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Entry version 212 (17 Jun 2020)
Sequence version 1 (01 Nov 1991)
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Protein

DNA repair protein complementing XP-A cells

Gene

XPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri105 – 129Add BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6782135 Dual incision in TC-NER

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P23025

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein complementing XP-A cells
Alternative name(s):
Xeroderma pigmentosum group A-complementing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XPA
Synonyms:XPAC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136936.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12814 XPA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611153 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P23025

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Xeroderma pigmentosum complementation group A (XP-A)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-A patients show the most severe skin symptoms and progressive neurological disorders.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00772794P → L in XP-A. 1
Natural variantiVAR_007728108C → F in XP-A; severe form. 2 PublicationsCorresponds to variant dbSNP:rs104894131EnsemblClinVar.1
Natural variantiVAR_007729130R → K in XP-A. Corresponds to variant dbSNP:rs1324310300EnsemblClinVar.1
Natural variantiVAR_007730185Q → H in XP-A. Corresponds to variant dbSNP:rs746617574EnsemblClinVar.1
Natural variantiVAR_007731244H → R in XP-A; mild form. 1 PublicationCorresponds to variant dbSNP:rs144725456EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Xeroderma pigmentosum

Organism-specific databases

DisGeNET

More...
DisGeNETi
7507

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
XPA

MalaCards human disease database

More...
MalaCardsi
XPA
MIMi278700 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136936

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
910 Xeroderma pigmentosum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA368

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P23025 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105801

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XPA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
139816

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002086482 – 273DNA repair protein complementing XP-A cellsAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki86Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei196PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage.1 Publication
Ubiquitinated by HERC2 leading to degradation by the proteasome.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P23025

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P23025

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P23025

MaxQB - The MaxQuant DataBase

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MaxQBi
P23025

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23025

PeptideAtlas

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PeptideAtlasi
P23025

PRoteomics IDEntifications database

More...
PRIDEi
P23025

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54051

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P23025

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P23025

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various cell lines and in skin fibroblasts.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000136936 Expressed in amniotic fluid and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P23025 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P23025 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136936 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GPN1.

Interacts with RPA1 and RPA2; the interaction is direct and associates XPA with the RPA complex.

Interacts (via N-terminus) with CEP164 upon UV irradiation.

Interacts with HERC2.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113344, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P23025

Database of interacting proteins

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DIPi
DIP-24191N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P23025

Protein interaction database and analysis system

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IntActi
P23025, 46 interactors

Molecular INTeraction database

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MINTi
P23025

STRING: functional protein association networks

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STRINGi
9606.ENSP00000364270

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P23025

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P23025 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P23025

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P23025

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4 – 97Interaction with CEP164 and required for UV resistance1 PublicationAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi26 – 47Nuclear localization signalSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 84Poly-Glu7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPA family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri105 – 129Add BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4017 Eukaryota
COG5145 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002721

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_053731_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P23025

KEGG Orthology (KO)

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KOi
K10847

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTKKTHE

Database of Orthologous Groups

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OrthoDBi
1542306at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P23025

TreeFam database of animal gene trees

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TreeFami
TF101241

Family and domain databases

Database of protein disorder

More...
DisProti
DP00243

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.530.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00196

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000465 XPA
IPR022656 XPA_C
IPR022658 XPA_CS
IPR037129 XPA_sf
IPR022652 Znf_XPA_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10142 PTHR10142, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05181 XPA_C, 1 hit
PF01286 XPA_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46955 SSF46955, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00598 rad14, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00752 XPA_1, 1 hit
PS00753 XPA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P23025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAADGALPE AAALEQPAEL PASVRASIER KRQRALMLRQ ARLAARPYSA
60 70 80 90 100
TAAAATGGMA NVKAAPKIID TGGGFILEEE EEEEQKIGKV VHQPGPVMEF
110 120 130 140 150
DYVICEECGK EFMDSYLMNH FDLPTCDNCR DADDKHKLIT KTEAKQEYLL
160 170 180 190 200
KDCDLEKREP PLKFIVKKNP HHSQWGDMKL YLKLQIVKRS LEVWGSQEAL
210 220 230 240 250
EEAKEVRQEN REKMKQKKFD KKVKELRRAV RSSVWKRETI VHQHEYGPEE
260 270
NLEDDMYRKT CTMCGHELTY EKM
Length:273
Mass (Da):31,368
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF89F735219A8494B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2T2F2Z2T2_HUMAN
DNA repair protein-complementing XP...
XPA
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01420378Missing 1 Publication1
Natural variantiVAR_00772794P → L in XP-A. 1
Natural variantiVAR_03790797V → I. Corresponds to variant dbSNP:rs10983315Ensembl.1
Natural variantiVAR_007728108C → F in XP-A; severe form. 2 PublicationsCorresponds to variant dbSNP:rs104894131EnsemblClinVar.1
Natural variantiVAR_007729130R → K in XP-A. Corresponds to variant dbSNP:rs1324310300EnsemblClinVar.1
Natural variantiVAR_007730185Q → H in XP-A. Corresponds to variant dbSNP:rs746617574EnsemblClinVar.1
Natural variantiVAR_014799228R → Q. Corresponds to variant dbSNP:rs1805160EnsemblClinVar.1
Natural variantiVAR_029325234V → L. Corresponds to variant dbSNP:rs3176749Ensembl.1
Natural variantiVAR_007731244H → R in XP-A; mild form. 1 PublicationCorresponds to variant dbSNP:rs144725456EnsemblClinVar.1
Natural variantiVAR_020324252L → V. Corresponds to variant dbSNP:rs3176750EnsemblClinVar.1
Natural variantiVAR_061987256M → V. Corresponds to variant dbSNP:rs57519506EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D14533 mRNA Translation: BAA03403.1
BT019518 mRNA Translation: AAV38325.1
AF503166 Genomic DNA Translation: AAM18969.1
AL445531 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58855.1
BC014965 mRNA Translation: AAH14965.1
U16815 Genomic DNA Translation: AAB60404.1
U10347 U10346 Genomic DNA Translation: AAA92883.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6729.1

Protein sequence database of the Protein Information Resource

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PIRi
I38886
JG0190

NCBI Reference Sequences

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RefSeqi
NP_000371.1, NM_000380.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375128; ENSP00000364270; ENSG00000136936

Database of genes from NCBI RefSeq genomes

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GeneIDi
7507

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7507

UCSC genome browser

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UCSCi
uc004axr.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
Protein Spotlight

Nature's flaws - Issue 142 of September 2012

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14533 mRNA Translation: BAA03403.1
BT019518 mRNA Translation: AAV38325.1
AF503166 Genomic DNA Translation: AAM18969.1
AL445531 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58855.1
BC014965 mRNA Translation: AAH14965.1
U16815 Genomic DNA Translation: AAB60404.1
U10347 U10346 Genomic DNA Translation: AAA92883.1
CCDSiCCDS6729.1
PIRiI38886
JG0190
RefSeqiNP_000371.1, NM_000380.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4UNMR-A98-208[»]
1XPANMR-A98-219[»]
2JNWNMR-B67-80[»]
6J44X-ray2.06A98-239[»]
6LAEX-ray2.81A/B98-239[»]
6RO4electron microscopy3.50G1-273[»]
SMRiP23025
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113344, 33 interactors
CORUMiP23025
DIPiDIP-24191N
ELMiP23025
IntActiP23025, 46 interactors
MINTiP23025
STRINGi9606.ENSP00000364270

Chemistry databases

BindingDBiP23025
ChEMBLiCHEMBL4105801

PTM databases

iPTMnetiP23025
PhosphoSitePlusiP23025

Polymorphism and mutation databases

BioMutaiXPA
DMDMi139816

Proteomic databases

EPDiP23025
jPOSTiP23025
MassIVEiP23025
MaxQBiP23025
PaxDbiP23025
PeptideAtlasiP23025
PRIDEiP23025
ProteomicsDBi54051

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3603 473 antibodies

The DNASU plasmid repository

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DNASUi
7507

Genome annotation databases

EnsembliENST00000375128; ENSP00000364270; ENSG00000136936
GeneIDi7507
KEGGihsa:7507
UCSCiuc004axr.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7507
DisGeNETi7507
EuPathDBiHostDB:ENSG00000136936.10

GeneCards: human genes, protein and diseases

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GeneCardsi
XPA
GeneReviewsiXPA
HGNCiHGNC:12814 XPA
HPAiENSG00000136936 Low tissue specificity
MalaCardsiXPA
MIMi278700 phenotype
611153 gene
neXtProtiNX_P23025
OpenTargetsiENSG00000136936
Orphaneti910 Xeroderma pigmentosum
PharmGKBiPA368

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4017 Eukaryota
COG5145 LUCA
GeneTreeiENSGT00390000002721
HOGENOMiCLU_053731_1_0_1
InParanoidiP23025
KOiK10847
OMAiYTKKTHE
OrthoDBi1542306at2759
PhylomeDBiP23025
TreeFamiTF101241

Enzyme and pathway databases

ReactomeiR-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6782135 Dual incision in TC-NER
SIGNORiP23025

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7507 2 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
XPA human
EvolutionaryTraceiP23025

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
XPA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7507
PharosiP23025 Tbio

Protein Ontology

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PROi
PR:P23025
RNActiP23025 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136936 Expressed in amniotic fluid and 223 other tissues
ExpressionAtlasiP23025 baseline and differential
GenevisibleiP23025 HS

Family and domain databases

DisProtiDP00243
Gene3Di3.90.530.10, 1 hit
IDEALiIID00196
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000465 XPA
IPR022656 XPA_C
IPR022658 XPA_CS
IPR037129 XPA_sf
IPR022652 Znf_XPA_CS
PANTHERiPTHR10142 PTHR10142, 1 hit
PfamiView protein in Pfam
PF05181 XPA_C, 1 hit
PF01286 XPA_N, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR00598 rad14, 1 hit
PROSITEiView protein in PROSITE
PS00752 XPA_1, 1 hit
PS00753 XPA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23025
Secondary accession number(s): Q5T1U9, Q6LCW7, Q6LD02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 17, 2020
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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