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Protein

Calciseptin

Gene
N/A
Organism
Dendroaspis polylepis polylepis (Black mamba)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This specific blocker of the L-type calcium channel (Cav1/CACNA1) is a smooth muscle relaxant and an inhibitor of cardiac contractions.1 Publication

Miscellaneous

The sensitivity is higher in cells of the cardiovascular system. Neuronal, and insulinoma cells L-type calcium channel are more resistant. A total resistance is found in skeletal muscle cells.

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Cardiotoxin, Ion channel impairing toxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Calciseptin
Alternative name(s):
Calciseptine
Short name:
CaS
L-type calcium channel blocker
OrganismiDendroaspis polylepis polylepis (Black mamba)
Taxonomic identifieri8620 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000936671 – 60CalciseptinAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 22By similarity
Disulfide bondi17 ↔ 39By similarity
Disulfide bondi41 ↔ 52By similarity
Disulfide bondi53 ↔ 58By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP22947
SMRiP22947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 48Important for binding to L-type calcium channels1 Publication8

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

InterProiView protein in InterPro
IPR018354 Snake_toxin_con_site
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P22947-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT
60
ECCKGDRCNK
Length:60
Mass (Da):7,044
Last modified:August 1, 1991 - v1
Checksum:i2F14B05972A40FFF
GO

Sequence databases

PIRiA39165

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA39165

3D structure databases

ProteinModelPortaliP22947
SMRiP22947
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

InterProiView protein in InterPro
IPR018354 Snake_toxin_con_site
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3SLS_DENPO
AccessioniPrimary (citable) accession number: P22947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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