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Protein

Peptidyl-prolyl cis-trans isomerase B

Gene

PPIB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Enzyme regulationi

Inhibited by cyclosporin A (CsA).1 Publication

GO - Molecular functioni

  • cyclosporin A binding Source: UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
  • protein-containing complex binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • RNA polymerase binding Source: AgBase
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • bone development Source: UniProtKB
  • chaperone-mediated protein folding Source: UniProtKB
  • positive regulation by host of viral genome replication Source: AgBase
  • positive regulation by host of viral process Source: AgBase
  • positive regulation of multicellular organism growth Source: UniProtKB
  • protein peptidyl-prolyl isomerization Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciMetaCyc:HS09452-MONOMER
BRENDAi5.2.1.8 2681
ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.81 Publication)
Short name:
PPIase B
Alternative name(s):
CYP-S1
Cyclophilin B
Rotamase B
S-cyclophilin
Short name:
SCYLP
Gene namesi
Name:PPIB
Synonyms:CYPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166794.4
HGNCiHGNC:9255 PPIB
MIMi123841 gene
neXtProtiNX_P23284

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Osteogenesis imperfecta 9 (OI9)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder.
See also OMIM:259440
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0634369M → R in OI9; patients have white sclerae, normal dentition, no rhizomelia or severe deformity of long bones. 1 PublicationCorresponds to variant dbSNP:rs137853864EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi129K → A: Impairs interaction with CLGN and CANX. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Osteogenesis imperfecta

Organism-specific databases

DisGeNETi5479
MalaCardsiPPIB
MIMi259440 phenotype
OpenTargetsiENSG00000166794
Orphaneti216804 Osteogenesis imperfecta type 2
216812 Osteogenesis imperfecta type 3
216820 Osteogenesis imperfecta type 4
PharmGKBiPA33580

Chemistry databases

ChEMBLiCHEMBL2075
DrugBankiDB00172 L-Proline

Polymorphism and mutation databases

BioMutaiPPIB
DMDMi215273869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000002547934 – 216Peptidyl-prolyl cis-trans isomerase BAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84N6-succinyllysineBy similarity1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei165N6-acetyllysineBy similarity1
Modified residuei202S-nitrosocysteineBy similarity1
Modified residuei209N6-acetyllysine; alternateBy similarity1
Modified residuei209N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, S-nitrosylation

Proteomic databases

EPDiP23284
MaxQBiP23284
PaxDbiP23284
PeptideAtlasiP23284
PRIDEiP23284
ProteomicsDBi54078
TopDownProteomicsiP23284

2D gel databases

OGPiP23284
REPRODUCTION-2DPAGEiIPI00646304
SWISS-2DPAGEiP23284

PTM databases

iPTMnetiP23284
PhosphoSitePlusiP23284
SwissPalmiP23284

Expressioni

Gene expression databases

BgeeiENSG00000166794
CleanExiHS_PPIB
GenevisibleiP23284 HS

Organism-specific databases

HPAiCAB011487
HPA012720

Interactioni

Subunit structurei

Interacts with DYM. Interacts with CALR, CLGN and CANX.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • RNA polymerase binding Source: AgBase
  • unfolded protein binding Source: ProtInc

Protein-protein interaction databases

BioGridi111475, 97 interactors
IntActiP23284, 44 interactors
MINTiP23284
STRINGi9606.ENSP00000300026

Chemistry databases

BindingDBiP23284

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 52Combined sources12
Beta strandi55 – 64Combined sources10
Turni66 – 68Combined sources3
Helixi70 – 81Combined sources12
Turni82 – 84Combined sources3
Beta strandi95 – 97Combined sources3
Turni98 – 100Combined sources3
Beta strandi101 – 104Combined sources4
Turni107 – 109Combined sources3
Beta strandi110 – 113Combined sources4
Beta strandi137 – 140Combined sources4
Beta strandi142 – 144Combined sources3
Beta strandi152 – 157Combined sources6
Helixi160 – 162Combined sources3
Turni163 – 165Combined sources3
Beta strandi168 – 174Combined sources7
Helixi176 – 183Combined sources8
Beta strandi193 – 195Combined sources3
Beta strandi197 – 212Combined sources16

3D structure databases

ProteinModelPortaliP23284
SMRiP23284
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23284

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 204PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi213 – 216Prevents secretion from ER4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0880 Eukaryota
ENOG410Z0G4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiP23284
KOiK03768
OMAiEPFAVSK
OrthoDBiEOG091G0BGL
PhylomeDBiP23284
TreeFamiTF354259

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLSERNMK VLLAAALIAG SVFFLLLPGP SAADEKKKGP KVTVKVYFDL
60 70 80 90 100
RIGDEDVGRV IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF
110 120 130 140 150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS
160 170 180 190 200
QFFITTVKTA WLDGKHVVFG KVLEGMEVVR KVESTKTDSR DKPLKDVIIA
210
DCGKIEVEKP FAIAKE
Length:216
Mass (Da):23,743
Last modified:November 25, 2008 - v2
Checksum:i2D0410A07AA9E420
GO

Sequence cautioni

The sequence AAA52150 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5S → R in AAA52150 (PubMed:2000394).Curated1
Sequence conflicti216E → D in CAG33110 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0634369M → R in OI9; patients have white sclerae, normal dentition, no rhizomelia or severe deformity of long bones. 1 PublicationCorresponds to variant dbSNP:rs137853864EnsemblClinVar.1
Natural variantiVAR_04771160V → L. Corresponds to variant dbSNP:rs11558595EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63573 mRNA Translation: AAA36601.1
AK291149 mRNA Translation: BAF83838.1
CR456829 mRNA Translation: CAG33110.1
AY962310 Genomic DNA Translation: AAX44050.1
AC100840 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77669.1
BC001125 mRNA Translation: AAH01125.1
BC008848 mRNA Translation: AAH08848.1
BC020800 mRNA Translation: AAH20800.1
BC032138 mRNA Translation: AAH32138.1
M60857 mRNA Translation: AAA52150.1 Different initiation.
M60457 mRNA Translation: AAA35733.1
CCDSiCCDS10191.1
PIRiA39118 CSHUB
RefSeqiNP_000933.1, NM_000942.4
UniGeneiHs.434937

Genome annotation databases

EnsembliENST00000300026; ENSP00000300026; ENSG00000166794
GeneIDi5479
KEGGihsa:5479
UCSCiuc002and.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPPIB_HUMAN
AccessioniPrimary (citable) accession number: P23284
Secondary accession number(s): A8K534, Q6IBH5, Q9BVK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 25, 2008
Last modified: July 18, 2018
This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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