UniProtKB - P23246 (SFPQ_HUMAN)
Splicing factor, proline- and glutamine-rich
SFPQ
Functioni
Caution
GO - Molecular functioni
- chromatin binding Source: BHF-UCL
- DNA binding Source: UniProtKB
- E-box binding Source: UniProtKB
- histone deacetylase binding Source: ParkinsonsUK-UCL
- nucleic acid binding Source: GO_Central
- protein homodimerization activity Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- transcription regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCL
GO - Biological processi
- activation of innate immune response Source: UniProtKB
- alternative mRNA splicing, via spliceosome Source: BHF-UCL
- double-strand break repair via homologous recombination Source: MGI
- histone H3 deacetylation Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- mRNA processing Source: ProtInc
- mRNA splicing, via spliceosome Source: GO_Central
- negative regulation of circadian rhythm Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of sister chromatid cohesion Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
- rhythmic process Source: UniProtKB-KW
- RNA splicing Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding, Repressor, RNA-binding |
Biological process | Biological rhythms, DNA damage, DNA recombination, DNA repair, Immunity, Innate immunity, mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P23246 |
Reactomei | R-HSA-8849468, PTK6 Regulates Proteins Involved in RNA Processing R-HSA-9635465, Suppression of apoptosis |
SIGNORi | P23246 |
Names & Taxonomyi
Protein namesi | Recommended name: Splicing factor, proline- and glutamine-richAlternative name(s): 100 kDa DNA-pairing protein Short name: hPOMp100 DNA-binding p52/p100 complex, 100 kDa subunit Polypyrimidine tract-binding protein-associated-splicing factor1 Publication Short name: PSF1 Publication Short name: PTB-associated-splicing factor |
Gene namesi | Name:SFPQ Synonyms:PSF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000116560.10 |
HGNCi | HGNC:10774, SFPQ |
MIMi | 605199, gene |
neXtProti | NX_P23246 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
- Nucleus matrix 3 Publications
Other locations
- Cytoplasm 1 Publication
Note: Predominantly in nuclear matrix.1 Publication
Nucleus
- nuclear matrix Source: BHF-UCL
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: BHF-UCL
- nucleus Source: ParkinsonsUK-UCL
- paraspeckles Source: UniProtKB
Other locations
- chromatin Source: ParkinsonsUK-UCL
- cytoplasm Source: UniProtKB-SubCell
- RNA polymerase II transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 535 | L → A: Impairs DNA binding and ability to mediate transcriptional activation; when associated with A-539; A-546 and A-549. 1 Publication | 1 | |
Mutagenesisi | 539 | L → A: Impairs DNA binding and ability to mediate transcriptional activation; when associated with A-535; A-546 and A-549. 1 Publication | 1 | |
Mutagenesisi | 546 | L → A: Impairs DNA binding and ability to mediate transcriptional activation; when associated with A-535; A-539 and A-549. 1 Publication | 1 | |
Mutagenesisi | 549 | M → A: Impairs DNA binding and ability to mediate transcriptional activation; when associated with A-535; A-539 and A-546. 1 Publication | 1 | |
Mutagenesisi | 687 | T → A: Abolishes phosphorylation by GSK3B. Impairs interaction with THRAP3. 1 Publication | 1 | |
Mutagenesisi | 687 | T → D: No effect on interaction with THRAP3 (phosphomimetic). 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 662 – 663 | Breakpoint for translocation to form SFPQ-TFE3 | 2 |
Organism-specific databases
DisGeNETi | 6421 |
MalaCardsi | SFPQ |
OpenTargetsi | ENSG00000116560 |
Orphaneti | 319308, MiT family translocation renal cell carcinoma |
PharmGKBi | PA35690 |
Miscellaneous databases
Pharosi | P23246, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol DB09130, Copper |
Polymorphism and mutation databases
BioMutai | SFPQ |
DMDMi | 1709851 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081909 | 1 – 707 | Splicing factor, proline- and glutamine-richAdd BLAST | 707 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | Phosphoserine; by MKNK21 Publication | 1 | |
Modified residuei | 9 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 9 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 208 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 236 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 242 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 245 | Omega-N-methylarginineCombined sources | 1 | |
Cross-linki | 271 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Cross-linki | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 283 | Phosphoserine; by MKNK2Combined sources1 Publication | 1 | |
Modified residuei | 293 | Phosphotyrosine; by ALK1 Publication | 1 | |
Modified residuei | 314 | N6,N6-dimethyllysine1 Publication | 1 | |
Modified residuei | 319 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 338 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 338 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 368 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 374 | PhosphoserineCombined sources | 1 | |
Modified residuei | 379 | PhosphoserineCombined sources | 1 | |
Modified residuei | 421 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 472 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 496 | PhosphoserineCombined sources | 1 | |
Modified residuei | 571 | Dimethylated arginine1 Publication | 1 | |
Modified residuei | 626 | PhosphoserineCombined sources | 1 | |
Modified residuei | 681 | Omega-N-methylarginineCombined sources1 Publication | 1 | |
Modified residuei | 687 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 691 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 693 | Dimethylated arginine; alternate1 Publication | 1 | |
Modified residuei | 693 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 695 | Omega-N-methylarginineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P23246 |
jPOSTi | P23246 |
MassIVEi | P23246 |
MaxQBi | P23246 |
PaxDbi | P23246 |
PeptideAtlasi | P23246 |
PRIDEi | P23246 |
ProteomicsDBi | 54073 [P23246-1] 54074 [P23246-2] |
2D gel databases
SWISS-2DPAGEi | P23246 |
PTM databases
iPTMneti | P23246 |
MetOSitei | P23246 |
PhosphoSitePlusi | P23246 |
SwissPalmi | P23246 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116560, Expressed in oviduct epithelium and 245 other tissues |
ExpressionAtlasi | P23246, baseline and differential |
Genevisiblei | P23246, HS |
Organism-specific databases
HPAi | ENSG00000116560, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with NONO (PubMed:25765647). Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits (PubMed:8439294, PubMed:25765647). The coiled coil domain mediates interaction with NONO, and can also mediate formation of long, linear homooligomers (in vitro) (PubMed:25765647). SFPQ is a component of spliceosome and U5.4/6 snRNP complexes (PubMed:9409622, PubMed:8045264, PubMed:12403470).
Interacts with SNRPA/U1A (PubMed:9848648).
Component of a snRNP-free complex with SNRPA/U1A (PubMed:9848648). Part of complex consisting of SFPQ, NONO and MATR3 (PubMed:11525732).
Interacts with polypyrimidine tract-binding protein 1/PTB (PubMed:10653975).
Part of a complex consisting of SFPQ, NONO and NR5A1 (PubMed:11897684).
Interacts with RXRA, probably THRA, and SIN3A (PubMed:11259580).
Interacts with TOP1 (PubMed:9756848).
Part of a complex consisting of SFPQ, NONO and TOP1 (PubMed:9756848).
Interacts with SNRNP70 in apoptotic cells (PubMed:11514619).
Interacts with PSPC1.
Interacts with RNF43 (PubMed:18655028).
Interacts with PITX3 and NR4A2/NURR1 (By similarity).
Interacts with PTK6 (PubMed:19439179).
Interacts with THRAP3; the interaction is dependent on SFPQ phosphorylation at 'Thr-687' and inhibits binding of SFPQ to a ESS1 exonic splicing silencer element-containing RNA (PubMed:20932480). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A.
Interacts with PER1 and PER2 (By similarity).
Interacts with PQBP1 (PubMed:21933836).
Component of a multiprotein complex with NONO and WASL (PubMed:16767080).
Interacts with ERCC6 (PubMed:26030138).
By similarity19 Publications(Microbial infection) Interacts with M.tuberculosis protein Rv3654c, which probably leads to the cleavage of PSF, diminishes the level of caspase-8 in macrophages and suppresses macrophage apoptosis by blocking the extrinsic pathway. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA.
2 PublicationsBinary interactionsi
Hide detailsP23246
Isoform Long [P23246-1]
With | #Exp. | IntAct |
---|---|---|
Rxra [P28700] from Mus musculus. | 3 | EBI-355463,EBI-346715 |
THRA [P04625] from Gallus gallus. | 2 | EBI-355463,EBI-286261 |
GO - Molecular functioni
- histone deacetylase binding Source: ParkinsonsUK-UCL
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112319, 344 interactors |
CORUMi | P23246 |
DIPi | DIP-31272N |
IntActi | P23246, 110 interactors |
MINTi | P23246 |
STRINGi | 9606.ENSP00000349748 |
Miscellaneous databases
RNActi | P23246, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | P23246 |
SMRi | P23246 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 9 – 11 | 1 | 3 | |
Repeati | 19 – 21 | 2 | 3 | |
Repeati | 25 – 27 | 3 | 3 | |
Domaini | 297 – 369 | RRM 1PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 371 – 452 | RRM 2PROSITE-ProRule annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 9 – 27 | 3 X 3 AA repeats of R-G-GAdd BLAST | 19 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 497 – 596 | Sequence analysis1 PublicationAdd BLAST | 100 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 266 | Gln/Glu/Pro-richAdd BLAST | 257 | |
Compositional biasi | 10 – 15 | Poly-Gly | 6 | |
Compositional biasi | 20 – 27 | Poly-Gly | 8 | |
Compositional biasi | 56 – 65 | Poly-Pro | 10 | |
Compositional biasi | 67 – 71 | Poly-Gln | 5 | |
Compositional biasi | 95 – 98 | Poly-Gln | 4 | |
Compositional biasi | 99 – 103 | Poly-Pro | 5 | |
Compositional biasi | 184 – 188 | Poly-Pro | 5 | |
Compositional biasi | 571 – 574 | Poly-Arg | 4 | |
Compositional biasi | 613 – 616 | Poly-Gly | 4 | |
Compositional biasi | 635 – 641 | Poly-Gly | 7 |
Domaini
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0115, Eukaryota |
GeneTreei | ENSGT00940000156221 |
HOGENOMi | CLU_027185_1_0_1 |
InParanoidi | P23246 |
OMAi | DMRAERF |
OrthoDBi | 1274880at2759 |
PhylomeDBi | P23246 |
TreeFami | TF315795 |
Family and domain databases
CDDi | cd12948, NOPS_PSF, 1 hit cd12587, RRM1_PSF, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012975, NOPS IPR012677, Nucleotide-bd_a/b_plait_sf IPR034526, PSF_NOPS IPR034525, PSF_RRM1 IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF08075, NOPS, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG
60 70 80 90 100
PGQSGPKPPI PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP
110 120 130 140 150
PPPQDSSKPV VAQGPGPAPG VGSAPPASSS APPATPPTSG APPGSGPGPT
160 170 180 190 200
PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ AGGPPPPPAA VPGPGPGPKQ
210 220 230 240 250
GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPHRGGGE PRGGRQHHPP
260 270 280 290 300
YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF
310 320 330 340 350
VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA
360 370 380 390 400
ELDDTPMRGR QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA
410 420 430 440 450
VVIVDDRGRS TGKGIVEFAS KPAARKAFER CSEGVFLLTT TPRPVIVEPL
460 470 480 490 500
EQLDDEDGLP EKLAQKNPMY QKERETPPRF AQHGTFEYEY SQRWKSLDEM
510 520 530 540 550
EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM RRQEELRRME
560 570 580 590 600
ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEEQMR RQREESYSRM
610 620 630 640 650
GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP
660 670 680 690 700
ATMSGSMMGS DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG
PNKKPRF
The sequence of this isoform differs from the canonical sequence as follows:
663-707: RTERFGQGGAGPVGGQGPRGMGPGTPAGYGRGREEYEGPNKKPRF → VRMIDVG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y9K7 | H0Y9K7_HUMAN | Splicing factor, proline- and gluta... | SFPQ | 223 | Annotation score: | ||
H0Y9U2 | H0Y9U2_HUMAN | Splicing factor, proline- and gluta... | SFPQ | 88 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 243 | G → R AA sequence (PubMed:8439294).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005855 | 663 – 707 | RTERF…KKPRF → VRMIDVG in isoform Short. CuratedAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70944 mRNA Translation: CAA50283.1 AL590434 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07426.1 X16850 mRNA Translation: CAA34747.1 |
CCDSi | CCDS388.1 [P23246-1] |
PIRi | A46302 S29770 |
RefSeqi | NP_005057.1, NM_005066.2 [P23246-1] XP_005271169.1, XM_005271112.4 [P23246-1] XP_005271170.1, XM_005271113.4 [P23246-1] XP_005271172.1, XM_005271115.4 [P23246-2] XP_016857542.1, XM_017002053.1 [P23246-1] XP_016857543.1, XM_017002054.1 [P23246-1] |
Genome annotation databases
Ensembli | ENST00000357214; ENSP00000349748; ENSG00000116560 [P23246-1] |
GeneIDi | 6421 |
KEGGi | hsa:6421 |
UCSCi | uc001bys.4, human [P23246-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70944 mRNA Translation: CAA50283.1 AL590434 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07426.1 X16850 mRNA Translation: CAA34747.1 |
CCDSi | CCDS388.1 [P23246-1] |
PIRi | A46302 S29770 |
RefSeqi | NP_005057.1, NM_005066.2 [P23246-1] XP_005271169.1, XM_005271112.4 [P23246-1] XP_005271170.1, XM_005271113.4 [P23246-1] XP_005271172.1, XM_005271115.4 [P23246-2] XP_016857542.1, XM_017002053.1 [P23246-1] XP_016857543.1, XM_017002054.1 [P23246-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4WII | X-ray | 2.05 | A/B | 276-535 | [»] | |
4WIJ | X-ray | 3.49 | A/B | 276-598 | [»] | |
4WIK | X-ray | 3.00 | A/B | 369-598 | [»] | |
5WPA | X-ray | 2.29 | A | 276-535 | [»] | |
6NCQ | X-ray | 1.90 | A | 276-535 | [»] | |
6OWJ | X-ray | 1.94 | A/B | 276-535 | [»] | |
SASBDBi | P23246 | |||||
SMRi | P23246 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112319, 344 interactors |
CORUMi | P23246 |
DIPi | DIP-31272N |
IntActi | P23246, 110 interactors |
MINTi | P23246 |
STRINGi | 9606.ENSP00000349748 |
Chemistry databases
DrugBanki | DB11638, Artenimol DB09130, Copper |
PTM databases
iPTMneti | P23246 |
MetOSitei | P23246 |
PhosphoSitePlusi | P23246 |
SwissPalmi | P23246 |
Polymorphism and mutation databases
BioMutai | SFPQ |
DMDMi | 1709851 |
2D gel databases
SWISS-2DPAGEi | P23246 |
Proteomic databases
EPDi | P23246 |
jPOSTi | P23246 |
MassIVEi | P23246 |
MaxQBi | P23246 |
PaxDbi | P23246 |
PeptideAtlasi | P23246 |
PRIDEi | P23246 |
ProteomicsDBi | 54073 [P23246-1] 54074 [P23246-2] |
Protocols and materials databases
Antibodypediai | 4083, 299 antibodies |
Genome annotation databases
Ensembli | ENST00000357214; ENSP00000349748; ENSG00000116560 [P23246-1] |
GeneIDi | 6421 |
KEGGi | hsa:6421 |
UCSCi | uc001bys.4, human [P23246-1] |
Organism-specific databases
CTDi | 6421 |
DisGeNETi | 6421 |
EuPathDBi | HostDB:ENSG00000116560.10 |
GeneCardsi | SFPQ |
HGNCi | HGNC:10774, SFPQ |
HPAi | ENSG00000116560, Low tissue specificity |
MalaCardsi | SFPQ |
MIMi | 605199, gene |
neXtProti | NX_P23246 |
OpenTargetsi | ENSG00000116560 |
Orphaneti | 319308, MiT family translocation renal cell carcinoma |
PharmGKBi | PA35690 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0115, Eukaryota |
GeneTreei | ENSGT00940000156221 |
HOGENOMi | CLU_027185_1_0_1 |
InParanoidi | P23246 |
OMAi | DMRAERF |
OrthoDBi | 1274880at2759 |
PhylomeDBi | P23246 |
TreeFami | TF315795 |
Enzyme and pathway databases
PathwayCommonsi | P23246 |
Reactomei | R-HSA-8849468, PTK6 Regulates Proteins Involved in RNA Processing R-HSA-9635465, Suppression of apoptosis |
SIGNORi | P23246 |
Miscellaneous databases
BioGRID-ORCSi | 6421, 731 hits in 845 CRISPR screens |
ChiTaRSi | SFPQ, human |
GeneWikii | SFPQ |
GenomeRNAii | 6421 |
Pharosi | P23246, Tbio |
PROi | PR:P23246 |
RNActi | P23246, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116560, Expressed in oviduct epithelium and 245 other tissues |
ExpressionAtlasi | P23246, baseline and differential |
Genevisiblei | P23246, HS |
Family and domain databases
CDDi | cd12948, NOPS_PSF, 1 hit cd12587, RRM1_PSF, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012975, NOPS IPR012677, Nucleotide-bd_a/b_plait_sf IPR034526, PSF_NOPS IPR034525, PSF_RRM1 IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF08075, NOPS, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFPQ_HUMAN | |
Accessioni | P23246Primary (citable) accession number: P23246 Secondary accession number(s): P30808, Q5SZ71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 228 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM