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UniProtKB - P23229 (ITA6_HUMAN)

Protein

Integrin alpha-6

Gene

ITGA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi363 – 371Sequence analysis9
Calcium bindingi425 – 433Sequence analysis9
Calcium bindingi480 – 488Sequence analysis9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-210991 Basigin interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000170 Syndecan interactions
R-HSA-446107 Type I hemidesmosome assembly
SignaLinkiP23229
SIGNORiP23229

Protein family/group databases

TCDBi8.A.54.1.2 the integrin (integrin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
CD49 antigen-like family member F
VLA-6
CD_antigen: CD49f
Cleaved into the following 3 chains:
Integrin alpha-6 heavy chain
Integrin alpha-6 light chain
Processed integrin alpha-6
Short name:
Alpha6p
Gene namesi
Name:ITGA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000091409.14
HGNCiHGNC:6142 ITGA6
MIMi147556 gene
neXtProtiNX_P23229

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 1050ExtracellularSequence analysisAdd BLAST1027
Transmembranei1051 – 1076HelicalSequence analysisAdd BLAST26
Topological domaini1077 – 1130CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
See also OMIM:226730

Keywords - Diseasei

Epidermolysis bullosa

Organism-specific databases

DisGeNETi3655
GeneReviewsiITGA6
MalaCardsiITGA6
MIMi226730 phenotype
OpenTargetsiENSG00000091409
Orphaneti79403 Junctional epidermolysis bullosa - pyloric atresia
PharmGKBiPA29942

Chemistry databases

ChEMBLiCHEMBL3716

Polymorphism and mutation databases

BioMutaiITGA6
DMDMi519668687

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 233 PublicationsAdd BLAST23
ChainiPRO_000001625824 – 1130Integrin alpha-6Add BLAST1107
ChainiPRO_000001625924 – 938Integrin alpha-6 heavy chainSequence analysisAdd BLAST915
ChainiPRO_0000425742636 – 1130Processed integrin alpha-6Add BLAST495
ChainiPRO_0000016260942 – 1130Integrin alpha-6 light chainSequence analysisAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi86 ↔ 94By similarity
Disulfide bondi131 ↔ 154By similarity
Disulfide bondi175 ↔ 188By similarity
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi528 ↔ 535By similarity
Disulfide bondi541 ↔ 601By similarity
Disulfide bondi665 ↔ 671By similarity
Disulfide bondi765 ↔ 776By similarity
Glycosylationi770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi920 ↔ 967Interchain (between heavy and light chains)By similarity
Glycosylationi930N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi973 ↔ 978By similarity
Glycosylationi997N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi1078S-palmitoyl cysteine; by DHHC32 Publications1
Isoform Alpha-6X2A (identifier: P23229-4)
Modified residuei1059Phosphoserine1 Publication1
Isoform Alpha-6X1A (identifier: P23229-2)
Modified residuei1064Phosphoserine1 Publication1
Isoform Alpha-6X1X2A (identifier: P23229-6)
Modified residuei1103Phosphoserine1 Publication1

Post-translational modificationi

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.1 Publication
Palmitoylation by DHHC3 enhances stability and cell surface expression.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei634 – 635Cleavage; by PLAU in invasive prostate cancer1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP23229
MaxQBiP23229
PaxDbiP23229
PeptideAtlasiP23229
PRIDEiP23229
ProteomicsDBi54065
54066 [P23229-2]
54067 [P23229-3]
54068 [P23229-4]
54069 [P23229-5]
54070 [P23229-6]
54071 [P23229-7]
54072 [P23229-9]

2D gel databases

OGPiP23229

PTM databases

CarbonylDBiP23229
iPTMnetiP23229
PhosphoSitePlusiP23229
SwissPalmiP23229

Miscellaneous databases

PMAP-CutDBiQ53RX7

Expressioni

Tissue specificityi

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).1 Publication

Gene expression databases

BgeeiENSG00000091409 Expressed in 241 organ(s), highest expression level in tibial nerve
CleanExiHS_ITGA6
ExpressionAtlasiP23229 baseline and differential
GenevisibleiP23229 HS

Organism-specific databases

HPAiCAB009009
HPA012696
HPA027582

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R (PubMed:22351760). ITGA6:ITGB4 interacts with IGF2 (PubMed:28873464). Interacts with ADAM9 (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161443EBI-2436548,EBI-948678

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi109864, 46 interactors
ComplexPortaliCPX-1803 Integrin alpha6-beta1 complex
CPX-1822 Integrin alpha6-beta4 complex
CORUMiP23229
IntActiP23229, 8 interactors
MINTiP23229
STRINGi9606.ENSP00000386896

Structurei

3D structure databases

ProteinModelPortaliP23229
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 95FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati101 – 166FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati176 – 229FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati283 – 339FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati340 – 402FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati403 – 458FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati459 – 518FG-GAP 7PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1077 – 1083Interaction with HPS57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1079 – 1083GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00760000118782
HOVERGENiHBG108011
InParanoidiP23229
KOiK06485
OMAiYVYINQQ
OrthoDBiEOG091G012D
PhylomeDBiP23229
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 2 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform Alpha-6X1X2B (identifier: P23229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 
       960        970        980        990       1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 
      1010       1020       1030       1040       1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 
      1060       1070       1080       1090       1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK 
      1110       1120       1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS
Length:1,130
Mass (Da):126,606
Last modified:June 26, 2013 - v5
Checksum:iB53712888B7FE3B6
GO
Isoform Alpha-6X1A (identifier: P23229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,073
Mass (Da):119,476
Checksum:iD5291DAEAE855B6C
GO
Isoform Alpha-6X1B (identifier: P23229-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-297: Missing.

Show »
Length:1,091
Mass (Da):122,053
Checksum:i9CBF2E4DD0521D9A
GO
Isoform Alpha-6X2A (identifier: P23229-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,068
Mass (Da):119,088
Checksum:iAC0543FE6C6AD304
GO
Isoform Alpha-6X2B (identifier: P23229-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:1,086
Mass (Da):121,665
Checksum:iBE4FA13704B1FC07
GO
Isoform Alpha-6X1X2A (identifier: P23229-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,112
Mass (Da):124,029
Checksum:i3B3FA491633C798C
GO
Isoform 7 (identifier: P23229-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:954
Mass (Da):106,577
Checksum:iD40E820AF20A5FEA
GO
Isoform 9 (identifier: P23229-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     918-932: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

Show »
Length:1,097
Mass (Da):122,358
Checksum:i88DAB7B462FA6508
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXX7C9JXX7_HUMAN
Integrin alpha-6
ITGA6
231Annotation score:
H7BZ97H7BZ97_HUMAN
Integrin alpha-6
ITGA6
258Annotation score:

Sequence cautioni

The sequence BAG57680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69A → G in CAA37655 (PubMed:1976638).Curated1
Sequence conflicti69A → G in CAA42099 (PubMed:2070796).Curated1
Sequence conflicti419A → T in BAG59130 (PubMed:14702039).Curated1
Sequence conflicti419A → T in AAI36456 (PubMed:15489334).Curated1
Sequence conflicti419A → T in AAI36457 (PubMed:15489334).Curated1
Sequence conflicti501F → L in CAA42099 (PubMed:2070796).Curated1
Sequence conflicti805D → Y in CAA37655 (PubMed:1976638).Curated1
Sequence conflicti805D → Y in AAD48469 (Ref. 3) Curated1
Sequence conflicti1125E → R in AAB20355 (PubMed:1976638).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364061 – 114Missing in isoform 7. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_002723215 – 258Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_002724259 – 297Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_036407918 – 932Missing in isoform 9. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0027251084 – 1130SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53586 mRNA Translation: CAA37655.1
AF166343
, AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA Translation: AAD48469.1
AK294436 mRNA Translation: BAG57680.1 Different initiation.
AK296496 mRNA Translation: BAG59130.1
AC078883 Genomic DNA Translation: AAX93133.1
CH471058 Genomic DNA Translation: EAX11176.1
CH471058 Genomic DNA Translation: EAX11177.1
BC050585 mRNA Translation: AAH50585.1
BC136455 mRNA Translation: AAI36456.1
BC136456 mRNA Translation: AAI36457.1
X59512 mRNA Translation: CAA42099.1
S66213 mRNA Translation: AAB20355.1
S66196 mRNA Translation: AAB20354.1
S52135 Genomic DNA Translation: AAB24829.1
L40385 Genomic DNA No translation available.
AB208842 mRNA Translation: BAD92079.1
DQ858220 mRNA Translation: ABH11650.1
CCDSiCCDS2249.1 [P23229-2]
CCDS46451.1 [P23229-3]
CCDS82534.1 [P23229-7]
PIRiA41543
B36429
RefSeqiNP_000201.2, NM_000210.3 [P23229-2]
NP_001073286.1, NM_001079818.2 [P23229-3]
NP_001303235.1, NM_001316306.1 [P23229-7]
UniGeneiHs.133397

Genome annotation databases

EnsembliENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5]
GeneIDi3655
KEGGihsa:3655
UCSCiuc002uho.2 human [P23229-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53586 mRNA Translation: CAA37655.1
AF166343
, AF166335, AF166336, AF166337, AF166338, AF166339, AF166340, AF166341, AF166342 Genomic DNA Translation: AAD48469.1
AK294436 mRNA Translation: BAG57680.1 Different initiation.
AK296496 mRNA Translation: BAG59130.1
AC078883 Genomic DNA Translation: AAX93133.1
CH471058 Genomic DNA Translation: EAX11176.1
CH471058 Genomic DNA Translation: EAX11177.1
BC050585 mRNA Translation: AAH50585.1
BC136455 mRNA Translation: AAI36456.1
BC136456 mRNA Translation: AAI36457.1
X59512 mRNA Translation: CAA42099.1
S66213 mRNA Translation: AAB20355.1
S66196 mRNA Translation: AAB20354.1
S52135 Genomic DNA Translation: AAB24829.1
L40385 Genomic DNA No translation available.
AB208842 mRNA Translation: BAD92079.1
DQ858220 mRNA Translation: ABH11650.1
CCDSiCCDS2249.1 [P23229-2]
CCDS46451.1 [P23229-3]
CCDS82534.1 [P23229-7]
PIRiA41543
B36429
RefSeqiNP_000201.2, NM_000210.3 [P23229-2]
NP_001073286.1, NM_001079818.2 [P23229-3]
NP_001303235.1, NM_001316306.1 [P23229-7]
UniGeneiHs.133397

3D structure databases

ProteinModelPortaliP23229
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109864, 46 interactors
ComplexPortaliCPX-1803 Integrin alpha6-beta1 complex
CPX-1822 Integrin alpha6-beta4 complex
CORUMiP23229
IntActiP23229, 8 interactors
MINTiP23229
STRINGi9606.ENSP00000386896

Chemistry databases

ChEMBLiCHEMBL3716

Protein family/group databases

TCDBi8.A.54.1.2 the integrin (integrin) family

PTM databases

CarbonylDBiP23229
iPTMnetiP23229
PhosphoSitePlusiP23229
SwissPalmiP23229

Polymorphism and mutation databases

BioMutaiITGA6
DMDMi519668687

2D gel databases

OGPiP23229

Proteomic databases

EPDiP23229
MaxQBiP23229
PaxDbiP23229
PeptideAtlasiP23229
PRIDEiP23229
ProteomicsDBi54065
54066 [P23229-2]
54067 [P23229-3]
54068 [P23229-4]
54069 [P23229-5]
54070 [P23229-6]
54071 [P23229-7]
54072 [P23229-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2]
ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3]
ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7]
ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1]
ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5]
GeneIDi3655
KEGGihsa:3655
UCSCiuc002uho.2 human [P23229-1]

Organism-specific databases

CTDi3655
DisGeNETi3655
EuPathDBiHostDB:ENSG00000091409.14
GeneCardsiITGA6
GeneReviewsiITGA6
H-InvDBiHIX0023932
HGNCiHGNC:6142 ITGA6
HPAiCAB009009
HPA012696
HPA027582
MalaCardsiITGA6
MIMi147556 gene
226730 phenotype
neXtProtiNX_P23229
OpenTargetsiENSG00000091409
Orphaneti79403 Junctional epidermolysis bullosa - pyloric atresia
PharmGKBiPA29942
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00760000118782
HOVERGENiHBG108011
InParanoidiP23229
KOiK06485
OMAiYVYINQQ
OrthoDBiEOG091G012D
PhylomeDBiP23229
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-210991 Basigin interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-3000170 Syndecan interactions
R-HSA-446107 Type I hemidesmosome assembly
SignaLinkiP23229
SIGNORiP23229

Miscellaneous databases

ChiTaRSiITGA6 human
GeneWikiiITGA6
GenomeRNAii3655
PMAP-CutDBiQ53RX7
PROiPR:P23229
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091409 Expressed in 241 organ(s), highest expression level in tibial nerve
CleanExiHS_ITGA6
ExpressionAtlasiP23229 baseline and differential
GenevisibleiP23229 HS

Family and domain databases

Gene3Di2.130.10.130, 2 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITA6_HUMAN
AccessioniPrimary (citable) accession number: P23229
Secondary accession number(s): B2RMU9
, B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: June 26, 2013
Last modified: September 12, 2018
This is version 200 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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