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UniProtKB - P23280 (CAH6_HUMAN)

Entry version 186 (12 Aug 2020)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Carbonic anhydrase 6

Gene

CA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei85Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi111Zinc; catalytic1 Publication1
Metal bindingi113Zinc; catalytic1 Publication1
Metal bindingi138Zinc; catalytic1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.1.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23280

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1475029, Reversible hydration of carbon dioxide

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbonic anhydrase 6 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name:
CA-VI
Salivary carbonic anhydrase
Secreted carbonic anhydrase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CA6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000131686.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:1380, CA6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114780, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23280

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		765

Open Targets

More...OpenTargetsi		ENSG00000131686

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25995

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23280, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3025

Drug and drug target database

More...DrugBanki		DB08846, Ellagic acid
DB06795, Mafenide
DB00909, Zonisamide

DrugCentral

More...DrugCentrali		P23280

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CA6

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000424118 – 308Carbonic anhydrase 6Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 224Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23280

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23280

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23280

PeptideAtlas

More...PeptideAtlasi		P23280

PRoteomics IDEntifications database

More...PRIDEi		P23280

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		16991
54077 [P23280-1]
62797

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P23280-1 [P23280-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1924, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23280, 3 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Major constituent of saliva.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131686, Expressed in parotid gland and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23280, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23280, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131686, Tissue enriched (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107220, 15 interactors

Protein interaction database and analysis system

More...IntActi		P23280, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366654

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P23280

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23280, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23280

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23280

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 278Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni220 – 221Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0382, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160409

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039326_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23280

KEGG Orthology (KO)

More...KOi		K01672

Identification of Orthologs from Complete Genome Data

More...OMAi		PPTMRMT

Database of Orthologous Groups

More...OrthoDBi		1377476at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23280

TreeFam database of animal gene trees

More...TreeFami		TF316425

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.200.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001148, CA_dom
IPR036398, CA_dom_sf
IPR023561, Carbonic_anhydrase_a-class
IPR018338, Carbonic_anhydrase_a-class_CS
IPR018428, Carbonic_anhydrase_CA6

The PANTHER Classification System

More...PANTHERi		PTHR18952, PTHR18952, 1 hit
PTHR18952:SF110, PTHR18952:SF110, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00194, Carb_anhydrase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01057, Carb_anhydrase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51069, SSF51069, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00162, ALPHA_CA_1, 1 hit
PS51144, ALPHA_CA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23280-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI 
        60         70         80         90        100
NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA 
       110        120        130        140        150
DGTVYIAQQM HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD 
       160        170        180        190        200
IAQDAPDGLA VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD 
       210        220        230        240        250
VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS 
       260        270        280        290        300
LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL 

DYLRRALN
Length:308
Mass (Da):35,367
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EBFF15085E7112D
GO
Isoform 2 (identifier: P23280-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-308: EYTLGSEFQFYLHKIEEILDYLRRALN → GKGHGGHRGRSQNPRVQPTSTRHPLALGSLEA

Show »
Length:313
Mass (Da):35,365
Checksum:i1CF67B5ED1BD9384
GO
Isoform 3 (identifier: P23280-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-86: Missing.

Show »
Length:248
Mass (Da):28,687
Checksum:i39A6223C958A3029
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N4G4Q8N4G4_HUMAN
Carbonate dehydratase VI
CA6
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W148F8W148_HUMAN
Carbonic anhydrase
CA6
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103T → I in AAA51892 (PubMed:1899030).Curated1
Sequence conflicti103T → I in BAD89434 (PubMed:16710414).Curated1
Sequence conflicti148S → T in AAA51892 (PubMed:1899030).Curated1
Sequence conflicti148S → T in AAF22565 (Ref. 2) Curated1
Sequence conflicti148S → T in BAD89434 (PubMed:16710414).Curated1
Sequence conflicti270N → K in AAA51892 (PubMed:1899030).Curated1
Sequence conflicti270N → K in AAF22565 (Ref. 2) Curated1
Sequence conflicti270N → K in BAD89434 (PubMed:16710414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03371237Q → L. Corresponds to variant dbSNP:rs34265054Ensembl.1
Natural variantiVAR_02826855T → M. Corresponds to variant dbSNP:rs2274327Ensembl.1
Natural variantiVAR_06109358R → W. Corresponds to variant dbSNP:rs58800854Ensembl.1
Natural variantiVAR_02826968M → L. Corresponds to variant dbSNP:rs2274328Ensembl.1
Natural variantiVAR_02827070G → A. Corresponds to variant dbSNP:rs2274329Ensembl.1
Natural variantiVAR_02827190S → G3 PublicationsCorresponds to variant dbSNP:rs2274333Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04666827 – 86Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_045435282 – 308EYTLG…RRALN → GKGHGGHRGRSQNPRVQPTS TRHPLALGSLEA in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M57892 mRNA Translation: AAA51892.1
AF128418 AF128417 Genomic DNA Translation: AAF22565.1
AB102863 mRNA Translation: BAD89397.1
AB103091 mRNA Translation: BAD89434.1
AL139415 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30578.1 [P23280-1]
CCDS57970.1 [P23280-2]
CCDS57971.1 [P23280-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A37917, CRHU6

NCBI Reference Sequences

More...RefSeqi		NP_001206.2, NM_001215.3 [P23280-1]
NP_001257429.1, NM_001270500.1 [P23280-2]
NP_001257430.1, NM_001270501.1 [P23280-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377436; ENSP00000366654; ENSG00000131686 [P23280-2]
ENST00000377442; ENSP00000366661; ENSG00000131686 [P23280-3]
ENST00000377443; ENSP00000366662; ENSG00000131686 [P23280-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		765

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:765

UCSC genome browser

More...UCSCi		uc001apm.5, human [P23280-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57892 mRNA Translation: AAA51892.1
AF128418 AF128417 Genomic DNA Translation: AAF22565.1
AB102863 mRNA Translation: BAD89397.1
AB103091 mRNA Translation: BAD89434.1
AL139415 Genomic DNA No translation available.
CCDSiCCDS30578.1 [P23280-1]
CCDS57970.1 [P23280-2]
CCDS57971.1 [P23280-3]
PIRiA37917, CRHU6
RefSeqiNP_001206.2, NM_001215.3 [P23280-1]
NP_001257429.1, NM_001270500.1 [P23280-2]
NP_001257430.1, NM_001270501.1 [P23280-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FE4X-ray1.90A/B21-290[»]
SMRiP23280
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107220, 15 interactors
IntActiP23280, 1 interactor
STRINGi9606.ENSP00000366654

Chemistry databases

BindingDBiP23280
ChEMBLiCHEMBL3025
DrugBankiDB08846, Ellagic acid
DB06795, Mafenide
DB00909, Zonisamide
DrugCentraliP23280

PTM databases

GlyConnecti1924, 2 N-Linked glycans (1 site)
GlyGeniP23280, 3 sites

Polymorphism and mutation databases

BioMutaiCA6
DMDMi116241278

Proteomic databases

jPOSTiP23280
MassIVEiP23280
PaxDbiP23280
PeptideAtlasiP23280
PRIDEiP23280
ProteomicsDBi16991
54077 [P23280-1]
62797
TopDownProteomicsiP23280-1 [P23280-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27596, 338 antibodies

The DNASU plasmid repository

More...DNASUi		765

Genome annotation databases

EnsembliENST00000377436; ENSP00000366654; ENSG00000131686 [P23280-2]
ENST00000377442; ENSP00000366661; ENSG00000131686 [P23280-3]
ENST00000377443; ENSP00000366662; ENSG00000131686 [P23280-1]
GeneIDi765
KEGGihsa:765
UCSCiuc001apm.5, human [P23280-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		765
DisGeNETi765
EuPathDBiHostDB:ENSG00000131686.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		CA6
HGNCiHGNC:1380, CA6
HPAiENSG00000131686, Tissue enriched (salivary)
MIMi114780, gene
neXtProtiNX_P23280
OpenTargetsiENSG00000131686
PharmGKBiPA25995

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0382, Eukaryota
GeneTreeiENSGT00940000160409
HOGENOMiCLU_039326_1_0_1
InParanoidiP23280
KOiK01672
OMAiPPTMRMT
OrthoDBi1377476at2759
PhylomeDBiP23280
TreeFamiTF316425

Enzyme and pathway databases

BRENDAi4.2.1.1, 2681
PathwayCommonsiP23280
ReactomeiR-HSA-1475029, Reversible hydration of carbon dioxide

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		765, 6 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CA6, human
EvolutionaryTraceiP23280

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Carbonic_anhydrase_VI

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		765
PharosiP23280, Tclin

Protein Ontology

More...PROi		PR:P23280
RNActiP23280, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131686, Expressed in parotid gland and 97 other tissues
ExpressionAtlasiP23280, baseline and differential
GenevisibleiP23280, HS

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148, CA_dom
IPR036398, CA_dom_sf
IPR023561, Carbonic_anhydrase_a-class
IPR018338, Carbonic_anhydrase_a-class_CS
IPR018428, Carbonic_anhydrase_CA6
PANTHERiPTHR18952, PTHR18952, 1 hit
PTHR18952:SF110, PTHR18952:SF110, 1 hit
PfamiView protein in Pfam
PF00194, Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057, Carb_anhydrase, 1 hit
SUPFAMiSSF51069, SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162, ALPHA_CA_1, 1 hit
PS51144, ALPHA_CA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAH6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23280
Secondary accession number(s): E7EMQ1
, Q5FBW3, Q5FC00, Q96QX8, Q9UF03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 17, 2006
Last modified: August 12, 2020
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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