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Protein

Tumor necrosis factor receptor superfamily member 1A

Gene

Tnfrsf1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: RGD
  • protein-containing complex binding Source: RGD
  • tumor necrosis factor-activated receptor activity Source: RGD
  • tumor necrosis factor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1A
Alternative name(s):
Tumor necrosis factor receptor 1
Short name:
TNF-R1
Tumor necrosis factor receptor type I
Short name:
TNF-RI
Short name:
TNFR-I
p55
p60
CD_antigen: CD120a
Gene namesi
Name:Tnfrsf1a
Synonyms:Tnfr-1, Tnfr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621237 Tnfrsf1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 211ExtracellularSequence analysisAdd BLAST182
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Topological domaini235 – 461CytoplasmicSequence analysisAdd BLAST227

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000003454730 – 461Tumor necrosis factor receptor superfamily member 1AAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi105 ↔ 125PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 158PROSITE-ProRule annotation
Disulfide bondi149 ↔ 166PROSITE-ProRule annotation
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 179PROSITE-ProRule annotation
Disulfide bondi182 ↔ 195PROSITE-ProRule annotation
Disulfide bondi185 ↔ 191PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22934
PRIDEiP22934

PTM databases

PhosphoSitePlusiP22934

Interactioni

Subunit structurei

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway. Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP22934, 1 interactor
STRINGi10116.ENSRNOP00000042371

Structurei

3D structure databases

ProteinModelPortaliP22934
SMRiP22934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 82TNFR-Cys 1Add BLAST40
Repeati83 – 125TNFR-Cys 2Add BLAST43
Repeati126 – 166TNFR-Cys 3Add BLAST41
Repeati167 – 196TNFR-Cys 4Add BLAST30
Domaini363 – 448DeathPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 354N-SMase activation domain (NSD)Add BLAST11

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
HOGENOMiHOG000133001
HOVERGENiHBG058842
InParanoidiP22934
KOiK03158
PhylomeDBiP22934
TreeFamiTF333916

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 3 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 3 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P22934-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPIVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DNLCPQGKYA
60 70 80 90 100
HPKNNSICCT KCHKGTYLVS DCPSPGQETV CEVCDKGTFT ASQNHVRQCL
110 120 130 140 150
SCKTCRKEMF QVEISPCKAD MDTVCGCKKN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE KQNTVCNCHA GFFLSGNECT PCSHCKKNQE CMKLCLPPVA
210 220 230 240 250
NVTNPQDSGT AVLLPLVIFL GLCLLFFICI SLLCRYPQWR PRVYSIICRD
260 270 280 290 300
SAPVKEVEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST
310 320 330 340 350
PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV
360 370 380 390 400
VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG
410 420 430 440 450
RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES
460
PAHSSTTHLP R
Length:461
Mass (Da):50,969
Last modified:March 1, 1992 - v2
Checksum:iEB23C05450FBD202
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JSU9A0A0G2JSU9_RAT
Tumor necrosis factor receptor supe...
Tnfrsf1a rCG_29818
461Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti230I → V in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd. 2 Publications1
Natural varianti295H → P in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63122 mRNA Translation: AAA42256.1
AF329976 mRNA Translation: AAK53562.1
AF329977 mRNA Translation: AAK53563.1
AF329978 mRNA Translation: AAK53564.1
AF329979 mRNA Translation: AAK53565.1
AF329980 mRNA Translation: AAK53566.1
AF329981 mRNA Translation: AAK53567.1
BC086413 mRNA Translation: AAH86413.1
PIRiB36555 GQRTT1
RefSeqiNP_037223.1, NM_013091.1
UniGeneiRn.11119

Genome annotation databases

GeneIDi25625
KEGGirno:25625
UCSCiRGD:621237 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63122 mRNA Translation: AAA42256.1
AF329976 mRNA Translation: AAK53562.1
AF329977 mRNA Translation: AAK53563.1
AF329978 mRNA Translation: AAK53564.1
AF329979 mRNA Translation: AAK53565.1
AF329980 mRNA Translation: AAK53566.1
AF329981 mRNA Translation: AAK53567.1
BC086413 mRNA Translation: AAH86413.1
PIRiB36555 GQRTT1
RefSeqiNP_037223.1, NM_013091.1
UniGeneiRn.11119

3D structure databases

ProteinModelPortaliP22934
SMRiP22934
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP22934, 1 interactor
STRINGi10116.ENSRNOP00000042371

PTM databases

PhosphoSitePlusiP22934

Proteomic databases

PaxDbiP22934
PRIDEiP22934

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25625
KEGGirno:25625
UCSCiRGD:621237 rat

Organism-specific databases

CTDi7132
RGDi621237 Tnfrsf1a

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
HOGENOMiHOG000133001
HOVERGENiHBG058842
InParanoidiP22934
KOiK03158
PhylomeDBiP22934
TreeFamiTF333916

Miscellaneous databases

PROiPR:P22934

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 3 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 3 hits
PS50050 TNFR_NGFR_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNR1A_RAT
AccessioniPrimary (citable) accession number: P22934
Secondary accession number(s): Q5U1X6, Q91V30, Q91Y93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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