Tnfrsf1a

Functionⁱ

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).By similarity

GO - Molecular functionⁱ

protease binding
Source: RGD
Inferred from physical interactionⁱ
- 20649583
protein-containing complex binding
Source: RGD
Inferred from physical interactionⁱ
- 15590916
tumor necrosis factor-activated receptor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 20649583
tumor necrosis factor binding
Source: RGD
Inferred from physical interactionⁱ
- 20649583

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell surface receptor signaling pathway Source: UniProtKB
cellular response to estradiol stimulus
Source: RGD
Inferred from expression patternⁱ
- 21252492
cytokine-mediated signaling pathway Source: UniProtKB
defense response Source: UniProtKB
inflammatory response
Source: RGD
Inferred from expression patternⁱ
- 14552870
negative regulation of apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 23028454
negative regulation of gene expression
Source: RGD
Inferred from direct assayⁱ
- 20501675
negative regulation of interleukin-6 production
Source: RGD
Inferred from direct assayⁱ
- 20501675
positive regulation of angiogenesis
Source: RGD
Inferred from mutant phenotypeⁱ
- 14970118
positive regulation of gene expression
Source: RGD
Inferred from mutant phenotypeⁱ
- 20700128
positive regulation of inflammatory response Source: UniProtKB
positive regulation of neuron apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 22522145
positive regulation of protein import into nucleus, translocation
Source: RGD
Inferred from mutant phenotypeⁱ
- 20967881
positive regulation of transcription by RNA polymerase II Source: UniProtKB
positive regulation of tumor necrosis factor production
Source: RGD
Inferred from mutant phenotypeⁱ
- 20967881
prostaglandin metabolic process Source: InterPro
protein heterooligomerization
Source: RGD
Inferred from physical interactionⁱ
- 12786973
regulation of apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 20967881
response to alkaloid
Source: RGD
Inferred from expression patternⁱ
- 20717874
response to amino acid
Source: RGD
Inferred from expression patternⁱ
- 20828607
response to ethanol
Source: RGD
Inferred from expression patternⁱ
- 15353169
response to hypoxia
Source: RGD
Inferred from expression patternⁱ
- 21404274
response to lipopolysaccharide
Source: RGD
Inferred from expression patternⁱ
- 15509749
response to wounding
Source: RGD
Inferred from expression patternⁱ
- 14552870
tumor necrosis factor-mediated signaling pathway
Source: RGD
Inferred from mutant phenotypeⁱ
- 20967881

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 1A Alternative name(s): Tumor necrosis factor receptor 1 Short name: TNF-R1 Tumor necrosis factor receptor type I Short name: TNF-RI Short name: TNFR-I p55 p60 CD_antigen: CD120a
Gene namesⁱ	Name:Tnfrsf1a Synonyms:Tnfr-1, Tnfr1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	621237 Tnfrsf1a

RGDⁱ

621237 Tnfrsf1a

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	30 – 211	ExtracellularSequence analysisAdd BLAST	182
Transmembraneⁱ	212 – 234	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	235 – 461	CytoplasmicSequence analysisAdd BLAST	227

Keywords - Cellular componentⁱ

Cell membrane, Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	By similarityAdd BLAST		29
ChainⁱPRO_0000034547	30 – 461	Tumor necrosis factor receptor superfamily member 1AAdd BLAST		432

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	44 ↔ 58	PROSITE-ProRule annotation
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	59 ↔ 72	PROSITE-ProRule annotation
Disulfide bondⁱ	62 ↔ 81	PROSITE-ProRule annotation
Disulfide bondⁱ	84 ↔ 99	PROSITE-ProRule annotation
Disulfide bondⁱ	102 ↔ 117	PROSITE-ProRule annotation
Disulfide bondⁱ	105 ↔ 125	PROSITE-ProRule annotation
Disulfide bondⁱ	127 ↔ 143	PROSITE-ProRule annotation
Disulfide bondⁱ	146 ↔ 158	PROSITE-ProRule annotation
Disulfide bondⁱ	149 ↔ 166	PROSITE-ProRule annotation
Glycosylationⁱ	151	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	168 ↔ 179	PROSITE-ProRule annotation
Disulfide bondⁱ	182 ↔ 195	PROSITE-ProRule annotation
Disulfide bondⁱ	185 ↔ 191	PROSITE-ProRule annotation
Glycosylationⁱ	201	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P22934
PRIDEⁱ	P22934

PTM databases

PhosphoSitePlusⁱ	P22934

PhosphoSitePlusⁱ

P22934

Interactionⁱ

Subunit structureⁱ

Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with DAB2IP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway. Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process.By similarity

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P22934, 1 interactor
STRINGⁱ	10116.ENSRNOP00000042371

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P22934
SMRⁱ	P22934
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	43 – 82	TNFR-Cys 1Add BLAST	40
Repeatⁱ	83 – 125	TNFR-Cys 2Add BLAST	43
Repeatⁱ	126 – 166	TNFR-Cys 3Add BLAST	41
Repeatⁱ	167 – 196	TNFR-Cys 4Add BLAST	30
Domainⁱ	363 – 448	DeathPROSITE-ProRule annotationAdd BLAST	86

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	344 – 354	N-SMase activation domain (NSD)Add BLAST		11

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXBX Eukaryota ENOG4111YG2 LUCA
HOGENOMⁱ	HOG000133001
HOVERGENⁱ	HBG058842
InParanoidⁱ	P22934
KEGG Orthology (KO) More...KOⁱ	K03158
PhylomeDBⁱ	P22934
TreeFamⁱ	TF333916

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08313 Death_TNFR1, 1 hit cd10576 TNFRSF1A, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001368 TNFR/NGFR_Cys_rich_reg IPR020419 TNFR_1A IPR033994 TNFRSF1A_death IPR033993 TNFRSF1A_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 3 hits
PRINTSⁱ	PR01918 TNFACTORR1A
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 4 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 3 hits PS50050 TNFR_NGFR_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P22934-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLPIVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DNLCPQGKYA 
        60         70         80         90        100
HPKNNSICCT KCHKGTYLVS DCPSPGQETV CEVCDKGTFT ASQNHVRQCL 
       110        120        130        140        150
SCKTCRKEMF QVEISPCKAD MDTVCGCKKN QFQRYLSETH FQCVDCSPCF 
       160        170        180        190        200
NGTVTIPCKE KQNTVCNCHA GFFLSGNECT PCSHCKKNQE CMKLCLPPVA 
       210        220        230        240        250
NVTNPQDSGT AVLLPLVIFL GLCLLFFICI SLLCRYPQWR PRVYSIICRD 
       260        270        280        290        300
SAPVKEVEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST 
       310        320        330        340        350
PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV 
       360        370        380        390        400
VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG 
       410        420        430        440        450
RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES 
       460 
PAHSSTTHLP R

Length:461

Mass (Da):50,969

Last modified:March 1, 1992 - v2

Checksum:ⁱEB23C05450FBD202

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JSU9	A0A0G2JSU9_RAT		Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor superfamily, member 1a)	Tnfrsf1a rCG_29818	461	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	230	I → V in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl and F344/NHsd. 2 Publications		1
Natural variantⁱ	295	H → P in strain: LEW/NHsd, ACI/SegHsd, DA/Bkl, F344/NHsd and BN/SsNHsd. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63122 mRNA Translation: AAA42256.1 AF329976 mRNA Translation: AAK53562.1 AF329977 mRNA Translation: AAK53563.1 AF329978 mRNA Translation: AAK53564.1 AF329979 mRNA Translation: AAK53565.1 AF329980 mRNA Translation: AAK53566.1 AF329981 mRNA Translation: AAK53567.1 BC086413 mRNA Translation: AAH86413.1
PIRⁱ	B36555 GQRTT1
NCBI Reference Sequences More...RefSeqⁱ	NP_037223.1, NM_013091.1
UniGeneⁱ	Rn.11119

Genome annotation databases

GeneIDⁱ	25625
KEGGⁱ	rno:25625
UCSC genome browser More...UCSCⁱ	RGD:621237 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P22934	Tumor necrosis factor receptor superfamily member 1A		RAT		461	UniRef90_P22934

Protein	Similar proteins		Species	Score	Length	Source
P22934	Tumor necrosis factor receptor superfamily member 1A	)	HUMAN		455	UniRef50_P19438
Tumor necrosis factor receptor superfamily member 1A		MOUSE		454
Uncharacterized protein		PAPAN		459
Uncharacterized protein		COLAP		455
Uncharacterized protein		CERAT		455
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63122 mRNA Translation: AAA42256.1 AF329976 mRNA Translation: AAK53562.1 AF329977 mRNA Translation: AAK53563.1 AF329978 mRNA Translation: AAK53564.1 AF329979 mRNA Translation: AAK53565.1 AF329980 mRNA Translation: AAK53566.1 AF329981 mRNA Translation: AAK53567.1 BC086413 mRNA Translation: AAH86413.1
PIRⁱ	B36555 GQRTT1
RefSeqⁱ	NP_037223.1, NM_013091.1
UniGeneⁱ	Rn.11119

3D structure databases

ProteinModelPortalⁱ	P22934
SMRⁱ	P22934
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P22934, 1 interactor
STRINGⁱ	10116.ENSRNOP00000042371

PTM databases

PhosphoSitePlusⁱ	P22934

PhosphoSitePlusⁱ

P22934

Proteomic databases

PaxDbⁱ	P22934
PRIDEⁱ	P22934

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	25625
KEGGⁱ	rno:25625
UCSCⁱ	RGD:621237 rat

Organism-specific databases

CTDⁱ	7132
RGDⁱ	621237 Tnfrsf1a

Phylogenomic databases

eggNOGⁱ	ENOG410IXBX Eukaryota ENOG4111YG2 LUCA
HOGENOMⁱ	HOG000133001
HOVERGENⁱ	HBG058842
InParanoidⁱ	P22934
KOⁱ	K03158
PhylomeDBⁱ	P22934
TreeFamⁱ	TF333916

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P22934

PROⁱ

PR:P22934

Family and domain databases

CDDⁱ	cd08313 Death_TNFR1, 1 hit cd10576 TNFRSF1A, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001368 TNFR/NGFR_Cys_rich_reg IPR020419 TNFR_1A IPR033994 TNFRSF1A_death IPR033993 TNFRSF1A_N
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 3 hits
PRINTSⁱ	PR01918 TNFACTORR1A
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 4 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 3 hits PS50050 TNFR_NGFR_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR1A_RAT
Accessionⁱ	P22934Primary (citable) accession number: P22934 Secondary accession number(s): Q5U1X6, Q91V30, Q91Y93
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P22934 (TNR1A_RAT)

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Tumor necrosis factor receptor superfamily member 1A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Cytosol

Extracellular region or secreted

Golgi apparatus

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ