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UniProtKB - P23229 (ITA6_HUMAN)

Entry version 220 (02 Jun 2021)
Sequence version 5 (26 Jun 2013)
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Protein

Integrin alpha-6

Gene

ITGA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).

Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).

ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).

ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).

ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).

By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi363 – 371Sequence analysis9
Calcium bindingi425 – 433Sequence analysis9
Calcium bindingi480 – 488Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23229

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-210991, Basigin interactions
R-HSA-216083, Integrin cell surface interactions
R-HSA-3000157, Laminin interactions
R-HSA-3000170, Syndecan interactions
R-HSA-446107, Type I hemidesmosome assembly

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P23229

SIGNOR Signaling Network Open Resource

More...SIGNORi		P23229

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.54.1.2, the integrin (integrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
CD49 antigen-like family member F
VLA-6
CD_antigen: CD49f
Cleaved into the following 3 chains:
Integrin alpha-6 heavy chain
Integrin alpha-6 light chain
Processed integrin alpha-6
Short name:
Alpha6p1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6142, ITGA6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147556, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23229

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000091409.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 1050ExtracellularSequence analysisAdd BLAST1027
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1051 – 1076HelicalSequence analysisAdd BLAST26
Topological domaini1077 – 1130CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Related information in OMIM

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

DisGeNET

More...DisGeNETi		3655

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ITGA6

MalaCards human disease database

More...MalaCardsi		ITGA6
MIMi226730, phenotype

Open Targets

More...OpenTargetsi		ENSG00000091409

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		79403, Junctional epidermolysis bullosa with pyloric atresia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29942

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23229, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3716

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ITGA6

Domain mapping of disease mutations (DMDM)

More...DMDMi		519668687

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 233 PublicationsAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001625824 – 1130Integrin alpha-6Add BLAST1107
ChainiPRO_000001625924 – 938Integrin alpha-6 heavy chainSequence analysisAdd BLAST915
ChainiPRO_0000425742636 – 1130Processed integrin alpha-61 PublicationAdd BLAST495
ChainiPRO_0000016260942 – 1130Integrin alpha-6 light chainSequence analysisAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi86 ↔ 94By similarity
Disulfide bondi131 ↔ 154By similarity
Disulfide bondi175 ↔ 188By similarity
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi528 ↔ 535By similarity
Disulfide bondi541 ↔ 601By similarity
Disulfide bondi665 ↔ 671By similarity
Disulfide bondi765 ↔ 776By similarity
Glycosylationi770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi920 ↔ 967Interchain (between heavy and light chains)By similarity
Glycosylationi930N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi973 ↔ 978By similarity
Glycosylationi997N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1078S-palmitoyl cysteine; by DHHC32 Publications1
Isoform Alpha-6X2A (identifier: P23229-4)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1059Phosphoserine1 Publication1
Isoform Alpha-6X1A (identifier: P23229-2)
Modified residuei1064Phosphoserine1 Publication1
Isoform Alpha-6X1X2A (identifier: P23229-6)
Modified residuei1103Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p) (PubMed:11359780, PubMed:15023541, PubMed:17303120). Production of alpha6p enhances prostate cancer cell invasion and migration (PubMed:17303120).3 Publications
Palmitoylation by DHHC3 enhances stability and cell surface expression.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei634 – 635Cleavage; by PLAU in invasive prostate cancer1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-528
CPTAC-529

Encyclopedia of Proteome Dynamics

More...EPDi		P23229

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23229

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23229

MaxQB - The MaxQuant DataBase

More...MaxQBi		P23229

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23229

PeptideAtlas

More...PeptideAtlasi		P23229

PRoteomics IDEntifications database

More...PRIDEi		P23229

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33937
54065 [P23229-1]
54066 [P23229-2]
54067 [P23229-3]
54068 [P23229-4]
54069 [P23229-5]
54070 [P23229-6]
54071 [P23229-7]
54072 [P23229-9]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P23229

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P23229

GlyConnect protein glycosylation platform

More...GlyConnecti		1408, 20 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23229, 13 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23229

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23229

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P23229

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Processed integrin alpha-6: Expressed at low levels in normal prostate tissue with elevated levels in prostate cancer tissue (at protein level) (PubMed:15023541).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000091409, Expressed in sural nerve and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23229, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23229, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000091409, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond (By similarity). Alpha-6 associates with either beta-1 (ITGB1) or beta-4 (ITGB4) to form ITGA6:ITGB1 and ITGA6:ITGB4, respectively (By similarity). ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R (PubMed:22351760). ITGA6:ITGB4 interacts with IGF2 (PubMed:28873464).

Interacts with ADAM9 (By similarity).

Interacts with RAB21 (PubMed:16754960).

Interacts with MDK (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109864, 77 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1803, Integrin alpha6-beta1 complex
CPX-1822, Integrin alpha6-beta4 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P23229

Protein interaction database and analysis system

More...IntActi		P23229, 35 interactors

Molecular INTeraction database

More...MINTi		P23229

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386896

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23229, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati30 – 95FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati101 – 166FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati176 – 229FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati283 – 339FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati340 – 402FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati403 – 458FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati459 – 518FG-GAP 7PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1077 – 1083Interaction with HPS57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1079 – 1083GFFKR motif5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3637, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155353

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004111_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23229

Identification of Orthologs from Complete Genome Data

More...OMAi		KCSCPLE

Database of Orthologous Groups

More...OrthoDBi		743479at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23229

TreeFam database of animal gene trees

More...TreeFami		TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.130, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01839, FG-GAP, 2 hits
PF08441, Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01185, INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00191, Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF69179, SSF69179, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-6X1X2B (identifier: P23229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 
       960        970        980        990       1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 
      1010       1020       1030       1040       1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 
      1060       1070       1080       1090       1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK 
      1110       1120       1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS
Length:1,130
Mass (Da):126,606
Last modified:June 26, 2013 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB53712888B7FE3B6
GO
Isoform Alpha-6X1A (identifier: P23229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,073
Mass (Da):119,476
Checksum:iD5291DAEAE855B6C
GO
Isoform Alpha-6X1B (identifier: P23229-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.

Show »
Length:1,091
Mass (Da):122,053
Checksum:i9CBF2E4DD0521D9A
GO
Isoform Alpha-6X2A (identifier: P23229-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,068
Mass (Da):119,088
Checksum:iAC0543FE6C6AD304
GO
Isoform Alpha-6X2B (identifier: P23229-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:1,086
Mass (Da):121,665
Checksum:iBE4FA13704B1FC07
GO
Isoform Alpha-6X1X2A (identifier: P23229-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,112
Mass (Da):124,029
Checksum:i3B3FA491633C798C
GO
Isoform 7 (identifier: P23229-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:954
Mass (Da):106,577
Checksum:iD40E820AF20A5FEA
GO
Isoform 9 (identifier: P23229-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     918-932: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,097
Mass (Da):122,358
Checksum:i88DAB7B462FA6508
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXX7C9JXX7_HUMAN
Integrin alpha-6
ITGA6
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ97H7BZ97_HUMAN
Integrin alpha-6
ITGA6
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG57680 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69A → G in CAA37655 (PubMed:1976638).Curated1
Sequence conflicti69A → G in CAA42099 (PubMed:2070796).Curated1
Sequence conflicti419A → T in BAG59130 (PubMed:14702039).Curated1
Sequence conflicti419A → T in AAI36456 (PubMed:15489334).Curated1
Sequence conflicti419A → T in AAI36457 (PubMed:15489334).Curated1
Sequence conflicti501F → L in CAA42099 (PubMed:2070796).Curated1
Sequence conflicti805D → Y in CAA37655 (PubMed:1976638).Curated1
Sequence conflicti805D → Y in AAD48469 (Ref. 3) Curated1
Sequence conflicti1125E → R in AAB20355 (PubMed:1976638).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0364061 – 114Missing in isoform 7. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_002723215 – 258Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_002724259 – 297Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_036407918 – 932Missing in isoform 9. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0027251084 – 1130SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X53586 mRNA Translation: CAA37655.1
AF166343 AF166342 Genomic DNA Translation: AAD48469.1
AK294436 mRNA Translation: BAG57680.1 Different initiation.
AK296496 mRNA Translation: BAG59130.1
AC078883 Genomic DNA Translation: AAX93133.1
CH471058 Genomic DNA Translation: EAX11176.1
CH471058 Genomic DNA Translation: EAX11177.1
BC050585 mRNA Translation: AAH50585.1
BC136455 mRNA Translation: AAI36456.1
BC136456 mRNA Translation: AAI36457.1
X59512 mRNA Translation: CAA42099.1
S66213 mRNA Translation: AAB20355.1
S66196 mRNA Translation: AAB20354.1
S52135 Genomic DNA Translation: AAB24829.1
L40385 Genomic DNA No translation available.
AB208842 mRNA Translation: BAD92079.1
DQ858220 mRNA Translation: ABH11650.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2249.1 [P23229-2]
CCDS46451.1 [P23229-3]
CCDS82534.1 [P23229-7]

Protein sequence database of the Protein Information Resource

More...PIRi		A41543
B36429

NCBI Reference Sequences

More...RefSeqi		NP_000201.2, NM_000210.3 [P23229-2]
NP_001073286.1, NM_001079818.2 [P23229-3]
NP_001303235.1, NM_001316306.1 [P23229-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3655

UCSC genome browser

More...UCSCi		uc002uho.2, human [P23229-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53586 mRNA Translation: CAA37655.1
AF166343 AF166342 Genomic DNA Translation: AAD48469.1
AK294436 mRNA Translation: BAG57680.1 Different initiation.
AK296496 mRNA Translation: BAG59130.1
AC078883 Genomic DNA Translation: AAX93133.1
CH471058 Genomic DNA Translation: EAX11176.1
CH471058 Genomic DNA Translation: EAX11177.1
BC050585 mRNA Translation: AAH50585.1
BC136455 mRNA Translation: AAI36456.1
BC136456 mRNA Translation: AAI36457.1
X59512 mRNA Translation: CAA42099.1
S66213 mRNA Translation: AAB20355.1
S66196 mRNA Translation: AAB20354.1
S52135 Genomic DNA Translation: AAB24829.1
L40385 Genomic DNA No translation available.
AB208842 mRNA Translation: BAD92079.1
DQ858220 mRNA Translation: ABH11650.1
CCDSiCCDS2249.1 [P23229-2]
CCDS46451.1 [P23229-3]
CCDS82534.1 [P23229-7]
PIRiA41543
B36429
RefSeqiNP_000201.2, NM_000210.3 [P23229-2]
NP_001073286.1, NM_001079818.2 [P23229-3]
NP_001303235.1, NM_001316306.1 [P23229-7]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109864, 77 interactors
ComplexPortaliCPX-1803, Integrin alpha6-beta1 complex
CPX-1822, Integrin alpha6-beta4 complex
CORUMiP23229
IntActiP23229, 35 interactors
MINTiP23229
STRINGi9606.ENSP00000386896

Chemistry databases

ChEMBLiCHEMBL3716

Protein family/group databases

TCDBi8.A.54.1.2, the integrin (integrin) family

PTM databases

CarbonylDBiP23229
GlyConnecti1408, 20 N-Linked glycans (4 sites)
GlyGeniP23229, 13 sites, 1 N-linked glycan (1 site)
iPTMnetiP23229
PhosphoSitePlusiP23229
SwissPalmiP23229

Genetic variation databases

BioMutaiITGA6
DMDMi519668687

2D gel databases

OGPiP23229

Proteomic databases

CPTACiCPTAC-528
CPTAC-529
EPDiP23229
jPOSTiP23229
MassIVEiP23229
MaxQBiP23229
PaxDbiP23229
PeptideAtlasiP23229
PRIDEiP23229
ProteomicsDBi33937
54065 [P23229-1]
54066 [P23229-2]
54067 [P23229-3]
54068 [P23229-4]
54069 [P23229-5]
54070 [P23229-6]
54071 [P23229-7]
54072 [P23229-9]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P23229, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1485, 1323 antibodies

The DNASU plasmid repository

More...DNASUi		3655

Genome annotation databases

EnsembliENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5]
GeneIDi3655
KEGGihsa:3655
UCSCiuc002uho.2, human [P23229-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3655
DisGeNETi3655

GeneCards: human genes, protein and diseases

More...GeneCardsi		ITGA6
GeneReviewsiITGA6
HGNCiHGNC:6142, ITGA6
HPAiENSG00000091409, Low tissue specificity
MalaCardsiITGA6
MIMi147556, gene
226730, phenotype
neXtProtiNX_P23229
OpenTargetsiENSG00000091409
Orphaneti79403, Junctional epidermolysis bullosa with pyloric atresia
PharmGKBiPA29942
VEuPathDBiHostDB:ENSG00000091409.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3637, Eukaryota
GeneTreeiENSGT00940000155353
HOGENOMiCLU_004111_1_0_1
InParanoidiP23229
OMAiKCSCPLE
OrthoDBi743479at2759
PhylomeDBiP23229
TreeFamiTF105391

Enzyme and pathway databases

PathwayCommonsiP23229
ReactomeiR-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-210991, Basigin interactions
R-HSA-216083, Integrin cell surface interactions
R-HSA-3000157, Laminin interactions
R-HSA-3000170, Syndecan interactions
R-HSA-446107, Type I hemidesmosome assembly
SignaLinkiP23229
SIGNORiP23229

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3655, 16 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITGA6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ITGA6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3655
PharosiP23229, Tbio

Protein Ontology

More...PROi		PR:P23229
RNActiP23229, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000091409, Expressed in sural nerve and 251 other tissues
ExpressionAtlasiP23229, baseline and differential
GenevisibleiP23229, HS

Family and domain databases

Gene3Di2.130.10.130, 2 hits
InterProiView protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
PfamiView protein in Pfam
PF01839, FG-GAP, 2 hits
PF08441, Integrin_alpha2, 1 hit
PRINTSiPR01185, INTEGRINA
SMARTiView protein in SMART
SM00191, Int_alpha, 5 hits
SUPFAMiSSF69179, SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470, FG_GAP, 7 hits
PS00242, INTEGRIN_ALPHA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23229
Secondary accession number(s): B2RMU9
, B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 220 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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