UniProtKB - P23142 (FBLN1_HUMAN)
Fibulin-1
FBLN1
Functioni
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
3 PublicationsGO - Molecular functioni
- calcium ion binding Source: UniProtKB
- extracellular matrix structural constituent Source: UniProtKB
- fibrinogen binding Source: UniProtKB
- fibronectin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- integrin binding Source: UniProtKB
- peptidase activator activity Source: Ensembl
- protein-containing complex binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
GO - Biological processi
- blood coagulation, fibrin clot formation Source: UniProtKB
- embryo implantation Source: Ensembl
- extracellular matrix organization Source: Ensembl
- negative regulation of cell adhesion Source: UniProtKB
- negative regulation of cell motility Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of protein phosphorylation Source: UniProtKB
- negative regulation of stem cell proliferation Source: UniProtKB
- negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- negative regulation of transformation of host cell by virus Source: UniProtKB
- negative regulation of transforming growth factor beta production Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of substrate-dependent cell migration, cell attachment to substrate Source: UniProtKB
Keywordsi
Biological process | Host-virus interaction |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P23142 |
Reactomei | R-HSA-2129379, Molecules associated with elastic fibres |
SignaLinki | P23142 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibulin-1Short name: FIBL-1 |
Gene namesi | Name:FBLN1 ORF Names:PP213 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3600, FBLN1 |
MIMi | 135820, gene |
neXtProti | NX_P23142 |
VEuPathDBi | HostDB:ENSG00000077942 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Other locations
- basement membrane Source: Ensembl
- collagen-containing extracellular matrix Source: BHF-UCL
- elastic fiber Source: UniProtKB
- extracellular matrix Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Organism-specific databases
DisGeNETi | 2192 |
MalaCardsi | FBLN1 |
MIMi | 608180, phenotype |
OpenTargetsi | ENSG00000077942 |
Orphaneti | 404451, FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome 295197, Synpolydactyly type 2 |
PharmGKBi | PA28013 |
Miscellaneous databases
Pharosi | P23142, Tbio |
Genetic variation databases
BioMutai | FBLN1 |
DMDMi | 215274249 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000007563 | 30 – 703 | Fibulin-1Add BLAST | 674 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 61 | By similarity | ||
Disulfide bondi | 37 ↔ 68 | By similarity | ||
Disulfide bondi | 50 ↔ 69 | By similarity | ||
Disulfide bondi | 78 ↔ 109 | By similarity | ||
Disulfide bondi | 91 ↔ 110 | By similarity | ||
Glycosylationi | 98 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 112 ↔ 136 | By similarity | ||
Disulfide bondi | 113 ↔ 143 | By similarity | ||
Disulfide bondi | 126 ↔ 144 | By similarity | ||
Disulfide bondi | 180 ↔ 190 | By similarity | ||
Disulfide bondi | 186 ↔ 199 | By similarity | ||
Disulfide bondi | 201 ↔ 214 | By similarity | ||
Disulfide bondi | 220 ↔ 233 | By similarity | ||
Disulfide bondi | 227 ↔ 242 | By similarity | ||
Disulfide bondi | 248 ↔ 260 | By similarity | ||
Disulfide bondi | 266 ↔ 279 | By similarity | ||
Disulfide bondi | 273 ↔ 288 | By similarity | ||
Disulfide bondi | 294 ↔ 306 | By similarity | ||
Disulfide bondi | 312 ↔ 325 | By similarity | ||
Disulfide bondi | 319 ↔ 334 | By similarity | ||
Disulfide bondi | 341 ↔ 354 | By similarity | ||
Disulfide bondi | 360 ↔ 373 | By similarity | ||
Disulfide bondi | 367 ↔ 382 | By similarity | ||
Disulfide bondi | 384 ↔ 397 | By similarity | ||
Disulfide bondi | 403 ↔ 415 | By similarity | ||
Disulfide bondi | 411 ↔ 424 | By similarity | ||
Disulfide bondi | 426 ↔ 439 | By similarity | ||
Disulfide bondi | 445 ↔ 454 | By similarity | ||
Disulfide bondi | 450 ↔ 463 | By similarity | ||
Disulfide bondi | 465 ↔ 479 | By similarity | ||
Disulfide bondi | 485 ↔ 498 | By similarity | ||
Disulfide bondi | 494 ↔ 507 | By similarity | ||
Disulfide bondi | 509 ↔ 523 | By similarity | ||
Disulfide bondi | 529 ↔ 542 | By similarity | ||
Glycosylationi | 535 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 536 ↔ 551 | By similarity | ||
Glycosylationi | 539 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 556 ↔ 577 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-1123 |
EPDi | P23142 |
jPOSTi | P23142 |
MassIVEi | P23142 |
MaxQBi | P23142 |
PaxDbi | P23142 |
PeptideAtlasi | P23142 |
PRIDEi | P23142 |
ProteomicsDBi | 2960 54057 [P23142-1] 54058 [P23142-2] 54059 [P23142-3] 54060 [P23142-4] |
PTM databases
GlyConnecti | 1244, 8 N-Linked glycans (2 sites) |
GlyGeni | P23142, 4 sites, 10 N-linked glycans (2 sites), 1 O-linked glycan (1 site) |
iPTMneti | P23142 |
PhosphoSitePlusi | P23142 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000077942, Expressed in endocervix and 230 other tissues |
ExpressionAtlasi | P23142, baseline and differential |
Genevisiblei | P23142, HS |
Organism-specific databases
HPAi | ENSG00000077942, Low tissue specificity |
Interactioni
Subunit structurei
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen.
Interacts also with APP and FGB.
Interacts with FBLN7 (By similarity).
Interacts with CCN3 (PubMed:9927660).
By similarity1 Publication(Microbial infection) Interacts with human papillomavirus/HPV type 16, 18 and 31 proteins E6.
1 PublicationBinary interactionsi
Isoform C [P23142-4]
GO - Molecular functioni
- fibronectin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- integrin binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108486, 113 interactors |
IntActi | P23142, 82 interactors |
MINTi | P23142 |
STRINGi | 9606.ENSP00000331544 |
Miscellaneous databases
RNActi | P23142, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 76 | Anaphylatoxin-like 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 77 – 111 | Anaphylatoxin-like 2PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 112 – 144 | Anaphylatoxin-like 3PROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 176 – 215 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 216 – 261 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 262 – 307 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 308 – 355 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 356 – 398 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 399 – 440 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 441 – 480 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 481 – 524 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 525 – 578 | EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 356 – 440 | Self-association and FN1-binding; calcium is necessary for homotypic binding, but not for heterotypic bindingAdd BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000156642 |
HOGENOMi | CLU_004826_1_1_1 |
InParanoidi | P23142 |
OMAi | FEECINT |
OrthoDBi | 1174178at2759 |
PhylomeDBi | P23142 |
TreeFami | TF317514 |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017048, Fibulin-1 IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 4 hits |
PIRSFi | PIRSF036313, Fibulin-1, 1 hit |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 9 hits SM00179, EGF_CA, 8 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 3 hits PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 5 hits PS01187, EGF_CA, 8 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERAAPSRRV PLPLLLLGGL ALLAAGVDAD VLLEACCADG HRMATHQKDC
60 70 80 90 100
SLPYATESKE CRMVQEQCCH SQLEELHCAT GISLANEQDR CATPHGDNAS
110 120 130 140 150
LEATFVKRCC HCCLLGRAAQ AQGQSCEYSL MVGYQCGQVF QACCVKSQET
160 170 180 190 200
GDLDVGGLQE TDKIIEVEEE QEDPYLNDRC RGGGPCKQQC RDTGDEVVCS
210 220 230 240 250
CFVGYQLLSD GVSCEDVNEC ITGSHSCRLG ESCINTVGSF RCQRDSSCGT
260 270 280 290 300
GYELTEDNSC KDIDECESGI HNCLPDFICQ NTLGSFRCRP KLQCKSGFIQ
310 320 330 340 350
DALGNCIDIN ECLSISAPCP IGHTCINTEG SYTCQKNVPN CGRGYHLNEE
360 370 380 390 400
GTRCVDVDEC APPAEPCGKG HRCVNSPGSF RCECKTGYYF DGISRMCVDV
410 420 430 440 450
NECQRYPGRL CGHKCENTLG SYLCSCSVGF RLSVDGRSCE DINECSSSPC
460 470 480 490 500
SQECANVYGS YQCYCRRGYQ LSDVDGVTCE DIDECALPTG GHICSYRCIN
510 520 530 540 550
IPGSFQCSCP SSGYRLAPNG RNCQDIDECV TGIHNCSINE TCFNIQGGFR
560 570 580 590 600
CLAFECPENY RRSAATLQQE KTDTVRCIKS CRPNDVTCVF DPVHTISHTV
610 620 630 640 650
ISLPTFREFT RPEEIIFLRA ITPPHPASQA NIIFDITEGN LRDSFDIIKR
660 670 680 690 700
YMDGMTVGVV RQVRPIVGPF HAVLKLEMNY VVGGVVSHRN VVNVHIFVSE
YWF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AHL2 | B1AHL2_HUMAN | Fibulin-1 | FBLN1 | 721 | Annotation score: | ||
B1AHN3 | B1AHN3_HUMAN | Fibulin-1 | FBLN1 | 172 | Annotation score: | ||
B1AHM8 | B1AHM8_HUMAN | Fibulin-1 | FBLN1 | 181 | Annotation score: | ||
H7C1M6 | H7C1M6_HUMAN | Fibulin-1 | FBLN1 | 183 | Annotation score: | ||
B1AHM9 | B1AHM9_HUMAN | Fibulin-1 | FBLN1 | 189 | Annotation score: | ||
B1AHM7 | B1AHM7_HUMAN | Fibulin-1 | FBLN1 | 139 | Annotation score: | ||
B1AHM5 | B1AHM5_HUMAN | Fibulin-1 | FBLN1 | 92 | Annotation score: | ||
B1AHM6 | B1AHM6_HUMAN | Fibulin-1 | FBLN1 | 65 | Annotation score: | ||
A0A0U1RRA4 | A0A0U1RRA4_HUMAN | Fibulin-1 | FBLN1 | 60 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 13 | P → Q in AAH22497 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 36 | C → S AA sequence (PubMed:2527614).Curated | 1 | ||
Sequence conflicti | 41 – 42 | HR → SH AA sequence (PubMed:2527614).Curated | 2 | ||
Sequence conflicti | 521 | R → S in AAH22497 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 548 | G → A in CAA37770 (PubMed:2269669).Curated | 1 | ||
Sequence conflicti | 548 | G → A in CAA37771 (PubMed:2269669).Curated | 1 | ||
Sequence conflicti | 548 | G → A in CAA37772 (PubMed:2269669).Curated | 1 | ||
Sequence conflicti | 548 | G → A in AAB17099 (PubMed:9106159).Curated | 1 | ||
Sequence conflicti | 548 | G → A in AAK37822 (PubMed:10318851).Curated | 1 | ||
Isoform C (identifier: P23142-4) | |||||
Sequence conflicti | 650 | E → K in AAG17241 (PubMed:15498874).Curated | 1 | ||
Sequence conflicti | 662 | L → F in AAG17241 (PubMed:15498874).Curated | 1 | ||
Sequence conflicti | 680 – 682 | SAE → FAK in AAG17241 (PubMed:15498874).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015650 | 141 | Q → R5 PublicationsCorresponds to variant dbSNP:rs136730Ensembl. | 1 | |
Natural variantiVAR_072739 | 397 | C → F Found in a family with syndactyly, undescended testes, delayed motor milestones, mental retardation and signs of brain atrophy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs397509432EnsemblClinVar. | 1 | |
Natural variantiVAR_055720 | 509 | C → S. Corresponds to variant dbSNP:rs1802787Ensembl. | 1 | |
Natural variantiVAR_055721 | 695 | H → R1 PublicationCorresponds to variant dbSNP:rs13268EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001383 | 567 – 703 | Missing in isoform A. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_001384 | 567 – 703 | LQQEK…SEYWF → QKSKKGRQNTPAGSSKEDCR VLPWKQGLEDTHLDA in isoform B. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_001385 | 567 – 703 | LQQEK…SEYWF → RCERLPCHENRECSKLPLRI TYYHLSFPTNIQAPAVVFRM GPSSAVPGDSMQLAITGGNE EGFFTTRKVSPHSGVVALTK PVPEPRDLLLTVKMDLSRHG TVSSFVAKLFIFVSAEL in isoform C. 3 PublicationsAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53741 mRNA Translation: CAA37770.1 X53742 mRNA Translation: CAA37771.1 X53743 mRNA Translation: CAA37772.1 U01244 mRNA Translation: AAB17099.1 AF126110 mRNA Translation: AAK37822.1 AF217999 mRNA Translation: AAG17241.1 Frameshift. AL021391 Genomic DNA No translation available. Z95331 Genomic DNA No translation available. Z98047 Genomic DNA No translation available. BC022497 mRNA Translation: AAH22497.1 AY040589 Genomic DNA Translation: AAK82945.1 |
CCDSi | CCDS14067.1 [P23142-1] CCDS14068.1 [P23142-3] CCDS14069.1 [P23142-4] CCDS43028.1 [P23142-2] |
PIRi | C36346 |
RefSeqi | NP_001987.2, NM_001996.3 [P23142-4] NP_006476.2, NM_006485.3 [P23142-3] NP_006477.2, NM_006486.2 [P23142-1] NP_006478.2, NM_006487.2 [P23142-2] |
Genome annotation databases
Ensembli | ENST00000262722; ENSP00000262722; ENSG00000077942 [P23142-4] ENST00000327858; ENSP00000331544; ENSG00000077942 ENST00000340923; ENSP00000342212; ENSG00000077942 [P23142-2] ENST00000442170; ENSP00000393812; ENSG00000077942 [P23142-3] |
GeneIDi | 2192 |
KEGGi | hsa:2192 |
MANE-Selecti | ENST00000327858.11; ENSP00000331544.6; NM_006486.3; NP_006477.3 |
UCSCi | uc003bgg.2, human [P23142-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53741 mRNA Translation: CAA37770.1 X53742 mRNA Translation: CAA37771.1 X53743 mRNA Translation: CAA37772.1 U01244 mRNA Translation: AAB17099.1 AF126110 mRNA Translation: AAK37822.1 AF217999 mRNA Translation: AAG17241.1 Frameshift. AL021391 Genomic DNA No translation available. Z95331 Genomic DNA No translation available. Z98047 Genomic DNA No translation available. BC022497 mRNA Translation: AAH22497.1 AY040589 Genomic DNA Translation: AAK82945.1 |
CCDSi | CCDS14067.1 [P23142-1] CCDS14068.1 [P23142-3] CCDS14069.1 [P23142-4] CCDS43028.1 [P23142-2] |
PIRi | C36346 |
RefSeqi | NP_001987.2, NM_001996.3 [P23142-4] NP_006476.2, NM_006485.3 [P23142-3] NP_006477.2, NM_006486.2 [P23142-1] NP_006478.2, NM_006487.2 [P23142-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108486, 113 interactors |
IntActi | P23142, 82 interactors |
MINTi | P23142 |
STRINGi | 9606.ENSP00000331544 |
PTM databases
GlyConnecti | 1244, 8 N-Linked glycans (2 sites) |
GlyGeni | P23142, 4 sites, 10 N-linked glycans (2 sites), 1 O-linked glycan (1 site) |
iPTMneti | P23142 |
PhosphoSitePlusi | P23142 |
Genetic variation databases
BioMutai | FBLN1 |
DMDMi | 215274249 |
Proteomic databases
CPTACi | non-CPTAC-1123 |
EPDi | P23142 |
jPOSTi | P23142 |
MassIVEi | P23142 |
MaxQBi | P23142 |
PaxDbi | P23142 |
PeptideAtlasi | P23142 |
PRIDEi | P23142 |
ProteomicsDBi | 2960 54057 [P23142-1] 54058 [P23142-2] 54059 [P23142-3] 54060 [P23142-4] |
Protocols and materials databases
Antibodypediai | 886, 327 antibodies from 34 providers |
DNASUi | 2192 |
Genome annotation databases
Ensembli | ENST00000262722; ENSP00000262722; ENSG00000077942 [P23142-4] ENST00000327858; ENSP00000331544; ENSG00000077942 ENST00000340923; ENSP00000342212; ENSG00000077942 [P23142-2] ENST00000442170; ENSP00000393812; ENSG00000077942 [P23142-3] |
GeneIDi | 2192 |
KEGGi | hsa:2192 |
MANE-Selecti | ENST00000327858.11; ENSP00000331544.6; NM_006486.3; NP_006477.3 |
UCSCi | uc003bgg.2, human [P23142-1] |
Organism-specific databases
CTDi | 2192 |
DisGeNETi | 2192 |
GeneCardsi | FBLN1 |
HGNCi | HGNC:3600, FBLN1 |
HPAi | ENSG00000077942, Low tissue specificity |
MalaCardsi | FBLN1 |
MIMi | 135820, gene 608180, phenotype |
neXtProti | NX_P23142 |
OpenTargetsi | ENSG00000077942 |
Orphaneti | 404451, FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome 295197, Synpolydactyly type 2 |
PharmGKBi | PA28013 |
VEuPathDBi | HostDB:ENSG00000077942 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000156642 |
HOGENOMi | CLU_004826_1_1_1 |
InParanoidi | P23142 |
OMAi | FEECINT |
OrthoDBi | 1174178at2759 |
PhylomeDBi | P23142 |
TreeFami | TF317514 |
Enzyme and pathway databases
PathwayCommonsi | P23142 |
Reactomei | R-HSA-2129379, Molecules associated with elastic fibres |
SignaLinki | P23142 |
Miscellaneous databases
BioGRID-ORCSi | 2192, 3 hits in 1037 CRISPR screens |
ChiTaRSi | FBLN1, human |
GeneWikii | FBLN1 |
GenomeRNAii | 2192 |
Pharosi | P23142, Tbio |
PROi | PR:P23142 |
RNActi | P23142, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077942, Expressed in endocervix and 230 other tissues |
ExpressionAtlasi | P23142, baseline and differential |
Genevisiblei | P23142, HS |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017048, Fibulin-1 IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 4 hits |
PIRSFi | PIRSF036313, Fibulin-1, 1 hit |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 9 hits SM00179, EGF_CA, 8 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 3 hits PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 5 hits PS01187, EGF_CA, 8 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FBLN1_HUMAN | |
Accessioni | P23142Primary (citable) accession number: P23142 Secondary accession number(s): B0QY42 Q9UH41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 23, 2022 | |
This is version 243 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families