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UniProtKB - P23141 (EST1_HUMAN)

Entry version 210 (23 Feb 2022)
Sequence version 2 (01 Aug 1992)
Previous versions | rss
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Protein

Liver carboxylesterase 1

Gene

CES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277).

Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277).

Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644).

Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644).

Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644).

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).

Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:18762277, PubMed:16024911, PubMed:11015575, PubMed:16971496).

First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:18762277, PubMed:18599737, PubMed:16971496).

9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by CHAPS (PubMed:9490062). Inhibited by chlorpyrifos oxon (IC50=0.21 nM), paraoxon (IC50=0.29 nM), or methyl paraoxon (IC50=49 nM) (PubMed:18762277).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 59 min(-1), 29 min(-1), 90 min(-1) with 2-arachidonoylglycerol, prostaglandin F2alpha 1-glyceryl ester and prostaglandin E2 1-glyceryl ester as substrates, respectively.1 Publication
  1. KM=106.6 µM for p-nitrophenyl acetate4 Publications
  2. KM=775.7 µM for L-methylphenidate4 Publications
  3. KM=663.5 µM for D-methylphenidate4 Publications
  4. KM=116 µM for cocaine4 Publications
  5. KM=43 mM for ethanol4 Publications
  6. KM=0.8 mM for 4-methylumbelliferyl acetate4 Publications
  7. KM=6.3 mM for heroin4 Publications
  8. KM=8.3 mM for 6-monoacetylmorphine4 Publications
  9. KM=49 µM for 2-arachidonoylglycerol1 Publication
  10. KM=250 µM for prostaglandin E2 1-glyceryl ester1 Publication
  11. KM=93 µM for prostaglandin F2alpha 1-glyceryl ester1 Publication
  1. Vmax=493.9 nmol/min/mg enzyme with p-nitrophenyl acetate as substrate4 Publications
  2. Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate4 Publications
  3. Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate4 Publications

pH dependencei

Optimum pH is 6.5.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1 Publication1
Active sitei354Charge relay system1 Publication1
Active sitei468Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processLipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23141

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
R-HSA-211945, Phase I - Functionalization of compounds

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P23141

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P23141

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-CES1, Carb_B_Chordata

MEROPS protease database

More...MEROPSi		S09.982

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001265

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liver carboxylesterase 1Curated
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase
Short name:
ACAT
Brain carboxylesterase hBr1
Carboxylesterase 1 (EC:3.1.1.13 Publications)
Short name:
CE-1
Short name:
hCE-1
Cholesteryl ester hydrolase1 Publication (EC:3.1.1.134 Publications)
Short name:
CEH1 Publication
Cocaine carboxylesterase
Egasyn
HMSE
Methylumbelliferyl-acetate deacetylase 1 (EC:3.1.1.562 Publications)
Monocyte/macrophage serine esterase
Retinyl ester hydrolase
Short name:
REH
Serine esterase 1
Triacylglycerol hydrolase
Short name:
TGH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CES1Imported
Synonyms:CES2, SES1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1863, CES1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114835, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23141

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198848

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi79N → A: Abolishes glycosylation. 1 Publication1
Mutagenesisi221S → A: Loss of activity. 1 Publication1
Mutagenesisi354E → A: Loss of activity. 1 Publication1
Mutagenesisi468H → A: Loss of activity. 1 Publication1
Mutagenesisi564 – 567Missing : Does not result in secretion. 1 Publication4

Organism-specific databases

DisGeNET

More...DisGeNETi		1066

MalaCards human disease database

More...MalaCardsi		CES1
MIMi618057, phenotype

Open Targets

More...OpenTargetsi		ENSG00000198848

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA107

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23141, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2265

Drug and drug target database

More...DrugBanki		DB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
DB08224, (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
DB03056, 4-Piperidino-Piperidine
DB06442, Avasimibe
DB01086, Benzocaine
DB01101, Capecitabine
DB02659, Cholic Acid
DB01410, Ciclesonide
DB00758, Clopidogrel
DB00907, Cocaine
DB04838, Cyclandelate
DB06695, Dabigatran etexilate
DB00647, Dextropropoxyphene
DB01452, Diamorphine
DB01039, Fenofibrate
DB14845, Filgotinib
DB11181, Homatropine
DB02161, Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
DB00328, Indomethacin
DB00762, Irinotecan
DB00583, Levocarnitine
DB00454, Meperidine
DB06693, Mevastatin
DB00688, Mycophenolate mofetil
DB03721, N-acetyl-alpha-neuraminic acid
DB01183, Naloxone
DB00198, Oseltamivir
DB09269, Phenylacetic acid
DB01599, Probucol
DB09342, Propoxycaine
DB00881, Quinapril
DB14761, Remdesivir
DB12404, Remimazolam
DB06201, Rufinamide
DB11362, Selexipag
DB00382, Tacrine
DB00675, Tamoxifen
DB09299, Tenofovir alafenamide
DB04795, Thenoyltrifluoroacetone
DB00519, Trandolapril

DrugCentral

More...DrugCentrali		P23141

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2592

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CES1

Domain mapping of disease mutations (DMDM)

More...DMDMi		119576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 172 PublicationsAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039135918 – 567Liver carboxylesterase 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi87 ↔ 116
Disulfide bondi274 ↔ 285
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei380PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains sialic acid.
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23141

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23141

MaxQB - The MaxQuant DataBase

More...MaxQBi		P23141

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23141

PeptideAtlas

More...PeptideAtlasi		P23141

PRoteomics IDEntifications database

More...PRIDEi		P23141

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19083
54055 [P23141-1]
54056 [P23141-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1462, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23141, 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23141

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23141

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in liver with lower levels in heart and lung (PubMed:10562416). Expressed in macrophages (PubMed:11015575, PubMed:21049984, PubMed:18762277).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198848, Expressed in right lobe of liver and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23141, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23141, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198848, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer and homohexamer. Binds to beta-glucuronidase.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107494, 25 interactors

Protein interaction database and analysis system

More...IntActi		P23141, 13 interactors

Molecular INTeraction database

More...MINTi		P23141

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353720

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P23141

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23141, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23141

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23141

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154623

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006586_13_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23141

Identification of Orthologs from Complete Genome Data

More...OMAi		DSNSGPY

Database of Orthologous Groups

More...OrthoDBi		754103at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23141

TreeFam database of animal gene trees

More...TreeFami		TF315470

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00135, COesterase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23141-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF 
        60         70         80         90        100
LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL 
       110        120        130        140        150
FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS 
       160        170        180        190        200
TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW 
       210        220        230        240        250
VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA 
       260        270        280        290        300
LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK 
       310        320        330        340        350
MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI 
       360        370        380        390        400
NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT 
       410        420        430        440        450
EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ 
       460        470        480        490        500
YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW 
       510        520        530        540        550
ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL 
       560 
FAKKAVEKPP QTEHIEL
Length:567
Mass (Da):62,521
Last modified:August 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3A00BDCDC7E5DFF
GO
Isoform 2 (identifier: P23141-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-17: W → WA

Show »
Length:568
Mass (Da):62,592
Checksum:iAEC3C3DB33D1DDAC
GO
Isoform 3 (identifier: P23141-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-362: Missing.

Show »
Length:566
Mass (Da):62,393
Checksum:iAE8F6F2B7004416D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQV8H3BQV8_HUMAN
Liver carboxylesterase 1
CES1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSU0H3BSU0_HUMAN
Liver carboxylesterase 1
CES1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQR4H3BQR4_HUMAN
Liver carboxylesterase 1
CES1
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA63A0A140TA63_HUMAN
Liver carboxylesterase 1
CES1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA83932 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2W → L in AAD53175 (PubMed:10562416).Curated1
Sequence conflicti4 – 7RAFI → PALV in BAA04650 (PubMed:8406473).Curated4
Sequence conflicti4 – 7RAFI → PALV in BAC87749 (Ref. 8) Curated4
Sequence conflicti4 – 7RAFI → PALV in BAC87751 (Ref. 8) Curated4
Sequence conflicti4 – 7RAFI → PALV in BAF83312 (PubMed:14702039).Curated4
Sequence conflicti4 – 7RAFI → PALV in BAF84898 (PubMed:14702039).Curated4
Sequence conflicti4 – 7RAFI → PALV in AAH12418 (PubMed:15489334).Curated4
Sequence conflicti12S → A in BAA04650 (PubMed:8406473).Curated1
Sequence conflicti12S → A in BAC87749 (Ref. 8) Curated1
Sequence conflicti12S → A in BAC87751 (Ref. 8) Curated1
Sequence conflicti12S → A in BAF83312 (PubMed:14702039).Curated1
Sequence conflicti12S → A in BAF84898 (PubMed:14702039).Curated1
Sequence conflicti12S → A in AAH12418 (PubMed:15489334).Curated1
Sequence conflicti19 – 21HPS → GPP AA sequence (PubMed:8597091).Curated3
Sequence conflicti19H → N AA sequence (PubMed:9490062).Curated1
Sequence conflicti21 – 24SSPP → EAVV AA sequence (PubMed:9490062).Curated4
Sequence conflicti27 – 28DT → AK AA sequence (PubMed:9490062).Curated2
Sequence conflicti28 – 29TV → DT AA sequence (PubMed:8597091).Curated2
Sequence conflicti56A → G in AAA16036 (PubMed:8218228).Curated1
Sequence conflicti56A → G in AAA35711 (PubMed:8218228).Curated1
Sequence conflicti64R → G in CAA37147 (PubMed:2070086).Curated1
Sequence conflicti65F → S in AAP20868 (PubMed:11015575).Curated1
Sequence conflicti75S → A AA sequence (PubMed:9490062).Curated1
Sequence conflicti78K → I AA sequence (PubMed:9490062).Curated1
Sequence conflicti89Q → R in AAP20868 (PubMed:11015575).Curated1
Sequence conflicti98S → F AA sequence (PubMed:9490062).Curated1
Sequence conflicti105 – 107KEN → PAD AA sequence (PubMed:9490062).Curated3
Sequence conflicti115D → H in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti186R → G in CAA37147 (PubMed:2070086).Curated1
Sequence conflicti247S → I AA sequence (PubMed:9490062).Curated1
Sequence conflicti251L → K AA sequence (PubMed:9490062).Curated1
Sequence conflicti253S → G AA sequence (PubMed:9490062).Curated1
Sequence conflicti255L → P in BAF83312 (PubMed:14702039).Curated1
Sequence conflicti258K → Q AA sequence (PubMed:9490062).Curated1
Sequence conflicti281V → A in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti298T → I AA sequence (PubMed:9490062).Curated1
Sequence conflicti302K → A AA sequence (PubMed:9490062).Curated1
Sequence conflicti305S → M AA sequence (PubMed:9490062).Curated1
Sequence conflicti337A → R in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti417F → I in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti512E → K in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti536A → G in AAA16036 (PubMed:8218228).Curated1
Sequence conflicti536A → G in AAA35711 (PubMed:8218228).Curated1
Sequence conflicti563E → D in AAA83932 (PubMed:1748313).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variants in CES1 are associated with clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates [MIMi:618057].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00235718G → GA. 1
Natural variantiVAR_01431475S → N. Corresponds to variant dbSNP:rs2307240Ensembl.1
Natural variantiVAR_046954143G → E 5.4-fold decrease in activity with p-nitrophenyl acetate as substrate; no change in affinity for p-nitrophenyl acetate; loss of activity with L- or D-methylphenidate as substrate. 1 PublicationCorresponds to variant dbSNP:rs71647871Ensembl.1
Natural variantiVAR_014594199R → H. Corresponds to variant dbSNP:rs2307243Ensembl.1
Natural variantiVAR_014595203D → E. Corresponds to variant dbSNP:rs2307227Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02102617W → WA in isoform 2. 2 Publications1
Alternative sequenceiVSP_047158362Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M73499 mRNA Translation: AAA35649.1
L07764 mRNA Translation: AAA16036.1
L07765 mRNA Translation: AAA35711.1
D21088 Genomic DNA Translation: BAA04650.1
S73751 mRNA Translation: AAC60631.2
AF177775 mRNA Translation: AAD53175.1
AY268104 mRNA Translation: AAP20868.1
AB119995 mRNA Translation: BAC87748.1
AB119996 mRNA Translation: BAC87749.1
AB119997 Genomic DNA Translation: BAC87750.1
AB119998 Genomic DNA Translation: BAC87751.1
AK290623 mRNA Translation: BAF83312.1
AK292209 mRNA Translation: BAF84898.1
AC147362 Genomic DNA No translation available.
BC012418 mRNA Translation: AAH12418.1
BC110338 mRNA Translation: AAI10339.1
AB025026 mRNA Translation: BAA84995.1
M55509 mRNA Translation: AAA35650.1
X52973 mRNA Translation: CAA37147.1
M65261 mRNA Translation: AAA83932.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32450.1 [P23141-2]
CCDS45488.1 [P23141-1]
CCDS45489.1 [P23141-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A41010

NCBI Reference Sequences

More...RefSeqi		NP_001020365.1, NM_001025194.1 [P23141-1]
NP_001020366.1, NM_001025195.1 [P23141-2]
NP_001257.4, NM_001266.4 [P23141-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360526; ENSP00000353720; ENSG00000198848 [P23141-2]
ENST00000361503; ENSP00000355193; ENSG00000198848
ENST00000422046; ENSP00000390492; ENSG00000198848 [P23141-3]
ENST00000571922; ENSP00000460045; ENSG00000262243
ENST00000574513; ENSP00000461208; ENSG00000262243
ENST00000576783; ENSP00000458586; ENSG00000262243

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1066

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000360526.8; ENSP00000353720.4; NM_001025195.2; NP_001020366.1 [P23141-2]

UCSC genome browser

More...UCSCi		uc002eil.4, human [P23141-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73499 mRNA Translation: AAA35649.1
L07764 mRNA Translation: AAA16036.1
L07765 mRNA Translation: AAA35711.1
D21088 Genomic DNA Translation: BAA04650.1
S73751 mRNA Translation: AAC60631.2
AF177775 mRNA Translation: AAD53175.1
AY268104 mRNA Translation: AAP20868.1
AB119995 mRNA Translation: BAC87748.1
AB119996 mRNA Translation: BAC87749.1
AB119997 Genomic DNA Translation: BAC87750.1
AB119998 Genomic DNA Translation: BAC87751.1
AK290623 mRNA Translation: BAF83312.1
AK292209 mRNA Translation: BAF84898.1
AC147362 Genomic DNA No translation available.
BC012418 mRNA Translation: AAH12418.1
BC110338 mRNA Translation: AAI10339.1
AB025026 mRNA Translation: BAA84995.1
M55509 mRNA Translation: AAA35650.1
X52973 mRNA Translation: CAA37147.1
M65261 mRNA Translation: AAA83932.1 Frameshift.
CCDSiCCDS32450.1 [P23141-2]
CCDS45488.1 [P23141-1]
CCDS45489.1 [P23141-3]
PIRiA41010
RefSeqiNP_001020365.1, NM_001025194.1 [P23141-1]
NP_001020366.1, NM_001025195.1 [P23141-2]
NP_001257.4, NM_001266.4 [P23141-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MX1X-ray2.40A/B/C/D/E/F19-567[»]
1MX5X-ray2.80A/B/C/D/E/F19-567[»]
1MX9X-ray2.90A/B/C/D/E/F/G/H/I/J/K/L19-567[»]
1YA4X-ray3.20A/B/C21-552[»]
1YA8X-ray3.00A/B/C21-552[»]
1YAHX-ray3.00A/B/C21-552[»]
1YAJX-ray3.20A/B/C/D/E/F/G/H/I/J/K/L21-552[»]
2DQYX-ray3.00A/B/C19-561[»]
2DQZX-ray2.80A/B/C19-561[»]
2DR0X-ray3.20A/B/C19-561[»]
2H7CX-ray2.00A/B/C/D/E/F19-561[»]
2HRQX-ray2.70A/B/C/D/E/F21-553[»]
2HRRX-ray2.70A/B/C21-553[»]
3K9BX-ray3.10A/B/C24-553[»]
4AB1X-ray2.20A21-553[»]
5A7FX-ray1.86A21-553[»]
5A7GX-ray1.48A21-553[»]
5A7HX-ray2.01A22-553[»]
SMRiP23141
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107494, 25 interactors
IntActiP23141, 13 interactors
MINTiP23141
STRINGi9606.ENSP00000353720

Chemistry databases

BindingDBiP23141
ChEMBLiCHEMBL2265
DrugBankiDB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
DB08224, (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
DB03056, 4-Piperidino-Piperidine
DB06442, Avasimibe
DB01086, Benzocaine
DB01101, Capecitabine
DB02659, Cholic Acid
DB01410, Ciclesonide
DB00758, Clopidogrel
DB00907, Cocaine
DB04838, Cyclandelate
DB06695, Dabigatran etexilate
DB00647, Dextropropoxyphene
DB01452, Diamorphine
DB01039, Fenofibrate
DB14845, Filgotinib
DB11181, Homatropine
DB02161, Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
DB00328, Indomethacin
DB00762, Irinotecan
DB00583, Levocarnitine
DB00454, Meperidine
DB06693, Mevastatin
DB00688, Mycophenolate mofetil
DB03721, N-acetyl-alpha-neuraminic acid
DB01183, Naloxone
DB00198, Oseltamivir
DB09269, Phenylacetic acid
DB01599, Probucol
DB09342, Propoxycaine
DB00881, Quinapril
DB14761, Remdesivir
DB12404, Remimazolam
DB06201, Rufinamide
DB11362, Selexipag
DB00382, Tacrine
DB00675, Tamoxifen
DB09299, Tenofovir alafenamide
DB04795, Thenoyltrifluoroacetone
DB00519, Trandolapril
DrugCentraliP23141
GuidetoPHARMACOLOGYi2592
SwissLipidsiSLP:000001265

Protein family/group databases

ESTHERihuman-CES1, Carb_B_Chordata
MEROPSiS09.982

PTM databases

GlyConnecti1462, 3 N-Linked glycans (1 site)
GlyGeniP23141, 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiP23141
PhosphoSitePlusiP23141

Genetic variation databases

BioMutaiCES1
DMDMi119576

Proteomic databases

jPOSTiP23141
MassIVEiP23141
MaxQBiP23141
PaxDbiP23141
PeptideAtlasiP23141
PRIDEiP23141
ProteomicsDBi19083
54055 [P23141-1]
54056 [P23141-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28513, 320 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		1066

Genome annotation databases

EnsembliENST00000360526; ENSP00000353720; ENSG00000198848 [P23141-2]
ENST00000361503; ENSP00000355193; ENSG00000198848
ENST00000422046; ENSP00000390492; ENSG00000198848 [P23141-3]
ENST00000571922; ENSP00000460045; ENSG00000262243
ENST00000574513; ENSP00000461208; ENSG00000262243
ENST00000576783; ENSP00000458586; ENSG00000262243
GeneIDi1066
KEGGihsa:1066
MANE-SelectiENST00000360526.8; ENSP00000353720.4; NM_001025195.2; NP_001020366.1 [P23141-2]
UCSCiuc002eil.4, human [P23141-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1066
DisGeNETi1066

GeneCards: human genes, protein and diseases

More...GeneCardsi		CES1
HGNCiHGNC:1863, CES1
HPAiENSG00000198848, Tissue enriched (liver)
MalaCardsiCES1
MIMi114835, gene
618057, phenotype
neXtProtiNX_P23141
OpenTargetsiENSG00000198848
PharmGKBiPA107
VEuPathDBiHostDB:ENSG00000198848

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1516, Eukaryota
GeneTreeiENSGT00940000154623
HOGENOMiCLU_006586_13_0_1
InParanoidiP23141
OMAiDSNSGPY
OrthoDBi754103at2759
PhylomeDBiP23141
TreeFamiTF315470

Enzyme and pathway databases

BRENDAi3.1.1.1, 2681
PathwayCommonsiP23141
ReactomeiR-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
R-HSA-211945, Phase I - Functionalization of compounds
SABIO-RKiP23141
SignaLinkiP23141

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1066, 10 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CES1, human
EvolutionaryTraceiP23141

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Carboxylesterase_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1066
PharosiP23141, Tchem

Protein Ontology

More...PROi		PR:P23141
RNActiP23141, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198848, Expressed in right lobe of liver and 114 other tissues
ExpressionAtlasiP23141, baseline and differential
GenevisibleiP23141, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135, COesterase, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEST1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23141
Secondary accession number(s): A6NIM1
, A8K3K8, A8K844, E9PAU8, P82127, Q00015, Q13657, Q14062, Q16737, Q16788, Q549X7, Q549X8, Q86UK2, Q96EE8, Q9UC52, Q9UDG8, Q9UK77, Q9ULY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: August 1, 1992
Last modified: February 23, 2022
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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