Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisome proliferator-activated receptor alpha

Gene

Ppara

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei433Essential for heterodimerization with RXRABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi99 – 173Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-4090294 SUMOylation of intracellular receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor alpha
Short name:
PPAR-alpha
Alternative name(s):
Nuclear receptor subfamily 1 group C member 1
Gene namesi
Name:Ppara
Synonyms:Nr1c1, Ppar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:104740 Ppara

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs, herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119C → A: Reduces DNA binding and strongly decreases transcriptional activation; when associated with A-122. 1 Publication1
Mutagenesisi122C → A: Reduces DNA binding and strongly decreases transcriptional activation; when associated with A-119. 1 Publication1
Mutagenesisi292K → A: No effect on interaction with PER2. 1 Publication1
Mutagenesisi459 – 468Missing : Slightly reduces interaction with PER2. 1 Publication10

Chemistry databases

ChEMBLiCHEMBL2128
GuidetoPHARMACOLOGYi593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534821 – 468Peroxisome proliferator-activated receptor alphaAdd BLAST468

Proteomic databases

PaxDbiP23204
PRIDEiP23204

PTM databases

iPTMnetiP23204
PhosphoSitePlusiP23204

Expressioni

Tissue specificityi

Highly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.

Developmental stagei

It appears first at 13.5 dpc and increases until birth.

Gene expression databases

BgeeiENSMUSG00000022383 Expressed in 141 organ(s), highest expression level in jejunum
CleanExiMM_PPARA
ExpressionAtlasiP23204 baseline and differential
GenevisibleiP23204 MM

Interactioni

Subunit structurei

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD+ levels (By similarity).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Men1O885592EBI-5273083,EBI-3990176

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202317, 17 interactors
DIPiDIP-5958N
IntActiP23204, 4 interactors
MINTiP23204
STRINGi10090.ENSMUSP00000059719

Chemistry databases

BindingDBiP23204

Structurei

3D structure databases

ProteinModelPortaliP23204
SMRiP23204
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 466NR LBDPROSITE-ProRule annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni304 – 433Required for heterodimerization with RXRABy similarityAdd BLAST130

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 122NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri139 – 161NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000261626
HOVERGENiHBG106004
InParanoidiP23204
KOiK07294
OMAiFSFTEYQ
OrthoDBiEOG091G05U8
PhylomeDBiP23204
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003076 PPAR-alpha
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01289 PROXISOMPAAR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEESSGSFG
60 70 80 90 100
FADYQYLGSC PGSEGSVITD TLSPASSPSS VSCPVIPAST DESPGSALNI
110 120 130 140 150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDLKDSET
210 220 230 240 250
ADLKSLGKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKMVA NGVEDKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL
410 420 430 440 450
QEGIVHVLKL HLQSNHPDDT FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT
460
ESDAALHPLL QEIYRDMY
Length:468
Mass (Da):52,347
Last modified:October 1, 1996 - v2
Checksum:i2930A5191C610B6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75A → R in CAA40856 (PubMed:2129546).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57638 mRNA Translation: CAA40856.1
X75289
, X75290, X75291, X75292, X75293, X75294 Genomic DNA Translation: CAA53042.1
BC016892 mRNA Translation: AAH16892.1
X89577 mRNA Translation: CAA61754.1
CCDSiCCDS27721.1
PIRiJC2085
RefSeqiNP_001106889.1, NM_001113418.1
NP_035274.2, NM_011144.6
XP_006520682.1, XM_006520619.1
XP_006520683.1, XM_006520620.3
XP_006520684.1, XM_006520621.3
XP_006520685.1, XM_006520622.3
XP_006520686.1, XM_006520623.3
XP_011243818.1, XM_011245516.2
XP_011243819.1, XM_011245517.2
XP_011243821.1, XM_011245519.2
UniGeneiMm.212789

Genome annotation databases

EnsembliENSMUST00000057979; ENSMUSP00000059719; ENSMUSG00000022383
ENSMUST00000109422; ENSMUSP00000105049; ENSMUSG00000022383
ENSMUST00000109423; ENSMUSP00000105050; ENSMUSG00000022383
GeneIDi19013
KEGGimmu:19013
UCSCiuc007xdj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57638 mRNA Translation: CAA40856.1
X75289
, X75290, X75291, X75292, X75293, X75294 Genomic DNA Translation: CAA53042.1
BC016892 mRNA Translation: AAH16892.1
X89577 mRNA Translation: CAA61754.1
CCDSiCCDS27721.1
PIRiJC2085
RefSeqiNP_001106889.1, NM_001113418.1
NP_035274.2, NM_011144.6
XP_006520682.1, XM_006520619.1
XP_006520683.1, XM_006520620.3
XP_006520684.1, XM_006520621.3
XP_006520685.1, XM_006520622.3
XP_006520686.1, XM_006520623.3
XP_011243818.1, XM_011245516.2
XP_011243819.1, XM_011245517.2
XP_011243821.1, XM_011245519.2
UniGeneiMm.212789

3D structure databases

ProteinModelPortaliP23204
SMRiP23204
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202317, 17 interactors
DIPiDIP-5958N
IntActiP23204, 4 interactors
MINTiP23204
STRINGi10090.ENSMUSP00000059719

Chemistry databases

BindingDBiP23204
ChEMBLiCHEMBL2128
GuidetoPHARMACOLOGYi593

PTM databases

iPTMnetiP23204
PhosphoSitePlusiP23204

Proteomic databases

PaxDbiP23204
PRIDEiP23204

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057979; ENSMUSP00000059719; ENSMUSG00000022383
ENSMUST00000109422; ENSMUSP00000105049; ENSMUSG00000022383
ENSMUST00000109423; ENSMUSP00000105050; ENSMUSG00000022383
GeneIDi19013
KEGGimmu:19013
UCSCiuc007xdj.2 mouse

Organism-specific databases

CTDi5465
MGIiMGI:104740 Ppara

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000261626
HOVERGENiHBG106004
InParanoidiP23204
KOiK07294
OMAiFSFTEYQ
OrthoDBiEOG091G05U8
PhylomeDBiP23204
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

PROiPR:P23204
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022383 Expressed in 141 organ(s), highest expression level in jejunum
CleanExiMM_PPARA
ExpressionAtlasiP23204 baseline and differential
GenevisibleiP23204 MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003076 PPAR-alpha
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01289 PROXISOMPAAR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPARA_MOUSE
AccessioniPrimary (citable) accession number: P23204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again