Tumor necrosis factor receptor superfamily member 1A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protease binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway."
    Roy D.N., Mandal S., Sen G., Mukhopadhyay S., Biswas T.
    Br J Pharmacol 160:1823-1843(2010) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death."
    Shinoda S., Skradski S.L., Araki T., Schindler C.K., Meller R., Lan J.Q., Taki W., Simon R.P., Henshall D.C.
    Eur J Neurosci 17:2065-2076(2003) [PubMed] [Europe PMC] [Abstract]
  • "Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain."
    Lotocki G., Alonso O.F., Dietrich W.D., Keane R.W.
    J Neurosci 24:11010-11016(2004) [PubMed] [Europe PMC] [Abstract]
• tumor necrosis factor-activated receptor activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway."
    Roy D.N., Mandal S., Sen G., Mukhopadhyay S., Biswas T.
    Br J Pharmacol 160:1823-1843(2010) [PubMed] [Europe PMC] [Abstract]
• tumor necrosis factor binding Source: RGDInferred from physical interactionⁱ
  • "14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway."
    Roy D.N., Mandal S., Sen G., Mukhopadhyay S., Biswas T.
    Br J Pharmacol 160:1823-1843(2010) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aortic valve development Source: RGD
• cell surface receptor signaling pathway Source: UniProtKB
• cellular response to estradiol stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Estradiol increases the expression of TNF-alpha and TNF receptor 1 in lactotropes."
    Zaldivar V., Magri M.L., Zarate S., Jaita G., Eijo G., Radl D., Ferraris J., Pisera D., Seilicovich A.
    Neuroendocrinology 93:106-113(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to mechanical stimulus Source: RGD
• cytokine-mediated signaling pathway Source: UniProtKB
• defense response Source: UniProtKB
• defense response to bacterium Source: RGD
• inflammatory response Source: RGDInferred from expression patternⁱ
  • "Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats."
    Yan P., Liu N., Kim G.M., Xu J., Xu J., Li Q., Hsu C.Y., Xu X.M.
    Exp Neurol 183:286-297(2003) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage Source: RGD
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves."
    Wang Y., Tang X., Yu B., Gu Y., Yuan Y., Yao D., Ding F., Gu X.
    PLoS One 7:e43436-e43436(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cardiac muscle hypertrophy Source: RGD
• negative regulation of extracellular matrix constituent secretion Source: RGD
• negative regulation of gene expression Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration."
    Sanchez E., Singru P.S., Wittmann G., Nouriel S.S., Barrett P., Fekete C., Lechan R.M.
    Endocrinology 151:3827-3835(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: RGD
• negative regulation of interleukin-6 production Source: RGDInferred from direct assayⁱ
  • "Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration."
    Sanchez E., Singru P.S., Wittmann G., Nouriel S.S., Barrett P., Fekete C., Lechan R.M.
    Endocrinology 151:3827-3835(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "Intramuscular gene transfer of soluble tumor necrosis factor-alpha receptor 1 activates vascular endothelial growth factor receptor and accelerates angiogenesis in a rat model of hindlimb ischemia."
    Sugano M., Tsuchida K., Makino N.
    Circulation 109:797-802(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process involved in morphogenesis Source: RGD
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Tumor necrosis factor alpha primes cerebral endothelial cells for erythropoietin-induced angiogenesis."
    Wang L., Chopp M., Teng H., Bolz M., Francisco M.A., Francisco M.A., Aluigi D.M., Wang X.L., Zhang R.L., Chrsitensen S., Sager T.N., Szalad A., Zhang Z.G.
    J Cereb Blood Flow Metab 31:640-647(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
• positive regulation of inflammatory response Source: UniProtKB
• positive regulation of neuron apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose."
    Costa G.N., Vindeirinho J., Cavadas C., Ambrosio A.F., Santos P.F.
    Mol Cell Neurosci 50:113-123(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein import into nucleus Source: RGDInferred from mutant phenotypeⁱ
  • "Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways."
    Fernandes A., Barateiro A., Falcao A.S., Silva S.L., Vaz A.R., Brito M.A., Silva R.F., Brites D.
    Glia 59:14-25(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• positive regulation of tumor necrosis factor production Source: RGDInferred from mutant phenotypeⁱ
  • "Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways."
    Fernandes A., Barateiro A., Falcao A.S., Silva S.L., Vaz A.R., Brito M.A., Silva R.F., Brites D.
    Glia 59:14-25(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
• prostaglandin metabolic process Source: InterPro
• protein localization to plasma membrane Source: RGD
• pulmonary valve development Source: RGD
• regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways."
    Fernandes A., Barateiro A., Falcao A.S., Silva S.L., Vaz A.R., Brito M.A., Silva R.F., Brites D.
    Glia 59:14-25(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of establishment of endothelial barrier Source: RGD
• response to alkaloid Source: RGDInferred from expression patternⁱ
  • "Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats."
    Li Y., Li F., Gong Q., Wu Q., Shi J.
    Planta Med 77:117-121(2011) [PubMed] [Europe PMC] [Abstract]
• response to amino acid Source: RGDInferred from expression patternⁱ
  • "S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-kappaB pathway in rats."
    Gong Q.H., Wang Q., Pan L.L., Liu X.H., Xin H., Zhu Y.Z.
    Brain Behav Immun 25:110-119(2011) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: RGDInferred from expression patternⁱ
  • "Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells."
    Rodriguez D.A., Moncada C., Nunez M.T., Lavandero S., Ponnappa B.C., Israel Y.
    Alcohol 33:9-15(2004) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from expression patternⁱ
  • "Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina."
    Sivakumar V., Foulds W.S., Luu C.D., Ling E.A., Kaur C.
    J Pathol 224:245-260(2011) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion."
    Li Y., Ji A., Weihe E., Schafer M.K.
    J Neurosci 24:9623-9631(2004) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: RGDInferred from expression patternⁱ
  • "Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats."
    Yan P., Liu N., Kim G.M., Xu J., Xu J., Li Q., Hsu C.Y., Xu X.M.
    Exp Neurol 183:286-297(2003) [PubMed] [Europe PMC] [Abstract]
• tumor necrosis factor-mediated signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways."
    Fernandes A., Barateiro A., Falcao A.S., Silva S.L., Vaz A.R., Brito M.A., Silva R.F., Brites D.
    Glia 59:14-25(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protease binding Source: RGDInferred from physical interactionⁱ
  • "14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway."
    Roy D.N., Mandal S., Sen G., Mukhopadhyay S., Biswas T.
    Br J Pharmacol 160:1823-1843(2010) [PubMed] [Europe PMC] [Abstract]
• tumor necrosis factor binding Source: RGDInferred from physical interactionⁱ
  • "14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway."
    Roy D.N., Mandal S., Sen G., Mukhopadhyay S., Biswas T.
    Br J Pharmacol 160:1823-1843(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGLPIVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DNLCPQGKYA 
        60         70         80         90        100
HPKNNSICCT KCHKGTYLVS DCPSPGQETV CEVCDKGTFT ASQNHVRQCL 
       110        120        130        140        150
SCKTCRKEMF QVEISPCKAD MDTVCGCKKN QFQRYLSETH FQCVDCSPCF 
       160        170        180        190        200
NGTVTIPCKE KQNTVCNCHA GFFLSGNECT PCSHCKKNQE CMKLCLPPVA 
       210        220        230        240        250
NVTNPQDSGT AVLLPLVIFL GLCLLFFICI SLLCRYPQWR PRVYSIICRD 
       260        270        280        290        300
SAPVKEVEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST 
       310        320        330        340        350
PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV 
       360        370        380        390        400
VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG 
       410        420        430        440        450
RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES 
       460 
PAHSSTTHLP R                                           

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ