The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P22933 (GBRD_MOUSE)
Protein
Gamma-aminobutyric acid receptor subunit delta
Gene
Gabrd
Organism
Mus musculus (Mouse)
Status
Functioni
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- GABA-A receptor activity Source: MGI
- neurotransmitter receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGO
GO - Biological processi
- chemical synaptic transmission Source: MGI
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit deltaAlternative name(s): GABA(A) receptor subunit delta |
Gene namesi | Name:Gabrd |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95622, Gabrd |
VEuPathDBi | HostDB:ENSMUSG00000029054 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: SynGO
Other locations
- axon Source: CACAO
- chloride channel complex Source: UniProtKB-KW
- dendrite Source: CACAO
- GABA-A receptor complex Source: GO_Central
- GABA-ergic synapse Source: SynGO
- glutamatergic synapse Source: MGI
- neuron projection Source: GO_Central
- neuronal cell body Source: CACAO
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 248 | ExtracellularCuratedAdd BLAST | 232 | |
Transmembranei | 249 – 271 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 275 – 297 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 309 – 331 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 332 – 426 | CytoplasmicCuratedAdd BLAST | 95 | |
Transmembranei | 427 – 449 | HelicalCuratedAdd BLAST | 23 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Add BLAST | 16 | |
ChainiPRO_0000000469 | 17 – 449 | Gamma-aminobutyric acid receptor subunit deltaAdd BLAST | 433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 164 ↔ 178 | By similarity | ||
Modified residuei | 390 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P22933 |
PeptideAtlasi | P22933 |
PRIDEi | P22933 |
ProteomicsDBi | 266781 |
PTM databases
GlyGeni | P22933, 2 sites |
iPTMneti | P22933 |
PhosphoSitePlusi | P22933 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029054, Expressed in cerebellum and 115 other tissues |
ExpressionAtlasi | P22933, baseline and differential |
Genevisiblei | P22933, MM |
Interactioni
Subunit structurei
Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.
Protein-protein interaction databases
ComplexPortali | CPX-2986, GABA-A receptor, alpha-6/beta-3/delta CPX-2987, GABA-A receptor, alpha-6/beta-2/delta CPX-2988, GABA-A receptor, alpha-4/beta-2/delta CPX-2989, GABA-A receptor, alpha-4/beta-3/delta |
STRINGi | 10090.ENSMUSP00000030925 |
Miscellaneous databases
RNActi | P22933, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000160122 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | P22933 |
OMAi | YRCVEME |
OrthoDBi | 480926at2759 |
PhylomeDBi | P22933 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008098, GABAAd_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF34, PTHR18945:SF34, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01722, GABAARDELTA PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P22933-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG
60 70 80 90 100
YARNFRPGIG GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL
110 120 130 140 150
SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG
160 170 180 190 200
VILYSIRITS TVACDMDLAK YPLDEQECML DLESYGYSSE DIVYYWSENQ
210 220 230 240 250
EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY
260 270 280 290 300
IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
310 320 330 340 350
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP
360 370 380 390 400
RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK
410 420 430 440
EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 255 | Y → H in AAB22967 (PubMed:1324097).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH001900 Genomic DNA Translation: AAA37652.1 S42882 mRNA Translation: AAB22967.1 |
CCDSi | CCDS19028.1 |
PIRi | A36303 I52630 |
RefSeqi | NP_032098.2, NM_008072.2 |
Genome annotation databases
Ensembli | ENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054 |
GeneIDi | 14403 |
KEGGi | mmu:14403 |
UCSCi | uc008wdf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH001900 Genomic DNA Translation: AAA37652.1 S42882 mRNA Translation: AAB22967.1 |
CCDSi | CCDS19028.1 |
PIRi | A36303 I52630 |
RefSeqi | NP_032098.2, NM_008072.2 |
3D structure databases
AlphaFoldDBi | P22933 |
SMRi | P22933 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-2986, GABA-A receptor, alpha-6/beta-3/delta CPX-2987, GABA-A receptor, alpha-6/beta-2/delta CPX-2988, GABA-A receptor, alpha-4/beta-2/delta CPX-2989, GABA-A receptor, alpha-4/beta-3/delta |
STRINGi | 10090.ENSMUSP00000030925 |
Chemistry databases
ChEMBLi | CHEMBL2094133 |
DrugCentrali | P22933 |
PTM databases
GlyGeni | P22933, 2 sites |
iPTMneti | P22933 |
PhosphoSitePlusi | P22933 |
Proteomic databases
PaxDbi | P22933 |
PeptideAtlasi | P22933 |
PRIDEi | P22933 |
ProteomicsDBi | 266781 |
Protocols and materials databases
ABCDi | P22933, 1 sequenced antibody |
Antibodypediai | 12525, 251 antibodies from 32 providers |
DNASUi | 14403 |
Genome annotation databases
Ensembli | ENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054 |
GeneIDi | 14403 |
KEGGi | mmu:14403 |
UCSCi | uc008wdf.2, mouse |
Organism-specific databases
CTDi | 2563 |
MGIi | MGI:95622, Gabrd |
VEuPathDBi | HostDB:ENSMUSG00000029054 |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000160122 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | P22933 |
OMAi | YRCVEME |
OrthoDBi | 480926at2759 |
PhylomeDBi | P22933 |
TreeFami | TF315453 |
Miscellaneous databases
BioGRID-ORCSi | 14403, 1 hit in 74 CRISPR screens |
ChiTaRSi | Gabrd, mouse |
PROi | PR:P22933 |
RNActi | P22933, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029054, Expressed in cerebellum and 115 other tissues |
ExpressionAtlasi | P22933, baseline and differential |
Genevisiblei | P22933, MM |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008098, GABAAd_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF34, PTHR18945:SF34, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01722, GABAARDELTA PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRD_MOUSE | |
Accessioni | P22933Primary (citable) accession number: P22933 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1991 |
Last sequence update: | August 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families