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Protein

Protein SPA2

Gene

SPA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pheromone-induced morphogenesis and efficient mating, perhaps as a cytoskeletal protein.

Miscellaneous

Present with 274 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • MAP-kinase scaffold activity Source: SGD

GO - Biological processi

  • bipolar cellular bud site selection Source: SGD
  • budding cell apical bud growth Source: SGD
  • establishment of cell polarity Source: SGD
  • invasive filamentous growth Source: SGD
  • mating projection assembly Source: SGD
  • positive regulation of actin cytoskeleton reorganization Source: SGD
  • pseudohyphal growth Source: SGD
  • regulation of cell shape Source: UniProtKB-KW
  • regulation of cellular protein localization Source: SGD
  • regulation of initiation of mating projection growth Source: SGD
  • regulation of protein localization Source: SGD
  • regulation of termination of mating projection growth Source: SGD

Keywordsi

Biological processCell shape

Enzyme and pathway databases

BioCyciYEAST:G3O-32125-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SPA2
Gene namesi
Name:SPA2
Synonyms:PEA1
Ordered Locus Names:YLL021W
ORF Names:L1209
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL021W
SGDiS000003944 SPA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720901 – 1466Protein SPA2Add BLAST1466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei182PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei865PhosphoserineCombined sources1
Modified residuei883PhosphoserineCombined sources1
Modified residuei910PhosphoserineCombined sources1
Modified residuei937PhosphoserineCombined sources1
Modified residuei961PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1053PhosphoserineCombined sources1
Modified residuei1056PhosphoserineCombined sources1
Modified residuei1080PhosphoserineCombined sources1
Modified residuei1173PhosphoserineCombined sources1
Modified residuei1179PhosphothreonineCombined sources1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1251PhosphothreonineCombined sources1
Modified residuei1263PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23201
PaxDbiP23201
PRIDEiP23201

PTM databases

iPTMnetiP23201

Interactioni

Subunit structurei

Interacts with SHS1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PEA2P400912EBI-17803,EBI-13106

GO - Molecular functioni

  • MAP-kinase scaffold activity Source: SGD

Protein-protein interaction databases

BioGridi31232, 172 interactors
ComplexPortaliCPX-3188 Polarisome
DIPiDIP-99N
IntActiP23201, 14 interactors
MINTiP23201
STRINGi4932.YLL021W

Structurei

3D structure databases

ProteinModelPortaliP23201
SMRiP23201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati818 – 82518
Repeati826 – 83429
Repeati835 – 84339
Repeati860 – 86849
Repeati875 – 88359
Repeati884 – 89269
Repeati893 – 90179
Repeati902 – 91089
Repeati911 – 91999
Repeati920 – 928109
Repeati929 – 937119
Repeati938 – 946129
Repeati947 – 953137
Repeati954 – 961148
Repeati962 – 970159
Repeati971 – 979169
Repeati980 – 988179
Repeati989 – 997189
Repeati998 – 1006199
Repeati1007 – 1015209
Repeati1036 – 1044219
Repeati1045 – 1053229
Repeati1054 – 1062239
Repeati1072 – 1080249
Repeati1081 – 1087257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni818 – 108725 X 9 AA approximate tandem repeatsAdd BLAST270

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili286 – 388Sequence analysisAdd BLAST103
Coiled coili1169 – 1189Sequence analysisAdd BLAST21
Coiled coili1275 – 1302Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00650000094229
InParanoidiP23201
KOiK19846
OMAiADKNFKQ
OrthoDBiEOG092C3TGJ

Family and domain databases

InterProiView protein in InterPro
IPR022018 GIT1_C
IPR013724 GIT_SHD
PfamiView protein in Pfam
PF12205 GIT1_C, 1 hit
PF08518 GIT_SHD, 2 hits
SMARTiView protein in SMART
SM00555 GIT, 4 hits

Sequencei

Sequence statusi: Complete.

P23201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSSEVSLA HHRDIFHYYV SLKTFFEVTG ENRDRSNSTR AQKARAKLLK
60 70 80 90 100
LSSSQFYELS TDVSDELQRR IGEDANQPDY LLPKANFHMK RNQARQKLAN
110 120 130 140 150
LSQTRFNDLL DDILFEIKRR GFDKDLDAPR PPLPQPMKQE VSKDSDDTAR
160 170 180 190 200
TSTNSSSVTQ VAPNVSVQPS LVIPKMASID WSSEEEEEEQ VKEKPNEPEG
210 220 230 240 250
KQTSMDEKKE AKPALNPIVT DSDLPDSQVL ARDITSMART PTTTHKNYWD
260 270 280 290 300
VNDSPIIKVD KDIDNEKGPE QLKSPEVQRA ENNNPNSEME DKVKELTDLN
310 320 330 340 350
SDLHLQIEDL NAKLASLTSE KEKEKKEEKE EKEKEKNLKI NYTIDESFQK
360 370 380 390 400
ELLSLNSQIG ELSIENENLK QKISEFELHQ KKNDNHNDLK ITDGFISKYS
410 420 430 440 450
SADGLIPAQY ILNANNLIIQ FTTRLSAVPI GDSTAISHQI GEELFQILSQ
460 470 480 490 500
LSNLISQLLL SADLLQYKDQ VILLKASLSH AITSIRYFSV YGPVLIPKIT
510 520 530 540 550
VQAAVSEVCF AMCNLIDSAK IKSDSNGEST TSNEGNRQVL EYSSPTATTP
560 570 580 590 600
MTPTFPSTSG INMKKGFINP RKPASFLNDV EEEESPVKPL KITQKAINSP
610 620 630 640 650
IIRPSSSNGV PTTSRKPSGT GLFSLMIDSS IAKNSSHKED NDKYVSPIKA
660 670 680 690 700
VTSASNSASS NISEIPKLTL PPQAKIGTVI PPSENQVPNI KIENTEEDNK
710 720 730 740 750
RSDITNEISV KPTSSIADKL KQFEQSSEKK SSPKENPIAK EEMDSKPKLS
760 770 780 790 800
NKFITSMNDV STDDSSSDGN ENDDADDDDD FTYMALKQTM KREGSKIEKN
810 820 830 840 850
NDSKLPANIV ELDLHESPES VKIESPESIK EITSSEMSSE MPSSSLPKRL
860 870 880 890 900
VEDVEPSEMP EKGASVESVR KKNFQEPLGN VESPDMTQKV KSLGMTGKAV
910 920 930 940 950
GPESDSRVES PGMTGQIKSL NMAGKVVGPE ADSRVESPGM KEQIKSLGMT
960 970 980 990 1000
GKITAQESIK SPEAARKLAS SGEVDKIESP RMVRESESLE AVGNTIPSNM
1010 1020 1030 1040 1050
TVKMESPNLK GNTVSEPQEI RRDIASSEPI ENVDPPKVLK KIVFPKAVNR
1060 1070 1080 1090 1100
TGSPKSVEKT PSSATLKKSG LPEPNSQIVS PELAKNSPLA PIKKNVELRE
1110 1120 1130 1140 1150
TNKPHTETIT SVEPTNKDAN TSWRDADLNR TIKREEEDED FDRVNHNIQI
1160 1170 1180 1190 1200
TGAYTKTGKI DYHKIPVDRK AKSEAEVHTS EEDIDESNNV NGKRADAQIH
1210 1220 1230 1240 1250
ITERKHAFVN PTENSQVKKT SHSPFLNSKP VQYENSESNG GINNHIKIKN
1260 1270 1280 1290 1300
TGETTAHDEK HYSDDDDSSY QFVPMKHEEQ EQEQNRSEEE ESEDDDEEEE
1310 1320 1330 1340 1350
DSDFDVDTFD IENPDNTLSE LLLYLEHQTM DVISTIQSLL TSIKKPQVTK
1360 1370 1380 1390 1400
GNLRGESNAI NQVIGQMVDA TSISMEQSRN ANLKKHGDWV VQSLRDCSRR
1410 1420 1430 1440 1450
MTILCQLTGD GILAKEKSDQ DYADKNFKQR LAGIAFDVAK CTKELVKTVE
1460
EASLKDEINY LNSKLK
Length:1,466
Mass (Da):163,143
Last modified:November 1, 1991 - v1
Checksum:i2EBB616152382C89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53731 Genomic DNA Translation: CAA37763.1
X97560 Genomic DNA Translation: CAA66170.1
Z73126 Genomic DNA Translation: CAA97469.1
BK006945 Genomic DNA Translation: DAA09299.1
PIRiA36426
RefSeqiNP_013079.1, NM_001181841.1

Genome annotation databases

EnsemblFungiiYLL021W; YLL021W; YLL021W
GeneIDi850639
KEGGisce:YLL021W

Similar proteinsi

Entry informationi

Entry nameiSPA2_YEAST
AccessioniPrimary (citable) accession number: P23201
Secondary accession number(s): D6VXY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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