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UniProtKB - P23173 (TNAB_ECOLI)

Entry version 154 (23 Feb 2022)
Sequence version 1 (01 Nov 1991)
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Protein

Low affinity tryptophan permease

Gene

tnaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically.

Caution

In strain W3110, the sequence is interrupted by the insertion of an IS5 element between positions 291 and 292.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport, Tryptophan catabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:TNAB-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.42.1.3, the hydroxy/aromatic amino acid permease (haaap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low affinity tryptophan permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tnaB
Synonyms:trpP
Ordered Locus Names:b3709, JW5619/JW5622
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33PeriplasmicSequence analysis1
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicSequence analysisAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 127PeriplasmicSequence analysisAdd BLAST20
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 153CytoplasmicSequence analysis5
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 191PeriplasmicSequence analysisAdd BLAST17
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 229CytoplasmicSequence analysisAdd BLAST17
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 286PeriplasmicSequence analysisAdd BLAST36
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326CytoplasmicSequence analysisAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348PeriplasmicSequence analysis1
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 387CytoplasmicSequence analysisAdd BLAST18
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 415PeriplasmicSequence analysis7

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000938001 – 415Low affinity tryptophan permeaseAdd BLAST415

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23173

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23173

PRoteomics IDEntifications database

More...PRIDEi		P23173

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By tryptophan. Is subject to catabolic repression.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		511145.b3709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23173

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0814, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1956281_0_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23173

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23173

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018227, Amino_acid_transport_2
IPR013061, Trp/try_permease_CS
IPR013059, Trp_tyr_transpt

The PANTHER Classification System

More...PANTHERi		PTHR46997, PTHR46997, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03222, Trp_Tyr_perm, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00166, AROAAPRMEASE

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00837, araaP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00594, AROMATIC_AA_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDQAEKKHS AFWGVMVIAG TVIGGGMFAL PVDLAGAWFF WGAFILIIAW 
        60         70         80         90        100
FSMLHSGLLL LEANLNYPVG SSFNTITKDL IGNTWNIISG ITVAFVLYIL 
       110        120        130        140        150
TYAYISANGA IISETISMNL GYHANPRIVG ICTAIFVASV LWLSSLAASR 
       160        170        180        190        200
ITSLFLGLKI ISFVIVFGSF FFQVDYSILR DATSSTAGTS YFPYIFMALP 
       210        220        230        240        250
VCLASFGFHG NIPSLIICYG KRKDKLIKSV VFGSLLALVI YLFWLYCTMG 
       260        270        280        290        300
NIPRESFKAI ISSGGNVDSL VKSFLGTKQH GIIEFCLLVF SNLAVASSFF 
       310        320        330        340        350
GVTLGLFDYL ADLFKIDNSH GGRFKTVLLT FLPPALLYLI FPNGFIYGIG 
       360        370        380        390        400
GAGLCATIWA VIIPAVLAIK ARKKFPNQMF TVWGGNLIPA IVILFGITVI 
       410 
LCWFGNVFNV LPKFG
Length:415
Mass (Da):45,211
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E34C7DE3DF6E9D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3D → V in AAA24677 (PubMed:6268608).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M59914 Genomic DNA Translation: AAA62792.1
L10328 Genomic DNA Translation: AAA62060.1
U00096 Genomic DNA Translation: AAC76732.1
AP009048 Genomic DNA Translation: BAE77581.1 Sequence problems.
AP009048 Genomic DNA Translation: BAE77583.1 Sequence problems.
K00032 Genomic DNA Translation: AAA24677.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39412

NCBI Reference Sequences

More...RefSeqi		NP_418165.1, NC_000913.3
WP_000131925.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76732; AAC76732; b3709
BAE77581; BAE77581; BAE77581
BAE77583; BAE77583; BAE77583

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5619
ecj:JW5622
eco:b3709

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2992

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59914 Genomic DNA Translation: AAA62792.1
L10328 Genomic DNA Translation: AAA62060.1
U00096 Genomic DNA Translation: AAC76732.1
AP009048 Genomic DNA Translation: BAE77581.1 Sequence problems.
AP009048 Genomic DNA Translation: BAE77583.1 Sequence problems.
K00032 Genomic DNA Translation: AAA24677.1
PIRiA39412
RefSeqiNP_418165.1, NC_000913.3
WP_000131925.1, NZ_LN832404.1

3D structure databases

SMRiP23173
ModBaseiSearch...

Protein-protein interaction databases

STRINGi511145.b3709

Protein family/group databases

TCDBi2.A.42.1.3, the hydroxy/aromatic amino acid permease (haaap) family

Proteomic databases

jPOSTiP23173
PaxDbiP23173
PRIDEiP23173

Genome annotation databases

EnsemblBacteriaiAAC76732; AAC76732; b3709
BAE77581; BAE77581; BAE77581
BAE77583; BAE77583; BAE77583
GeneIDi948220
KEGGiecj:JW5619
ecj:JW5622
eco:b3709
PATRICifig|1411691.4.peg.2992

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0999

Phylogenomic databases

eggNOGiCOG0814, Bacteria
HOGENOMiCLU_1956281_0_0_6
InParanoidiP23173
PhylomeDBiP23173

Enzyme and pathway databases

BioCyciEcoCyc:TNAB-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P23173

Family and domain databases

InterProiView protein in InterPro
IPR018227, Amino_acid_transport_2
IPR013061, Trp/try_permease_CS
IPR013059, Trp_tyr_transpt
PANTHERiPTHR46997, PTHR46997, 1 hit
PfamiView protein in Pfam
PF03222, Trp_Tyr_perm, 1 hit
PRINTSiPR00166, AROAAPRMEASE
TIGRFAMsiTIGR00837, araaP, 1 hit
PROSITEiView protein in PROSITE
PS00594, AROMATIC_AA_PERMEASE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNAB_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23173
Secondary accession number(s): Q2M823, Q2M825
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: February 23, 2022
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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