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UniProtKB - P23027 (PA2HB_PSETE)
Protein
Basic phospholipase A2 homolog textilotoxin B chain
Gene
N/A
Organism
Pseudonaja textilis (Eastern brown snake)
Status
Functioni
Snake venom oligomeric phospholipase A2 that has potent presynaptic neurotoxicity. Chain B is not itself neurotoxic, but it is essential for the neurotoxicity of textilotoxin. Subunit B possesses a very low phospholipase activity.
1 PublicationGO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Neurotoxin, Presynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 homolog textilotoxin B chainShort name: svPLA2 homolog |
Organismi | Pseudonaja textilis (Eastern brown snake) |
Taxonomic identifieri | 8673 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Acanthophiinae › Pseudonaja |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
Oligomer: LD50 is 1 µg/kg by intraperitoneal injection into mice.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161695 | 1 – 121 | Basic phospholipase A2 homolog textilotoxin B chainAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 11 ↔ 72 | By similarity | ||
Disulfide bondi | 27 ↔ 120 | By similarity | ||
Disulfide bondi | 29 ↔ 45 | By similarity | ||
Disulfide bondi | 44 ↔ 101 | By similarity | ||
Disulfide bondi | 51 ↔ 94 | By similarity | ||
Disulfide bondi | 61 ↔ 87 | By similarity | ||
Disulfide bondi | 80 ↔ 92 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Heterohexamer. 2 forms exist: 2 A or 2 B chains, 2 C chains and 2 covalently-linked D chains, and 1 A or 1 B, 1 C, 2 covalently-linked D chains and 2 differentially glycosylated covalently-linked D chains. Textilotoxin was originally described as pentameric (PubMed:8431471).
2 PublicationsFamily & Domainsi
Sequence similaritiesi
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P23027-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DLVEFGFMIR CANRNSQPAW QYMDYGCYCG KRGSGTPVDD VDRCCQTHNE
60 70 80 90 100
CYDEAAKIPG CKPKWTFYFY QCGSGSQFTC RKSKDVCRNV VCDCDFKAAL
110 120
CLTGARYNSA NYNIDIKTHC R
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | D → N AA sequence (PubMed:3651474).Curated | 1 | |
Sequence conflicti | 4 | E → Q AA sequence (PubMed:3651474).Curated | 1 | |
Sequence conflicti | 16 | S → D AA sequence (PubMed:3651474).Curated | 1 | |
Sequence conflicti | 24 | D → N AA sequence (PubMed:3651474).Curated | 1 |
Sequence databases
PIRi | S29652 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | S29652 |
3D structure databases
SMRi | P23027 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2HB_PSETE | |
Accessioni | P23027Primary (citable) accession number: P23027 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families