Integrin alpha-6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cadherin binding Source: BHF-UCLInferred from high throughput direct assayⁱ
  • 25468996
• insulin-like growth factor I binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 22351760
• integrin binding Source: Ensembl
• laminin binding Source: Ensembl
• metal ion binding Source: UniProtKB-KW
• neuregulin binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 20682778

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• amelogenesis Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23496044
• brown fat cell differentiation Source: Ensembl
• cell adhesion mediated by integrin Source: Ensembl
• cell-cell adhesion Source: Ensembl
• cell-matrix adhesion Source: Ensembl
• cell-substrate adhesion Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 19933311
• cell-substrate junction assembly Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 9185503
• cellular response to extracellular stimulus Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• digestive tract development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23496044
• ectodermal cell differentiation Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 23154389
• extracellular matrix organization Source: Reactome
• filopodium assembly Source: Ensembl
• hemidesmosome assembly Source: Reactome
• integrin-mediated signaling pathway Source: UniProtKB-KW
• leukocyte migration Source: Reactome
• nail development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23496044
• negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 21310825
• positive regulation of apoptotic process Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 19364818
• positive regulation of cell-cell adhesion Source: Ensembl
• positive regulation of cell migration Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 24091622
• positive regulation of cell-substrate adhesion Source: Ensembl
• positive regulation of GTPase activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 25911094
• positive regulation of phosphorylation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 21310825
• positive regulation of transcription by RNA polymerase II Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 21310825
• renal system development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23496044
• skin development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23496044

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cadherin binding Source: BHF-UCLInferred from high throughput direct assayⁱ
  • 25468996
• insulin-like growth factor I binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 22351760
• integrin binding Source: Ensembl
• laminin binding Source: Ensembl
• neuregulin binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 20682778

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 
       960        970        980        990       1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 
      1010       1020       1030       1040       1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 
      1060       1070       1080       1090       1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK 
      1110       1120       1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS                       

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH 
       310        320        330        340        350
LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA 
       360        370        380        390        400
VYVYMNQQGR WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP 
       410        420        430        440        450
YDDLGKVFIY HGSANGINTK PTQVLKGISP YFGYSIAGNM DLDRNSYPDV 
       460        470        480        490        500
AVGSLSDSVT IFRSRPVINI QKTITVTPNR IDLRQKTACG APSGICLQVK 
       510        520        530        540        550
SCFEYTANPA GYNPSISIVG TLEAEKERRK SGLSSRVQFR NQGSEPKYTQ 
       560        570        580        590        600
ELTLKRQKQK VCMEETLWLQ DNIRDKLRPI PITASVEIQE PSSRRRVNSL 
       610        620        630        640        650
PEVLPILNSD EPKTAHIDVH FLKEGCGDDN VCNSNLKLEY KFCTREGNQD 
       660        670        680        690        700
KFSYLPIQKG VPELVLKDQK DIALEITVTN SPSNPRNPTK DGDDAHEAKL 
       710        720        730        740        750
IATFPDTLTY SAYRELRAFP EKQLSCVANQ NGSQADCELG NPFKRNSNVT 
       760        770        780        790        800
FYLVLSTTEV TFDTPDLDIN LKLETTSNQD NLAPITAKAK VVIELLLSVS 
       810        820        830        840        850
GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG KPLTNLGTAT 
       860        870        880        890        900
LNIQWPKEIS NGKWLLYLVK VESKGLEKVT CEPQKEINSL NLTESHNSRK 
       910        920        930        940        950
KREITEKQID DNRKFSLFAE RKYQTLNCSV NVNCVNIRCP LRGLDSKASL 
       960        970        980        990       1000
ILRSRLWNST FLEEYSKLNY LDILMRAFID VTAAAENIRL PNAGTQVRVT 
      1010       1020       1030       1040       1050
VFPSKTVAQY SGVPWWIILV AILAGILMLA LLVFILWKCG FFKRNKKDHY 
      1060       1070 
DATYHKAEIH AQPSDKERLT SDA                              

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH 
       310        320        330        340        350
LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA 
       360        370        380        390        400
VYVYMNQQGR WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP 
       410        420        430        440        450
YDDLGKVFIY HGSANGINTK PTQVLKGISP YFGYSIAGNM DLDRNSYPDV 
       460        470        480        490        500
AVGSLSDSVT IFRSRPVINI QKTITVTPNR IDLRQKTACG APSGICLQVK 
       510        520        530        540        550
SCFEYTANPA GYNPSISIVG TLEAEKERRK SGLSSRVQFR NQGSEPKYTQ 
       560        570        580        590        600
ELTLKRQKQK VCMEETLWLQ DNIRDKLRPI PITASVEIQE PSSRRRVNSL 
       610        620        630        640        650
PEVLPILNSD EPKTAHIDVH FLKEGCGDDN VCNSNLKLEY KFCTREGNQD 
       660        670        680        690        700
KFSYLPIQKG VPELVLKDQK DIALEITVTN SPSNPRNPTK DGDDAHEAKL 
       710        720        730        740        750
IATFPDTLTY SAYRELRAFP EKQLSCVANQ NGSQADCELG NPFKRNSNVT 
       760        770        780        790        800
FYLVLSTTEV TFDTPDLDIN LKLETTSNQD NLAPITAKAK VVIELLLSVS 
       810        820        830        840        850
GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG KPLTNLGTAT 
       860        870        880        890        900
LNIQWPKEIS NGKWLLYLVK VESKGLEKVT CEPQKEINSL NLTESHNSRK 
       910        920        930        940        950
KREITEKQID DNRKFSLFAE RKYQTLNCSV NVNCVNIRCP LRGLDSKASL 
       960        970        980        990       1000
ILRSRLWNST FLEEYSKLNY LDILMRAFID VTAAAENIRL PNAGTQVRVT 
      1010       1020       1030       1040       1050
VFPSKTVAQY SGVPWWIILV AILAGILMLA LLVFILWKCG FFKRSRYDDS 
      1060       1070       1080       1090 
VPRYHAVRIR KEEREIKDEK YIDNLEKKQW ITKWNENESY S          

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGLLFLT SVSYTDPDQF VYKTRPPREQ PDTFPDVMMN 
       260        270        280        290        300
SYLGFSLDSG KGIVSKDEIT FVSGAPRANH SGAVVLLKRD MKSAHLLPEH 
       310        320        330        340        350
IFDGEGLASS FGYDVAVVDL NKDGWQDIVI GAPQYFDRDG EVGGAVYVYM 
       360        370        380        390        400
NQQGRWNNVK PIRLNGTKDS MFGIAVKNIG DINQDGYPDI AVGAPYDDLG 
       410        420        430        440        450
KVFIYHGSAN GINTKPTQVL KGISPYFGYS IAGNMDLDRN SYPDVAVGSL 
       460        470        480        490        500
SDSVTIFRSR PVINIQKTIT VTPNRIDLRQ KTACGAPSGI CLQVKSCFEY 
       510        520        530        540        550
TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE PKYTQELTLK 
       560        570        580        590        600
RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP 
       610        620        630        640        650
ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL 
       660        670        680        690        700
PIQKGVPELV LKDQKDIALE ITVTNSPSNP RNPTKDGDDA HEAKLIATFP 
       710        720        730        740        750
DTLTYSAYRE LRAFPEKQLS CVANQNGSQA DCELGNPFKR NSNVTFYLVL 
       760        770        780        790        800
STTEVTFDTP DLDINLKLET TSNQDNLAPI TAKAKVVIEL LLSVSGVAKP 
       810        820        830        840        850
SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR VINLGKPLTN LGTATLNIQW 
       860        870        880        890        900
PKEISNGKWL LYLVKVESKG LEKVTCEPQK EINSLNLTES HNSRKKREIT 
       910        920        930        940        950
EKQIDDNRKF SLFAERKYQT LNCSVNVNCV NIRCPLRGLD SKASLILRSR 
       960        970        980        990       1000
LWNSTFLEEY SKLNYLDILM RAFIDVTAAA ENIRLPNAGT QVRVTVFPSK 
      1010       1020       1030       1040       1050
TVAQYSGVPW WIILVAILAG ILMLALLVFI LWKCGFFKRN KKDHYDATYH 
      1060 
KAEIHAQPSD KERLTSDA                                    

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGLLFLT SVSYTDPDQF VYKTRPPREQ PDTFPDVMMN 
       260        270        280        290        300
SYLGFSLDSG KGIVSKDEIT FVSGAPRANH SGAVVLLKRD MKSAHLLPEH 
       310        320        330        340        350
IFDGEGLASS FGYDVAVVDL NKDGWQDIVI GAPQYFDRDG EVGGAVYVYM 
       360        370        380        390        400
NQQGRWNNVK PIRLNGTKDS MFGIAVKNIG DINQDGYPDI AVGAPYDDLG 
       410        420        430        440        450
KVFIYHGSAN GINTKPTQVL KGISPYFGYS IAGNMDLDRN SYPDVAVGSL 
       460        470        480        490        500
SDSVTIFRSR PVINIQKTIT VTPNRIDLRQ KTACGAPSGI CLQVKSCFEY 
       510        520        530        540        550
TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE PKYTQELTLK 
       560        570        580        590        600
RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP 
       610        620        630        640        650
ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL 
       660        670        680        690        700
PIQKGVPELV LKDQKDIALE ITVTNSPSNP RNPTKDGDDA HEAKLIATFP 
       710        720        730        740        750
DTLTYSAYRE LRAFPEKQLS CVANQNGSQA DCELGNPFKR NSNVTFYLVL 
       760        770        780        790        800
STTEVTFDTP DLDINLKLET TSNQDNLAPI TAKAKVVIEL LLSVSGVAKP 
       810        820        830        840        850
SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR VINLGKPLTN LGTATLNIQW 
       860        870        880        890        900
PKEISNGKWL LYLVKVESKG LEKVTCEPQK EINSLNLTES HNSRKKREIT 
       910        920        930        940        950
EKQIDDNRKF SLFAERKYQT LNCSVNVNCV NIRCPLRGLD SKASLILRSR 
       960        970        980        990       1000
LWNSTFLEEY SKLNYLDILM RAFIDVTAAA ENIRLPNAGT QVRVTVFPSK 
      1010       1020       1030       1040       1050
TVAQYSGVPW WIILVAILAG ILMLALLVFI LWKCGFFKRS RYDDSVPRYH 
      1060       1070       1080 
AVRIRKEERE IKDEKYIDNL EKKQWITKWN ENESYS                

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 
       960        970        980        990       1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 
      1010       1020       1030       1040       1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 
      1060       1070       1080       1090       1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRNKKDHYD ATYHKAEIHA 
      1110 
QPSDKERLTS DA                                          

        10         20         30         40         50
MGVTVQSQGP GGKVVTCAHR YEKRQHVNTK QESRDIFGRC YVLSQNLRIE 
        60         70         80         90        100
DDMDGGDWSF CDGRLRGHEK FGSCQQGVAA TFTKDFHYIV FGAPGTYNWK 
       110        120        130        140        150
GLLFLTSVSY TDPDQFVYKT RPPREQPDTF PDVMMNSYLG FSLDSGKGIV 
       160        170        180        190        200
SKDEITFVSG APRANHSGAV VLLKRDMKSA HLLPEHIFDG EGLASSFGYD 
       210        220        230        240        250
VAVVDLNKDG WQDIVIGAPQ YFDRDGEVGG AVYVYMNQQG RWNNVKPIRL 
       260        270        280        290        300
NGTKDSMFGI AVKNIGDINQ DGYPDIAVGA PYDDLGKVFI YHGSANGINT 
       310        320        330        340        350
KPTQVLKGIS PYFGYSIAGN MDLDRNSYPD VAVGSLSDSV TIFRSRPVIN 
       360        370        380        390        400
IQKTITVTPN RIDLRQKTAC GAPSGICLQV KSCFEYTANP AGYNPSISIV 
       410        420        430        440        450
GTLEAEKERR KSGLSSRVQF RNQGSEPKYT QELTLKRQKQ KVCMEETLWL 
       460        470        480        490        500
QDNIRDKLRP IPITASVEIQ EPSSRRRVNS LPEVLPILNS DEPKTAHIDV 
       510        520        530        540        550
HFLKEGCGDD NVCNSNLKLE YKFCTREGNQ DKFSYLPIQK GVPELVLKDQ 
       560        570        580        590        600
KDIALEITVT NSPSNPRNPT KDGDDAHEAK LIATFPDTLT YSAYRELRAF 
       610        620        630        640        650
PEKQLSCVAN QNGSQADCEL GNPFKRNSNV TFYLVLSTTE VTFDTPDLDI 
       660        670        680        690        700
NLKLETTSNQ DNLAPITAKA KVVIELLLSV SGVAKPSQVY FGGTVVGEQA 
       710        720        730        740        750
MKSEDEVGSL IEYEFRVINL GKPLTNLGTA TLNIQWPKEI SNGKWLLYLV 
       760        770        780        790        800
KVESKGLEKV TCEPQKEINS LNLTESHNSR KKREITEKQI DDNRKFSLFA 
       810        820        830        840        850
ERKYQTLNCS VNVNCVNIRC PLRGLDSKAS LILRSRLWNS TFLEEYSKLN 
       860        870        880        890        900
YLDILMRAFI DVTAAAENIR LPNAGTQVRV TVFPSKTVAQ YSGVPWWIIL 
       910        920        930        940        950
VAILAGILML ALLVFILWKC GFFKRNKKDH YDATYHKAEI HAQPSDKERL 

TSDA                                                   

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKESH NSRKKREITE KQIDDNRKFS LFAERKYQTL 
       960        970        980        990       1000
NCSVNVNCVN IRCPLRGLDS KASLILRSRL WNSTFLEEYS KLNYLDILMR 
      1010       1020       1030       1040       1050
AFIDVTAAAE NIRLPNAGTQ VRVTVFPSKT VAQYSGVPWW IILVAILAGI 
      1060       1070       1080       1090 
LMLALLVFIL WKCGFFKRNK KDHYDATYHK AEIHAQPSDK ERLTSDA    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human cell differentiation molecules
   CD nomenclature of surface proteins of human leucocytes and list of entries
2. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. SIMILARITY comments
   Index of protein domains and families