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Protein

Tubulin gamma-1 chain

Gene

TUBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: GO_Central
  • identical protein binding Source: IntAct
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiP23258

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-1 chain
Alternative name(s):
Gamma-1-tubulin
Gamma-tubulin complex component 1
Short name:
GCP-1
Gene namesi
Name:TUBG1
Synonyms:TUBG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131462.7
HGNCiHGNC:12417 TUBG1
MIMi191135 gene
neXtProtiNX_P23258

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients.
See also OMIM:615412
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07057792Y → C in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123046EnsemblClinVar.1
Natural variantiVAR_070578331T → P in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123047EnsemblClinVar.1
Natural variantiVAR_070579387L → P in CDCBM4; the chaperonin-dependent folding and hence the yield of monomeric gamma-tubulin is compromised. 1 PublicationCorresponds to variant dbSNP:rs398123045EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi7283
MalaCardsiTUBG1
MIMi615412 phenotype
OpenTargetsiENSG00000131462
PharmGKBiPA37079

Chemistry databases

DrugBankiDB00570 Vinblastine

Polymorphism and mutation databases

BioMutaiTUBG1
DMDMi20455518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484651 – 451Tubulin gamma-1 chainAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine; by BRSK1By similarity1

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP23258
MaxQBiP23258
PaxDbiP23258
PeptideAtlasiP23258
PRIDEiP23258
ProteomicsDBi54075

2D gel databases

REPRODUCTION-2DPAGEiIPI00295081

PTM databases

iPTMnetiP23258
PhosphoSitePlusiP23258

Miscellaneous databases

PMAP-CutDBiP23258

Expressioni

Gene expression databases

BgeeiENSG00000131462 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_TUBG1
ExpressionAtlasiP23258 baseline and differential
GenevisibleiP23258 HS

Organism-specific databases

HPAiCAB004608

Interactioni

Subunit structurei

Interacts with TUBGCP2 and TUBGCP3 (PubMed:9566969, PubMed:9566969). Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2 (PubMed:17959831). Interacts with PIFO (PubMed:20643351). Interacts with SAS6 and NUP62 at the centrosome (PubMed:24107630).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113134, 246 interactors
CORUMiP23258
DIPiDIP-29890N
IntActiP23258, 131 interactors
MINTiP23258
STRINGi9606.ENSP00000251413

Structurei

Secondary structure

1451
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23258
SMRiP23258
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23258

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiP23258
KOiK10389
OMAiEGFMLMH
OrthoDBiEOG091G08A9
PhylomeDBiP23258
TreeFamiTF300477

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P23258-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK
410 420 430 440 450
REAFLEQFRK EDMFKDNFDE MDTSREIVQQ LIDEYHAATR PDYISWGTQE

Q
Length:451
Mass (Da):51,170
Last modified:May 2, 2002 - v2
Checksum:iE2A4C0179ED0CFE8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIS0K7EIS0_HUMAN
Tubulin gamma chain
TUBG1
265Annotation score:
K7EKE5K7EKE5_HUMAN
Tubulin gamma-1 chain
TUBG1
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → A in AAA52620 (PubMed:1904010).Curated1
Sequence conflicti202V → L in AAA52620 (PubMed:1904010).Curated1

Mass spectrometryi

Molecular mass is 51197.98 Da from positions 1 - 451. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07057792Y → C in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123046EnsemblClinVar.1
Natural variantiVAR_070578331T → P in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123047EnsemblClinVar.1
Natural variantiVAR_070579387L → P in CDCBM4; the chaperonin-dependent folding and hence the yield of monomeric gamma-tubulin is compromised. 1 PublicationCorresponds to variant dbSNP:rs398123045EnsemblClinVar.1
Natural variantiVAR_052674413M → V. Corresponds to variant dbSNP:rs13663Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61764 mRNA Translation: AAA52620.1
BT019931 mRNA Translation: AAV38734.1
CR407642 mRNA Translation: CAG28570.1
AK313339 mRNA Translation: BAG36143.1
BC000619 mRNA Translation: AAH00619.1
CCDSiCCDS11433.1
PIRiA39527 UBHUG
RefSeqiNP_001061.2, NM_001070.4
UniGeneiHs.279669

Genome annotation databases

EnsembliENST00000251413; ENSP00000251413; ENSG00000131462
GeneIDi7283
KEGGihsa:7283
UCSCiuc002ian.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61764 mRNA Translation: AAA52620.1
BT019931 mRNA Translation: AAV38734.1
CR407642 mRNA Translation: CAG28570.1
AK313339 mRNA Translation: BAG36143.1
BC000619 mRNA Translation: AAH00619.1
CCDSiCCDS11433.1
PIRiA39527 UBHUG
RefSeqiNP_001061.2, NM_001070.4
UniGeneiHs.279669

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z5VX-ray2.71A1-449[»]
1Z5WX-ray3.00A1-449[»]
3CB2X-ray2.30A/B1-451[»]
ProteinModelPortaliP23258
SMRiP23258
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113134, 246 interactors
CORUMiP23258
DIPiDIP-29890N
IntActiP23258, 131 interactors
MINTiP23258
STRINGi9606.ENSP00000251413

Chemistry databases

DrugBankiDB00570 Vinblastine

PTM databases

iPTMnetiP23258
PhosphoSitePlusiP23258

Polymorphism and mutation databases

BioMutaiTUBG1
DMDMi20455518

2D gel databases

REPRODUCTION-2DPAGEiIPI00295081

Proteomic databases

EPDiP23258
MaxQBiP23258
PaxDbiP23258
PeptideAtlasiP23258
PRIDEiP23258
ProteomicsDBi54075

Protocols and materials databases

DNASUi7283
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251413; ENSP00000251413; ENSG00000131462
GeneIDi7283
KEGGihsa:7283
UCSCiuc002ian.4 human

Organism-specific databases

CTDi7283
DisGeNETi7283
EuPathDBiHostDB:ENSG00000131462.7
GeneCardsiTUBG1
HGNCiHGNC:12417 TUBG1
HPAiCAB004608
MalaCardsiTUBG1
MIMi191135 gene
615412 phenotype
neXtProtiNX_P23258
OpenTargetsiENSG00000131462
PharmGKBiPA37079
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiP23258
KOiK10389
OMAiEGFMLMH
OrthoDBiEOG091G08A9
PhylomeDBiP23258
TreeFamiTF300477

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiP23258

Miscellaneous databases

ChiTaRSiTUBG1 human
EvolutionaryTraceiP23258
GeneWikiiTUBG1
GenomeRNAii7283
PMAP-CutDBiP23258
PROiPR:P23258
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131462 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_TUBG1
ExpressionAtlasiP23258 baseline and differential
GenevisibleiP23258 HS

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBG1_HUMAN
AccessioniPrimary (citable) accession number: P23258
Secondary accession number(s): Q53X79, Q9BW59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 2, 2002
Last modified: November 7, 2018
This is version 196 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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