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Protein

Casein kinase I homolog 1

Gene

YCK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.1 Publication

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98ATPPROSITE-ProRule annotation1
Active sitei188Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 83ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • cell morphogenesis Source: SGD
  • endocytosis Source: SGD
  • glucose mediated signaling pathway Source: SGD
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: SGD
  • regulation of cell shape Source: GO_Central
  • response to glucose Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YHR135C-MONOMER
BRENDAi2.7.11.1 984
ReactomeiR-SCE-202670 ERKs are inactivated

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I homolog 1 (EC:2.7.11.1)
Gene namesi
Name:YCK1
Synonyms:CKI2
Ordered Locus Names:YHR135C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR135C
SGDiS000001177 YCK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928561 – 538Casein kinase I homolog 1Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei522PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Lipidationi537S-palmitoyl cysteineBy similarity1
Lipidationi538S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated by AKR1.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP23291
PaxDbiP23291
PRIDEiP23291

PTM databases

iPTMnetiP23291
SwissPalmiP23291

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi36568, 485 interactors
DIPiDIP-719N
IntActiP23291, 85 interactors
MINTiP23291
STRINGi4932.YHR135C

Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23291
SMRiP23291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 353Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00920000148988
HOGENOMiHOG000182055
InParanoidiP23291
KOiK02218
OMAiFFMIMEL
OrthoDBiEOG092C30PR

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P23291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMPIASTTL AVNNLTNING NANFNVQANK QLHHQAVDSP ARSSMTATTA
60 70 80 90 100
ANSNSNSSRD DSTIVGLHYK IGKKIGEGSF GVLFEGTNMI NGVPVAIKFE
110 120 130 140 150
PRKTEAPQLR DEYKTYKILN GTPNIPYAYY FGQEGLHNIL VIDLLGPSLE
160 170 180 190 200
DLFDWCGRKF SVKTVVQVAV QMITLIEDLH AHDLIYRDIK PDNFLIGRPG
210 220 230 240 250
QPDANNIHLI DFGMAKQYRD PKTKQHIPYR EKKSLSGTAR YMSINTHLGR
260 270 280 290 300
EQSRRDDMEA LGHVFFYFLR GHLPWQGLKA PNNKQKYEKI GEKKRSTNVY
310 320 330 340 350
DLAQGLPVQF GRYLEIVRSL SFEECPDYEG YRKLLLSVLD DLGETADGQY
360 370 380 390 400
DWMKLNDGRG WDLNINKKPN LHGYGHPNPP NEKSRKHRNK QLQMQQLQMQ
410 420 430 440 450
QLQQQQQQQQ YAQKTEADMR NSQYKPKLDP TSYEAYQHQT QQKYLQEQQK
460 470 480 490 500
RQQQQKLQEQ QLQEQQLQQQ QQQQQQLRAT GQPPSQPQAQ TQSQQFGARY
510 520 530
QPQQQPSAAL RTPEQHPNDD NSSLAASHKG FFQKLGCC
Length:538
Mass (Da):61,715
Last modified:November 1, 1991 - v1
Checksum:i77344717818C2D17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201Q → H in AAU09743 (PubMed:17322287).Curated1
Sequence conflicti367K → E in CAA42897 (PubMed:1627830).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74552 Genomic DNA Translation: AAA35229.1
X60327 Genomic DNA Translation: CAA42897.1
U10398 Genomic DNA Translation: AAB68417.1
Y13625 Genomic DNA Translation: CAA73948.1
BK006934 Genomic DNA Translation: DAA06828.1
AY723826 Genomic DNA Translation: AAU09743.1
PIRiS29521
RefSeqiNP_012003.1, NM_001179265.1

Genome annotation databases

EnsemblFungiiYHR135C; YHR135C; YHR135C
GeneIDi856537
KEGGisce:YHR135C

Similar proteinsi

Entry informationi

Entry nameiKC11_YEAST
AccessioniPrimary (citable) accession number: P23291
Secondary accession number(s): D3DL84, E9P958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 12, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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