaneous databases

GeneWikiiS100_calcium-binding_protein_A1
GenomeRNAii6271
PROiPR:P23297
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160678 Expressed in 176 organ(s), highest expression level in apex of heart
CleanExiHS_S100A1
ExpressionAtlasiP23297 baseline and differential
GenevisibleiP23297 HS

Family and domain databases

CDDicd05025 S-100A1, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028486 S100-A1
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF66 PTHR11639:SF66, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A1_HUMAN
AccessioniPrimary (citable) accession number: P23297
Secondary accession number(s): B2R5D9, Q5T7Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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