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Entry version 142 (11 Dec 2019)
Sequence version 1 (01 Nov 1991)
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Protein

Galactoside transport system permease protein MglC

Gene

mglC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • galactose transmembrane transporter activity Source: EcoCyc
  • methylgalactoside transmembrane transporter activity Source: EcoCyc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:MGLC-MONOMER
ECOL316407:JW2135-MONOMER
MetaCyc:MGLC-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.2.3 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galactoside transport system permease protein MglC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mglC
Ordered Locus Names:b2148, JW2135
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 52PeriplasmicSequence analysisAdd BLAST15
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 106CytoplasmicSequence analysisAdd BLAST33
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 180PeriplasmicSequence analysisAdd BLAST53
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 226CytoplasmicSequence analysisAdd BLAST25
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 256PeriplasmicSequence analysis9
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278CytoplasmicSequence analysis1
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 305PeriplasmicSequence analysis6
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 336CytoplasmicSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000601061 – 336Galactoside transport system permease protein MglCAdd BLAST336

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P23200

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P23200

PRoteomics IDEntifications database

More...
PRIDEi
P23200

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259171, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4341 Beta-methyl-D-galactoside/galactose ABC transporter complex

STRING: functional protein association networks

More...
STRINGi
511145.b2148

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108HWV Bacteria
COG4211 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000212232

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23200

KEGG Orthology (KO)

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KOi
K10541

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23200

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001851 ABC_transp_permease
IPR030158 MglC

The PANTHER Classification System

More...
PANTHERi
PTHR32196:SF18 PTHR32196:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02653 BPD_transp_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALNKKSFL TYLKEGGIYV VLLVLLAIII FQDPTFLSLL NLSNILTQSS
60 70 80 90 100
VRIIIALGVA GLIVTQGTDL SAGRQVGLAA VVAATLLQSM DNANKVFPEM
110 120 130 140 150
ATMPIALVIL IVCAIGAVIG LINGLIIAYL NVTPFITTLG TMIIVYGINS
160 170 180 190 200
LYYDFVGASP ISGFDSGFST FAQGFVALGS FRLSYITFYA LIAVAFVWVL
210 220 230 240 250
WNKTRFGKNI FAIGGNPEAA KVSGVNVGLN LLMIYALSGV FYAFGGMLEA
260 270 280 290 300
GRIGSATNNL GFMYELDAIA ACVVGGVSFS GGVGTVIGVV TGVIIFTVIN
310 320 330
YGLTYIGVNP YWQYIIKGAI IIFAVALDSL KYARKK
Length:336
Mass (Da):35,550
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3199C101AFD4196D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M59444 Genomic DNA Translation: AAA24171.1
U00096 Genomic DNA Translation: AAC75209.1
AP009048 Genomic DNA Translation: BAE76625.1

Protein sequence database of the Protein Information Resource

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PIRi
C37277

NCBI Reference Sequences

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RefSeqi
NP_416653.1, NC_000913.3
WP_001275118.1, NZ_STEB01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75209; AAC75209; b2148
BAE76625; BAE76625; BAE76625

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
949039

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2135
eco:b2148

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.93

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59444 Genomic DNA Translation: AAA24171.1
U00096 Genomic DNA Translation: AAC75209.1
AP009048 Genomic DNA Translation: BAE76625.1
PIRiC37277
RefSeqiNP_416653.1, NC_000913.3
WP_001275118.1, NZ_STEB01000002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4259171, 6 interactors
ComplexPortaliCPX-4341 Beta-methyl-D-galactoside/galactose ABC transporter complex
STRINGi511145.b2148

Protein family/group databases

TCDBi3.A.1.2.3 the atp-binding cassette (abc) superfamily

Proteomic databases

jPOSTiP23200
PaxDbiP23200
PRIDEiP23200

Genome annotation databases

EnsemblBacteriaiAAC75209; AAC75209; b2148
BAE76625; BAE76625; BAE76625
GeneIDi949039
KEGGiecj:JW2135
eco:b2148
PATRICifig|1411691.4.peg.93

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0589

Phylogenomic databases

eggNOGiENOG4108HWV Bacteria
COG4211 LUCA
HOGENOMiHOG000212232
InParanoidiP23200
KOiK10541
PhylomeDBiP23200

Enzyme and pathway databases

BioCyciEcoCyc:MGLC-MONOMER
ECOL316407:JW2135-MONOMER
MetaCyc:MGLC-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23200

Family and domain databases

InterProiView protein in InterPro
IPR001851 ABC_transp_permease
IPR030158 MglC
PANTHERiPTHR32196:SF18 PTHR32196:SF18, 1 hit
PfamiView protein in Pfam
PF02653 BPD_transp_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGLC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23200
Secondary accession number(s): Q2MAT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: December 11, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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