UniProtKB - P23229 (ITA6_HUMAN)
Integrin alpha-6
ITGA6
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 363 – 371 | Sequence analysis | 9 | |
Calcium bindingi | 425 – 433 | Sequence analysis | 9 | |
Calcium bindingi | 480 – 488 | Sequence analysis | 9 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- insulin-like growth factor I binding Source: UniProtKB
- laminin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- neuregulin binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- brown fat cell differentiation Source: Ensembl
- cell-cell adhesion Source: Ensembl
- cell-matrix adhesion Source: Ensembl
- cell-substrate adhesion Source: UniProtKB
- cell-substrate junction assembly Source: ProtInc
- cellular response to extracellular stimulus Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- ectodermal cell differentiation Source: UniProtKB
- extracellular matrix organization Source: Reactome
- filopodium assembly Source: Ensembl
- hemidesmosome assembly Source: Reactome
- integrin-mediated signaling pathway Source: UniProtKB-KW
- leukocyte migration Source: Reactome
- nail development Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell-cell adhesion Source: Ensembl
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell-substrate adhesion Source: Ensembl
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- positive regulation of phosphorylation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- skin morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Integrin, Receptor |
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P23229 |
Reactomei | R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-210991, Basigin interactions R-HSA-216083, Integrin cell surface interactions R-HSA-3000157, Laminin interactions R-HSA-3000170, Syndecan interactions R-HSA-446107, Type I hemidesmosome assembly |
SignaLinki | P23229 |
SIGNORi | P23229 |
Protein family/group databases
TCDBi | 8.A.54.1.2, the integrin (integrin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Integrin alpha-6Alternative name(s): CD49 antigen-like family member F VLA-6 CD_antigen: CD49f Cleaved into the following 3 chains: |
Gene namesi | Name:ITGA6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6142, ITGA6 |
MIMi | 147556, gene |
neXtProti | NX_P23229 |
VEuPathDBi | HostDB:ENSG00000091409.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
- Cell membrane 1 Publication; Lipid-anchor 1 Publication
Extracellular region or secreted
- basement membrane Source: Ensembl
Plasma Membrane
- basal plasma membrane Source: Ensembl
- external side of plasma membrane Source: Ensembl
- integrin alpha6-beta4 complex Source: Ensembl
- plasma membrane Source: BHF-UCL
Other locations
- adherens junction Source: Ensembl
- cell surface Source: UniProtKB
- filopodium Source: Ensembl
- focal adhesion Source: UniProtKB
- hemidesmosome Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 1050 | ExtracellularSequence analysisAdd BLAST | 1027 | |
Transmembranei | 1051 – 1076 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 1077 – 1130 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
Keywords - Diseasei
Epidermolysis bullosaOrganism-specific databases
DisGeNETi | 3655 |
GeneReviewsi | ITGA6 |
MalaCardsi | ITGA6 |
MIMi | 226730, phenotype |
OpenTargetsi | ENSG00000091409 |
Orphaneti | 79403, Junctional epidermolysis bullosa-pyloric atresia syndrome |
PharmGKBi | PA29942 |
Miscellaneous databases
Pharosi | P23229, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3716 |
Genetic variation databases
BioMutai | ITGA6 |
DMDMi | 519668687 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 3 PublicationsAdd BLAST | 23 | |
ChainiPRO_0000016258 | 24 – 1130 | Integrin alpha-6Add BLAST | 1107 | |
ChainiPRO_0000016259 | 24 – 938 | Integrin alpha-6 heavy chainSequence analysisAdd BLAST | 915 | |
ChainiPRO_0000425742 | 636 – 1130 | Processed integrin alpha-61 PublicationAdd BLAST | 495 | |
ChainiPRO_0000016260 | 942 – 1130 | Integrin alpha-6 light chainSequence analysisAdd BLAST | 189 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 86 ↔ 94 | By similarity | |||
Disulfide bondi | 131 ↔ 154 | By similarity | |||
Disulfide bondi | 175 ↔ 188 | By similarity | |||
Glycosylationi | 223 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 323 | N-linked (GlcNAc...) asparagine1 Publication | 1 | ||
Glycosylationi | 409 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 528 ↔ 535 | By similarity | |||
Disulfide bondi | 541 ↔ 601 | By similarity | |||
Disulfide bondi | 665 ↔ 671 | By similarity | |||
Disulfide bondi | 765 ↔ 776 | By similarity | |||
Glycosylationi | 770 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 787 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 920 ↔ 967 | Interchain (between heavy and light chains)By similarity | |||
Glycosylationi | 930 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 966 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 973 ↔ 978 | By similarity | |||
Glycosylationi | 997 | N-linked (GlcNAc...) asparagine1 Publication | 1 | ||
Lipidationi | 1078 | S-palmitoyl cysteine; by DHHC32 Publications | 1 | ||
Isoform Alpha-6X2A (identifier: P23229-4) | |||||
Modified residuei | 1059 | Phosphoserine1 Publication | 1 | ||
Isoform Alpha-6X1A (identifier: P23229-2) | |||||
Modified residuei | 1064 | Phosphoserine1 Publication | 1 | ||
Isoform Alpha-6X1X2A (identifier: P23229-6) | |||||
Modified residuei | 1103 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 634 – 635 | Cleavage; by PLAU in invasive prostate cancer1 Publication | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
CPTACi | CPTAC-528 CPTAC-529 |
EPDi | P23229 |
jPOSTi | P23229 |
MassIVEi | P23229 |
MaxQBi | P23229 |
PaxDbi | P23229 |
PeptideAtlasi | P23229 |
PRIDEi | P23229 |
ProteomicsDBi | 33937 54065 [P23229-1] 54066 [P23229-2] 54067 [P23229-3] 54068 [P23229-4] 54069 [P23229-5] 54070 [P23229-6] 54071 [P23229-7] 54072 [P23229-9] |
2D gel databases
OGPi | P23229 |
PTM databases
CarbonylDBi | P23229 |
GlyConnecti | 1408, 20 N-Linked glycans (4 sites) |
GlyGeni | P23229, 13 sites, 1 N-linked glycan (1 site) |
iPTMneti | P23229 |
PhosphoSitePlusi | P23229 |
SwissPalmi | P23229 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000091409, Expressed in sural nerve and 250 other tissues |
ExpressionAtlasi | P23229, baseline and differential |
Genevisiblei | P23229, HS |
Organism-specific databases
HPAi | ENSG00000091409, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond (By similarity). Alpha-6 associates with either beta-1 (ITGB1) or beta-4 (ITGB4) to form ITGA6:ITGB1 and ITGA6:ITGB4, respectively (By similarity). ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R (PubMed:22351760). ITGA6:ITGB4 interacts with IGF2 (PubMed:28873464).
Interacts with ADAM9 (By similarity).
Interacts with RAB21 (PubMed:16754960).
Interacts with MDK (PubMed:15466886). ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886).
By similarity5 PublicationsBinary interactionsi
P23229
With | #Exp. | IntAct |
---|---|---|
ITGB4 [P16144] | 3 | EBI-2436548,EBI-948678 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- insulin-like growth factor I binding Source: UniProtKB
- laminin binding Source: Ensembl
- neuregulin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109864, 76 interactors |
ComplexPortali | CPX-1803, Integrin alpha6-beta1 complex CPX-1822, Integrin alpha6-beta4 complex |
CORUMi | P23229 |
IntActi | P23229, 35 interactors |
MINTi | P23229 |
STRINGi | 9606.ENSP00000386896 |
Miscellaneous databases
RNActi | P23229, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 30 – 95 | FG-GAP 1PROSITE-ProRule annotationAdd BLAST | 66 | |
Repeati | 101 – 166 | FG-GAP 2PROSITE-ProRule annotationAdd BLAST | 66 | |
Repeati | 176 – 229 | FG-GAP 3PROSITE-ProRule annotationAdd BLAST | 54 | |
Repeati | 283 – 339 | FG-GAP 4PROSITE-ProRule annotationAdd BLAST | 57 | |
Repeati | 340 – 402 | FG-GAP 5PROSITE-ProRule annotationAdd BLAST | 63 | |
Repeati | 403 – 458 | FG-GAP 6PROSITE-ProRule annotationAdd BLAST | 56 | |
Repeati | 459 – 518 | FG-GAP 7PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1077 – 1083 | Interaction with HPS5 | 7 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1079 – 1083 | GFFKR motif | 5 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3637, Eukaryota |
GeneTreei | ENSGT00940000155353 |
HOGENOMi | CLU_004111_1_0_1 |
InParanoidi | P23229 |
OMAi | KCSCPLE |
OrthoDBi | 743479at2759 |
PhylomeDBi | P23229 |
TreeFami | TF105391 |
Family and domain databases
Gene3Di | 2.130.10.130, 2 hits |
InterProi | View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf |
Pfami | View protein in Pfam PF01839, FG-GAP, 2 hits PF08441, Integrin_alpha2, 1 hit |
PRINTSi | PR01185, INTEGRINA |
SMARTi | View protein in SMART SM00191, Int_alpha, 5 hits |
SUPFAMi | SSF69179, SSF69179, 3 hits |
PROSITEi | View protein in PROSITE PS51470, FG_GAP, 7 hits PS00242, INTEGRIN_ALPHA, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM
60 70 80 90 100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD
110 120 130 140 150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI
160 170 180 190 200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF
210 220 230 240 250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV
260 270 280 290 300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS
310 320 330 340 350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG
360 370 380 390 400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW
410 420 430 440 450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH
460 470 480 490 500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI
510 520 530 540 550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG
560 570 580 590 600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV
610 620 630 640 650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE
660 670 680 690 700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV
710 720 730 740 750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS
760 770 780 790 800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT
810 820 830 840 850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG
860 870 880 890 900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN
910 920 930 940 950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD
960 970 980 990 1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF
1010 1020 1030 1040 1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS
1060 1070 1080 1090 1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK
1110 1120 1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS
The sequence of this isoform differs from the canonical sequence as follows:
259-297: Missing.
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
The sequence of this isoform differs from the canonical sequence as follows:
259-297: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
215-258: Missing.
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
The sequence of this isoform differs from the canonical sequence as follows:
215-258: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JXX7 | C9JXX7_HUMAN | Integrin alpha-6 | ITGA6 | 231 | Annotation score: | ||
H7BZ97 | H7BZ97_HUMAN | Integrin alpha-6 | ITGA6 | 258 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 | A → G in CAA37655 (PubMed:1976638).Curated | 1 | |
Sequence conflicti | 69 | A → G in CAA42099 (PubMed:2070796).Curated | 1 | |
Sequence conflicti | 419 | A → T in BAG59130 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 419 | A → T in AAI36456 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 419 | A → T in AAI36457 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 501 | F → L in CAA42099 (PubMed:2070796).Curated | 1 | |
Sequence conflicti | 805 | D → Y in CAA37655 (PubMed:1976638).Curated | 1 | |
Sequence conflicti | 805 | D → Y in AAD48469 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1125 | E → R in AAB20355 (PubMed:1976638).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036406 | 1 – 114 | Missing in isoform 7. 1 PublicationAdd BLAST | 114 | |
Alternative sequenceiVSP_002723 | 215 – 258 | Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_002724 | 259 – 297 | Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsAdd BLAST | 39 | |
Alternative sequenceiVSP_036407 | 918 – 932 | Missing in isoform 9. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_002725 | 1084 – 1130 | SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53586 mRNA Translation: CAA37655.1 AF166343 , AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA Translation: AAD48469.1 AK294436 mRNA Translation: BAG57680.1 Different initiation. AK296496 mRNA Translation: BAG59130.1 AC078883 Genomic DNA Translation: AAX93133.1 CH471058 Genomic DNA Translation: EAX11176.1 CH471058 Genomic DNA Translation: EAX11177.1 BC050585 mRNA Translation: AAH50585.1 BC136455 mRNA Translation: AAI36456.1 BC136456 mRNA Translation: AAI36457.1 X59512 mRNA Translation: CAA42099.1 S66213 mRNA Translation: AAB20355.1 S66196 mRNA Translation: AAB20354.1 S52135 Genomic DNA Translation: AAB24829.1 L40385 Genomic DNA No translation available. AB208842 mRNA Translation: BAD92079.1 DQ858220 mRNA Translation: ABH11650.1 |
CCDSi | CCDS2249.1 [P23229-2] CCDS46451.1 [P23229-3] CCDS82534.1 [P23229-7] |
PIRi | A41543 B36429 |
RefSeqi | NP_000201.2, NM_000210.3 [P23229-2] NP_001073286.1, NM_001079818.2 [P23229-3] NP_001303235.1, NM_001316306.1 [P23229-7] |
Genome annotation databases
Ensembli | ENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2] ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3] ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7] ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1] ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5] |
GeneIDi | 3655 |
KEGGi | hsa:3655 |
UCSCi | uc002uho.2, human [P23229-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53586 mRNA Translation: CAA37655.1 AF166343 , AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA Translation: AAD48469.1 AK294436 mRNA Translation: BAG57680.1 Different initiation. AK296496 mRNA Translation: BAG59130.1 AC078883 Genomic DNA Translation: AAX93133.1 CH471058 Genomic DNA Translation: EAX11176.1 CH471058 Genomic DNA Translation: EAX11177.1 BC050585 mRNA Translation: AAH50585.1 BC136455 mRNA Translation: AAI36456.1 BC136456 mRNA Translation: AAI36457.1 X59512 mRNA Translation: CAA42099.1 S66213 mRNA Translation: AAB20355.1 S66196 mRNA Translation: AAB20354.1 S52135 Genomic DNA Translation: AAB24829.1 L40385 Genomic DNA No translation available. AB208842 mRNA Translation: BAD92079.1 DQ858220 mRNA Translation: ABH11650.1 |
CCDSi | CCDS2249.1 [P23229-2] CCDS46451.1 [P23229-3] CCDS82534.1 [P23229-7] |
PIRi | A41543 B36429 |
RefSeqi | NP_000201.2, NM_000210.3 [P23229-2] NP_001073286.1, NM_001079818.2 [P23229-3] NP_001303235.1, NM_001316306.1 [P23229-7] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109864, 76 interactors |
ComplexPortali | CPX-1803, Integrin alpha6-beta1 complex CPX-1822, Integrin alpha6-beta4 complex |
CORUMi | P23229 |
IntActi | P23229, 35 interactors |
MINTi | P23229 |
STRINGi | 9606.ENSP00000386896 |
Chemistry databases
ChEMBLi | CHEMBL3716 |
Protein family/group databases
TCDBi | 8.A.54.1.2, the integrin (integrin) family |
PTM databases
CarbonylDBi | P23229 |
GlyConnecti | 1408, 20 N-Linked glycans (4 sites) |
GlyGeni | P23229, 13 sites, 1 N-linked glycan (1 site) |
iPTMneti | P23229 |
PhosphoSitePlusi | P23229 |
SwissPalmi | P23229 |
Genetic variation databases
BioMutai | ITGA6 |
DMDMi | 519668687 |
2D gel databases
OGPi | P23229 |
Proteomic databases
CPTACi | CPTAC-528 CPTAC-529 |
EPDi | P23229 |
jPOSTi | P23229 |
MassIVEi | P23229 |
MaxQBi | P23229 |
PaxDbi | P23229 |
PeptideAtlasi | P23229 |
PRIDEi | P23229 |
ProteomicsDBi | 33937 54065 [P23229-1] 54066 [P23229-2] 54067 [P23229-3] 54068 [P23229-4] 54069 [P23229-5] 54070 [P23229-6] 54071 [P23229-7] 54072 [P23229-9] |
Protocols and materials databases
ABCDi | P23229, 1 sequenced antibody |
Antibodypediai | 1485, 1294 antibodies |
Genome annotation databases
Ensembli | ENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2] ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3] ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7] ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1] ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5] |
GeneIDi | 3655 |
KEGGi | hsa:3655 |
UCSCi | uc002uho.2, human [P23229-1] |
Organism-specific databases
CTDi | 3655 |
DisGeNETi | 3655 |
GeneCardsi | ITGA6 |
GeneReviewsi | ITGA6 |
HGNCi | HGNC:6142, ITGA6 |
HPAi | ENSG00000091409, Low tissue specificity |
MalaCardsi | ITGA6 |
MIMi | 147556, gene 226730, phenotype |
neXtProti | NX_P23229 |
OpenTargetsi | ENSG00000091409 |
Orphaneti | 79403, Junctional epidermolysis bullosa-pyloric atresia syndrome |
PharmGKBi | PA29942 |
VEuPathDBi | HostDB:ENSG00000091409.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3637, Eukaryota |
GeneTreei | ENSGT00940000155353 |
HOGENOMi | CLU_004111_1_0_1 |
InParanoidi | P23229 |
OMAi | KCSCPLE |
OrthoDBi | 743479at2759 |
PhylomeDBi | P23229 |
TreeFami | TF105391 |
Enzyme and pathway databases
PathwayCommonsi | P23229 |
Reactomei | R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-210991, Basigin interactions R-HSA-216083, Integrin cell surface interactions R-HSA-3000157, Laminin interactions R-HSA-3000170, Syndecan interactions R-HSA-446107, Type I hemidesmosome assembly |
SignaLinki | P23229 |
SIGNORi | P23229 |
Miscellaneous databases
BioGRID-ORCSi | 3655, 12 hits in 879 CRISPR screens |
ChiTaRSi | ITGA6, human |
GeneWikii | ITGA6 |
GenomeRNAii | 3655 |
Pharosi | P23229, Tbio |
PROi | PR:P23229 |
RNActi | P23229, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091409, Expressed in sural nerve and 250 other tissues |
ExpressionAtlasi | P23229, baseline and differential |
Genevisiblei | P23229, HS |
Family and domain databases
Gene3Di | 2.130.10.130, 2 hits |
InterProi | View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf |
Pfami | View protein in Pfam PF01839, FG-GAP, 2 hits PF08441, Integrin_alpha2, 1 hit |
PRINTSi | PR01185, INTEGRINA |
SMARTi | View protein in SMART SM00191, Int_alpha, 5 hits |
SUPFAMi | SSF69179, SSF69179, 3 hits |
PROSITEi | View protein in PROSITE PS51470, FG_GAP, 7 hits PS00242, INTEGRIN_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITA6_HUMAN | |
Accessioni | P23229Primary (citable) accession number: P23229 Secondary accession number(s): B2RMU9 Q9UN03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 218 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries