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Entry version 79 (02 Jun 2021)
Sequence version 1 (01 Nov 1991)
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Protein

Spike glycoprotein

Gene

S

Organism
Berne virus (BEV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the binding of virions to the host cell receptor and is involved in membrane fusion.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoprotein
Short name:
S glycoprotein
Alternative name(s):
E2
Peplomer protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:S
Synonyms:P
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBerne virus (BEV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11156 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesTornidovirineaeTobaniviridaeTorovirinaeTorovirusRenitovirusEquine torovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEquus caballus (Horse) [TaxID: 9796]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006571 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1551Virion surfaceSequence analysisAdd BLAST1531
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1552 – 1572HelicalSequence analysisAdd BLAST21
Topological domaini1573 – 1581IntravirionSequence analysis9

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003743421 – 1581Spike glycoproteinAdd BLAST1561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi935N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi969N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1267N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1297N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1385N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1389N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1428N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1431N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1438N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1483N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1487N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1495N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi1515N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the toroviruses spike protein family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031412, S_torovirinae

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17072, Spike_torovirin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P23052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLCFCAATV LCFWINSGGA DVVPNGTLIF SEPVPYPFSL DVLRSFSQHV
60 70 80 90 100
VLRNKRAVTT ISWSYSYQIT TSSLSVNSWY VTFTAPLGWN YYTGQSFGTV
110 120 130 140 150
LNQNAMMRAS QSTFTYDVIS YVGQRPNLDC QVNSLVNGGL DGWYSTVRVD
160 170 180 190 200
NCFNAPCHVG GRPGCSIGLP YMSNGVCTRV LSTTQSPGLQ YEIYSGQQFA
210 220 230 240 250
VYQITPYTQY TITMPSGILG YCQQTPLYVD CGTWTPFRVH SYGCDKVTQN
260 270 280 290 300
CKYTLTSNWV VAFQNKATAV ILPSELIVPV AQKVTRRLGV NTPDYFWLVK
310 320 330 340 350
QAYHYLSQAN LSPNYALFSA LCNSLYQQSA TLSTLCFGSP FFVAQECYNN
360 370 380 390 400
ALYLPDAVFT TLFSTLFSWD YQINYPLNQV LTQNETFLQL PATNYQGQTL
410 420 430 440 450
SQGRMLNLFK DAIVFLDFFD TKFYRTNDAP SSDIFVVVAR QAQLIRYGNF
460 470 480 490 500
RIEQINGYFQ VKCSSNIIST LEPHPAGVIM IARHHSMWSV AARNSTSFYC
510 520 530 540 550
VTHSLTTFGK LDISTSWFFH TLALPSGPVS QVSMPLLSTA AVGVYMHPMI
560 570 580 590 600
EHWIPLLTLA QSQYQPSFFN IGINKTITLT TQLQAYAQVY TAWFLSVIYV
610 620 630 640 650
RLPEARRLTL GVQLVPFIQA LLSIKQADLD ATDVDSVARY NVLSLMWGRK
660 670 680 690 700
YAVVNYNQLP EWTYPLFKGE IGESMWFRKK IMPTTEGCQT SAHFSSITGY
710 720 730 740 750
LQFSDYVYIP KYNKVSCPIS TLAPSVLQVY EVQSLFVILI QCVSGSYDWY
760 770 780 790 800
PGLSGGTAFV YKSYKLGTVC VLLPSDVLST GPNIGFYSGT ALSIVTVQTT
810 820 830 840 850
NDVLPNCIGL VQDNIFTPCH PSGCPVRNSY DNYIVCFDSS TYTFKNYHRT
860 870 880 890 900
TPPVMNVPIQ EVPLQMEIPT VILQSYELKH TESVLLQDIE GGIIVDHNTG
910 920 930 940 950
SIWYPDGQAY DVSFYVSVII RYAPPKLELP STLANFTSCL DYICFGNYQC
960 970 980 990 1000
RTEAQTFCTS MDYFEQVFNK SLISLKTALQ DLHYVLKLVL PETTLELTEL
1010 1020 1030 1040 1050
TRRRRRAVYE FDDTISLLSE SFERFMSPAS QAYMANMLWW DDAFDGFSLP
1060 1070 1080 1090 1100
QRTGSILSRS PSLSSVSSWN SYTSRTPLIS NVKTPKTTFN VKLSMPKLPK
1110 1120 1130 1140 1150
ASTLSKIGSV LSSGLSIASL GLSIFSIVED RRVTELTQQQ IMALEDQITI
1160 1170 1180 1190 1200
LTDYTEKNFK EIQSSLNTLG QQVQDFSQQV TMSLQQLSNG LEQITQQLDK
1210 1220 1230 1240 1250
SIYYVTATQQ YATYMSSLIN HLTELAAAVY KTQDMYVTCI HSLQSGVLSP
1260 1270 1280 1290 1300
NCITPSQIFQ LYQVARNLSG QCQPIFSERE VSRFYSLPLV TDAMVHNDTY
1310 1320 1330 1340 1350
WFSWSIPITC SNIQGSVYKV QPGYIVNPTH PTSLQYDLPS HVVTSNAGAL
1360 1370 1380 1390 1400
RFDDHYCDRY NQVYLCTKSA FDLQPSNYLT MLYSNISENV SLTFHPEPRP
1410 1420 1430 1440 1450
DPCVYLSSSA LYCYYSDQCN QCVVAVGNCS NQTVTYRNYT YPIMDPQCRG
1460 1470 1480 1490 1500
FDQITISSPI DIGVDFTALP SRPPLPLHLS YVNVTFNVTI PHGLNWTDLV
1510 1520 1530 1540 1550
LDYSFKDKIY EISKNITDLH QQILQVSSWA SGWFQRIRDF LYNLLPTWIT
1560 1570 1580
WLTLGFSLFS IVISGINIIL FFEMNGKVKK S
Length:1,581
Mass (Da):178,332
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00D91B41837AC769
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52506 mRNA Translation: CAA36748.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36759, VGWJBV

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52506 mRNA Translation: CAA36748.1
PIRiA36759, VGWJBV

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR031412, S_torovirinae
PfamiView protein in Pfam
PF17072, Spike_torovirin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_BEV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23052
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 2, 2021
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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