CA6

Functionⁱ

Reversible hydration of carbon dioxide. Its role in saliva is unknown.

Catalytic activityⁱ

H₂CO₃ = CO₂ + H₂O.

Cofactorⁱ

Zn²⁺By similarity

Activity regulationⁱ

Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	85	Proton acceptorBy similarity	1
Metal bindingⁱ	111	Zinc; catalytic1 Publication	1
Metal bindingⁱ	113	Zinc; catalytic1 Publication	1
Metal bindingⁱ	138	Zinc; catalytic1 Publication	1
Active siteⁱ	146	By similarity	1

GO - Molecular functionⁱ

carbonate dehydratase activity Source: Reactome
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bicarbonate transport Source: Reactome
detection of chemical stimulus involved in sensory perception of bitter taste
Source: UniProtKB
Inferred from direct assayⁱ
- 24248522
one-carbon metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	4.2.1.1 2681
Reactomeⁱ	R-HSA-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Carbonic anhydrase 6 (EC:4.2.1.1) Alternative name(s): Carbonate dehydratase VI Carbonic anhydrase VI Short name: CA-VI Salivary carbonic anhydrase Secreted carbonic anhydrase
Gene namesⁱ	Name:CA6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131686.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1380 CA6
MIMⁱ	114780 gene
neXtProtⁱ	NX_P23280

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	765
Open Targets More...OpenTargetsⁱ	ENSG00000131686
PharmGKBⁱ	PA25995

Chemistry databases

ChEMBLⁱ	CHEMBL3025
Drug and drug target database More...DrugBankⁱ	DB08846 Ellagic Acid DB06795 Mafenide DB00909 Zonisamide

Polymorphism and mutation databases

BioMutaⁱ	CA6
DMDMⁱ	116241278

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000004241	18 – 308	Carbonic anhydrase 6Add BLAST		291

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	42 ↔ 224	Sequence analysis
Glycosylationⁱ	67	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	256	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P23280
PeptideAtlas More...PeptideAtlasⁱ	P23280
PRIDEⁱ	P23280
ProteomicsDBⁱ	54077
TopDownProteomicsⁱ	P23280-1 [P23280-1]

Expressionⁱ

Tissue specificityⁱ

Major constituent of saliva.

Gene expression databases

Bgeeⁱ	ENSG00000131686 Expressed in 70 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_CA6
ExpressionAtlasⁱ	P23280 baseline and differential
Genevisibleⁱ	P23280 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028550 HPA028692

HPAⁱ

HPA028550
HPA028692

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107220, 15 interactors
STRINGⁱ	9606.ENSP00000366662

Chemistry databases

BindingDBⁱ

P23280

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 38	Combined sources	4
Helixⁱ	40 – 43	Combined sources	4
Beta strandⁱ	44 – 46	Combined sources	3
Helixⁱ	54 – 56	Combined sources	3
Beta strandⁱ	68 – 70	Combined sources	3
Beta strandⁱ	72 – 82	Combined sources	11
Beta strandⁱ	87 – 90	Combined sources	4
Beta strandⁱ	96 – 98	Combined sources	3
Beta strandⁱ	104 – 114	Combined sources	11
Beta strandⁱ	125 – 128	Combined sources	4
Beta strandⁱ	134 – 143	Combined sources	10
Beta strandⁱ	146 – 148	Combined sources	3
Helixⁱ	149 – 152	Combined sources	4
Beta strandⁱ	159 – 167	Combined sources	9
Helixⁱ	175 – 177	Combined sources	3
Helixⁱ	178 – 183	Combined sources	6
Helixⁱ	184 – 187	Combined sources	4
Beta strandⁱ	193 – 199	Combined sources	7
Helixⁱ	201 – 204	Combined sources	4
Beta strandⁱ	212 – 217	Combined sources	6
Beta strandⁱ	228 – 235	Combined sources	8
Helixⁱ	241 – 249	Combined sources	9
Beta strandⁱ	256 – 258	Combined sources	3
Beta strandⁱ	275 – 277	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P23280
SMRⁱ	P23280
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P23280

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – 278	Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST		258

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	220 – 221	Substrate bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG0382 Eukaryota COG3338 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118915
HOGENOMⁱ	HOG000112637
HOVERGENⁱ	HBG002837
InParanoidⁱ	P23280
KEGG Orthology (KO) More...KOⁱ	K01672
OMAⁱ	WSEHTIN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XFM
PhylomeDBⁱ	P23280
TreeFamⁱ	TF316425

Family and domain databases

Gene3Dⁱ	3.10.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR001148 CA_dom IPR036398 CA_dom_sf IPR023561 Carbonic_anhydrase_a-class IPR018338 Carbonic_anhydrase_a-class_CS IPR018428 Carbonic_anhydrase_CA6
PANTHERⁱ	PTHR18952 PTHR18952, 1 hit PTHR18952:SF110 PTHR18952:SF110, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00194 Carb_anhydrase, 1 hit
SMARTⁱ	View protein in SMART SM01057 Carb_anhydrase, 1 hit
SUPFAMⁱ	SSF51069 SSF51069, 1 hit
PROSITEⁱ	View protein in PROSITE PS00162 ALPHA_CA_1, 1 hit PS51144 ALPHA_CA_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P23280-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI 
        60         70         80         90        100
NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA 
       110        120        130        140        150
DGTVYIAQQM HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD 
       160        170        180        190        200
IAQDAPDGLA VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD 
       210        220        230        240        250
VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS 
       260        270        280        290        300
LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL 

DYLRRALN

Length:308

Mass (Da):35,367

Last modified:October 17, 2006 - v3

Checksum:ⁱ6EBFF15085E7112D

GO

Isoform 2 (identifier: P23280-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
282-308: EYTLGSEFQFYLHKIEEILDYLRRALN → GKGHGGHRGRSQNPRVQPTSTRHPLALGSLEA

« Hide

        10         20         30         40         50
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI 
        60         70         80         90        100
NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA 
       110        120        130        140        150
DGTVYIAQQM HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD 
       160        170        180        190        200
IAQDAPDGLA VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD 
       210        220        230        240        250
VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS 
       260        270        280        290        300
LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QGKGHGGHRG RSQNPRVQPT 
       310 
STRHPLALGS LEA

Note: No experimental confirmation available.

Show »

Length:313

Mass (Da):35,365

Checksum:ⁱ1CF67B5ED1BD9384

GO

Isoform 3 (identifier: P23280-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
27-86: Missing.

« Hide

        10         20         30         40         50
MRALVLLLSL FLLGGQAQHV SDWTYSVQIS LPSTMRMTVA DGTVYIAQQM 
        60         70         80         90        100
HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD IAQDAPDGLA 
       110        120        130        140        150
VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD VQDMLPRNLQ 
       160        170        180        190        200
HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS LLDHRNKTIH 
       210        220        230        240 
NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL DYLRRALN

Note: No experimental confirmation available.

Show »

Length:248

Mass (Da):28,687

Checksum:ⁱ39A6223C958A3029

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8N4G4	Q8N4G4_HUMAN	CA6 protein CA6 protein (Carbonic anhydrase 6)	CA6	179	Annotation score:
F8W148	F8W148_HUMAN	Carbonic anhydrase 6 Carbonic anhydrase 6	CA6	187	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	103	T → I in AAA51892 (PubMed:1899030).Curated	1
Sequence conflictⁱ	103	T → I in BAD89434 (PubMed:16710414).Curated	1
Sequence conflictⁱ	148	S → T in AAA51892 (PubMed:1899030).Curated	1
Sequence conflictⁱ	148	S → T in AAF22565 (Ref. 2) Curated	1
Sequence conflictⁱ	148	S → T in BAD89434 (PubMed:16710414).Curated	1
Sequence conflictⁱ	270	N → K in AAA51892 (PubMed:1899030).Curated	1
Sequence conflictⁱ	270	N → K in AAF22565 (Ref. 2) Curated	1
Sequence conflictⁱ	270	N → K in BAD89434 (PubMed:16710414).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033712	37	Q → L. Corresponds to variant dbSNP:rs34265054Ensembl.	1
Natural variantⁱVAR_028268	55	T → M. Corresponds to variant dbSNP:rs2274327Ensembl.	1
Natural variantⁱVAR_061093	58	R → W. Corresponds to variant dbSNP:rs58800854Ensembl.	1
Natural variantⁱVAR_028269	68	M → L. Corresponds to variant dbSNP:rs2274328Ensembl.	1
Natural variantⁱVAR_028270	70	G → A. Corresponds to variant dbSNP:rs2274329Ensembl.	1
Natural variantⁱVAR_028271	90	S → G3 PublicationsCorresponds to variant dbSNP:rs2274333Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046668	27 – 86	Missing in isoform 3. 1 PublicationAdd BLAST		60
Alternative sequenceⁱVSP_045435	282 – 308	EYTLG…RRALN → GKGHGGHRGRSQNPRVQPTS TRHPLALGSLEA in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57892 mRNA Translation: AAA51892.1 AF128418 AF128417 Genomic DNA Translation: AAF22565.1 AB102863 mRNA Translation: BAD89397.1 AB103091 mRNA Translation: BAD89434.1 AL139415 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30578.1 [P23280-1] CCDS57970.1 [P23280-2] CCDS57971.1 [P23280-3]
PIRⁱ	A37917 CRHU6
NCBI Reference Sequences More...RefSeqⁱ	NP_001206.2, NM_001215.3 [P23280-1] NP_001257429.1, NM_001270500.1 [P23280-2] NP_001257430.1, NM_001270501.1 [P23280-3]
UniGeneⁱ	Hs.100322

Genome annotation databases

Ensemblⁱ	ENST00000377436; ENSP00000366654; ENSG00000131686 [P23280-2] ENST00000377442; ENSP00000366661; ENSG00000131686 [P23280-3] ENST00000377443; ENSP00000366662; ENSG00000131686 [P23280-1]
GeneIDⁱ	765
KEGGⁱ	hsa:765
UCSC genome browser More...UCSCⁱ	uc001apm.5 human [P23280-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23280	cDNA FLJ60163, highly similar to Carbonic anhydrase 6		HUMAN		312	UniRef100_P23280

Protein	Similar proteins		Species	Score	Length	Source
P23280	cDNA FLJ60163, highly similar to Carbonic anhydrase 6		HUMAN		312	UniRef90_P23280
CA6 isoform 1		PANTR		308
Uncharacterized protein		PANPA		308
Carbonic anhydrase 6		PONAB		308
Carbonic anhydrase 6		GORGO		308
+11
P23280-2	CA6 isoform 5		PONAB		312	UniRef90_P23280-2
Carbonic anhydrase 6		PANTR		312
Uncharacterized protein		PANPA		312
Uncharacterized protein		NOMLE		312
Carbonic anhydrase 6		GORGO		312
+4
P23280-3	Uncharacterized protein		NOMLE		248	UniRef90_P23280-3
CA6 isoform 3		PANTR		248
Uncharacterized protein		PANPA		248
Carbonic anhydrase 6		GORGO		248
CA6 isoform 6		PONAB		248
+10

Protein	Similar proteins		Species	Score	Length	Source
P23280	cDNA FLJ60163, highly similar to Carbonic anhydrase 6		HUMAN		312	UniRef50_P23280
Uncharacterized protein		NOMLE		308
Uncharacterized protein		MACMU		308
CA6 isoform 4		PONAB		308
CA6 isoform 1		PANTR		308
+16
P23280-2	Carbonic anhydrase 6		SHEEP		307	UniRef50_P23280-2
Carbonic anhydrase 6		BOVIN		319
Carbonic anhydrase 6		PANTR		312
Uncharacterized protein		PANPA		312
CA6 isoform 5		PONAB		312
+81
P23280-3	Uncharacterized protein		CERAT		248	UniRef50_P23280-3
Uncharacterized protein		MACMU		248
Uncharacterized protein		MACFA		248
Uncharacterized protein		MACNE		248
CA6 isoform 6		PONAB		248
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57892 mRNA Translation: AAA51892.1 AF128418 AF128417 Genomic DNA Translation: AAF22565.1 AB102863 mRNA Translation: BAD89397.1 AB103091 mRNA Translation: BAD89434.1 AL139415 Genomic DNA No translation available.
CCDSⁱ	CCDS30578.1 [P23280-1] CCDS57970.1 [P23280-2] CCDS57971.1 [P23280-3]
PIRⁱ	A37917 CRHU6
RefSeqⁱ	NP_001206.2, NM_001215.3 [P23280-1] NP_001257429.1, NM_001270500.1 [P23280-2] NP_001257430.1, NM_001270501.1 [P23280-3]
UniGeneⁱ	Hs.100322

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3FE4	X-ray	1.90	A/B	21-290	[»]
ProteinModelPortalⁱ	P23280
SMRⁱ	P23280
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107220, 15 interactors
STRINGⁱ	9606.ENSP00000366662

Chemistry databases

BindingDBⁱ	P23280
ChEMBLⁱ	CHEMBL3025
DrugBankⁱ	DB08846 Ellagic Acid DB06795 Mafenide DB00909 Zonisamide

Polymorphism and mutation databases

BioMutaⁱ	CA6
DMDMⁱ	116241278

Proteomic databases

PaxDbⁱ	P23280
PeptideAtlasⁱ	P23280
PRIDEⁱ	P23280
ProteomicsDBⁱ	54077
TopDownProteomicsⁱ	P23280-1 [P23280-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	765
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377436; ENSP00000366654; ENSG00000131686 [P23280-2] ENST00000377442; ENSP00000366661; ENSG00000131686 [P23280-3] ENST00000377443; ENSP00000366662; ENSG00000131686 [P23280-1]
GeneIDⁱ	765
KEGGⁱ	hsa:765
UCSCⁱ	uc001apm.5 human [P23280-1]

Organism-specific databases

CTDⁱ	765
DisGeNETⁱ	765
EuPathDBⁱ	HostDB:ENSG00000131686.14
GeneCardsⁱ	CA6
H-InvDBⁱ	HIX0028508 HIX0116265
HGNCⁱ	HGNC:1380 CA6
HPAⁱ	HPA028550 HPA028692
MIMⁱ	114780 gene
neXtProtⁱ	NX_P23280
OpenTargetsⁱ	ENSG00000131686
PharmGKBⁱ	PA25995
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0382 Eukaryota COG3338 LUCA
GeneTreeⁱ	ENSGT00760000118915
HOGENOMⁱ	HOG000112637
HOVERGENⁱ	HBG002837
InParanoidⁱ	P23280
KOⁱ	K01672
OMAⁱ	WSEHTIN
OrthoDBⁱ	EOG091G0XFM
PhylomeDBⁱ	P23280
TreeFamⁱ	TF316425

Enzyme and pathway databases

BRENDAⁱ	4.2.1.1 2681
Reactomeⁱ	R-HSA-1475029 Reversible hydration of carbon dioxide

Miscellaneous databases

EvolutionaryTraceⁱ	P23280
GeneWikiⁱ	Carbonic_anhydrase_VI
GenomeRNAiⁱ	765
Protein Ontology More...PROⁱ	PR:P23280
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131686 Expressed in 70 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_CA6
ExpressionAtlasⁱ	P23280 baseline and differential
Genevisibleⁱ	P23280 HS

Family and domain databases

Gene3Dⁱ	3.10.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR001148 CA_dom IPR036398 CA_dom_sf IPR023561 Carbonic_anhydrase_a-class IPR018338 Carbonic_anhydrase_a-class_CS IPR018428 Carbonic_anhydrase_CA6
PANTHERⁱ	PTHR18952 PTHR18952, 1 hit PTHR18952:SF110 PTHR18952:SF110, 1 hit
Pfamⁱ	View protein in Pfam PF00194 Carb_anhydrase, 1 hit
SMARTⁱ	View protein in SMART SM01057 Carb_anhydrase, 1 hit
SUPFAMⁱ	SSF51069 SSF51069, 1 hit
PROSITEⁱ	View protein in PROSITE PS00162 ALPHA_CA_1, 1 hit PS51144 ALPHA_CA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAH6_HUMAN
Accessionⁱ	P23280Primary (citable) accession number: P23280 Secondary accession number(s): E7EMQ1 , Q5FBW3, Q5FC00, Q96QX8, Q9UF03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	October 17, 2006
	Last modified:	October 10, 2018
	This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P23280 (CAH6_HUMAN)

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Carbonic anhydrase 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ