ITGA6

Functionⁱ

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).By similarity3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	363 – 371	Sequence analysis	9
Calcium bindingⁱ	425 – 433	Sequence analysis	9
Calcium bindingⁱ	480 – 488	Sequence analysis	9

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
insulin-like growth factor I binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22351760
integrin binding Source: Ensembl
laminin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
neuregulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20682778

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amelogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23496044
brown fat cell differentiation Source: Ensembl
cell adhesion mediated by integrin Source: Ensembl
cell-cell adhesion Source: Ensembl
cell-matrix adhesion Source: Ensembl
cell-substrate adhesion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19933311
cell-substrate junction assembly
Source: ProtInc
Traceable author statementⁱ
- 9185503
cellular response to extracellular stimulus Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
digestive tract development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23496044
ectodermal cell differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 23154389
extracellular matrix organization Source: Reactome
filopodium assembly Source: Ensembl
hemidesmosome assembly Source: Reactome
integrin-mediated signaling pathway Source: UniProtKB-KW
leukocyte migration Source: Reactome
nail development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23496044
negative regulation of extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21310825
positive regulation of apoptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 19364818
positive regulation of cell-cell adhesion Source: Ensembl
positive regulation of cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24091622
positive regulation of cell-substrate adhesion Source: Ensembl
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25911094
positive regulation of phosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21310825
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21310825
renal system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23496044
skin development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23496044

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Integrin, Receptor
Biological process	Cell adhesion
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-210991 Basigin interactions R-HSA-216083 Integrin cell surface interactions R-HSA-3000157 Laminin interactions R-HSA-3000170 Syndecan interactions R-HSA-446107 Type I hemidesmosome assembly
SignaLinkⁱ	P23229
SIGNORⁱ	P23229

Protein family/group databases

TCDBⁱ	8.A.54.1.2 the integrin (integrin) family

TCDBⁱ

8.A.54.1.2 the integrin (integrin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Integrin alpha-6 Alternative name(s): CD49 antigen-like family member F VLA-6 CD_antigen: CD49f Cleaved into the following 3 chains: Integrin alpha-6 heavy chain Integrin alpha-6 light chain Processed integrin alpha-6 Short name: Alpha6p
Gene namesⁱ	Name:ITGA6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000091409.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6142 ITGA6
MIMⁱ	147556 gene
neXtProtⁱ	NX_P23229

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 1050	ExtracellularSequence analysisAdd BLAST	1027
Transmembraneⁱ	1051 – 1076	HelicalSequence analysisAdd BLAST	26
Topological domainⁱ	1077 – 1130	CytoplasmicSequence analysisAdd BLAST	54

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.

Keywords - Diseaseⁱ

Epidermolysis bullosa

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3655
GeneReviewsⁱ	ITGA6
MalaCards human disease database More...MalaCardsⁱ	ITGA6
MIMⁱ	226730 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000091409
Orphanetⁱ	79403 Junctional epidermolysis bullosa - pyloric atresia
PharmGKBⁱ	PA29942

Chemistry databases

ChEMBLⁱ	CHEMBL3716

ChEMBLⁱ

CHEMBL3716

Polymorphism and mutation databases

BioMutaⁱ	ITGA6
DMDMⁱ	519668687

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	3 PublicationsAdd BLAST	23
ChainⁱPRO_0000016258	24 – 1130	Integrin alpha-6Add BLAST	1107
ChainⁱPRO_0000016259	24 – 938	Integrin alpha-6 heavy chainSequence analysisAdd BLAST	915
ChainⁱPRO_0000425742	636 – 1130	Processed integrin alpha-6Add BLAST	495
ChainⁱPRO_0000016260	942 – 1130	Integrin alpha-6 light chainSequence analysisAdd BLAST	189

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	78	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	86 ↔ 94	By similarity
Disulfide bondⁱ	131 ↔ 154	By similarity
Disulfide bondⁱ	175 ↔ 188	By similarity
Glycosylationⁱ	223	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	323	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	409	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	528 ↔ 535	By similarity
Disulfide bondⁱ	541 ↔ 601	By similarity
Disulfide bondⁱ	665 ↔ 671	By similarity
Disulfide bondⁱ	765 ↔ 776	By similarity
Glycosylationⁱ	770	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	787	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	920 ↔ 967	Interchain (between heavy and light chains)By similarity
Glycosylationⁱ	930	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	966	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	973 ↔ 978	By similarity
Glycosylationⁱ	997	N-linked (GlcNAc...) asparagine1 Publication	1
Lipidationⁱ	1078	S-palmitoyl cysteine; by DHHC32 Publications	1
Isoform Alpha-6X2A (identifier: P23229-4)
Modified residueⁱ	1059	Phosphoserine1 Publication	1
Isoform Alpha-6X1A (identifier: P23229-2)
Modified residueⁱ	1064	Phosphoserine1 Publication	1
Isoform Alpha-6X1X2A (identifier: P23229-6)
Modified residueⁱ	1103	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.

In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.1 Publication

Palmitoylation by DHHC3 enhances stability and cell surface expression.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	634 – 635	Cleavage; by PLAU in invasive prostate cancer1 Publication		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	P23229
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P23229
PaxDbⁱ	P23229
PeptideAtlas More...PeptideAtlasⁱ	P23229
PRIDEⁱ	P23229
ProteomicsDBⁱ	54065 54066 [P23229-2] 54067 [P23229-3] 54068 [P23229-4] 54069 [P23229-5] 54070 [P23229-6] 54071 [P23229-7] 54072 [P23229-9]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P23229

OGPⁱ

P23229

PTM databases

CarbonylDBⁱ	P23229
GlyConnectⁱ	1408
iPTMnetⁱ	P23229
PhosphoSitePlusⁱ	P23229
SwissPalmⁱ	P23229

Expressionⁱ

Tissue specificityⁱ

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000091409 Expressed in 241 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_ITGA6
ExpressionAtlasⁱ	P23229 baseline and differential
Genevisibleⁱ	P23229 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009009 HPA012696 HPA027582

HPAⁱ

CAB009009
HPA012696
HPA027582

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R (PubMed:22351760). ITGA6:ITGB4 interacts with IGF2 (PubMed:28873464). Interacts with ADAM9 (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ITGB4	P16144	3	EBI-2436548,EBI-948678

With

Entry

#Exp.

IntAct

Notes

ITGB4

P16144

3

EBI-2436548,EBI-948678

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
insulin-like growth factor I binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22351760
integrin binding Source: Ensembl
laminin binding Source: Ensembl
neuregulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20682778

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109864, 46 interactors
ComplexPortalⁱ	CPX-1803 Integrin alpha6-beta1 complex CPX-1822 Integrin alpha6-beta4 complex
CORUMⁱ	P23229
IntActⁱ	P23229, 9 interactors
Molecular INTeraction database More...MINTⁱ	P23229
STRINGⁱ	9606.ENSP00000386896

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	30 – 95	FG-GAP 1PROSITE-ProRule annotationAdd BLAST	66
Repeatⁱ	101 – 166	FG-GAP 2PROSITE-ProRule annotationAdd BLAST	66
Repeatⁱ	176 – 229	FG-GAP 3PROSITE-ProRule annotationAdd BLAST	54
Repeatⁱ	283 – 339	FG-GAP 4PROSITE-ProRule annotationAdd BLAST	57
Repeatⁱ	340 – 402	FG-GAP 5PROSITE-ProRule annotationAdd BLAST	63
Repeatⁱ	403 – 458	FG-GAP 6PROSITE-ProRule annotationAdd BLAST	56
Repeatⁱ	459 – 518	FG-GAP 7PROSITE-ProRule annotationAdd BLAST	60

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1077 – 1083	Interaction with HPS5		7

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1079 – 1083	GFFKR motif		5

Sequence similaritiesⁱ

Belongs to the integrin alpha chain family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPBB Eukaryota ENOG410XVGZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118782
HOVERGENⁱ	HBG108011
InParanoidⁱ	P23229
KEGG Orthology (KO) More...KOⁱ	K06485
OMAⁱ	YVYINQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G012D
PhylomeDBⁱ	P23229
TreeFamⁱ	TF105391

Family and domain databases

Gene3Dⁱ	2.130.10.130, 2 hits
InterProⁱ	View protein in InterPro IPR013517 FG-GAP IPR013519 Int_alpha_beta-p IPR000413 Integrin_alpha IPR013649 Integrin_alpha-2 IPR018184 Integrin_alpha_C_CS IPR028994 Integrin_alpha_N IPR032695 Integrin_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01839 FG-GAP, 2 hits PF08441 Integrin_alpha2, 1 hit
PRINTSⁱ	PR01185 INTEGRINA
SMARTⁱ	View protein in SMART SM00191 Int_alpha, 5 hits
SUPFAMⁱ	SSF69179 SSF69179, 3 hits
PROSITEⁱ	View protein in PROSITE PS51470 FG_GAP, 7 hits PS00242 INTEGRIN_ALPHA, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms.

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform Alpha-6X1X2B (identifier: P23229-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 
       960        970        980        990       1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 
      1010       1020       1030       1040       1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 
      1060       1070       1080       1090       1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK 
      1110       1120       1130
EEREIKDEKY IDNLEKKQWI TKWNENESYS

Length:1,130

Mass (Da):126,606

Last modified:June 26, 2013 - v5

Checksum:ⁱB53712888B7FE3B6

GO

Isoform Alpha-6X1A (identifier: P23229-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-297: Missing.
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH 
       310        320        330        340        350
LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA 
       360        370        380        390        400
VYVYMNQQGR WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP 
       410        420        430        440        450
YDDLGKVFIY HGSANGINTK PTQVLKGISP YFGYSIAGNM DLDRNSYPDV 
       460        470        480        490        500
AVGSLSDSVT IFRSRPVINI QKTITVTPNR IDLRQKTACG APSGICLQVK 
       510        520        530        540        550
SCFEYTANPA GYNPSISIVG TLEAEKERRK SGLSSRVQFR NQGSEPKYTQ 
       560        570        580        590        600
ELTLKRQKQK VCMEETLWLQ DNIRDKLRPI PITASVEIQE PSSRRRVNSL 
       610        620        630        640        650
PEVLPILNSD EPKTAHIDVH FLKEGCGDDN VCNSNLKLEY KFCTREGNQD 
       660        670        680        690        700
KFSYLPIQKG VPELVLKDQK DIALEITVTN SPSNPRNPTK DGDDAHEAKL 
       710        720        730        740        750
IATFPDTLTY SAYRELRAFP EKQLSCVANQ NGSQADCELG NPFKRNSNVT 
       760        770        780        790        800
FYLVLSTTEV TFDTPDLDIN LKLETTSNQD NLAPITAKAK VVIELLLSVS 
       810        820        830        840        850
GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG KPLTNLGTAT 
       860        870        880        890        900
LNIQWPKEIS NGKWLLYLVK VESKGLEKVT CEPQKEINSL NLTESHNSRK 
       910        920        930        940        950
KREITEKQID DNRKFSLFAE RKYQTLNCSV NVNCVNIRCP LRGLDSKASL 
       960        970        980        990       1000
ILRSRLWNST FLEEYSKLNY LDILMRAFID VTAAAENIRL PNAGTQVRVT 
      1010       1020       1030       1040       1050
VFPSKTVAQY SGVPWWIILV AILAGILMLA LLVFILWKCG FFKRNKKDHY 
      1060       1070 
DATYHKAEIH AQPSDKERLT SDA

Show »

Length:1,073

Mass (Da):119,476

Checksum:ⁱD5291DAEAE855B6C

GO

Isoform Alpha-6X1B (identifier: P23229-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-297: Missing.

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH 
       310        320        330        340        350
LLPEHIFDGE GLASSFGYDV AVVDLNKDGW QDIVIGAPQY FDRDGEVGGA 
       360        370        380        390        400
VYVYMNQQGR WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP 
       410        420        430        440        450
YDDLGKVFIY HGSANGINTK PTQVLKGISP YFGYSIAGNM DLDRNSYPDV 
       460        470        480        490        500
AVGSLSDSVT IFRSRPVINI QKTITVTPNR IDLRQKTACG APSGICLQVK 
       510        520        530        540        550
SCFEYTANPA GYNPSISIVG TLEAEKERRK SGLSSRVQFR NQGSEPKYTQ 
       560        570        580        590        600
ELTLKRQKQK VCMEETLWLQ DNIRDKLRPI PITASVEIQE PSSRRRVNSL 
       610        620        630        640        650
PEVLPILNSD EPKTAHIDVH FLKEGCGDDN VCNSNLKLEY KFCTREGNQD 
       660        670        680        690        700
KFSYLPIQKG VPELVLKDQK DIALEITVTN SPSNPRNPTK DGDDAHEAKL 
       710        720        730        740        750
IATFPDTLTY SAYRELRAFP EKQLSCVANQ NGSQADCELG NPFKRNSNVT 
       760        770        780        790        800
FYLVLSTTEV TFDTPDLDIN LKLETTSNQD NLAPITAKAK VVIELLLSVS 
       810        820        830        840        850
GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG KPLTNLGTAT 
       860        870        880        890        900
LNIQWPKEIS NGKWLLYLVK VESKGLEKVT CEPQKEINSL NLTESHNSRK 
       910        920        930        940        950
KREITEKQID DNRKFSLFAE RKYQTLNCSV NVNCVNIRCP LRGLDSKASL 
       960        970        980        990       1000
ILRSRLWNST FLEEYSKLNY LDILMRAFID VTAAAENIRL PNAGTQVRVT 
      1010       1020       1030       1040       1050
VFPSKTVAQY SGVPWWIILV AILAGILMLA LLVFILWKCG FFKRSRYDDS 
      1060       1070       1080       1090 
VPRYHAVRIR KEEREIKDEK YIDNLEKKQW ITKWNENESY S

Show »

Length:1,091

Mass (Da):122,053

Checksum:ⁱ9CBF2E4DD0521D9A

GO

Isoform Alpha-6X2A (identifier: P23229-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
215-258: Missing.
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGLLFLT SVSYTDPDQF VYKTRPPREQ PDTFPDVMMN 
       260        270        280        290        300
SYLGFSLDSG KGIVSKDEIT FVSGAPRANH SGAVVLLKRD MKSAHLLPEH 
       310        320        330        340        350
IFDGEGLASS FGYDVAVVDL NKDGWQDIVI GAPQYFDRDG EVGGAVYVYM 
       360        370        380        390        400
NQQGRWNNVK PIRLNGTKDS MFGIAVKNIG DINQDGYPDI AVGAPYDDLG 
       410        420        430        440        450
KVFIYHGSAN GINTKPTQVL KGISPYFGYS IAGNMDLDRN SYPDVAVGSL 
       460        470        480        490        500
SDSVTIFRSR PVINIQKTIT VTPNRIDLRQ KTACGAPSGI CLQVKSCFEY 
       510        520        530        540        550
TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE PKYTQELTLK 
       560        570        580        590        600
RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP 
       610        620        630        640        650
ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL 
       660        670        680        690        700
PIQKGVPELV LKDQKDIALE ITVTNSPSNP RNPTKDGDDA HEAKLIATFP 
       710        720        730        740        750
DTLTYSAYRE LRAFPEKQLS CVANQNGSQA DCELGNPFKR NSNVTFYLVL 
       760        770        780        790        800
STTEVTFDTP DLDINLKLET TSNQDNLAPI TAKAKVVIEL LLSVSGVAKP 
       810        820        830        840        850
SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR VINLGKPLTN LGTATLNIQW 
       860        870        880        890        900
PKEISNGKWL LYLVKVESKG LEKVTCEPQK EINSLNLTES HNSRKKREIT 
       910        920        930        940        950
EKQIDDNRKF SLFAERKYQT LNCSVNVNCV NIRCPLRGLD SKASLILRSR 
       960        970        980        990       1000
LWNSTFLEEY SKLNYLDILM RAFIDVTAAA ENIRLPNAGT QVRVTVFPSK 
      1010       1020       1030       1040       1050
TVAQYSGVPW WIILVAILAG ILMLALLVFI LWKCGFFKRN KKDHYDATYH 
      1060 
KAEIHAQPSD KERLTSDA

Show »

Length:1,068

Mass (Da):119,088

Checksum:ⁱAC0543FE6C6AD304

GO

Isoform Alpha-6X2B (identifier: P23229-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
215-258: Missing.

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGLLFLT SVSYTDPDQF VYKTRPPREQ PDTFPDVMMN 
       260        270        280        290        300
SYLGFSLDSG KGIVSKDEIT FVSGAPRANH SGAVVLLKRD MKSAHLLPEH 
       310        320        330        340        350
IFDGEGLASS FGYDVAVVDL NKDGWQDIVI GAPQYFDRDG EVGGAVYVYM 
       360        370        380        390        400
NQQGRWNNVK PIRLNGTKDS MFGIAVKNIG DINQDGYPDI AVGAPYDDLG 
       410        420        430        440        450
KVFIYHGSAN GINTKPTQVL KGISPYFGYS IAGNMDLDRN SYPDVAVGSL 
       460        470        480        490        500
SDSVTIFRSR PVINIQKTIT VTPNRIDLRQ KTACGAPSGI CLQVKSCFEY 
       510        520        530        540        550
TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE PKYTQELTLK 
       560        570        580        590        600
RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP 
       610        620        630        640        650
ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL 
       660        670        680        690        700
PIQKGVPELV LKDQKDIALE ITVTNSPSNP RNPTKDGDDA HEAKLIATFP 
       710        720        730        740        750
DTLTYSAYRE LRAFPEKQLS CVANQNGSQA DCELGNPFKR NSNVTFYLVL 
       760        770        780        790        800
STTEVTFDTP DLDINLKLET TSNQDNLAPI TAKAKVVIEL LLSVSGVAKP 
       810        820        830        840        850
SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR VINLGKPLTN LGTATLNIQW 
       860        870        880        890        900
PKEISNGKWL LYLVKVESKG LEKVTCEPQK EINSLNLTES HNSRKKREIT 
       910        920        930        940        950
EKQIDDNRKF SLFAERKYQT LNCSVNVNCV NIRCPLRGLD SKASLILRSR 
       960        970        980        990       1000
LWNSTFLEEY SKLNYLDILM RAFIDVTAAA ENIRLPNAGT QVRVTVFPSK 
      1010       1020       1030       1040       1050
TVAQYSGVPW WIILVAILAG ILMLALLVFI LWKCGFFKRS RYDDSVPRYH 
      1060       1070       1080 
AVRIRKEERE IKDEKYIDNL EKKQWITKWN ENESYS

Show »

Length:1,086

Mass (Da):121,665

Checksum:ⁱBE4FA13704B1FC07

GO

Isoform Alpha-6X1X2A (identifier: P23229-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD 
       960        970        980        990       1000
NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF 
      1010       1020       1030       1040       1050
LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS 
      1060       1070       1080       1090       1100
GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRNKKDHYD ATYHKAEIHA 
      1110 
QPSDKERLTS DA

Show »

Length:1,112

Mass (Da):124,029

Checksum:ⁱ3B3FA491633C798C

GO

Isoform 7 (identifier: P23229-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     215-258: Missing.
     1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

« Hide

        10         20         30         40         50
MGVTVQSQGP GGKVVTCAHR YEKRQHVNTK QESRDIFGRC YVLSQNLRIE 
        60         70         80         90        100
DDMDGGDWSF CDGRLRGHEK FGSCQQGVAA TFTKDFHYIV FGAPGTYNWK 
       110        120        130        140        150
GLLFLTSVSY TDPDQFVYKT RPPREQPDTF PDVMMNSYLG FSLDSGKGIV 
       160        170        180        190        200
SKDEITFVSG APRANHSGAV VLLKRDMKSA HLLPEHIFDG EGLASSFGYD 
       210        220        230        240        250
VAVVDLNKDG WQDIVIGAPQ YFDRDGEVGG AVYVYMNQQG RWNNVKPIRL 
       260        270        280        290        300
NGTKDSMFGI AVKNIGDINQ DGYPDIAVGA PYDDLGKVFI YHGSANGINT 
       310        320        330        340        350
KPTQVLKGIS PYFGYSIAGN MDLDRNSYPD VAVGSLSDSV TIFRSRPVIN 
       360        370        380        390        400
IQKTITVTPN RIDLRQKTAC GAPSGICLQV KSCFEYTANP AGYNPSISIV 
       410        420        430        440        450
GTLEAEKERR KSGLSSRVQF RNQGSEPKYT QELTLKRQKQ KVCMEETLWL 
       460        470        480        490        500
QDNIRDKLRP IPITASVEIQ EPSSRRRVNS LPEVLPILNS DEPKTAHIDV 
       510        520        530        540        550
HFLKEGCGDD NVCNSNLKLE YKFCTREGNQ DKFSYLPIQK GVPELVLKDQ 
       560        570        580        590        600
KDIALEITVT NSPSNPRNPT KDGDDAHEAK LIATFPDTLT YSAYRELRAF 
       610        620        630        640        650
PEKQLSCVAN QNGSQADCEL GNPFKRNSNV TFYLVLSTTE VTFDTPDLDI 
       660        670        680        690        700
NLKLETTSNQ DNLAPITAKA KVVIELLLSV SGVAKPSQVY FGGTVVGEQA 
       710        720        730        740        750
MKSEDEVGSL IEYEFRVINL GKPLTNLGTA TLNIQWPKEI SNGKWLLYLV 
       760        770        780        790        800
KVESKGLEKV TCEPQKEINS LNLTESHNSR KKREITEKQI DDNRKFSLFA 
       810        820        830        840        850
ERKYQTLNCS VNVNCVNIRC PLRGLDSKAS LILRSRLWNS TFLEEYSKLN 
       860        870        880        890        900
YLDILMRAFI DVTAAAENIR LPNAGTQVRV TVFPSKTVAQ YSGVPWWIIL 
       910        920        930        940        950
VAILAGILML ALLVFILWKC GFFKRNKKDH YDATYHKAEI HAQPSDKERL 

TSDA

Show »

Length:954

Mass (Da):106,577

Checksum:ⁱD40E820AF20A5FEA

GO

Isoform 9 (identifier: P23229-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
918-932: Missing.
1084-1130: SRYDDSVPRY...TKWNENESYS → NKKDHYDATYHKAEIHAQPSDKERLTSDA

« Hide

        10         20         30         40         50
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM 
        60         70         80         90        100
HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD 
       110        120        130        140        150
NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI 
       160        170        180        190        200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF 
       210        220        230        240        250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV 
       260        270        280        290        300
PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS 
       310        320        330        340        350
LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG 
       360        370        380        390        400
LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW 
       410        420        430        440        450
NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH 
       460        470        480        490        500
GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI 
       510        520        530        540        550
FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG 
       560        570        580        590        600
YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV 
       610        620        630        640        650
CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE 
       660        670        680        690        700
PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV 
       710        720        730        740        750
PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS 
       760        770        780        790        800
AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT 
       810        820        830        840        850
FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG 
       860        870        880        890        900
GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN 
       910        920        930        940        950
GKWLLYLVKV ESKGLEKESH NSRKKREITE KQIDDNRKFS LFAERKYQTL 
       960        970        980        990       1000
NCSVNVNCVN IRCPLRGLDS KASLILRSRL WNSTFLEEYS KLNYLDILMR 
      1010       1020       1030       1040       1050
AFIDVTAAAE NIRLPNAGTQ VRVTVFPSKT VAQYSGVPWW IILVAILAGI 
      1060       1070       1080       1090 
LMLALLVFIL WKCGFFKRNK KDHYDATYHK AEIHAQPSDK ERLTSDA

Show »

Length:1,097

Mass (Da):122,358

Checksum:ⁱ88DAB7B462FA6508

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JXX7	C9JXX7_HUMAN	Integrin alpha-6 Integrin alpha-6	ITGA6	231	Annotation score:
H7BZ97	H7BZ97_HUMAN	Integrin alpha-6 Integrin alpha-6	ITGA6	258	Annotation score:

Sequence cautionⁱ

The sequence BAG57680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	69	A → G in CAA37655 (PubMed:1976638).Curated	1
Sequence conflictⁱ	69	A → G in CAA42099 (PubMed:2070796).Curated	1
Sequence conflictⁱ	419	A → T in BAG59130 (PubMed:14702039).Curated	1
Sequence conflictⁱ	419	A → T in AAI36456 (PubMed:15489334).Curated	1
Sequence conflictⁱ	419	A → T in AAI36457 (PubMed:15489334).Curated	1
Sequence conflictⁱ	501	F → L in CAA42099 (PubMed:2070796).Curated	1
Sequence conflictⁱ	805	D → Y in CAA37655 (PubMed:1976638).Curated	1
Sequence conflictⁱ	805	D → Y in AAD48469 (Ref. 3) Curated	1
Sequence conflictⁱ	1125	E → R in AAB20355 (PubMed:1976638).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_036406	1 – 114	Missing in isoform 7. 1 PublicationAdd BLAST	114
Alternative sequenceⁱVSP_002723	215 – 258	Missing in isoform Alpha-6X2A, isoform Alpha-6X2B and isoform 7. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_002724	259 – 297	Missing in isoform Alpha-6X1A and isoform Alpha-6X1B. 2 PublicationsAdd BLAST	39
Alternative sequenceⁱVSP_036407	918 – 932	Missing in isoform 9. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_002725	1084 – 1130	SRYDD…NESYS → NKKDHYDATYHKAEIHAQPS DKERLTSDA in isoform Alpha-6X1A, isoform Alpha-6X2A, isoform Alpha-6X1X2A, isoform 7 and isoform 9. 3 PublicationsAdd BLAST	47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53586 mRNA Translation: CAA37655.1 AF166343 AF166342 Genomic DNA Translation: AAD48469.1 AK294436 mRNA Translation: BAG57680.1 Different initiation. AK296496 mRNA Translation: BAG59130.1 AC078883 Genomic DNA Translation: AAX93133.1 CH471058 Genomic DNA Translation: EAX11176.1 CH471058 Genomic DNA Translation: EAX11177.1 BC050585 mRNA Translation: AAH50585.1 BC136455 mRNA Translation: AAI36456.1 BC136456 mRNA Translation: AAI36457.1 X59512 mRNA Translation: CAA42099.1 S66213 mRNA Translation: AAB20355.1 S66196 mRNA Translation: AAB20354.1 S52135 Genomic DNA Translation: AAB24829.1 L40385 Genomic DNA No translation available. AB208842 mRNA Translation: BAD92079.1 DQ858220 mRNA Translation: ABH11650.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2249.1 [P23229-2] CCDS46451.1 [P23229-3] CCDS82534.1 [P23229-7]
PIRⁱ	A41543 B36429
NCBI Reference Sequences More...RefSeqⁱ	NP_000201.2, NM_000210.3 [P23229-2] NP_001073286.1, NM_001079818.2 [P23229-3] NP_001303235.1, NM_001316306.1 [P23229-7]
UniGeneⁱ	Hs.133397

Genome annotation databases

Ensemblⁱ	ENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2] ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3] ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7] ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1] ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5]
GeneIDⁱ	3655
KEGGⁱ	hsa:3655
UCSC genome browser More...UCSCⁱ	uc002uho.2 human [P23229-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23229	ITGA6 isoform 6		PANTR		1130	UniRef90_P23229
Uncharacterized protein		PROCO		1130
Uncharacterized protein		CALJA		1130
Uncharacterized protein		MACMU		1130
Uncharacterized protein		MACFA		1130
+37
P23229-2	Isoform Alpha-6X1B of Integrin alpha-6		HUMAN		1091	UniRef90_P23229-3
Integrin alpha-6		MOUSE		1091
Integrin subunit alpha 6		GORGO		1091
integrin alpha-6 isoform X1		Florida manatee		1093
Uncharacterized protein		RHIRO		1092
+177
P23229-3	Integrin alpha-6		MOUSE		1091	UniRef90_P23229-3
Integrin subunit alpha 6		GORGO		1091
integrin alpha-6 isoform X1		Florida manatee		1093
Uncharacterized protein		RHIRO		1092
Uncharacterized protein		RHIBE		1092
+177
P23229-4	Isoform 7 of Integrin alpha-6		HUMAN		954	UniRef90_P23229-4
integrin alpha-6 isoform X2		Florida manatee		1074
integrin alpha-6 isoform X3		ODORO		1073
Integrin subunit alpha 6		BOVIN		1073
integrin alpha-6 isoform X2		DELLE		1073
+22
P23229-5	Isoform Alpha-6X1B of Integrin alpha-6		HUMAN		1091	UniRef90_P23229-3
Integrin alpha-6		MOUSE		1091
Integrin subunit alpha 6		GORGO		1091
integrin alpha-6 isoform X1		Florida manatee		1093
Uncharacterized protein		RHIRO		1092
+177
P23229-7	Isoform Alpha-6X2A of Integrin alpha-6		HUMAN		1068	UniRef90_P23229-4
integrin alpha-6 isoform X2		Florida manatee		1074
integrin alpha-6 isoform X3		ODORO		1073
Integrin subunit alpha 6		BOVIN		1073
integrin alpha-6 isoform X2		DELLE		1073
+22

Protein	Similar proteins		Species	Score	Length	Source
P23229	Integrin alpha-6		CHICK		1072	UniRef50_P23229
Integrin alpha-6		MOUSE		1091
Uncharacterized protein		PROCO		1130
Uncharacterized protein		CERAT		1130
Uncharacterized protein		MANLE		1069
+566

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53586 mRNA Translation: CAA37655.1 AF166343 AF166342 Genomic DNA Translation: AAD48469.1 AK294436 mRNA Translation: BAG57680.1 Different initiation. AK296496 mRNA Translation: BAG59130.1 AC078883 Genomic DNA Translation: AAX93133.1 CH471058 Genomic DNA Translation: EAX11176.1 CH471058 Genomic DNA Translation: EAX11177.1 BC050585 mRNA Translation: AAH50585.1 BC136455 mRNA Translation: AAI36456.1 BC136456 mRNA Translation: AAI36457.1 X59512 mRNA Translation: CAA42099.1 S66213 mRNA Translation: AAB20355.1 S66196 mRNA Translation: AAB20354.1 S52135 Genomic DNA Translation: AAB24829.1 L40385 Genomic DNA No translation available. AB208842 mRNA Translation: BAD92079.1 DQ858220 mRNA Translation: ABH11650.1
CCDSⁱ	CCDS2249.1 [P23229-2] CCDS46451.1 [P23229-3] CCDS82534.1 [P23229-7]
PIRⁱ	A41543 B36429
RefSeqⁱ	NP_000201.2, NM_000210.3 [P23229-2] NP_001073286.1, NM_001079818.2 [P23229-3] NP_001303235.1, NM_001316306.1 [P23229-7]
UniGeneⁱ	Hs.133397

3D structure databases

ProteinModelPortalⁱ	P23229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109864, 46 interactors
ComplexPortalⁱ	CPX-1803 Integrin alpha6-beta1 complex CPX-1822 Integrin alpha6-beta4 complex
CORUMⁱ	P23229
IntActⁱ	P23229, 9 interactors
MINTⁱ	P23229
STRINGⁱ	9606.ENSP00000386896

Chemistry databases

ChEMBLⁱ	CHEMBL3716

ChEMBLⁱ

CHEMBL3716

Protein family/group databases

TCDBⁱ	8.A.54.1.2 the integrin (integrin) family

TCDBⁱ

8.A.54.1.2 the integrin (integrin) family

PTM databases

CarbonylDBⁱ	P23229
GlyConnectⁱ	1408
iPTMnetⁱ	P23229
PhosphoSitePlusⁱ	P23229
SwissPalmⁱ	P23229

Polymorphism and mutation databases

BioMutaⁱ	ITGA6
DMDMⁱ	519668687

2D gel databases

OGPⁱ	P23229

OGPⁱ

P23229

Proteomic databases

EPDⁱ	P23229
MaxQBⁱ	P23229
PaxDbⁱ	P23229
PeptideAtlasⁱ	P23229
PRIDEⁱ	P23229
ProteomicsDBⁱ	54065 54066 [P23229-2] 54067 [P23229-3] 54068 [P23229-4] 54069 [P23229-5] 54070 [P23229-6] 54071 [P23229-7] 54072 [P23229-9]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000264107; ENSP00000264107; ENSG00000091409 [P23229-2] ENST00000409080; ENSP00000386896; ENSG00000091409 [P23229-3] ENST00000409532; ENSP00000386614; ENSG00000091409 [P23229-7] ENST00000442250; ENSP00000406694; ENSG00000091409 [P23229-1] ENST00000458358; ENSP00000394169; ENSG00000091409 [P23229-5]
GeneIDⁱ	3655
KEGGⁱ	hsa:3655
UCSCⁱ	uc002uho.2 human [P23229-1]

Organism-specific databases

CTDⁱ	3655
DisGeNETⁱ	3655
EuPathDBⁱ	HostDB:ENSG00000091409.14
GeneCardsⁱ	ITGA6
GeneReviewsⁱ	ITGA6
H-InvDBⁱ	HIX0023932
HGNCⁱ	HGNC:6142 ITGA6
HPAⁱ	CAB009009 HPA012696 HPA027582
MalaCardsⁱ	ITGA6
MIMⁱ	147556 gene 226730 phenotype
neXtProtⁱ	NX_P23229
OpenTargetsⁱ	ENSG00000091409
Orphanetⁱ	79403 Junctional epidermolysis bullosa - pyloric atresia
PharmGKBⁱ	PA29942
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPBB Eukaryota ENOG410XVGZ LUCA
GeneTreeⁱ	ENSGT00760000118782
HOVERGENⁱ	HBG108011
InParanoidⁱ	P23229
KOⁱ	K06485
OMAⁱ	YVYINQQ
OrthoDBⁱ	EOG091G012D
PhylomeDBⁱ	P23229
TreeFamⁱ	TF105391

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-210991 Basigin interactions R-HSA-216083 Integrin cell surface interactions R-HSA-3000157 Laminin interactions R-HSA-3000170 Syndecan interactions R-HSA-446107 Type I hemidesmosome assembly
SignaLinkⁱ	P23229
SIGNORⁱ	P23229

Miscellaneous databases

ChiTaRSⁱ	ITGA6 human
GeneWikiⁱ	ITGA6
GenomeRNAiⁱ	3655
Protein Ontology More...PROⁱ	PR:P23229
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000091409 Expressed in 241 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_ITGA6
ExpressionAtlasⁱ	P23229 baseline and differential
Genevisibleⁱ	P23229 HS

Family and domain databases

Gene3Dⁱ	2.130.10.130, 2 hits
InterProⁱ	View protein in InterPro IPR013517 FG-GAP IPR013519 Int_alpha_beta-p IPR000413 Integrin_alpha IPR013649 Integrin_alpha-2 IPR018184 Integrin_alpha_C_CS IPR028994 Integrin_alpha_N IPR032695 Integrin_dom_sf
Pfamⁱ	View protein in Pfam PF01839 FG-GAP, 2 hits PF08441 Integrin_alpha2, 1 hit
PRINTSⁱ	PR01185 INTEGRINA
SMARTⁱ	View protein in SMART SM00191 Int_alpha, 5 hits
SUPFAMⁱ	SSF69179 SSF69179, 3 hits
PROSITEⁱ	View protein in PROSITE PS51470 FG_GAP, 7 hits PS00242 INTEGRIN_ALPHA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITA6_HUMAN
Accessionⁱ	P23229Primary (citable) accession number: P23229 Secondary accession number(s): B2RMU9 Q9UN03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	June 26, 2013
	Last modified:	October 10, 2018
	This is version 201 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P23229 (ITA6_HUMAN)

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Integrin alpha-6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ