UniProtKB - P22934 (TNR1A_RAT)
Tumor necrosis factor receptor superfamily member 1A
Tnfrsf1a
Functioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protease binding Source: RGD
- protein-containing complex binding Source: RGD
- tumor necrosis factor-activated receptor activity Source: RGD
- tumor necrosis factor binding Source: RGD
GO - Biological processi
- aortic valve development Source: RGD
- cell surface receptor signaling pathway Source: UniProtKB
- cellular response to estradiol stimulus Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cytokine-mediated signaling pathway Source: UniProtKB
- defense response Source: UniProtKB
- defense response to bacterium Source: RGD
- inflammatory response Source: RGD
- intrinsic apoptotic signaling pathway in response to DNA damage Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cardiac muscle hypertrophy Source: RGD
- negative regulation of extracellular matrix constituent secretion Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of inflammatory response Source: RGD
- negative regulation of interleukin-6 production Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of apoptotic process involved in morphogenesis Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
- positive regulation of inflammatory response Source: UniProtKB
- positive regulation of neuron apoptotic process Source: RGD
- positive regulation of protein import into nucleus Source: RGD
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: RGD
- positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
- prostaglandin metabolic process Source: InterPro
- protein localization to plasma membrane Source: RGD
- pulmonary valve development Source: RGD
- regulation of apoptotic process Source: RGD
- regulation of establishment of endothelial barrier Source: RGD
- response to alkaloid Source: RGD
- response to amino acid Source: RGD
- response to ethanol Source: RGD
- response to hypoxia Source: RGD
- response to lipopolysaccharide Source: RGD
- response to wounding Source: RGD
- tumor necrosis factor-mediated signaling pathway Source: RGD
Keywordsi
Molecular function | Receptor |
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-RNO-5357786, TNFR1-induced proapoptotic signaling R-RNO-5357905, Regulation of TNFR1 signaling R-RNO-5357956, TNFR1-induced NFkappaB signaling pathway R-RNO-5626978, TNFR1-mediated ceramide production R-RNO-5669034, TNFs bind their physiological receptors R-RNO-75893, TNF signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 1AAlternative name(s): Tumor necrosis factor receptor 1 Short name: TNF-R1 Tumor necrosis factor receptor type I Short name: TNF-RI Short name: TNFR-I p55 p60 CD_antigen: CD120a |
Gene namesi | Name:Tnfrsf1a Synonyms:Tnfr-1, Tnfr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621237, Tnfrsf1a |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type I membrane protein By similarity
Plasma membrane
Cytosol
- cytosol Source: RGD
Extracellular region or secreted
- extracellular space Source: RGD
Golgi apparatus
- Golgi membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- axon Source: RGD
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: RGD
- protein-containing complex Source: RGD
- receptor complex Source: RGD
- synapse Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 211 | ExtracellularSequence analysisAdd BLAST | 182 | |
Transmembranei | 212 – 234 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 235 – 461 | CytoplasmicSequence analysisAdd BLAST | 227 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | By similarityAdd BLAST | 29 | |
ChainiPRO_0000034547 | 30 – 461 | Tumor necrosis factor receptor superfamily member 1AAdd BLAST | 432 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 58 | PROSITE-ProRule annotation | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 59 ↔ 72 | PROSITE-ProRule annotation | ||
Disulfide bondi | 62 ↔ 81 | PROSITE-ProRule annotation | ||
Disulfide bondi | 84 ↔ 99 | PROSITE-ProRule annotation | ||
Disulfide bondi | 102 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 105 ↔ 125 | PROSITE-ProRule annotation | ||
Disulfide bondi | 127 ↔ 143 | PROSITE-ProRule annotation | ||
Disulfide bondi | 146 ↔ 158 | PROSITE-ProRule annotation | ||
Disulfide bondi | 149 ↔ 166 | PROSITE-ProRule annotation | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 168 ↔ 179 | PROSITE-ProRule annotation | ||
Disulfide bondi | 182 ↔ 195 | PROSITE-ProRule annotation | ||
Disulfide bondi | 185 ↔ 191 | PROSITE-ProRule annotation | ||
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P22934 |
PRIDEi | P22934 |
PTM databases
GlyGeni | P22934, 3 sites |
PhosphoSitePlusi | P22934 |
Interactioni
Subunit structurei
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling.
Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP.
Interacts with DAB2IP.
Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway.
Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
- protease binding Source: RGD
- tumor necrosis factor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247654, 2 interactors |
IntActi | P22934, 1 interactor |
STRINGi | 10116.ENSRNOP00000042371 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 43 – 82 | TNFR-Cys 1Add BLAST | 40 | |
Repeati | 83 – 125 | TNFR-Cys 2Add BLAST | 43 | |
Repeati | 126 – 166 | TNFR-Cys 3Add BLAST | 41 | |
Repeati | 167 – 196 | TNFR-Cys 4Add BLAST | 30 | |
Domaini | 363 – 448 | DeathPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 344 – 354 | N-SMase activation domain (NSD)Add BLAST | 11 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S050, Eukaryota |
InParanoidi | P22934 |
OrthoDBi | 726174at2759 |
PhylomeDBi | P22934 |
TreeFami | TF333916 |
Family and domain databases
CDDi | cd08313, Death_TNFR1, 1 hit cd10576, TNFRSF1A, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR001368, TNFR/NGFR_Cys_rich_reg IPR020419, TNFR_1A IPR033994, TNFRSF1A_death IPR033993, TNFRSF1A_N |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 3 hits |
PRINTSi | PR01918, TNFACTORR1A |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 4 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 3 hits PS50050, TNFR_NGFR_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGLPIVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DNLCPQGKYA
60 70 80 90 100
HPKNNSICCT KCHKGTYLVS DCPSPGQETV CEVCDKGTFT ASQNHVRQCL
110 120 130 140 150
SCKTCRKEMF QVEISPCKAD MDTVCGCKKN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE KQNTVCNCHA GFFLSGNECT PCSHCKKNQE CMKLCLPPVA
210 220 230 240 250
NVTNPQDSGT AVLLPLVIFL GLCLLFFICI SLLCRYPQWR PRVYSIICRD
260 270 280 290 300
SAPVKEVEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST
310 320 330 340 350
PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV
360 370 380 390 400
VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG
410 420 430 440 450
RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES
460
PAHSSTTHLP R
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JSU9 | A0A0G2JSU9_RAT | Tumor necrosis factor receptor 1 | Tnfrsf1a rCG_29818 | 461 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 230 | I → V in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd. 2 Publications | 1 | |
Natural varianti | 295 | H → P in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63122 mRNA Translation: AAA42256.1 AF329976 mRNA Translation: AAK53562.1 AF329977 mRNA Translation: AAK53563.1 AF329978 mRNA Translation: AAK53564.1 AF329979 mRNA Translation: AAK53565.1 AF329980 mRNA Translation: AAK53566.1 AF329981 mRNA Translation: AAK53567.1 BC086413 mRNA Translation: AAH86413.1 |
PIRi | B36555, GQRTT1 |
RefSeqi | NP_037223.1, NM_013091.1 |
Genome annotation databases
GeneIDi | 25625 |
KEGGi | rno:25625 |
UCSCi | RGD:621237, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63122 mRNA Translation: AAA42256.1 AF329976 mRNA Translation: AAK53562.1 AF329977 mRNA Translation: AAK53563.1 AF329978 mRNA Translation: AAK53564.1 AF329979 mRNA Translation: AAK53565.1 AF329980 mRNA Translation: AAK53566.1 AF329981 mRNA Translation: AAK53567.1 BC086413 mRNA Translation: AAH86413.1 |
PIRi | B36555, GQRTT1 |
RefSeqi | NP_037223.1, NM_013091.1 |
3D structure databases
SMRi | P22934 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247654, 2 interactors |
IntActi | P22934, 1 interactor |
STRINGi | 10116.ENSRNOP00000042371 |
PTM databases
GlyGeni | P22934, 3 sites |
PhosphoSitePlusi | P22934 |
Proteomic databases
PaxDbi | P22934 |
PRIDEi | P22934 |
Genome annotation databases
GeneIDi | 25625 |
KEGGi | rno:25625 |
UCSCi | RGD:621237, rat |
Organism-specific databases
CTDi | 7132 |
RGDi | 621237, Tnfrsf1a |
Phylogenomic databases
eggNOGi | ENOG502S050, Eukaryota |
InParanoidi | P22934 |
OrthoDBi | 726174at2759 |
PhylomeDBi | P22934 |
TreeFami | TF333916 |
Enzyme and pathway databases
Reactomei | R-RNO-5357786, TNFR1-induced proapoptotic signaling R-RNO-5357905, Regulation of TNFR1 signaling R-RNO-5357956, TNFR1-induced NFkappaB signaling pathway R-RNO-5626978, TNFR1-mediated ceramide production R-RNO-5669034, TNFs bind their physiological receptors R-RNO-75893, TNF signaling |
Miscellaneous databases
PROi | PR:P22934 |
Family and domain databases
CDDi | cd08313, Death_TNFR1, 1 hit cd10576, TNFRSF1A, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR001368, TNFR/NGFR_Cys_rich_reg IPR020419, TNFR_1A IPR033994, TNFRSF1A_death IPR033993, TNFRSF1A_N |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 3 hits |
PRINTSi | PR01918, TNFACTORR1A |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 4 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 3 hits PS50050, TNFR_NGFR_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR1A_RAT | |
Accessioni | P22934Primary (citable) accession number: P22934 Secondary accession number(s): Q5U1X6, Q91V30, Q91Y93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | March 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |