Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P23141 (EST1_HUMAN)

Protein

Liver carboxylesterase 1

Gene

CES1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.2 Publications

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation3 Publications
4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate.1 Publication

Activity regulationi

Activated by CHAPS.1 Publication

Kineticsi

  1. KM=106.6 µM for p-nitrophenyl acetate4 Publications
  2. KM=775.7 µM for L-methylphenidate4 Publications
  3. KM=663.5 µM for D-methylphenidate4 Publications
  4. KM=116 µM for cocaine4 Publications
  5. KM=43 mM for ethanol4 Publications
  6. KM=0.8 mM for 4-methylumbelliferyl acetate4 Publications
  7. KM=6.3 mM for heroin4 Publications
  8. KM=8.3 mM for 6-monoacetylmorphine4 Publications
  1. Vmax=493.9 nmol/min/mg enzyme with p-nitrophenyl acetate as substrate4 Publications
  2. Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate4 Publications
  3. Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate4 Publications

pH dependencei

Optimum pH is 6.5.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1 Publication1
Active sitei354Charge relay system1 Publication1
Active sitei468Charge relay system1 Publication1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BioCyciMetaCyc:HS11616-MONOMER
BRENDAi3.1.1.1 2681
ReactomeiR-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKiP23141

Protein family/group databases

ESTHERihuman-CES1 Carb_B_Chordata
MEROPSiS09.982

Chemistry databases

SwissLipidsiSLP:000001265

Names & Taxonomyi

Protein namesi
Recommended name:
Liver carboxylesterase 1
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase
Short name:
ACAT
Brain carboxylesterase hBr1
Carboxylesterase 1 (EC:3.1.1.13 Publications)
Short name:
CE-1
Short name:
hCE-1
Cocaine carboxylesterase
Egasyn
HMSE
Methylumbelliferyl-acetate deacetylase 1 (EC:3.1.1.561 Publication)
Monocyte/macrophage serine esterase
Retinyl ester hydrolase
Short name:
REH
Serine esterase 1
Triacylglycerol hydrolase
Short name:
TGH
Gene namesi
Name:CES1
Synonyms:CES2, SES1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000198848.12
HGNCiHGNC:1863 CES1
MIMi114835 gene+phenotype
neXtProtiNX_P23141

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79N → A: Abolishes glycosylation. 1 Publication1
Mutagenesisi221S → A: Loss of activity. 1 Publication1
Mutagenesisi354E → A: Loss of activity. 1 Publication1
Mutagenesisi468H → A: Loss of activity. 1 Publication1
Mutagenesisi564 – 567Missing : Does not result in secretion. 1 Publication4

Organism-specific databases

DisGeNETi1066
MIMi114835 gene+phenotype
OpenTargetsiENSG00000198848
PharmGKBiPA107

Chemistry databases

ChEMBLiCHEMBL2265
DrugBankiDB03056 4-Piperidino-Piperidine
DB01086 Benzocaine
DB01101 Capecitabine
DB02659 Cholic Acid
DB01410 Ciclesonide
DB00758 Clopidogrel
DB04838 Cyclandelate
DB06695 Dabigatran etexilate
DB02161 Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
DB00328 Indomethacin
DB00762 Irinotecan
DB00583 L-Carnitine
DB06693 Mevastatin
DB00688 Mycophenolate mofetil
DB03721 N-acetyl-alpha-neuraminic acid
DB04509 N-Methylnaloxonium
DB00198 Oseltamivir
DB09269 Phenylacetic acid
DB01599 Probucol
DB06201 Rufinamide
DB11362 Selexipag
DB00675 Tamoxifen
DB04795 Thenoyltrifluoroacetone
DB00519 Trandolapril
GuidetoPHARMACOLOGYi2592

Polymorphism and mutation databases

BioMutaiCES1
DMDMi119576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 172 PublicationsAdd BLAST17
ChainiPRO_000039135918 – 567Liver carboxylesterase 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi87 ↔ 116
Disulfide bondi274 ↔ 285
Modified residuei380PhosphoserineCombined sources1

Post-translational modificationi

Contains sialic acid.
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP23141
PaxDbiP23141
PeptideAtlasiP23141
PRIDEiP23141
ProteomicsDBi54055
54056 [P23141-2]

PTM databases

GlyConnecti1462
iPTMnetiP23141
PhosphoSitePlusiP23141

Expressioni

Tissue specificityi

Expressed predominantly in liver with lower levels in heart and lung.1 Publication

Gene expression databases

BgeeiENSG00000198848 Expressed in 90 organ(s), highest expression level in right lobe of liver
CleanExiHS_CES1
HS_CES2
ExpressionAtlasiP23141 baseline and differential
GenevisibleiP23141 HS

Organism-specific databases

HPAiHPA012023
HPA046717

Interactioni

Subunit structurei

Homotrimer and homohexamer. Binds to beta-glucuronidase.4 Publications

Protein-protein interaction databases

BioGridi107494, 11 interactors
IntActiP23141, 11 interactors
MINTiP23141
STRINGi9606.ENSP00000353720

Chemistry databases

BindingDBiP23141

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23141
SMRiP23141
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23141

Family & Domainsi

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOVERGENiHBG008839
InParanoidiP23141
KOiK01044
OMAiSEPRYDG
OrthoDBiEOG091G03ZC
PhylomeDBiP23141
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23141-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF 
        60         70         80         90        100
LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL 
       110        120        130        140        150
FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS 
       160        170        180        190        200
TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW 
       210        220        230        240        250
VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA 
       260        270        280        290        300
LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK 
       310        320        330        340        350
MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI 
       360        370        380        390        400
NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT 
       410        420        430        440        450
EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ 
       460        470        480        490        500
YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW 
       510        520        530        540        550
ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL 
       560 
FAKKAVEKPP QTEHIEL
Length:567
Mass (Da):62,521
Last modified:August 1, 1992 - v2
Checksum:iD3A00BDCDC7E5DFF
GO
Isoform 2 (identifier: P23141-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-17: W → WA

Show »
Length:568
Mass (Da):62,592
Checksum:iAEC3C3DB33D1DDAC
GO
Isoform 3 (identifier: P23141-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-362: Missing.

Show »
Length:566
Mass (Da):62,393
Checksum:iAE8F6F2B7004416D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQV8H3BQV8_HUMAN
Liver carboxylesterase 1
CES1
131Annotation score:
H3BSU0H3BSU0_HUMAN
Liver carboxylesterase 1
CES1
84Annotation score:
H3BQR4H3BQR4_HUMAN
Liver carboxylesterase 1
CES1
44Annotation score:
A0A140TA63A0A140TA63_HUMAN
Liver carboxylesterase 1
CES1
134Annotation score:

Sequence cautioni

The sequence AAA83932 differs from that shown. Reason: Frameshift at positions 301, 312, 318, 383 and 391.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2W → L in AAD53175 (PubMed:10562416).Curated1
Sequence conflicti4 – 7RAFI → PALV in BAA04650 (PubMed:8406473).Curated4
Sequence conflicti4 – 7RAFI → PALV in BAC87749 (Ref. 8) Curated4
Sequence conflicti4 – 7RAFI → PALV in BAC87751 (Ref. 8) Curated4
Sequence conflicti4 – 7RAFI → PALV in BAF83312 (PubMed:14702039).Curated4
Sequence conflicti4 – 7RAFI → PALV in BAF84898 (PubMed:14702039).Curated4
Sequence conflicti4 – 7RAFI → PALV in AAH12418 (PubMed:15489334).Curated4
Sequence conflicti12S → A in BAA04650 (PubMed:8406473).Curated1
Sequence conflicti12S → A in BAC87749 (Ref. 8) Curated1
Sequence conflicti12S → A in BAC87751 (Ref. 8) Curated1
Sequence conflicti12S → A in BAF83312 (PubMed:14702039).Curated1
Sequence conflicti12S → A in BAF84898 (PubMed:14702039).Curated1
Sequence conflicti12S → A in AAH12418 (PubMed:15489334).Curated1
Sequence conflicti19 – 21HPS → GPP AA sequence (PubMed:8597091).Curated3
Sequence conflicti19H → N AA sequence (PubMed:9490062).Curated1
Sequence conflicti21 – 24SSPP → EAVV AA sequence (PubMed:9490062).Curated4
Sequence conflicti27 – 28DT → AK AA sequence (PubMed:9490062).Curated2
Sequence conflicti28 – 29TV → DT AA sequence (PubMed:8597091).Curated2
Sequence conflicti56A → G in AAA16036 (PubMed:8218228).Curated1
Sequence conflicti56A → G in AAA35711 (PubMed:8218228).Curated1
Sequence conflicti64R → G in CAA37147 (PubMed:2070086).Curated1
Sequence conflicti65F → S in AAP20868 (PubMed:11015575).Curated1
Sequence conflicti75S → A AA sequence (PubMed:9490062).Curated1
Sequence conflicti78K → I AA sequence (PubMed:9490062).Curated1
Sequence conflicti89Q → R in AAP20868 (PubMed:11015575).Curated1
Sequence conflicti98S → F AA sequence (PubMed:9490062).Curated1
Sequence conflicti105 – 107KEN → PAD AA sequence (PubMed:9490062).Curated3
Sequence conflicti115D → H in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti186R → G in CAA37147 (PubMed:2070086).Curated1
Sequence conflicti247S → I AA sequence (PubMed:9490062).Curated1
Sequence conflicti251L → K AA sequence (PubMed:9490062).Curated1
Sequence conflicti253S → G AA sequence (PubMed:9490062).Curated1
Sequence conflicti255L → P in BAF83312 (PubMed:14702039).Curated1
Sequence conflicti258K → Q AA sequence (PubMed:9490062).Curated1
Sequence conflicti281V → A in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti298T → I AA sequence (PubMed:9490062).Curated1
Sequence conflicti302K → A AA sequence (PubMed:9490062).Curated1
Sequence conflicti305S → M AA sequence (PubMed:9490062).Curated1
Sequence conflicti337A → R in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti417F → I in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti512E → K in AAA83932 (PubMed:1748313).Curated1
Sequence conflicti536A → G in AAA16036 (PubMed:8218228).Curated1
Sequence conflicti536A → G in AAA35711 (PubMed:8218228).Curated1
Sequence conflicti563E → D in AAA83932 (PubMed:1748313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00235718G → GA. 1
Natural variantiVAR_01431475S → N. Corresponds to variant dbSNP:rs2307240Ensembl.1
Natural variantiVAR_046954143G → E 5.4-fold decrease in activity with p-nitrophenyl acetate as substrate; no change in affinity for p-nitrophenyl acetate; loss of activity with L- or D-methylphenidate as substrate. 1 PublicationCorresponds to variant dbSNP:rs71647871Ensembl.1
Natural variantiVAR_014594199R → H. Corresponds to variant dbSNP:rs2307243Ensembl.1
Natural variantiVAR_014595203D → E. Corresponds to variant dbSNP:rs2307227Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02102617W → WA in isoform 2. 2 Publications1
Alternative sequenceiVSP_047158362Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73499 mRNA Translation: AAA35649.1
L07764 mRNA Translation: AAA16036.1
L07765 mRNA Translation: AAA35711.1
D21088 Genomic DNA Translation: BAA04650.1
S73751 mRNA Translation: AAC60631.2
AF177775 mRNA Translation: AAD53175.1
AY268104 mRNA Translation: AAP20868.1
AB119995 mRNA Translation: BAC87748.1
AB119996 mRNA Translation: BAC87749.1
AB119997 Genomic DNA Translation: BAC87750.1
AB119998 Genomic DNA Translation: BAC87751.1
AK290623 mRNA Translation: BAF83312.1
AK292209 mRNA Translation: BAF84898.1
AC147362 Genomic DNA No translation available.
BC012418 mRNA Translation: AAH12418.1
BC110338 mRNA Translation: AAI10339.1
AB025026 mRNA Translation: BAA84995.1
M55509 mRNA Translation: AAA35650.1
X52973 mRNA Translation: CAA37147.1
M65261 mRNA Translation: AAA83932.1 Frameshift.
CCDSiCCDS32450.1 [P23141-2]
CCDS45488.1 [P23141-1]
CCDS45489.1 [P23141-3]
PIRiA41010
RefSeqiNP_001020365.1, NM_001025194.1 [P23141-1]
NP_001020366.1, NM_001025195.1 [P23141-2]
NP_001257.4, NM_001266.4 [P23141-3]
UniGeneiHs.558865

Genome annotation databases

EnsembliENST00000360526; ENSP00000353720; ENSG00000198848 [P23141-2]
ENST00000361503; ENSP00000355193; ENSG00000198848 [P23141-1]
ENST00000422046; ENSP00000390492; ENSG00000198848 [P23141-3]
ENST00000571922; ENSP00000460045; ENSG00000262243
ENST00000574513; ENSP00000461208; ENSG00000262243
ENST00000576783; ENSP00000458586; ENSG00000262243
GeneIDi1066
KEGGihsa:1066
UCSCiuc002eil.4 human [P23141-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73499 mRNA Translation: AAA35649.1
L07764 mRNA Translation: AAA16036.1
L07765 mRNA Translation: AAA35711.1
D21088 Genomic DNA Translation: BAA04650.1
S73751 mRNA Translation: AAC60631.2
AF177775 mRNA Translation: AAD53175.1
AY268104 mRNA Translation: AAP20868.1
AB119995 mRNA Translation: BAC87748.1
AB119996 mRNA Translation: BAC87749.1
AB119997 Genomic DNA Translation: BAC87750.1
AB119998 Genomic DNA Translation: BAC87751.1
AK290623 mRNA Translation: BAF83312.1
AK292209 mRNA Translation: BAF84898.1
AC147362 Genomic DNA No translation available.
BC012418 mRNA Translation: AAH12418.1
BC110338 mRNA Translation: AAI10339.1
AB025026 mRNA Translation: BAA84995.1
M55509 mRNA Translation: AAA35650.1
X52973 mRNA Translation: CAA37147.1
M65261 mRNA Translation: AAA83932.1 Frameshift.
CCDSiCCDS32450.1 [P23141-2]
CCDS45488.1 [P23141-1]
CCDS45489.1 [P23141-3]
PIRiA41010
RefSeqiNP_001020365.1, NM_001025194.1 [P23141-1]
NP_001020366.1, NM_001025195.1 [P23141-2]
NP_001257.4, NM_001266.4 [P23141-3]
UniGeneiHs.558865

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MX1X-ray2.40A/B/C/D/E/F19-567[»]
1MX5X-ray2.80A/B/C/D/E/F19-567[»]
1MX9X-ray2.90A/B/C/D/E/F/G/H/I/J/K/L19-567[»]
1YA4X-ray3.20A/B/C21-552[»]
1YA8X-ray3.00A/B/C21-552[»]
1YAHX-ray3.00A/B/C21-552[»]
1YAJX-ray3.20A/B/C/D/E/F/G/H/I/J/K/L21-552[»]
2DQYX-ray3.00A/B/C19-561[»]
2DQZX-ray2.80A/B/C19-561[»]
2DR0X-ray3.20A/B/C19-561[»]
2H7CX-ray2.00A/B/C/D/E/F19-561[»]
2HRQX-ray2.70A/B/C/D/E/F21-553[»]
2HRRX-ray2.70A/B/C21-553[»]
3K9BX-ray3.10A/B/C24-553[»]
4AB1X-ray2.20A21-553[»]
5A7FX-ray1.86A21-553[»]
5A7GX-ray1.48A21-553[»]
5A7HX-ray2.01A22-553[»]
ProteinModelPortaliP23141
SMRiP23141
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107494, 11 interactors
IntActiP23141, 11 interactors
MINTiP23141
STRINGi9606.ENSP00000353720

Chemistry databases

BindingDBiP23141
ChEMBLiCHEMBL2265
DrugBankiDB03056 4-Piperidino-Piperidine
DB01086 Benzocaine
DB01101 Capecitabine
DB02659 Cholic Acid
DB01410 Ciclesonide
DB00758 Clopidogrel
DB04838 Cyclandelate
DB06695 Dabigatran etexilate
DB02161 Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
DB00328 Indomethacin
DB00762 Irinotecan
DB00583 L-Carnitine
DB06693 Mevastatin
DB00688 Mycophenolate mofetil
DB03721 N-acetyl-alpha-neuraminic acid
DB04509 N-Methylnaloxonium
DB00198 Oseltamivir
DB09269 Phenylacetic acid
DB01599 Probucol
DB06201 Rufinamide
DB11362 Selexipag
DB00675 Tamoxifen
DB04795 Thenoyltrifluoroacetone
DB00519 Trandolapril
GuidetoPHARMACOLOGYi2592
SwissLipidsiSLP:000001265

Protein family/group databases

ESTHERihuman-CES1 Carb_B_Chordata
MEROPSiS09.982

PTM databases

GlyConnecti1462
iPTMnetiP23141
PhosphoSitePlusiP23141

Polymorphism and mutation databases

BioMutaiCES1
DMDMi119576

Proteomic databases

MaxQBiP23141
PaxDbiP23141
PeptideAtlasiP23141
PRIDEiP23141
ProteomicsDBi54055
54056 [P23141-2]

Protocols and materials databases

DNASUi1066
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360526; ENSP00000353720; ENSG00000198848 [P23141-2]
ENST00000361503; ENSP00000355193; ENSG00000198848 [P23141-1]
ENST00000422046; ENSP00000390492; ENSG00000198848 [P23141-3]
ENST00000571922; ENSP00000460045; ENSG00000262243
ENST00000574513; ENSP00000461208; ENSG00000262243
ENST00000576783; ENSP00000458586; ENSG00000262243
GeneIDi1066
KEGGihsa:1066
UCSCiuc002eil.4 human [P23141-1]

Organism-specific databases

CTDi1066
DisGeNETi1066
EuPathDBiHostDB:ENSG00000198848.12
GeneCardsiCES1
HGNCiHGNC:1863 CES1
HPAiHPA012023
HPA046717
MIMi114835 gene+phenotype
neXtProtiNX_P23141
OpenTargetsiENSG00000198848
PharmGKBiPA107
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOVERGENiHBG008839
InParanoidiP23141
KOiK01044
OMAiSEPRYDG
OrthoDBiEOG091G03ZC
PhylomeDBiP23141
TreeFamiTF315470

Enzyme and pathway databases

BioCyciMetaCyc:HS11616-MONOMER
BRENDAi3.1.1.1 2681
ReactomeiR-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKiP23141

Miscellaneous databases

ChiTaRSiCES1 human
EvolutionaryTraceiP23141
GeneWikiiCarboxylesterase_1
GenomeRNAii1066
PROiPR:P23141
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198848 Expressed in 90 organ(s), highest expression level in right lobe of liver
CleanExiHS_CES1
HS_CES2
ExpressionAtlasiP23141 baseline and differential
GenevisibleiP23141 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEST1_HUMAN
AccessioniPrimary (citable) accession number: P23141
Secondary accession number(s): A6NIM1
, A8K3K8, A8K844, E9PAU8, P82127, Q00015, Q13657, Q14062, Q16737, Q16788, Q549X7, Q549X8, Q86UK2, Q96EE8, Q9UC52, Q9UDG8, Q9UK77, Q9ULY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: August 1, 1992
Last modified: October 10, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again