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UniProtKB - P23054 (TCRB_BACSU)
Protein
Tetracycline resistance protein
Gene
tetB
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H+ antiporter.
GO - Molecular functioni
- antiporter activity Source: UniProtKB-KW
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- ion transport Source: UniProtKB-KW
- response to antibiotic Source: UniProtKB-KW
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Antibiotic resistance, Antiport, Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU40770-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.3.16, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Tetracycline resistance protein |
Gene namesi | Name:tetB Synonyms:tet Ordered Locus Names:BSU40770 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 33 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 81 – 100 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 111 – 129 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 162 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 223 – 240 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 297 – 317 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 324 – 344 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 346 – 365 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 432 – 451 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173383 | 1 – 458 | Tetracycline resistance proteinAdd BLAST | 458 |
Proteomic databases
PaxDbi | P23054 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
InParanoidi | P23054 |
OMAi | ESRAMNH |
PhylomeDBi | P23054 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P23054-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTSYSQSTL RHNQVLIWLC VLSFFSVLNE MVLNVSLPDI ANEFNKLPAS
60 70 80 90 100
ANWVNTAFML TFSIGTALYG KLSDQLGIKN LLLFGIMVNG LGSIIGFVGH
110 120 130 140 150
SFFPILILAR FIQGIGAAAF PALVMVVVAR YIPKENRGKA FGLIGSLVAM
160 170 180 190 200
GEGVGPAIGG MVAHYIHWSY LLLIPTATII TVPFLIKLLK KEERIRGHID
210 220 230 240 250
MAGIILMSAG IVFFMLFTTS YRFSFLIISI LAFFIFVQHI RKAQDPFVDP
260 270 280 290 300
ELGKNVFFVI GTLCGGLIFG TVAGFVSMVP YMMKDVHHLS TAAIGSGIIF
310 320 330 340 350
PGTMSVIIFG YIGGLLVDRK GSLYVLTIGS ALLSSGFLIA AFFIDAAPWI
360 370 380 390 400
MTIIVIFVFG GLSFTKTVIS TVVSSSLKEK EAGAGMSLLN FTSFLSEGTG
410 420 430 440 450
IAIVGGLLSI GFLDHRLLPI DVDHSTYLYS NMLILFAGII VICWLVILNV
YKRSRRHG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X08034 Genomic DNA Translation: CAA30827.1 D26185 Genomic DNA Translation: BAA05208.1 AL009126 Genomic DNA Translation: CAB16114.1 |
PIRi | JT0427, YTBSY8 |
RefSeqi | NP_391957.1, NC_000964.3 WP_003242953.1, NZ_JNCM01000034.1 |
Genome annotation databases
EnsemblBacteriai | CAB16114; CAB16114; BSU_40770 |
GeneIDi | 937890 |
KEGGi | ag:CAA30827 bsu:BSU40770 |
PATRICi | fig|224308.179.peg.4419 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X08034 Genomic DNA Translation: CAA30827.1 D26185 Genomic DNA Translation: BAA05208.1 AL009126 Genomic DNA Translation: CAB16114.1 |
PIRi | JT0427, YTBSY8 |
RefSeqi | NP_391957.1, NC_000964.3 WP_003242953.1, NZ_JNCM01000034.1 |
3D structure databases
SMRi | P23054 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU40770 |
Protein family/group databases
TCDBi | 2.A.1.3.16, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P23054 |
Genome annotation databases
EnsemblBacteriai | CAB16114; CAB16114; BSU_40770 |
GeneIDi | 937890 |
KEGGi | ag:CAA30827 bsu:BSU40770 |
PATRICi | fig|224308.179.peg.4419 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
InParanoidi | P23054 |
OMAi | ESRAMNH |
PhylomeDBi | P23054 |
Enzyme and pathway databases
BioCyci | BSUB:BSU40770-MONOMER |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCRB_BACSU | |
Accessioni | P23054Primary (citable) accession number: P23054 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families