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UniProtKB - P23258 (TBG1_HUMAN)

Entry version 217 (25 May 2022)
Sequence version 2 (02 May 2002)
Previous versions | rss
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Protein

Tubulin gamma-1 chain

Gene

TUBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi142 – 148GTPSequence analysis7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.5.6, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23258

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P23258

SIGNOR Signaling Network Open Resource

More...SIGNORi		P23258

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin gamma-1 chain
Alternative name(s):
Gamma-1-tubulin
Gamma-tubulin complex component 1
Short name:
GCP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUBG1
Synonyms:TUBG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12417, TUBG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		191135, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23258

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07057792Y → C in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123046EnsemblClinVar.1
Natural variantiVAR_070578331T → P in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123047EnsemblClinVar.1
Natural variantiVAR_070579387L → P in CDCBM4; the chaperonin-dependent folding and hence the yield of monomeric gamma-tubulin is compromised. 1 PublicationCorresponds to variant dbSNP:rs398123045EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Lissencephaly

Organism-specific databases

DisGeNET

More...DisGeNETi		7283

MalaCards human disease database

More...MalaCardsi		TUBG1
MIMi615412, phenotype

Open Targets

More...OpenTargetsi		ENSG00000131462

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		261183, 15q11.2 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37079

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23258, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00570, Vinblastine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TUBG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		20455518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000484651 – 451Tubulin gamma-1 chainAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131Phosphoserine; by BRSK1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P23258

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23258

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23258

MaxQB - The MaxQuant DataBase

More...MaxQBi		P23258

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23258

PeptideAtlas

More...PeptideAtlasi		P23258

PRoteomics IDEntifications database

More...PRIDEi		P23258

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54075

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00295081

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23258

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P23258

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23258

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131462, Expressed in testis and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23258, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23258, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131462, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TUBGCP2 and TUBGCP3 (PubMed:9566969, PubMed:9566969).

Interacts with B9D2 (By similarity).

Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2 (PubMed:17959831).

Interacts with PIFO (PubMed:20643351).

Interacts with SAS6 and NUP62 at the centrosome (PubMed:24107630).

Interacts with EML3 (phosphorylated at 'Thr-881') and HAUS8 (PubMed:30723163).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113134, 342 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P23258

Database of interacting proteins

More...DIPi		DIP-29890N

Protein interaction database and analysis system

More...IntActi		P23258, 157 interactors

Molecular INTeraction database

More...MINTi		P23258

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000251413

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23258, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1451
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P23258

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23258

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23258

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1374, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156957

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23258

Identification of Orthologs from Complete Genome Data

More...OMAi		EHGINKE

Database of Orthologous Groups

More...OrthoDBi		687389at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23258

TreeFam database of animal gene trees

More...TreeFami		TF300477

Family and domain databases

Conserved Domains Database

More...CDDi		cd02188, gamma_tubulin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002454, Gamma_tubulin
IPR008280, Tub_FtsZ_C
IPR000217, Tubulin
IPR037103, Tubulin/FtsZ-like_C
IPR018316, Tubulin/FtsZ_2-layer-sand-dom
IPR036525, Tubulin/FtsZ_GTPase_sf
IPR023123, Tubulin_C
IPR017975, Tubulin_CS
IPR003008, Tubulin_FtsZ_GTPase

The PANTHER Classification System

More...PANTHERi		PTHR11588, PTHR11588, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00091, Tubulin, 1 hit
PF03953, Tubulin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01164, GAMMATUBULIN
PR01161, TUBULIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00864, Tubulin, 1 hit
SM00865, Tubulin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52490, SSF52490, 1 hit
SSF55307, SSF55307, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00227, TUBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P23258-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV 
        60         70         80         90        100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA 
       110        120        130        140        150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG 
       160        170        180        190        200
SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD 
       210        220        230        240        250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN 
       260        270        280        290        300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP 
       310        320        330        340        350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP 
       360        370        380        390        400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK 
       410        420        430        440        450
REAFLEQFRK EDMFKDNFDE MDTSREIVQQ LIDEYHAATR PDYISWGTQE 

Q
Length:451
Mass (Da):51,170
Last modified:May 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2A4C0179ED0CFE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIS0K7EIS0_HUMAN
Tubulin gamma chain
TUBG1
265Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9G6A0A7P0T9G6_HUMAN
Tubulin gamma chain
TUBG1
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKE5K7EKE5_HUMAN
Tubulin gamma-1 chain
TUBG1
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35G → A in AAA52620 (PubMed:1904010).Curated1
Sequence conflicti202V → L in AAA52620 (PubMed:1904010).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 51197.98 Da. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07057792Y → C in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123046EnsemblClinVar.1
Natural variantiVAR_070578331T → P in CDCBM4. 1 PublicationCorresponds to variant dbSNP:rs398123047EnsemblClinVar.1
Natural variantiVAR_070579387L → P in CDCBM4; the chaperonin-dependent folding and hence the yield of monomeric gamma-tubulin is compromised. 1 PublicationCorresponds to variant dbSNP:rs398123045EnsemblClinVar.1
Natural variantiVAR_052674413M → V. Corresponds to variant dbSNP:rs13663Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M61764 mRNA Translation: AAA52620.1
BT019931 mRNA Translation: AAV38734.1
CR407642 mRNA Translation: CAG28570.1
AK313339 mRNA Translation: BAG36143.1
BC000619 mRNA Translation: AAH00619.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11433.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39527, UBHUG

NCBI Reference Sequences

More...RefSeqi		NP_001061.2, NM_001070.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000251413.8; ENSP00000251413.2; ENSG00000131462.9

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7283

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000251413.8; ENSP00000251413.2; NM_001070.5; NP_001061.2

UCSC genome browser

More...UCSCi		uc002ian.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61764 mRNA Translation: AAA52620.1
BT019931 mRNA Translation: AAV38734.1
CR407642 mRNA Translation: CAG28570.1
AK313339 mRNA Translation: BAG36143.1
BC000619 mRNA Translation: AAH00619.1
CCDSiCCDS11433.1
PIRiA39527, UBHUG
RefSeqiNP_001061.2, NM_001070.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z5VX-ray2.71A1-449[»]
1Z5WX-ray3.00A1-449[»]
3CB2X-ray2.30A/B1-451[»]
6V5Velectron microscopy3.80g1-451[»]
6V6Selectron microscopy4.30a/b/c/d/e/f/g/h/i/j/k/l/m/t1-451[»]
7AS4electron microscopy4.131/2/O/P/Q/R/S/T/U/V/W/X/Y/Z1-447[»]
7QJ0electron microscopy5.32U/V/W/X/Y/Z1-451[»]
7QJ1electron microscopy7.00U/V/W/X/Y/Z1-451[»]
7QJ2electron microscopy8.60S/T/U/V/W/X/Y/Z1-451[»]
7QJ3electron microscopy7.601/2/U/V/W/X/Y/Z1-451[»]
7QJ4electron microscopy9.001/2/S/T/U/V/W/X/Y/Z1-451[»]
7QJ5electron microscopy8.701/2/O/P/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJ6electron microscopy7.80Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJ7electron microscopy8.70O/P/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJ8electron microscopy8.701/2/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJ9electron microscopy8.10Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJAelectron microscopy9.20O/P/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJBelectron microscopy9.201/2/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJCelectron microscopy16.101/2/O/P/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJDelectron microscopy7.101/2/O/P/Q/R/S/T/U/V/W/X/Y/Z1-451[»]
7QJEelectron microscopy7.80W/X/Y/Z1-451[»]
AlphaFoldDBiP23258
SMRiP23258
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113134, 342 interactors
CORUMiP23258
DIPiDIP-29890N
IntActiP23258, 157 interactors
MINTiP23258
STRINGi9606.ENSP00000251413

Chemistry databases

DrugBankiDB00570, Vinblastine

PTM databases

iPTMnetiP23258
MetOSiteiP23258
PhosphoSitePlusiP23258

Genetic variation databases

BioMutaiTUBG1
DMDMi20455518

2D gel databases

REPRODUCTION-2DPAGEiIPI00295081

Proteomic databases

EPDiP23258
jPOSTiP23258
MassIVEiP23258
MaxQBiP23258
PaxDbiP23258
PeptideAtlasiP23258
PRIDEiP23258
ProteomicsDBi54075

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P23258, 6 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3898, 601 antibodies from 43 providers

The DNASU plasmid repository

More...DNASUi		7283

Genome annotation databases

EnsembliENST00000251413.8; ENSP00000251413.2; ENSG00000131462.9
GeneIDi7283
KEGGihsa:7283
MANE-SelectiENST00000251413.8; ENSP00000251413.2; NM_001070.5; NP_001061.2
UCSCiuc002ian.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7283
DisGeNETi7283

GeneCards: human genes, protein and diseases

More...GeneCardsi		TUBG1
HGNCiHGNC:12417, TUBG1
HPAiENSG00000131462, Tissue enhanced (testis)
MalaCardsiTUBG1
MIMi191135, gene
615412, phenotype
neXtProtiNX_P23258
OpenTargetsiENSG00000131462
Orphaneti261183, 15q11.2 microdeletion syndrome
PharmGKBiPA37079
VEuPathDBiHostDB:ENSG00000131462

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1374, Eukaryota
GeneTreeiENSGT00940000156957
InParanoidiP23258
OMAiEHGINKE
OrthoDBi687389at2759
PhylomeDBiP23258
TreeFamiTF300477

Enzyme and pathway databases

BRENDAi3.6.5.6, 2681
PathwayCommonsiP23258
ReactomeiR-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2
SignaLinkiP23258
SIGNORiP23258

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7283, 783 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TUBG1, human
EvolutionaryTraceiP23258

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TUBG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7283
PharosiP23258, Tbio

Protein Ontology

More...PROi		PR:P23258
RNActiP23258, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131462, Expressed in testis and 239 other tissues
ExpressionAtlasiP23258, baseline and differential
GenevisibleiP23258, HS

Family and domain databases

CDDicd02188, gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454, Gamma_tubulin
IPR008280, Tub_FtsZ_C
IPR000217, Tubulin
IPR037103, Tubulin/FtsZ-like_C
IPR018316, Tubulin/FtsZ_2-layer-sand-dom
IPR036525, Tubulin/FtsZ_GTPase_sf
IPR023123, Tubulin_C
IPR017975, Tubulin_CS
IPR003008, Tubulin_FtsZ_GTPase
PANTHERiPTHR11588, PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091, Tubulin, 1 hit
PF03953, Tubulin_C, 1 hit
PRINTSiPR01164, GAMMATUBULIN
PR01161, TUBULIN
SMARTiView protein in SMART
SM00864, Tubulin, 1 hit
SM00865, Tubulin_C, 1 hit
SUPFAMiSSF52490, SSF52490, 1 hit
SSF55307, SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227, TUBULIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23258
Secondary accession number(s): Q53X79, Q9BW59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 2, 2002
Last modified: May 25, 2022
This is version 217 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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