UniProtKB - P23219 (PGH1_HUMAN)
Protein
Prostaglandin G/H synthase 1
Gene
PTGS1
Organism
Homo sapiens (Human)
Status
Functioni
Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable).2 Publications1 Publication
Miscellaneous
The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
Catalytic activityi
- EC:1.14.99.11 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Cofactori
heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.By similarity
Activity regulationi
The cyclooxygenase activity is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, flurbiprofen, ketoprofen, naproxen, flurbiprofen, anirolac, fenclofenac and diclofenac.1 Publication
Kineticsi
- KM=5.1 µM for arachidonate1 Publication
: prostaglandin biosynthesis Pathwayi
This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 206 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 384 | For cyclooxygenase activityBy similarity | 1 | |
Metal bindingi | 387 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Sitei | 529 | Aspirin-acetylated serine | 1 |
GO - Molecular functioni
- dioxygenase activity Source: UniProtKB-KW
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- peroxidase activity Source: UniProtKB-KW
- prostaglandin-endoperoxide synthase activity Source: BHF-UCL
GO - Biological processi
- cyclooxygenase pathway Source: BHF-UCL
- inflammatory response Source: InterPro
- prostaglandin biosynthetic process Source: UniProtKB
- regulation of blood pressure Source: UniProtKB
- regulation of cell population proliferation Source: Ensembl
- response to oxidative stress Source: InterPro
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase, Peroxidase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS01815-MONOMER |
BRENDAi | 1.14.99.1, 2681 |
PathwayCommonsi | P23219 |
Reactomei | R-HSA-140180, COX reactions R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
SABIO-RKi | P23219 |
SIGNORi | P23219 |
UniPathwayi | UPA00662 |
Protein family/group databases
MoonDBi | P23219, Curated |
PeroxiBasei | 3320, HsPGHS01 |
Chemistry databases
SwissLipidsi | SLP:000001103 |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin G/H synthase 1Curated (EC:1.14.99.11 Publication)Alternative name(s): Cyclooxygenase-11 Publication Short name: COX-11 Publication Prostaglandin H2 synthase 1 Short name: PGH synthase 1 Short name: PGHS-1 Short name: PHS 1 Prostaglandin-endoperoxide synthase 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000095303.14 |
HGNCi | HGNC:9604, PTGS1 |
MIMi | 176805, gene |
neXtProti | NX_P23219 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: HPA
- photoreceptor outer segment Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 529 | S → N: Abolishes cyclooxygenase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5742 |
OpenTargetsi | ENSG00000095303 |
PharmGKBi | PA24346 |
Miscellaneous databases
Pharosi | P23219, Tclin |
Chemistry databases
ChEMBLi | CHEMBL221 |
DrugBanki | DB02047, (+)-2-(4-biphenyl)propionic acid DB02773, (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid DB07983, 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID DB07981, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide DB07984, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide DB02198, 2-Bromoacetyl Group DB06736, Aceclofenac DB13783, Acemetacin DB00316, Acetaminophen DB03667, Acetic Acid Salicyloyl-Amino-Ester DB00945, Acetylsalicylic acid DB01435, Antipyrine DB01419, Antrafenine DB04557, Arachidonic Acid DB01014, Balsalazide DB13501, Bendazac DB02379, Beta-D-Glucose DB00963, Bromfenac DB13346, Bufexamac DB13919, Candesartan DB00796, Candesartan cilexetil DB09061, Cannabidiol DB00821, Carprofen DB00672, Chlorpropamide DB01401, Choline magnesium trisalicylate DB00250, Dapsone DB00035, Desmopressin DB09213, Dexibuprofen DB09214, Dexketoprofen DB00829, Diazepam DB00586, Diclofenac DB00711, Diethylcarbamazine DB00861, Diflunisal DB00154, Dihomo-gamma-linolenic acid DB01075, Diphenhydramine DB00470, Dronabinol DB09215, Droxicam DB00216, Eletriptan DB00749, Etodolac DB00773, Etoposide DB00573, Fenoprofen DB02266, Flufenamic acid DB00712, Flurbiprofen DB03753, Flurbiprofen Methyl Ester DB11323, Glycol salicylate DB01355, Hexobarbital DB01892, Hyperforin DB01050, Ibuprofen DB00159, Icosapent DB01181, Ifosfamide DB00619, Imatinib DB00328, Indomethacin DB01029, Irbesartan DB01221, Ketamine DB06738, Ketobemidone DB01009, Ketoprofen DB00465, Ketorolac DB06725, Lornoxicam DB09212, Loxoprofen DB01283, Lumiracoxib DB01397, Magnesium salicylate DB00939, Meclofenamic acid DB14009, Medical Cannabis DB00784, Mefenamic acid DB00814, Meloxicam DB11201, Menthyl salicylate DB00244, Mesalazine DB04817, Metamizole DB00350, Minoxidil DB00471, Montelukast DB14011, Nabiximols DB00461, Nabumetone DB00788, Naproxen DB00731, Nateglinide DB06802, Nepafenac DB04552, Niflumic acid DB12445, Nitroaspirin DB01837, O-acetyl-L-serine DB00991, Oxaprozin DB03752, P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid DB03783, Phenacetin DB11071, Phenyl salicylate DB00812, Phenylbutazone DB00554, Piroxicam DB09288, Propacetamol DB02110, Protoporphyrin Ix Containing Co DB02709, Resveratrol DB00533, Rofecoxib DB00412, Rosiglitazone DB00936, Salicylic acid DB01399, Salsalate DB06739, Seratrodast DB00795, Sulfasalazine DB00605, Sulindac DB00870, Suprofen DB09295, Talniflumate DB00469, Tenoxicam DB00857, Terbinafine DB01041, Thalidomide DB01600, Tiaprofenic acid DB09216, Tolfenamic acid DB00500, Tolmetin DB05109, Trabectedin DB08814, Triflusal DB11079, Trolamine salicylate DB00313, Valproic acid DB00582, Voriconazole DB00549, Zafirlukast DB06737, Zaltoprofen DB00744, Zileuton DB01198, Zopiclone |
DrugCentrali | P23219 |
GuidetoPHARMACOLOGYi | 1375 |
Polymorphism and mutation databases
BioMutai | PTGS1 |
DMDMi | 317373262 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Add BLAST | 23 | |
ChainiPRO_0000023868 | 24 – 599 | Prostaglandin G/H synthase 1Add BLAST | 576 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 46 | By similarity | ||
Disulfide bondi | 36 ↔ 158 | By similarity | ||
Disulfide bondi | 40 ↔ 56 | By similarity | ||
Disulfide bondi | 58 ↔ 68 | By similarity | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 568 ↔ 574 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P23219 |
jPOSTi | P23219 |
MassIVEi | P23219 |
MaxQBi | P23219 |
PaxDbi | P23219 |
PeptideAtlasi | P23219 |
PRIDEi | P23219 |
ProteomicsDBi | 4239 54063 [P23219-1] 54064 [P23219-2] |
PTM databases
GlyConnecti | 1648, 1 N-Linked glycan (1 site) |
GlyGeni | P23219, 3 sites |
iPTMneti | P23219 |
PhosphoSitePlusi | P23219 |
Expressioni
Gene expression databases
Bgeei | ENSG00000095303, Expressed in fundus of stomach and 222 other tissues |
ExpressionAtlasi | P23219, baseline and differential |
Genevisiblei | P23219, HS |
Organism-specific databases
HPAi | ENSG00000095303, Tissue enhanced (smooth muscle, urinary bladder) |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGRIDi | 111714, 8 interactors |
CORUMi | P23219 |
IntActi | P23219, 3 interactors |
MINTi | P23219 |
STRINGi | 9606.ENSP00000354612 |
Chemistry databases
BindingDBi | P23219 |
Miscellaneous databases
RNActi | P23219, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P23219 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 69 | EGF-likePROSITE-ProRule annotationAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the prostaglandin G/H synthase family.Curated
Keywords - Domaini
EGF-like domain, SignalPhylogenomic databases
eggNOGi | KOG2408, Eukaryota |
GeneTreei | ENSGT00390000010743 |
HOGENOMi | CLU_022428_0_0_1 |
InParanoidi | P23219 |
OMAi | SWEAYAN |
OrthoDBi | 324380at2759 |
PhylomeDBi | P23219 |
TreeFami | TF329675 |
Family and domain databases
Gene3Di | 1.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR029580, COX-1 IPR000742, EGF-like_dom IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal |
PANTHERi | PTHR11903:SF6, PTHR11903:SF6, 1 hit |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit PF00008, EGF, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS50026, EGF_3, 1 hit PS50292, PEROXIDASE_3, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P23219-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG
60 70 80 90 100
LDRYQCDCTR TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE
110 120 130 140 150
FVNATFIREM LMRLVLTVRS NLIPSPPTYN SAHDYISWES FSNVSYYTRI
160 170 180 190 200
LPSVPKDCPT PMGTKGKKQL PDAQLLARRF LLRRKFIPDP QGTNLMFAFF
210 220 230 240 250
AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ YQLRLFKDGK
260 270 280 290 300
LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY
310 320 330 340 350
ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ
360 370 380 390 400
LSGYFLQLKF DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE
410 420 430 440 450
YSYEQFLFNT SMLVDYGVEA LVDAFSRQIA GRIGGGRNMD HHILHVAVDV
460 470 480 490 500
IRESREMRLQ PFNEYRKRFG MKPYTSFQEL VGEKEMAAEL EELYGDIDAL
510 520 530 540 550
EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS PEYWKPSTFG
560 570 580 590
GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X296 | A0A087X296_HUMAN | Cyclooxygenase-1 | PTGS1 | 551 | Annotation score: | ||
A0A2R8YDM0 | A0A2R8YDM0_HUMAN | Prostaglandin-endoperoxide synthase | PTGS1 | 402 | Annotation score: | ||
X6RJD6 | X6RJD6_HUMAN | Prostaglandin G/H synthase 1 | PTGS1 | 171 | Annotation score: | ||
A0A2R8Y6S0 | A0A2R8Y6S0_HUMAN | Prostaglandin G/H synthase 1 | PTGS1 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | F → L in AAA36439 (PubMed:2512924).Curated | 1 | |
Sequence conflicti | 113 | R → L in AAA36439 (PubMed:2512924).Curated | 1 | |
Sequence conflicti | 378 | M → T in AAA36439 (PubMed:2512924).Curated | 1 | |
Sequence conflicti | 423 | D → G in BAG65237 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013451 | 8 | W → R9 PublicationsCorresponds to variant dbSNP:rs1236913Ensembl. | 1 | |
Natural variantiVAR_013452 | 17 | P → L2 PublicationsCorresponds to variant dbSNP:rs3842787Ensembl. | 1 | |
Natural variantiVAR_019161 | 53 | R → H1 PublicationCorresponds to variant dbSNP:rs3842789Ensembl. | 1 | |
Natural variantiVAR_019162 | 149 | R → L1 PublicationCorresponds to variant dbSNP:rs10306140Ensembl. | 1 | |
Natural variantiVAR_056663 | 185 | K → T. Corresponds to variant dbSNP:rs3842792Ensembl. | 1 | |
Natural variantiVAR_019163 | 237 | L → M2 PublicationsCorresponds to variant dbSNP:rs5789Ensembl. | 1 | |
Natural variantiVAR_056664 | 341 | K → R. Corresponds to variant dbSNP:rs3842799Ensembl. | 1 | |
Natural variantiVAR_013453 | 359 | K → R. Corresponds to variant dbSNP:rs5791Ensembl. | 1 | |
Natural variantiVAR_013454 | 443 | I → V. Corresponds to variant dbSNP:rs5792Ensembl. | 1 | |
Natural variantiVAR_028017 | 481 | V → I1 PublicationCorresponds to variant dbSNP:rs5794Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046932 | 1 – 109 | Missing in isoform 4. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_053936 | 1 – 32 | MSRSL…APTPV → MRKPRLM in isoform 3. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_054862 | 1 – 3 | MSR → MSRECDPGARWGIFLASGGA LNARLSPSSLSSAG in isoform 5. 1 Publication | 3 | |
Alternative sequenceiVSP_054863 | 1 – 3 | MSR → MSRECDPGARWGIFLASWWS LECQLSPSSLSSAG in isoform 6. 1 Publication | 3 | |
Alternative sequenceiVSP_004673 | 396 – 432 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 37 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000223423; ENSP00000223423; ENSG00000095303 [P23219-2] ENST00000362012; ENSP00000354612; ENSG00000095303 [P23219-1] ENST00000373698; ENSP00000362802; ENSG00000095303 [P23219-4] ENST00000540753; ENSP00000437709; ENSG00000095303 [P23219-3] |
GeneIDi | 5742 |
KEGGi | hsa:5742 |
UCSCi | uc004bmf.3, human [P23219-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6Y3C | X-ray | 3.36 | A | 24-599 | [»] | |
SMRi | P23219 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111714, 8 interactors |
CORUMi | P23219 |
IntActi | P23219, 3 interactors |
MINTi | P23219 |
STRINGi | 9606.ENSP00000354612 |
Chemistry databases
BindingDBi | P23219 |
ChEMBLi | CHEMBL221 |
DrugBanki | DB02047, (+)-2-(4-biphenyl)propionic acid DB02773, (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid DB07983, 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID DB07981, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide DB07984, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide DB02198, 2-Bromoacetyl Group DB06736, Aceclofenac DB13783, Acemetacin DB00316, Acetaminophen DB03667, Acetic Acid Salicyloyl-Amino-Ester DB00945, Acetylsalicylic acid DB01435, Antipyrine DB01419, Antrafenine DB04557, Arachidonic Acid DB01014, Balsalazide DB13501, Bendazac DB02379, Beta-D-Glucose DB00963, Bromfenac DB13346, Bufexamac DB13919, Candesartan DB00796, Candesartan cilexetil DB09061, Cannabidiol DB00821, Carprofen DB00672, Chlorpropamide DB01401, Choline magnesium trisalicylate DB00250, Dapsone DB00035, Desmopressin DB09213, Dexibuprofen DB09214, Dexketoprofen DB00829, Diazepam DB00586, Diclofenac DB00711, Diethylcarbamazine DB00861, Diflunisal DB00154, Dihomo-gamma-linolenic acid DB01075, Diphenhydramine DB00470, Dronabinol DB09215, Droxicam DB00216, Eletriptan DB00749, Etodolac DB00773, Etoposide DB00573, Fenoprofen DB02266, Flufenamic acid DB00712, Flurbiprofen DB03753, Flurbiprofen Methyl Ester DB11323, Glycol salicylate DB01355, Hexobarbital DB01892, Hyperforin DB01050, Ibuprofen DB00159, Icosapent DB01181, Ifosfamide DB00619, Imatinib DB00328, Indomethacin DB01029, Irbesartan DB01221, Ketamine DB06738, Ketobemidone DB01009, Ketoprofen DB00465, Ketorolac DB06725, Lornoxicam DB09212, Loxoprofen DB01283, Lumiracoxib DB01397, Magnesium salicylate DB00939, Meclofenamic acid DB14009, Medical Cannabis DB00784, Mefenamic acid DB00814, Meloxicam DB11201, Menthyl salicylate DB00244, Mesalazine DB04817, Metamizole DB00350, Minoxidil DB00471, Montelukast DB14011, Nabiximols DB00461, Nabumetone DB00788, Naproxen DB00731, Nateglinide DB06802, Nepafenac DB04552, Niflumic acid DB12445, Nitroaspirin DB01837, O-acetyl-L-serine DB00991, Oxaprozin DB03752, P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid DB03783, Phenacetin DB11071, Phenyl salicylate DB00812, Phenylbutazone DB00554, Piroxicam DB09288, Propacetamol DB02110, Protoporphyrin Ix Containing Co DB02709, Resveratrol DB00533, Rofecoxib DB00412, Rosiglitazone DB00936, Salicylic acid DB01399, Salsalate DB06739, Seratrodast DB00795, Sulfasalazine DB00605, Sulindac DB00870, Suprofen DB09295, Talniflumate DB00469, Tenoxicam DB00857, Terbinafine DB01041, Thalidomide DB01600, Tiaprofenic acid DB09216, Tolfenamic acid DB00500, Tolmetin DB05109, Trabectedin DB08814, Triflusal DB11079, Trolamine salicylate DB00313, Valproic acid DB00582, Voriconazole DB00549, Zafirlukast DB06737, Zaltoprofen DB00744, Zileuton DB01198, Zopiclone |
DrugCentrali | P23219 |
GuidetoPHARMACOLOGYi | 1375 |
SwissLipidsi | SLP:000001103 |
Protein family/group databases
MoonDBi | P23219, Curated |
PeroxiBasei | 3320, HsPGHS01 |
PTM databases
GlyConnecti | 1648, 1 N-Linked glycan (1 site) |
GlyGeni | P23219, 3 sites |
iPTMneti | P23219 |
PhosphoSitePlusi | P23219 |
Polymorphism and mutation databases
BioMutai | PTGS1 |
DMDMi | 317373262 |
Proteomic databases
EPDi | P23219 |
jPOSTi | P23219 |
MassIVEi | P23219 |
MaxQBi | P23219 |
PaxDbi | P23219 |
PeptideAtlasi | P23219 |
PRIDEi | P23219 |
ProteomicsDBi | 4239 54063 [P23219-1] 54064 [P23219-2] |
Protocols and materials databases
Antibodypediai | 775, 671 antibodies |
DNASUi | 5742 |
Genome annotation databases
Ensembli | ENST00000223423; ENSP00000223423; ENSG00000095303 [P23219-2] ENST00000362012; ENSP00000354612; ENSG00000095303 [P23219-1] ENST00000373698; ENSP00000362802; ENSG00000095303 [P23219-4] ENST00000540753; ENSP00000437709; ENSG00000095303 [P23219-3] |
GeneIDi | 5742 |
KEGGi | hsa:5742 |
UCSCi | uc004bmf.3, human [P23219-1] |
Organism-specific databases
CTDi | 5742 |
DisGeNETi | 5742 |
EuPathDBi | HostDB:ENSG00000095303.14 |
GeneCardsi | PTGS1 |
HGNCi | HGNC:9604, PTGS1 |
HPAi | ENSG00000095303, Tissue enhanced (smooth muscle, urinary bladder) |
MIMi | 176805, gene |
neXtProti | NX_P23219 |
OpenTargetsi | ENSG00000095303 |
PharmGKBi | PA24346 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2408, Eukaryota |
GeneTreei | ENSGT00390000010743 |
HOGENOMi | CLU_022428_0_0_1 |
InParanoidi | P23219 |
OMAi | SWEAYAN |
OrthoDBi | 324380at2759 |
PhylomeDBi | P23219 |
TreeFami | TF329675 |
Enzyme and pathway databases
UniPathwayi | UPA00662 |
BioCyci | MetaCyc:HS01815-MONOMER |
BRENDAi | 1.14.99.1, 2681 |
PathwayCommonsi | P23219 |
Reactomei | R-HSA-140180, COX reactions R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
SABIO-RKi | P23219 |
SIGNORi | P23219 |
Miscellaneous databases
BioGRID-ORCSi | 5742, 4 hits in 846 CRISPR screens |
ChiTaRSi | PTGS1, human |
GeneWikii | PTGS1 |
GenomeRNAii | 5742 |
Pharosi | P23219, Tclin |
PROi | PR:P23219 |
RNActi | P23219, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095303, Expressed in fundus of stomach and 222 other tissues |
ExpressionAtlasi | P23219, baseline and differential |
Genevisiblei | P23219, HS |
Family and domain databases
Gene3Di | 1.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR029580, COX-1 IPR000742, EGF-like_dom IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal |
PANTHERi | PTHR11903:SF6, PTHR11903:SF6, 1 hit |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit PF00008, EGF, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS50026, EGF_3, 1 hit PS50292, PEROXIDASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGH1_HUMAN | |
Accessioni | P23219Primary (citable) accession number: P23219 Secondary accession number(s): A8K1V7 Q5T7T8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 216 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations