UniProtKB - P23280 (CAH6_HUMAN)
Protein
Carbonic anhydrase 6
Gene
CA6
Organism
Homo sapiens (Human)
Status
Functioni
Reversible hydration of carbon dioxide. Its role in saliva is unknown.
Catalytic activityi
- EC:4.2.1.1
Cofactori
Zn2+By similarity
Activity regulationi
Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).4 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 85 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 111 | Zinc; catalytic1 Publication | 1 | |
Metal bindingi | 113 | Zinc; catalytic1 Publication | 1 | |
Metal bindingi | 138 | Zinc; catalytic1 Publication | 1 | |
Active sitei | 146 | By similarity | 1 |
GO - Molecular functioni
- carbonate dehydratase activity Source: Reactome
- zinc ion binding Source: InterPro
GO - Biological processi
- bicarbonate transport Source: Reactome
- detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
- one-carbon metabolic process Source: InterPro
Keywordsi
Molecular function | Lyase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 4.2.1.1 2681 |
Reactomei | R-HSA-1475029 Reversible hydration of carbon dioxide |
Names & Taxonomyi
Protein namesi | Recommended name: Carbonic anhydrase 6 (EC:4.2.1.1)Alternative name(s): Carbonate dehydratase VI Carbonic anhydrase VI Short name: CA-VI Salivary carbonic anhydrase Secreted carbonic anhydrase |
Gene namesi | Name:CA6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000131686.14 |
HGNCi | HGNC:1380 CA6 |
MIMi | 114780 gene |
neXtProti | NX_P23280 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 765 |
OpenTargetsi | ENSG00000131686 |
PharmGKBi | PA25995 |
Chemistry databases
ChEMBLi | CHEMBL3025 |
DrugBanki | DB08846 Ellagic Acid DB06795 Mafenide DB00909 Zonisamide |
Polymorphism and mutation databases
BioMutai | CA6 |
DMDMi | 116241278 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000004241 | 18 – 308 | Carbonic anhydrase 6Add BLAST | 291 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 224 | Sequence analysis | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P23280 |
PaxDbi | P23280 |
PeptideAtlasi | P23280 |
PRIDEi | P23280 |
ProteomicsDBi | 54077 |
TopDownProteomicsi | P23280-1 [P23280-1] |
Expressioni
Tissue specificityi
Major constituent of saliva.
Gene expression databases
Bgeei | ENSG00000131686 Expressed in 70 organ(s), highest expression level in parotid gland |
ExpressionAtlasi | P23280 baseline and differential |
Genevisiblei | P23280 HS |
Organism-specific databases
HPAi | HPA028550 HPA028692 |
Interactioni
Protein-protein interaction databases
BioGridi | 107220, 15 interactors |
STRINGi | 9606.ENSP00000366662 |
Chemistry databases
BindingDBi | P23280 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3FE4 | X-ray | 1.90 | A/B | 21-290 | [»] | |
ProteinModelPortali | P23280 | |||||
SMRi | P23280 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23280 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 278 | Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 220 – 221 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the alpha-carbonic anhydrase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0382 Eukaryota COG3338 LUCA |
GeneTreei | ENSGT00940000160409 |
HOGENOMi | HOG000112637 |
HOVERGENi | HBG002837 |
InParanoidi | P23280 |
KOi | K01672 |
OMAi | WSEHTIN |
OrthoDBi | 1276906at2759 |
PhylomeDBi | P23280 |
TreeFami | TF316425 |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR001148 CA_dom IPR036398 CA_dom_sf IPR023561 Carbonic_anhydrase_a-class IPR018338 Carbonic_anhydrase_a-class_CS IPR018428 Carbonic_anhydrase_CA6 |
PANTHERi | PTHR18952 PTHR18952, 1 hit PTHR18952:SF110 PTHR18952:SF110, 1 hit |
Pfami | View protein in Pfam PF00194 Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057 Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069 SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162 ALPHA_CA_1, 1 hit PS51144 ALPHA_CA_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P23280-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI
60 70 80 90 100
NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA
110 120 130 140 150
DGTVYIAQQM HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD
160 170 180 190 200
IAQDAPDGLA VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD
210 220 230 240 250
VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS
260 270 280 290 300
LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL
DYLRRALN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8N4G4 | Q8N4G4_HUMAN | CA6 protein | CA6 | 179 | Annotation score: | ||
F8W148 | F8W148_HUMAN | Carbonic anhydrase 6 | CA6 | 187 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | T → I in AAA51892 (PubMed:1899030).Curated | 1 | |
Sequence conflicti | 103 | T → I in BAD89434 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 148 | S → T in AAA51892 (PubMed:1899030).Curated | 1 | |
Sequence conflicti | 148 | S → T in AAF22565 (Ref. 2) Curated | 1 | |
Sequence conflicti | 148 | S → T in BAD89434 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 270 | N → K in AAA51892 (PubMed:1899030).Curated | 1 | |
Sequence conflicti | 270 | N → K in AAF22565 (Ref. 2) Curated | 1 | |
Sequence conflicti | 270 | N → K in BAD89434 (PubMed:16710414).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033712 | 37 | Q → L. Corresponds to variant dbSNP:rs34265054Ensembl. | 1 | |
Natural variantiVAR_028268 | 55 | T → M. Corresponds to variant dbSNP:rs2274327Ensembl. | 1 | |
Natural variantiVAR_061093 | 58 | R → W. Corresponds to variant dbSNP:rs58800854Ensembl. | 1 | |
Natural variantiVAR_028269 | 68 | M → L. Corresponds to variant dbSNP:rs2274328Ensembl. | 1 | |
Natural variantiVAR_028270 | 70 | G → A. Corresponds to variant dbSNP:rs2274329Ensembl. | 1 | |
Natural variantiVAR_028271 | 90 | S → G3 PublicationsCorresponds to variant dbSNP:rs2274333Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046668 | 27 – 86 | Missing in isoform 3. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_045435 | 282 – 308 | EYTLG…RRALN → GKGHGGHRGRSQNPRVQPTS TRHPLALGSLEA in isoform 2. 1 PublicationAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57892 mRNA Translation: AAA51892.1 AF128418 AF128417 Genomic DNA Translation: AAF22565.1 AB102863 mRNA Translation: BAD89397.1 AB103091 mRNA Translation: BAD89434.1 AL139415 Genomic DNA No translation available. |
CCDSi | CCDS30578.1 [P23280-1] CCDS57970.1 [P23280-2] CCDS57971.1 [P23280-3] |
PIRi | A37917 CRHU6 |
RefSeqi | NP_001206.2, NM_001215.3 [P23280-1] NP_001257429.1, NM_001270500.1 [P23280-2] NP_001257430.1, NM_001270501.1 [P23280-3] |
UniGenei | Hs.100322 |
Genome annotation databases
Ensembli | ENST00000377436; ENSP00000366654; ENSG00000131686 [P23280-2] ENST00000377442; ENSP00000366661; ENSG00000131686 [P23280-3] ENST00000377443; ENSP00000366662; ENSG00000131686 [P23280-1] |
GeneIDi | 765 |
KEGGi | hsa:765 |
UCSCi | uc001apm.5 human [P23280-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57892 mRNA Translation: AAA51892.1 AF128418 AF128417 Genomic DNA Translation: AAF22565.1 AB102863 mRNA Translation: BAD89397.1 AB103091 mRNA Translation: BAD89434.1 AL139415 Genomic DNA No translation available. |
CCDSi | CCDS30578.1 [P23280-1] CCDS57970.1 [P23280-2] CCDS57971.1 [P23280-3] |
PIRi | A37917 CRHU6 |
RefSeqi | NP_001206.2, NM_001215.3 [P23280-1] NP_001257429.1, NM_001270500.1 [P23280-2] NP_001257430.1, NM_001270501.1 [P23280-3] |
UniGenei | Hs.100322 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3FE4 | X-ray | 1.90 | A/B | 21-290 | [»] | |
ProteinModelPortali | P23280 | |||||
SMRi | P23280 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 107220, 15 interactors |
STRINGi | 9606.ENSP00000366662 |
Chemistry databases
BindingDBi | P23280 |
ChEMBLi | CHEMBL3025 |
DrugBanki | DB08846 Ellagic Acid DB06795 Mafenide DB00909 Zonisamide |
Polymorphism and mutation databases
BioMutai | CA6 |
DMDMi | 116241278 |
Proteomic databases
jPOSTi | P23280 |
PaxDbi | P23280 |
PeptideAtlasi | P23280 |
PRIDEi | P23280 |
ProteomicsDBi | 54077 |
TopDownProteomicsi | P23280-1 [P23280-1] |
Protocols and materials databases
DNASUi | 765 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000377436; ENSP00000366654; ENSG00000131686 [P23280-2] ENST00000377442; ENSP00000366661; ENSG00000131686 [P23280-3] ENST00000377443; ENSP00000366662; ENSG00000131686 [P23280-1] |
GeneIDi | 765 |
KEGGi | hsa:765 |
UCSCi | uc001apm.5 human [P23280-1] |
Organism-specific databases
CTDi | 765 |
DisGeNETi | 765 |
EuPathDBi | HostDB:ENSG00000131686.14 |
GeneCardsi | CA6 |
H-InvDBi | HIX0028508 HIX0116265 |
HGNCi | HGNC:1380 CA6 |
HPAi | HPA028550 HPA028692 |
MIMi | 114780 gene |
neXtProti | NX_P23280 |
OpenTargetsi | ENSG00000131686 |
PharmGKBi | PA25995 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0382 Eukaryota COG3338 LUCA |
GeneTreei | ENSGT00940000160409 |
HOGENOMi | HOG000112637 |
HOVERGENi | HBG002837 |
InParanoidi | P23280 |
KOi | K01672 |
OMAi | WSEHTIN |
OrthoDBi | 1276906at2759 |
PhylomeDBi | P23280 |
TreeFami | TF316425 |
Enzyme and pathway databases
BRENDAi | 4.2.1.1 2681 |
Reactomei | R-HSA-1475029 Reversible hydration of carbon dioxide |
Miscellaneous databases
EvolutionaryTracei | P23280 |
GeneWikii | Carbonic_anhydrase_VI |
GenomeRNAii | 765 |
PROi | PR:P23280 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131686 Expressed in 70 organ(s), highest expression level in parotid gland |
ExpressionAtlasi | P23280 baseline and differential |
Genevisiblei | P23280 HS |
Family and domain databases
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR001148 CA_dom IPR036398 CA_dom_sf IPR023561 Carbonic_anhydrase_a-class IPR018338 Carbonic_anhydrase_a-class_CS IPR018428 Carbonic_anhydrase_CA6 |
PANTHERi | PTHR18952 PTHR18952, 1 hit PTHR18952:SF110 PTHR18952:SF110, 1 hit |
Pfami | View protein in Pfam PF00194 Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057 Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069 SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162 ALPHA_CA_1, 1 hit PS51144 ALPHA_CA_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CAH6_HUMAN | |
Accessioni | P23280Primary (citable) accession number: P23280 Secondary accession number(s): E7EMQ1 Q9UF03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 13, 2019 | |
This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations