UniProtKB - P23141 (EST1_HUMAN)
Liver carboxylesterase 1
CES1
Functioni
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277).
Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277).
Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644).
Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644).
Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644).
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:18762277, PubMed:16024911, PubMed:11015575, PubMed:16971496).
First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:18762277, PubMed:18599737, PubMed:16971496).
9 PublicationsCatalytic activityi
- EC:3.1.1.1PROSITE-ProRule annotation3 Publications
- EC:3.1.1.562 Publications
- EC:3.1.1.134 PublicationsThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Activity regulationi
Kineticsi
- KM=106.6 µM for p-nitrophenyl acetate4 Publications
- KM=775.7 µM for L-methylphenidate4 Publications
- KM=663.5 µM for D-methylphenidate4 Publications
- KM=116 µM for cocaine4 Publications
- KM=43 mM for ethanol4 Publications
- KM=0.8 mM for 4-methylumbelliferyl acetate4 Publications
- KM=6.3 mM for heroin4 Publications
- KM=8.3 mM for 6-monoacetylmorphine4 Publications
- KM=49 µM for 2-arachidonoylglycerol1 Publication
- KM=250 µM for prostaglandin E2 1-glyceryl ester1 Publication
- KM=93 µM for prostaglandin F2alpha 1-glyceryl ester1 Publication
- Vmax=493.9 nmol/min/mg enzyme with p-nitrophenyl acetate as substrate4 Publications
- Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate4 Publications
- Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate4 Publications
pH dependencei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 221 | Acyl-ester intermediatePROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 354 | Charge relay system1 Publication | 1 | |
Active sitei | 468 | Charge relay system1 Publication | 1 |
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: ARUK-UCL
- methyl indole-3-acetate esterase activity Source: UniProtKB-EC
- methylumbelliferyl-acetate deacetylase activity Source: UniProtKB-EC
- sterol esterase activity Source: UniProtKB
GO - Biological processi
- cellular response to cholesterol Source: ARUK-UCL
- cellular response to low-density lipoprotein particle stimulus Source: ARUK-UCL
- cholesterol biosynthetic process Source: BHF-UCL
- cholesterol ester hydrolysis involved in cholesterol transport Source: BHF-UCL
- cholesterol homeostasis Source: ARUK-UCL
- cholesterol metabolic process Source: UniProtKB
- epithelial cell differentiation Source: UniProtKB
- lipid catabolic process Source: GO_Central
- medium-chain fatty acid metabolic process Source: BHF-UCL
- negative regulation of cholesterol storage Source: UniProtKB
- positive regulation of cholesterol efflux Source: UniProtKB
- positive regulation of cholesterol metabolic process Source: UniProtKB
- regulation of bile acid biosynthetic process Source: UniProtKB
- regulation of bile acid secretion Source: UniProtKB
- response to toxic substance Source: ProtInc
- reverse cholesterol transport Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Serine esterase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 3.1.1.1, 2681 |
PathwayCommonsi | P23141 |
Reactomei | R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins R-HSA-211945, Phase I - Functionalization of compounds |
SABIO-RKi | P23141 |
SignaLinki | P23141 |
Protein family/group databases
ESTHERi | human-CES1, Carb_B_Chordata |
MEROPSi | S09.982 |
Chemistry databases
SwissLipidsi | SLP:000001265 |
Names & Taxonomyi
Protein namesi | Recommended name: Liver carboxylesterase 1CuratedAlternative name(s): Acyl-coenzyme A:cholesterol acyltransferase Short name: ACAT Brain carboxylesterase hBr1 Cocaine carboxylesterase Egasyn HMSE Methylumbelliferyl-acetate deacetylase 1 (EC:3.1.1.562 Publications) Monocyte/macrophage serine esterase Retinyl ester hydrolase Short name: REH Serine esterase 1 Triacylglycerol hydrolase Short name: TGH |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1863, CES1 |
MIMi | 114835, gene |
neXtProti | NX_P23141 |
VEuPathDBi | HostDB:ENSG00000198848 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Lipid droplet 1 Publication
Note: Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets.1 Publication
Cytosol
- cytosol Source: GOC
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum lumen Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- lipid droplet Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Lipid dropletPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 79 | N → A: Abolishes glycosylation. 1 Publication | 1 | |
Mutagenesisi | 221 | S → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 354 | E → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 468 | H → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 564 – 567 | Missing : Does not result in secretion. 1 Publication | 4 |
Organism-specific databases
DisGeNETi | 1066 |
MalaCardsi | CES1 |
MIMi | 618057, phenotype |
OpenTargetsi | ENSG00000198848 |
PharmGKBi | PA107 |
Miscellaneous databases
Pharosi | P23141, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2265 |
DrugBanki | DB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate DB08224, (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL DB03056, 4-Piperidino-Piperidine DB06442, Avasimibe DB01086, Benzocaine DB01101, Capecitabine DB02659, Cholic Acid DB01410, Ciclesonide DB00758, Clopidogrel DB00907, Cocaine DB04838, Cyclandelate DB06695, Dabigatran etexilate DB00647, Dextropropoxyphene DB01452, Diamorphine DB01039, Fenofibrate DB14845, Filgotinib DB11181, Homatropine DB02161, Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester DB00328, Indomethacin DB00762, Irinotecan DB00583, Levocarnitine DB00454, Meperidine DB06693, Mevastatin DB00688, Mycophenolate mofetil DB03721, N-acetyl-alpha-neuraminic acid DB01183, Naloxone DB00198, Oseltamivir DB09269, Phenylacetic acid DB01599, Probucol DB09342, Propoxycaine DB00881, Quinapril DB14761, Remdesivir DB12404, Remimazolam DB06201, Rufinamide DB11362, Selexipag DB00382, Tacrine DB00675, Tamoxifen DB09299, Tenofovir alafenamide DB04795, Thenoyltrifluoroacetone DB00519, Trandolapril |
DrugCentrali | P23141 |
GuidetoPHARMACOLOGYi | 2592 |
Genetic variation databases
BioMutai | CES1 |
DMDMi | 119576 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | 2 PublicationsAdd BLAST | 17 | |
ChainiPRO_0000391359 | 18 – 567 | Liver carboxylesterase 1Add BLAST | 550 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 79 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 87 ↔ 116 | |||
Disulfide bondi | 274 ↔ 285 | |||
Modified residuei | 380 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P23141 |
MassIVEi | P23141 |
MaxQBi | P23141 |
PaxDbi | P23141 |
PeptideAtlasi | P23141 |
PRIDEi | P23141 |
ProteomicsDBi | 19083 54055 [P23141-1] 54056 [P23141-2] |
PTM databases
GlyConnecti | 1462, 3 N-Linked glycans (1 site) |
GlyGeni | P23141, 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P23141 |
PhosphoSitePlusi | P23141 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198848, Expressed in right lobe of liver and 114 other tissues |
ExpressionAtlasi | P23141, baseline and differential |
Genevisiblei | P23141, HS |
Organism-specific databases
HPAi | ENSG00000198848, Tissue enriched (liver) |
Interactioni
Subunit structurei
Homotrimer and homohexamer. Binds to beta-glucuronidase.
4 PublicationsBinary interactionsi
Isoform 3 [P23141-3]
Protein-protein interaction databases
BioGRIDi | 107494, 25 interactors |
IntActi | P23141, 13 interactors |
MINTi | P23141 |
STRINGi | 9606.ENSP00000353720 |
Chemistry databases
BindingDBi | P23141 |
Miscellaneous databases
RNActi | P23141, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P23141 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P23141 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000154623 |
HOGENOMi | CLU_006586_13_0_1 |
InParanoidi | P23141 |
OMAi | DSNSGPY |
OrthoDBi | 754103at2759 |
PhylomeDBi | P23141 |
TreeFami | TF315470 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF
60 70 80 90 100
LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL
110 120 130 140 150
FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS
160 170 180 190 200
TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW
210 220 230 240 250
VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA
260 270 280 290 300
LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK
310 320 330 340 350
MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI
360 370 380 390 400
NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT
410 420 430 440 450
EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ
460 470 480 490 500
YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW
510 520 530 540 550
ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL
560
FAKKAVEKPP QTEHIEL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQV8 | H3BQV8_HUMAN | Liver carboxylesterase 1 | CES1 | 131 | Annotation score: | ||
H3BSU0 | H3BSU0_HUMAN | Liver carboxylesterase 1 | CES1 | 84 | Annotation score: | ||
H3BQR4 | H3BQR4_HUMAN | Liver carboxylesterase 1 | CES1 | 44 | Annotation score: | ||
A0A140TA63 | A0A140TA63_HUMAN | Liver carboxylesterase 1 | CES1 | 134 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | W → L in AAD53175 (PubMed:10562416).Curated | 1 | |
Sequence conflicti | 4 – 7 | RAFI → PALV in BAA04650 (PubMed:8406473).Curated | 4 | |
Sequence conflicti | 4 – 7 | RAFI → PALV in BAC87749 (Ref. 8) Curated | 4 | |
Sequence conflicti | 4 – 7 | RAFI → PALV in BAC87751 (Ref. 8) Curated | 4 | |
Sequence conflicti | 4 – 7 | RAFI → PALV in BAF83312 (PubMed:14702039).Curated | 4 | |
Sequence conflicti | 4 – 7 | RAFI → PALV in BAF84898 (PubMed:14702039).Curated | 4 | |
Sequence conflicti | 4 – 7 | RAFI → PALV in AAH12418 (PubMed:15489334).Curated | 4 | |
Sequence conflicti | 12 | S → A in BAA04650 (PubMed:8406473).Curated | 1 | |
Sequence conflicti | 12 | S → A in BAC87749 (Ref. 8) Curated | 1 | |
Sequence conflicti | 12 | S → A in BAC87751 (Ref. 8) Curated | 1 | |
Sequence conflicti | 12 | S → A in BAF83312 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 12 | S → A in BAF84898 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 12 | S → A in AAH12418 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 19 – 21 | HPS → GPP AA sequence (PubMed:8597091).Curated | 3 | |
Sequence conflicti | 19 | H → N AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 21 – 24 | SSPP → EAVV AA sequence (PubMed:9490062).Curated | 4 | |
Sequence conflicti | 27 – 28 | DT → AK AA sequence (PubMed:9490062).Curated | 2 | |
Sequence conflicti | 28 – 29 | TV → DT AA sequence (PubMed:8597091).Curated | 2 | |
Sequence conflicti | 56 | A → G in AAA16036 (PubMed:8218228).Curated | 1 | |
Sequence conflicti | 56 | A → G in AAA35711 (PubMed:8218228).Curated | 1 | |
Sequence conflicti | 64 | R → G in CAA37147 (PubMed:2070086).Curated | 1 | |
Sequence conflicti | 65 | F → S in AAP20868 (PubMed:11015575).Curated | 1 | |
Sequence conflicti | 75 | S → A AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 78 | K → I AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 89 | Q → R in AAP20868 (PubMed:11015575).Curated | 1 | |
Sequence conflicti | 98 | S → F AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 105 – 107 | KEN → PAD AA sequence (PubMed:9490062).Curated | 3 | |
Sequence conflicti | 115 | D → H in AAA83932 (PubMed:1748313).Curated | 1 | |
Sequence conflicti | 186 | R → G in CAA37147 (PubMed:2070086).Curated | 1 | |
Sequence conflicti | 247 | S → I AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 251 | L → K AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 253 | S → G AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 255 | L → P in BAF83312 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 258 | K → Q AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 281 | V → A in AAA83932 (PubMed:1748313).Curated | 1 | |
Sequence conflicti | 298 | T → I AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 302 | K → A AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 305 | S → M AA sequence (PubMed:9490062).Curated | 1 | |
Sequence conflicti | 337 | A → R in AAA83932 (PubMed:1748313).Curated | 1 | |
Sequence conflicti | 417 | F → I in AAA83932 (PubMed:1748313).Curated | 1 | |
Sequence conflicti | 512 | E → K in AAA83932 (PubMed:1748313).Curated | 1 | |
Sequence conflicti | 536 | A → G in AAA16036 (PubMed:8218228).Curated | 1 | |
Sequence conflicti | 536 | A → G in AAA35711 (PubMed:8218228).Curated | 1 | |
Sequence conflicti | 563 | E → D in AAA83932 (PubMed:1748313).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002357 | 18 | G → GA. | 1 | |
Natural variantiVAR_014314 | 75 | S → N. Corresponds to variant dbSNP:rs2307240Ensembl. | 1 | |
Natural variantiVAR_046954 | 143 | G → E 5.4-fold decrease in activity with p-nitrophenyl acetate as substrate; no change in affinity for p-nitrophenyl acetate; loss of activity with L- or D-methylphenidate as substrate. 1 PublicationCorresponds to variant dbSNP:rs71647871Ensembl. | 1 | |
Natural variantiVAR_014594 | 199 | R → H. Corresponds to variant dbSNP:rs2307243Ensembl. | 1 | |
Natural variantiVAR_014595 | 203 | D → E. Corresponds to variant dbSNP:rs2307227Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021026 | 17 | W → WA in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_047158 | 362 | Missing in isoform 3. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73499 mRNA Translation: AAA35649.1 L07764 mRNA Translation: AAA16036.1 L07765 mRNA Translation: AAA35711.1 D21088 Genomic DNA Translation: BAA04650.1 S73751 mRNA Translation: AAC60631.2 AF177775 mRNA Translation: AAD53175.1 AY268104 mRNA Translation: AAP20868.1 AB119995 mRNA Translation: BAC87748.1 AB119996 mRNA Translation: BAC87749.1 AB119997 Genomic DNA Translation: BAC87750.1 AB119998 Genomic DNA Translation: BAC87751.1 AK290623 mRNA Translation: BAF83312.1 AK292209 mRNA Translation: BAF84898.1 AC147362 Genomic DNA No translation available. BC012418 mRNA Translation: AAH12418.1 BC110338 mRNA Translation: AAI10339.1 AB025026 mRNA Translation: BAA84995.1 M55509 mRNA Translation: AAA35650.1 X52973 mRNA Translation: CAA37147.1 M65261 mRNA Translation: AAA83932.1 Frameshift. |
CCDSi | CCDS32450.1 [P23141-2] CCDS45488.1 [P23141-1] CCDS45489.1 [P23141-3] |
PIRi | A41010 |
RefSeqi | NP_001020365.1, NM_001025194.1 [P23141-1] NP_001020366.1, NM_001025195.1 [P23141-2] NP_001257.4, NM_001266.4 [P23141-3] |
Genome annotation databases
Ensembli | ENST00000360526; ENSP00000353720; ENSG00000198848 [P23141-2] ENST00000361503; ENSP00000355193; ENSG00000198848 ENST00000422046; ENSP00000390492; ENSG00000198848 [P23141-3] ENST00000571922; ENSP00000460045; ENSG00000262243 ENST00000574513; ENSP00000461208; ENSG00000262243 ENST00000576783; ENSP00000458586; ENSG00000262243 |
GeneIDi | 1066 |
KEGGi | hsa:1066 |
MANE-Selecti | ENST00000360526.8; ENSP00000353720.4; NM_001025195.2; NP_001020366.1 [P23141-2] |
UCSCi | uc002eil.4, human [P23141-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73499 mRNA Translation: AAA35649.1 L07764 mRNA Translation: AAA16036.1 L07765 mRNA Translation: AAA35711.1 D21088 Genomic DNA Translation: BAA04650.1 S73751 mRNA Translation: AAC60631.2 AF177775 mRNA Translation: AAD53175.1 AY268104 mRNA Translation: AAP20868.1 AB119995 mRNA Translation: BAC87748.1 AB119996 mRNA Translation: BAC87749.1 AB119997 Genomic DNA Translation: BAC87750.1 AB119998 Genomic DNA Translation: BAC87751.1 AK290623 mRNA Translation: BAF83312.1 AK292209 mRNA Translation: BAF84898.1 AC147362 Genomic DNA No translation available. BC012418 mRNA Translation: AAH12418.1 BC110338 mRNA Translation: AAI10339.1 AB025026 mRNA Translation: BAA84995.1 M55509 mRNA Translation: AAA35650.1 X52973 mRNA Translation: CAA37147.1 M65261 mRNA Translation: AAA83932.1 Frameshift. |
CCDSi | CCDS32450.1 [P23141-2] CCDS45488.1 [P23141-1] CCDS45489.1 [P23141-3] |
PIRi | A41010 |
RefSeqi | NP_001020365.1, NM_001025194.1 [P23141-1] NP_001020366.1, NM_001025195.1 [P23141-2] NP_001257.4, NM_001266.4 [P23141-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MX1 | X-ray | 2.40 | A/B/C/D/E/F | 19-567 | [»] | |
1MX5 | X-ray | 2.80 | A/B/C/D/E/F | 19-567 | [»] | |
1MX9 | X-ray | 2.90 | A/B/C/D/E/F/G/H/I/J/K/L | 19-567 | [»] | |
1YA4 | X-ray | 3.20 | A/B/C | 21-552 | [»] | |
1YA8 | X-ray | 3.00 | A/B/C | 21-552 | [»] | |
1YAH | X-ray | 3.00 | A/B/C | 21-552 | [»] | |
1YAJ | X-ray | 3.20 | A/B/C/D/E/F/G/H/I/J/K/L | 21-552 | [»] | |
2DQY | X-ray | 3.00 | A/B/C | 19-561 | [»] | |
2DQZ | X-ray | 2.80 | A/B/C | 19-561 | [»] | |
2DR0 | X-ray | 3.20 | A/B/C | 19-561 | [»] | |
2H7C | X-ray | 2.00 | A/B/C/D/E/F | 19-561 | [»] | |
2HRQ | X-ray | 2.70 | A/B/C/D/E/F | 21-553 | [»] | |
2HRR | X-ray | 2.70 | A/B/C | 21-553 | [»] | |
3K9B | X-ray | 3.10 | A/B/C | 24-553 | [»] | |
4AB1 | X-ray | 2.20 | A | 21-553 | [»] | |
5A7F | X-ray | 1.86 | A | 21-553 | [»] | |
5A7G | X-ray | 1.48 | A | 21-553 | [»] | |
5A7H | X-ray | 2.01 | A | 22-553 | [»] | |
SMRi | P23141 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107494, 25 interactors |
IntActi | P23141, 13 interactors |
MINTi | P23141 |
STRINGi | 9606.ENSP00000353720 |
Chemistry databases
BindingDBi | P23141 |
ChEMBLi | CHEMBL2265 |
DrugBanki | DB07821, (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate DB08224, (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL DB03056, 4-Piperidino-Piperidine DB06442, Avasimibe DB01086, Benzocaine DB01101, Capecitabine DB02659, Cholic Acid DB01410, Ciclesonide DB00758, Clopidogrel DB00907, Cocaine DB04838, Cyclandelate DB06695, Dabigatran etexilate DB00647, Dextropropoxyphene DB01452, Diamorphine DB01039, Fenofibrate DB14845, Filgotinib DB11181, Homatropine DB02161, Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester DB00328, Indomethacin DB00762, Irinotecan DB00583, Levocarnitine DB00454, Meperidine DB06693, Mevastatin DB00688, Mycophenolate mofetil DB03721, N-acetyl-alpha-neuraminic acid DB01183, Naloxone DB00198, Oseltamivir DB09269, Phenylacetic acid DB01599, Probucol DB09342, Propoxycaine DB00881, Quinapril DB14761, Remdesivir DB12404, Remimazolam DB06201, Rufinamide DB11362, Selexipag DB00382, Tacrine DB00675, Tamoxifen DB09299, Tenofovir alafenamide DB04795, Thenoyltrifluoroacetone DB00519, Trandolapril |
DrugCentrali | P23141 |
GuidetoPHARMACOLOGYi | 2592 |
SwissLipidsi | SLP:000001265 |
Protein family/group databases
ESTHERi | human-CES1, Carb_B_Chordata |
MEROPSi | S09.982 |
PTM databases
GlyConnecti | 1462, 3 N-Linked glycans (1 site) |
GlyGeni | P23141, 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P23141 |
PhosphoSitePlusi | P23141 |
Genetic variation databases
BioMutai | CES1 |
DMDMi | 119576 |
Proteomic databases
jPOSTi | P23141 |
MassIVEi | P23141 |
MaxQBi | P23141 |
PaxDbi | P23141 |
PeptideAtlasi | P23141 |
PRIDEi | P23141 |
ProteomicsDBi | 19083 54055 [P23141-1] 54056 [P23141-2] |
Protocols and materials databases
Antibodypediai | 28513, 320 antibodies from 37 providers |
DNASUi | 1066 |
Genome annotation databases
Ensembli | ENST00000360526; ENSP00000353720; ENSG00000198848 [P23141-2] ENST00000361503; ENSP00000355193; ENSG00000198848 ENST00000422046; ENSP00000390492; ENSG00000198848 [P23141-3] ENST00000571922; ENSP00000460045; ENSG00000262243 ENST00000574513; ENSP00000461208; ENSG00000262243 ENST00000576783; ENSP00000458586; ENSG00000262243 |
GeneIDi | 1066 |
KEGGi | hsa:1066 |
MANE-Selecti | ENST00000360526.8; ENSP00000353720.4; NM_001025195.2; NP_001020366.1 [P23141-2] |
UCSCi | uc002eil.4, human [P23141-1] |
Organism-specific databases
CTDi | 1066 |
DisGeNETi | 1066 |
GeneCardsi | CES1 |
HGNCi | HGNC:1863, CES1 |
HPAi | ENSG00000198848, Tissue enriched (liver) |
MalaCardsi | CES1 |
MIMi | 114835, gene 618057, phenotype |
neXtProti | NX_P23141 |
OpenTargetsi | ENSG00000198848 |
PharmGKBi | PA107 |
VEuPathDBi | HostDB:ENSG00000198848 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000154623 |
HOGENOMi | CLU_006586_13_0_1 |
InParanoidi | P23141 |
OMAi | DSNSGPY |
OrthoDBi | 754103at2759 |
PhylomeDBi | P23141 |
TreeFami | TF315470 |
Enzyme and pathway databases
BRENDAi | 3.1.1.1, 2681 |
PathwayCommonsi | P23141 |
Reactomei | R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins R-HSA-211945, Phase I - Functionalization of compounds |
SABIO-RKi | P23141 |
SignaLinki | P23141 |
Miscellaneous databases
BioGRID-ORCSi | 1066, 10 hits in 1036 CRISPR screens |
ChiTaRSi | CES1, human |
EvolutionaryTracei | P23141 |
GeneWikii | Carboxylesterase_1 |
GenomeRNAii | 1066 |
Pharosi | P23141, Tchem |
PROi | PR:P23141 |
RNActi | P23141, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198848, Expressed in right lobe of liver and 114 other tissues |
ExpressionAtlasi | P23141, baseline and differential |
Genevisiblei | P23141, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EST1_HUMAN | |
Accessioni | P23141Primary (citable) accession number: P23141 Secondary accession number(s): A6NIM1 Q9ULY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 210 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families