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Protein

Galactoside transport system permease protein MglC

Gene

mglC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • galactose transmembrane transporter activity Source: EcoCyc
  • methylgalactoside transmembrane transporter activity Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MGLC-MONOMER
MetaCyc:MGLC-MONOMER

Protein family/group databases

TCDBi3.A.1.2.3 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside transport system permease protein MglC
Gene namesi
Name:mglC
Ordered Locus Names:b2148, JW2135
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10594 mglC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 52PeriplasmicSequence analysisAdd BLAST15
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 106CytoplasmicSequence analysisAdd BLAST33
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 180PeriplasmicSequence analysisAdd BLAST53
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 226CytoplasmicSequence analysisAdd BLAST25
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 256PeriplasmicSequence analysis9
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278CytoplasmicSequence analysis1
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 305PeriplasmicSequence analysis6
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 336CytoplasmicSequence analysis10

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000601061 – 336Galactoside transport system permease protein MglCAdd BLAST336

Proteomic databases

PaxDbiP23200
PRIDEiP23200

Interactioni

Protein-protein interaction databases

BioGridi4259171, 6 interactors
STRINGi316385.ECDH10B_2305

Structurei

3D structure databases

ProteinModelPortaliP23200
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108HWV Bacteria
COG4211 LUCA
HOGENOMiHOG000212232
InParanoidiP23200
KOiK10541
PhylomeDBiP23200

Family and domain databases

InterProiView protein in InterPro
IPR001851 ABC_transp_permease
IPR030158 MglC
PANTHERiPTHR32196:SF18 PTHR32196:SF18, 1 hit
PfamiView protein in Pfam
PF02653 BPD_transp_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALNKKSFL TYLKEGGIYV VLLVLLAIII FQDPTFLSLL NLSNILTQSS
60 70 80 90 100
VRIIIALGVA GLIVTQGTDL SAGRQVGLAA VVAATLLQSM DNANKVFPEM
110 120 130 140 150
ATMPIALVIL IVCAIGAVIG LINGLIIAYL NVTPFITTLG TMIIVYGINS
160 170 180 190 200
LYYDFVGASP ISGFDSGFST FAQGFVALGS FRLSYITFYA LIAVAFVWVL
210 220 230 240 250
WNKTRFGKNI FAIGGNPEAA KVSGVNVGLN LLMIYALSGV FYAFGGMLEA
260 270 280 290 300
GRIGSATNNL GFMYELDAIA ACVVGGVSFS GGVGTVIGVV TGVIIFTVIN
310 320 330
YGLTYIGVNP YWQYIIKGAI IIFAVALDSL KYARKK
Length:336
Mass (Da):35,550
Last modified:November 1, 1991 - v1
Checksum:i3199C101AFD4196D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59444 Genomic DNA Translation: AAA24171.1
U00096 Genomic DNA Translation: AAC75209.1
AP009048 Genomic DNA Translation: BAE76625.1
PIRiC37277
RefSeqiNP_416653.1, NC_000913.3
WP_001275118.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75209; AAC75209; b2148
BAE76625; BAE76625; BAE76625
GeneIDi949039
KEGGiecj:JW2135
eco:b2148
PATRICifig|1411691.4.peg.93

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59444 Genomic DNA Translation: AAA24171.1
U00096 Genomic DNA Translation: AAC75209.1
AP009048 Genomic DNA Translation: BAE76625.1
PIRiC37277
RefSeqiNP_416653.1, NC_000913.3
WP_001275118.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP23200
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259171, 6 interactors
STRINGi316385.ECDH10B_2305

Protein family/group databases

TCDBi3.A.1.2.3 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP23200
PRIDEiP23200

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75209; AAC75209; b2148
BAE76625; BAE76625; BAE76625
GeneIDi949039
KEGGiecj:JW2135
eco:b2148
PATRICifig|1411691.4.peg.93

Organism-specific databases

EchoBASEiEB0589
EcoGeneiEG10594 mglC

Phylogenomic databases

eggNOGiENOG4108HWV Bacteria
COG4211 LUCA
HOGENOMiHOG000212232
InParanoidiP23200
KOiK10541
PhylomeDBiP23200

Enzyme and pathway databases

BioCyciEcoCyc:MGLC-MONOMER
MetaCyc:MGLC-MONOMER

Miscellaneous databases

PROiPR:P23200

Family and domain databases

InterProiView protein in InterPro
IPR001851 ABC_transp_permease
IPR030158 MglC
PANTHERiPTHR32196:SF18 PTHR32196:SF18, 1 hit
PfamiView protein in Pfam
PF02653 BPD_transp_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMGLC_ECOLI
AccessioniPrimary (citable) accession number: P23200
Secondary accession number(s): Q2MAT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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