UniProtKB - P23258 (TBG1_HUMAN)
Tubulin gamma-1 chain
TUBG1
Functioni
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 142 – 148 | GTPSequence analysis | 7 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
- identical protein binding Source: IntAct
- structural constituent of cytoskeleton Source: GO_Central
GO - Biological processi
- cytoplasmic microtubule organization Source: InterPro
- meiotic spindle organization Source: UniProtKB
- microtubule cytoskeleton organization Source: GO_Central
- microtubule nucleation Source: GO_Central
- mitotic cell cycle Source: GO_Central
- mitotic sister chromatid segregation Source: GO_Central
- mitotic spindle organization Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.5.6, 2681 |
PathwayCommonsi | P23258 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
SignaLinki | P23258 |
SIGNORi | P23258 |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin gamma-1 chainAlternative name(s): Gamma-1-tubulin Gamma-tubulin complex component 1 Short name: GCP-1 |
Gene namesi | Name:TUBG1 Synonyms:TUBG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12417, TUBG1 |
MIMi | 191135, gene |
neXtProti | NX_P23258 |
VEuPathDBi | HostDB:ENSG00000131462 |
Subcellular locationi
Cytoskeleton
- centrosome 4 Publications
- spindle 1 Publication
Note: Localizes to mitotic spindle microtubules.1 Publication
Cytoskeleton
- centriole Source: Ensembl
- centrosome Source: UniProtKB
- ciliary basal body Source: Ensembl
- cytoplasmic microtubule Source: Ensembl
- gamma-tubulin complex Source: GO_Central
- microtubule Source: GO_Central
- mitotic spindle microtubule Source: UniProtKB
- pericentriolar material Source: Ensembl
- polar microtubule Source: UniProtKB
- spindle Source: GO_Central
Cytosol
- cytosol Source: Reactome
Endosome
- recycling endosome Source: UniProtKB
Nucleus
- condensed nuclear chromosome Source: UniProtKB
- nucleus Source: GO_Central
Other locations
- apical part of cell Source: Ensembl
- cell leading edge Source: Ensembl
- cytoplasm Source: UniProtKB
- non-motile cilium Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Involvement in diseasei
Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070577 | 92 | Y → C in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123046EnsemblClinVar. | 1 | |
Natural variantiVAR_070578 | 331 | T → P in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123047EnsemblClinVar. | 1 | |
Natural variantiVAR_070579 | 387 | L → P in CDCBM4; the chaperonin-dependent folding and hence the yield of monomeric gamma-tubulin is compromised. 1 PublicationCorresponds to variant dbSNP:rs398123045EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, LissencephalyOrganism-specific databases
DisGeNETi | 7283 |
MalaCardsi | TUBG1 |
MIMi | 615412, phenotype |
OpenTargetsi | ENSG00000131462 |
Orphaneti | 261183, 15q11.2 microdeletion syndrome |
PharmGKBi | PA37079 |
Miscellaneous databases
Pharosi | P23258, Tbio |
Chemistry databases
DrugBanki | DB00570, Vinblastine |
Genetic variation databases
BioMutai | TUBG1 |
DMDMi | 20455518 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048465 | 1 – 451 | Tubulin gamma-1 chainAdd BLAST | 451 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 131 | Phosphoserine; by BRSK1By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P23258 |
jPOSTi | P23258 |
MassIVEi | P23258 |
MaxQBi | P23258 |
PaxDbi | P23258 |
PeptideAtlasi | P23258 |
PRIDEi | P23258 |
ProteomicsDBi | 54075 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00295081 |
PTM databases
iPTMneti | P23258 |
MetOSitei | P23258 |
PhosphoSitePlusi | P23258 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131462, Expressed in testis and 239 other tissues |
ExpressionAtlasi | P23258, baseline and differential |
Genevisiblei | P23258, HS |
Organism-specific databases
HPAi | ENSG00000131462, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with TUBGCP2 and TUBGCP3 (PubMed:9566969, PubMed:9566969).
Interacts with B9D2 (By similarity).
Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2 (PubMed:17959831).
Interacts with PIFO (PubMed:20643351).
Interacts with SAS6 and NUP62 at the centrosome (PubMed:24107630).
Interacts with EML3 (phosphorylated at 'Thr-881') and HAUS8 (PubMed:30723163).
By similarity6 PublicationsBinary interactionsi
P23258
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 113134, 342 interactors |
CORUMi | P23258 |
DIPi | DIP-29890N |
IntActi | P23258, 157 interactors |
MINTi | P23258 |
STRINGi | 9606.ENSP00000251413 |
Miscellaneous databases
RNActi | P23258, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P23258 |
SMRi | P23258 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23258 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1374, Eukaryota |
GeneTreei | ENSGT00940000156957 |
InParanoidi | P23258 |
OMAi | EHGINKE |
OrthoDBi | 687389at2759 |
PhylomeDBi | P23258 |
TreeFami | TF300477 |
Family and domain databases
CDDi | cd02188, gamma_tubulin, 1 hit |
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002454, Gamma_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR037103, Tubulin/FtsZ-like_C IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01164, GAMMATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK
410 420 430 440 450
REAFLEQFRK EDMFKDNFDE MDTSREIVQQ LIDEYHAATR PDYISWGTQE
Q
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EIS0 | K7EIS0_HUMAN | Tubulin gamma chain | TUBG1 | 265 | Annotation score: | ||
A0A7P0T9G6 | A0A7P0T9G6_HUMAN | Tubulin gamma chain | TUBG1 | 497 | Annotation score: | ||
K7EKE5 | K7EKE5_HUMAN | Tubulin gamma-1 chain | TUBG1 | 135 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 | G → A in AAA52620 (PubMed:1904010).Curated | 1 | |
Sequence conflicti | 202 | V → L in AAA52620 (PubMed:1904010).Curated | 1 |
Mass spectrometryi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070577 | 92 | Y → C in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123046EnsemblClinVar. | 1 | |
Natural variantiVAR_070578 | 331 | T → P in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123047EnsemblClinVar. | 1 | |
Natural variantiVAR_070579 | 387 | L → P in CDCBM4; the chaperonin-dependent folding and hence the yield of monomeric gamma-tubulin is compromised. 1 PublicationCorresponds to variant dbSNP:rs398123045EnsemblClinVar. | 1 | |
Natural variantiVAR_052674 | 413 | M → V. Corresponds to variant dbSNP:rs13663Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61764 mRNA Translation: AAA52620.1 BT019931 mRNA Translation: AAV38734.1 CR407642 mRNA Translation: CAG28570.1 AK313339 mRNA Translation: BAG36143.1 BC000619 mRNA Translation: AAH00619.1 |
CCDSi | CCDS11433.1 |
PIRi | A39527, UBHUG |
RefSeqi | NP_001061.2, NM_001070.4 |
Genome annotation databases
Ensembli | ENST00000251413.8; ENSP00000251413.2; ENSG00000131462.9 |
GeneIDi | 7283 |
KEGGi | hsa:7283 |
MANE-Selecti | ENST00000251413.8; ENSP00000251413.2; NM_001070.5; NP_001061.2 |
UCSCi | uc002ian.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61764 mRNA Translation: AAA52620.1 BT019931 mRNA Translation: AAV38734.1 CR407642 mRNA Translation: CAG28570.1 AK313339 mRNA Translation: BAG36143.1 BC000619 mRNA Translation: AAH00619.1 |
CCDSi | CCDS11433.1 |
PIRi | A39527, UBHUG |
RefSeqi | NP_001061.2, NM_001070.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z5V | X-ray | 2.71 | A | 1-449 | [»] | |
1Z5W | X-ray | 3.00 | A | 1-449 | [»] | |
3CB2 | X-ray | 2.30 | A/B | 1-451 | [»] | |
6V5V | electron microscopy | 3.80 | g | 1-451 | [»] | |
6V6S | electron microscopy | 4.30 | a/b/c/d/e/f/g/h/i/j/k/l/m/t | 1-451 | [»] | |
7AS4 | electron microscopy | 4.13 | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z | 1-447 | [»] | |
7QJ0 | electron microscopy | 5.32 | U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ1 | electron microscopy | 7.00 | U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ2 | electron microscopy | 8.60 | S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ3 | electron microscopy | 7.60 | 1/2/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ4 | electron microscopy | 9.00 | 1/2/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ5 | electron microscopy | 8.70 | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ6 | electron microscopy | 7.80 | Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ7 | electron microscopy | 8.70 | O/P/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ8 | electron microscopy | 8.70 | 1/2/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJ9 | electron microscopy | 8.10 | Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJA | electron microscopy | 9.20 | O/P/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJB | electron microscopy | 9.20 | 1/2/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJC | electron microscopy | 16.10 | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJD | electron microscopy | 7.10 | 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z | 1-451 | [»] | |
7QJE | electron microscopy | 7.80 | W/X/Y/Z | 1-451 | [»] | |
AlphaFoldDBi | P23258 | |||||
SMRi | P23258 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113134, 342 interactors |
CORUMi | P23258 |
DIPi | DIP-29890N |
IntActi | P23258, 157 interactors |
MINTi | P23258 |
STRINGi | 9606.ENSP00000251413 |
Chemistry databases
DrugBanki | DB00570, Vinblastine |
PTM databases
iPTMneti | P23258 |
MetOSitei | P23258 |
PhosphoSitePlusi | P23258 |
Genetic variation databases
BioMutai | TUBG1 |
DMDMi | 20455518 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00295081 |
Proteomic databases
EPDi | P23258 |
jPOSTi | P23258 |
MassIVEi | P23258 |
MaxQBi | P23258 |
PaxDbi | P23258 |
PeptideAtlasi | P23258 |
PRIDEi | P23258 |
ProteomicsDBi | 54075 |
Protocols and materials databases
ABCDi | P23258, 6 sequenced antibodies |
Antibodypediai | 3898, 601 antibodies from 43 providers |
DNASUi | 7283 |
Genome annotation databases
Ensembli | ENST00000251413.8; ENSP00000251413.2; ENSG00000131462.9 |
GeneIDi | 7283 |
KEGGi | hsa:7283 |
MANE-Selecti | ENST00000251413.8; ENSP00000251413.2; NM_001070.5; NP_001061.2 |
UCSCi | uc002ian.4, human |
Organism-specific databases
CTDi | 7283 |
DisGeNETi | 7283 |
GeneCardsi | TUBG1 |
HGNCi | HGNC:12417, TUBG1 |
HPAi | ENSG00000131462, Tissue enhanced (testis) |
MalaCardsi | TUBG1 |
MIMi | 191135, gene 615412, phenotype |
neXtProti | NX_P23258 |
OpenTargetsi | ENSG00000131462 |
Orphaneti | 261183, 15q11.2 microdeletion syndrome |
PharmGKBi | PA37079 |
VEuPathDBi | HostDB:ENSG00000131462 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1374, Eukaryota |
GeneTreei | ENSGT00940000156957 |
InParanoidi | P23258 |
OMAi | EHGINKE |
OrthoDBi | 687389at2759 |
PhylomeDBi | P23258 |
TreeFami | TF300477 |
Enzyme and pathway databases
BRENDAi | 3.6.5.6, 2681 |
PathwayCommonsi | P23258 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
SignaLinki | P23258 |
SIGNORi | P23258 |
Miscellaneous databases
BioGRID-ORCSi | 7283, 783 hits in 1081 CRISPR screens |
ChiTaRSi | TUBG1, human |
EvolutionaryTracei | P23258 |
GeneWikii | TUBG1 |
GenomeRNAii | 7283 |
Pharosi | P23258, Tbio |
PROi | PR:P23258 |
RNActi | P23258, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131462, Expressed in testis and 239 other tissues |
ExpressionAtlasi | P23258, baseline and differential |
Genevisiblei | P23258, HS |
Family and domain databases
CDDi | cd02188, gamma_tubulin, 1 hit |
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR002454, Gamma_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR037103, Tubulin/FtsZ-like_C IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01164, GAMMATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TBG1_HUMAN | |
Accessioni | P23258Primary (citable) accession number: P23258 Secondary accession number(s): Q53X79, Q9BW59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | May 2, 2002 | |
Last modified: | May 25, 2022 | |
This is version 217 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families