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UniProtKB - P23173 (TNAB_ECOLI)
Protein
Low affinity tryptophan permease
Gene
tnaB
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically.
Caution
In strain W3110, the sequence is interrupted by the insertion of an IS5 element between positions 291 and 292.Curated
GO - Molecular functioni
- aromatic amino acid transmembrane transporter activity Source: InterPro
- symporter activity Source: EcoCyc
GO - Biological processi
- amino acid transmembrane transport Source: EcoCyc
- tryptophan catabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Transport, Tryptophan catabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:TNAB-MONOMER |
Protein family/group databases
TCDBi | 2.A.42.1.3, the hydroxy/aromatic amino acid permease (haaap) family |
Names & Taxonomyi
Protein namesi | Recommended name: Low affinity tryptophan permease |
Gene namesi | Name:tnaB Synonyms:trpP Ordered Locus Names:b3709, JW5619/JW5622 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 86 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 127 | PeriplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 128 – 148 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 149 – 153 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 175 – 191 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 229 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 251 – 286 | PeriplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 326 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 348 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 349 – 369 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 370 – 387 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 388 – 408 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 409 – 415 | PeriplasmicSequence analysis | 7 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093800 | 1 – 415 | Low affinity tryptophan permeaseAdd BLAST | 415 |
Proteomic databases
jPOSTi | P23173 |
PaxDbi | P23173 |
PRIDEi | P23173 |
Expressioni
Inductioni
By tryptophan. Is subject to catabolic repression.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0814, Bacteria |
HOGENOMi | CLU_1956281_0_0_6 |
InParanoidi | P23173 |
PhylomeDBi | P23173 |
Family and domain databases
InterProi | View protein in InterPro IPR018227, Amino_acid_transport_2 IPR013061, Trp/try_permease_CS IPR013059, Trp_tyr_transpt |
PANTHERi | PTHR46997, PTHR46997, 1 hit |
Pfami | View protein in Pfam PF03222, Trp_Tyr_perm, 1 hit |
PRINTSi | PR00166, AROAAPRMEASE |
TIGRFAMsi | TIGR00837, araaP, 1 hit |
PROSITEi | View protein in PROSITE PS00594, AROMATIC_AA_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P23173-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDQAEKKHS AFWGVMVIAG TVIGGGMFAL PVDLAGAWFF WGAFILIIAW
60 70 80 90 100
FSMLHSGLLL LEANLNYPVG SSFNTITKDL IGNTWNIISG ITVAFVLYIL
110 120 130 140 150
TYAYISANGA IISETISMNL GYHANPRIVG ICTAIFVASV LWLSSLAASR
160 170 180 190 200
ITSLFLGLKI ISFVIVFGSF FFQVDYSILR DATSSTAGTS YFPYIFMALP
210 220 230 240 250
VCLASFGFHG NIPSLIICYG KRKDKLIKSV VFGSLLALVI YLFWLYCTMG
260 270 280 290 300
NIPRESFKAI ISSGGNVDSL VKSFLGTKQH GIIEFCLLVF SNLAVASSFF
310 320 330 340 350
GVTLGLFDYL ADLFKIDNSH GGRFKTVLLT FLPPALLYLI FPNGFIYGIG
360 370 380 390 400
GAGLCATIWA VIIPAVLAIK ARKKFPNQMF TVWGGNLIPA IVILFGITVI
410
LCWFGNVFNV LPKFG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | D → V in AAA24677 (PubMed:6268608).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59914 Genomic DNA Translation: AAA62792.1 L10328 Genomic DNA Translation: AAA62060.1 U00096 Genomic DNA Translation: AAC76732.1 AP009048 Genomic DNA Translation: BAE77581.1 Sequence problems. AP009048 Genomic DNA Translation: BAE77583.1 Sequence problems. K00032 Genomic DNA Translation: AAA24677.1 |
PIRi | A39412 |
RefSeqi | NP_418165.1, NC_000913.3 WP_000131925.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76732; AAC76732; b3709 BAE77581; BAE77581; BAE77581 BAE77583; BAE77583; BAE77583 |
GeneIDi | 948220 |
KEGGi | ecj:JW5619 ecj:JW5622 eco:b3709 |
PATRICi | fig|1411691.4.peg.2992 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59914 Genomic DNA Translation: AAA62792.1 L10328 Genomic DNA Translation: AAA62060.1 U00096 Genomic DNA Translation: AAC76732.1 AP009048 Genomic DNA Translation: BAE77581.1 Sequence problems. AP009048 Genomic DNA Translation: BAE77583.1 Sequence problems. K00032 Genomic DNA Translation: AAA24677.1 |
PIRi | A39412 |
RefSeqi | NP_418165.1, NC_000913.3 WP_000131925.1, NZ_LN832404.1 |
3D structure databases
SMRi | P23173 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 511145.b3709 |
Protein family/group databases
TCDBi | 2.A.42.1.3, the hydroxy/aromatic amino acid permease (haaap) family |
Proteomic databases
jPOSTi | P23173 |
PaxDbi | P23173 |
PRIDEi | P23173 |
Genome annotation databases
EnsemblBacteriai | AAC76732; AAC76732; b3709 BAE77581; BAE77581; BAE77581 BAE77583; BAE77583; BAE77583 |
GeneIDi | 948220 |
KEGGi | ecj:JW5619 ecj:JW5622 eco:b3709 |
PATRICi | fig|1411691.4.peg.2992 |
Organism-specific databases
EchoBASEi | EB0999 |
Phylogenomic databases
eggNOGi | COG0814, Bacteria |
HOGENOMi | CLU_1956281_0_0_6 |
InParanoidi | P23173 |
PhylomeDBi | P23173 |
Enzyme and pathway databases
BioCyci | EcoCyc:TNAB-MONOMER |
Miscellaneous databases
PROi | PR:P23173 |
Family and domain databases
InterProi | View protein in InterPro IPR018227, Amino_acid_transport_2 IPR013061, Trp/try_permease_CS IPR013059, Trp_tyr_transpt |
PANTHERi | PTHR46997, PTHR46997, 1 hit |
Pfami | View protein in Pfam PF03222, Trp_Tyr_perm, 1 hit |
PRINTSi | PR00166, AROAAPRMEASE |
TIGRFAMsi | TIGR00837, araaP, 1 hit |
PROSITEi | View protein in PROSITE PS00594, AROMATIC_AA_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TNAB_ECOLI | |
Accessioni | P23173Primary (citable) accession number: P23173 Secondary accession number(s): Q2M823, Q2M825 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families