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Protein

Macrophage mannose receptor 1

Gene

MRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.1 Publication
(Microbial infection) Interacts with Hepatitis B virus envelope protein.1 Publication

Miscellaneous

CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.

GO - Molecular functioni

  • cargo receptor activity Source: UniProtKB
  • mannose binding Source: ProtInc
  • transmembrane signaling receptor activity Source: GO_Central
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processEndocytosis, Host-virus interaction
LigandCalcium, Lectin

Enzyme and pathway databases

ReactomeiR-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
SIGNORiP22897

Protein family/group databases

UniLectiniP22897

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage mannose receptor 1
Short name:
MMR
Alternative name(s):
C-type lectin domain family 13 member D
C-type lectin domain family 13 member D-like
Human mannose receptor
Short name:
hMR
Macrophage mannose receptor 1-like protein 1
CD_antigen: CD206
Gene namesi
Name:MRC1
Synonyms:CLEC13D, CLEC13DL, MRC1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000260314.2
HGNCiHGNC:7228 MRC1
MIMi153618 gene
neXtProtiNX_P22897

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1389ExtracellularSequence analysisAdd BLAST1371
Transmembranei1390 – 1410HelicalSequence analysisAdd BLAST21
Topological domaini1411 – 1456CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4360
OpenTargetsiENSG00000260314
PharmGKBiPA134941260
PA30933

Chemistry databases

ChEMBLiCHEMBL2176854

Polymorphism and mutation databases

DMDMi126730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001754819 – 1456Macrophage mannose receptor 1Add BLAST1438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi74 ↔ 91By similarity
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 194By similarity
Disulfide bondi182 ↔ 209By similarity
Disulfide bondi247 ↔ 340By similarity
Disulfide bondi316 ↔ 332By similarity
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi391 ↔ 486By similarity
Disulfide bondi463 ↔ 478By similarity
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi532 ↔ 625By similarity
Disulfide bondi600 ↔ 617By similarity
Disulfide bondi646 ↔ 659
Disulfide bondi680 ↔ 777
Disulfide bondi753 ↔ 769
Disulfide bondi828 ↔ 922By similarity
Disulfide bondi899 ↔ 914By similarity
Glycosylationi926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi930N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi977 ↔ 1079By similarity
Disulfide bondi1052 ↔ 1071By similarity
Disulfide bondi1123 ↔ 1212By similarity
Glycosylationi1160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1190 ↔ 1204By similarity
Glycosylationi1205N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1263 ↔ 1355By similarity
Disulfide bondi1332 ↔ 1347By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22897
PeptideAtlasiP22897
PRIDEiP22897
ProteomicsDBi54048
54049 [P22897-2]

PTM databases

iPTMnetiP22897
PhosphoSitePlusiP22897

Expressioni

Gene expression databases

BgeeiENSG00000260314 Expressed in 208 organ(s), highest expression level in upper lobe of lung
CleanExiHS_MRC1
GenevisibleiP22897 HS

Organism-specific databases

HPAiCAB068203
HPA004114
HPA045134

Interactioni

Subunit structurei

(Microbial infection) Interacts with Dengue virus.1 Publication
(Microbial infection) May act as a receptor for hepatitis B virus, enabling uptake of the virus in hepatic dendritic cells.1 Publication

Protein-protein interaction databases

BioGridi110500, 1 interactor
DIPiDIP-101N
IntActiP22897, 2 interactors
STRINGi9606.ENSP00000239761

Chemistry databases

BindingDBiP22897

Structurei

Secondary structure

11456
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP22897
SMRiP22897
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22897

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 142Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST121
Domaini163 – 211Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini225 – 341C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini369 – 487C-type lectin 2PROSITE-ProRule annotationAdd BLAST119
Domaini511 – 626C-type lectin 3PROSITE-ProRule annotationAdd BLAST116
Domaini655 – 778C-type lectin 4PROSITE-ProRule annotationAdd BLAST124
Domaini807 – 923C-type lectin 5PROSITE-ProRule annotationAdd BLAST117
Domaini952 – 1080C-type lectin 6PROSITE-ProRule annotationAdd BLAST129
Domaini1102 – 1213C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1241 – 1356C-type lectin 8PROSITE-ProRule annotationAdd BLAST116

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS47 Eukaryota
ENOG410XRS3 LUCA
GeneTreeiENSGT00720000108514
HOGENOMiHOG000113647
HOVERGENiHBG107130
InParanoidiP22897
KOiK06560
OMAiVTLYACD
OrthoDBiEOG091G0EGC
PhylomeDBiP22897
TreeFamiTF316663

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
PF00652 Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 6 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P22897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLPLLLVFA SVIPGAVLLL DTRQFLIYNE DHKRCVDAVS PSAVQTAACN
60 70 80 90 100
QDAESQKFRW VSESQIMSVA FKLCLGVPSK TDWVAITLYA CDSKSEFQKW
110 120 130 140 150
ECKNDTLLGI KGEDLFFNYG NRQEKNIMLY KGSGLWSRWK IYGTTDNLCS
160 170 180 190 200
RGYEAMYTLL GNANGATCAF PFKFENKWYA DCTSAGRSDG WLWCGTTTDY
210 220 230 240 250
DTDKLFGYCP LKFEGSESLW NKDPLTSVSY QINSKSALTW HQARKSCQQQ
260 270 280 290 300
NAELLSITEI HEQTYLTGLT SSLTSGLWIG LNSLSFNSGW QWSDRSPFRY
310 320 330 340 350
LNWLPGSPSA EPGKSCVSLN PGKNAKWENL ECVQKLGYIC KKGNTTLNSF
360 370 380 390 400
VIPSESDVPT HCPSQWWPYA GHCYKIHRDE KKIQRDALTT CRKEGGDLTS
410 420 430 440 450
IHTIEELDFI ISQLGYEPND ELWIGLNDIK IQMYFEWSDG TPVTFTKWLR
460 470 480 490 500
GEPSHENNRQ EDCVVMKGKD GYWADRGCEW PLGYICKMKS RSQGPEIVEV
510 520 530 540 550
EKGCRKGWKK HHFYCYMIGH TLSTFAEANQ TCNNENAYLT TIEDRYEQAF
560 570 580 590 600
LTSFVGLRPE KYFWTGLSDI QTKGTFQWTI EEEVRFTHWN SDMPGRKPGC
610 620 630 640 650
VAMRTGIAGG LWDVLKCDEK AKFVCKHWAE GVTHPPKPTT TPEPKCPEDW
660 670 680 690 700
GASSRTSLCF KLYAKGKHEK KTWFESRDFC RALGGDLASI NNKEEQQTIW
710 720 730 740 750
RLITASGSYH KLFWLGLTYG SPSEGFTWSD GSPVSYENWA YGEPNNYQNV
760 770 780 790 800
EYCGELKGDP TMSWNDINCE HLNNWICQIQ KGQTPKPEPT PAPQDNPPVT
810 820 830 840 850
EDGWVIYKDY QYYFSKEKET MDNARAFCKR NFGDLVSIQS ESEKKFLWKY
860 870 880 890 900
VNRNDAQSAY FIGLLISLDK KFAWMDGSKV DYVSWATGEP NFANEDENCV
910 920 930 940 950
TMYSNSGFWN DINCGYPNAF ICQRHNSSIN ATTVMPTMPS VPSGCKEGWN
960 970 980 990 1000
FYSNKCFKIF GFMEEERKNW QEARKACIGF GGNLVSIQNE KEQAFLTYHM
1010 1020 1030 1040 1050
KDSTFSAWTG LNDVNSEHTF LWTDGRGVHY TNWGKGYPGG RRSSLSYEDA
1060 1070 1080 1090 1100
DCVVIIGGAS NEAGKWMDDT CDSKRGYICQ TRSDPSLTNP PATIQTDGFV
1110 1120 1130 1140 1150
KYGKSSYSLM RQKFQWHEAE TYCKLHNSLI ASILDPYSNA FAWLQMETSN
1160 1170 1180 1190 1200
ERVWIALNSN LTDNQYTWTD KWRVRYTNWA ADEPKLKSAC VYLDLDGYWK
1210 1220 1230 1240 1250
TAHCNESFYF LCKRSDEIPA TEPPQLPGRC PESDHTAWIP FHGHCYYIES
1260 1270 1280 1290 1300
SYTRNWGQAS LECLRMGSSL VSIESAAESS FLSYRVEPLK SKTNFWIGLF
1310 1320 1330 1340 1350
RNVEGTWLWI NNSPVSFVNW NTGDPSGERN DCVALHASSG FWSNIHCSSY
1360 1370 1380 1390 1400
KGYICKRPKI IDAKPTHELL TTKADTRKMD PSKPSSNVAG VVIIVILLIL
1410 1420 1430 1440 1450
TGAGLAAYFF YKKRRVHLPQ EGAFENTLYF NSQSSPGTSD MKDLVGNIEQ

NEHSVI
Length:1,456
Mass (Da):166,012
Last modified:August 1, 1991 - v1
Checksum:i264E5AF3C576A5E3
GO
Isoform 2 (identifier: P22897-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-498: DGYWADRGCEWPLGYICKMKSRSQGPEIV → AGVQWHNLGSMQPLPREFKRFSCLSLPSS
     499-1456: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):56,554
Checksum:i1305DE544A35A7F4
GO

Sequence cautioni

The sequence CAH70733 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH71176 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15339 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1334A → T in X55635 (PubMed:2258707).Curated1

Polymorphismi

Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019700167T → I1 PublicationCorresponds to variant dbSNP:rs2296414Ensembl.1
Natural variantiVAR_065250396G → S Probably protective against leprosy when associated with A-399 and F-407. 1 PublicationCorresponds to variant dbSNP:rs1926736Ensembl.1
Natural variantiVAR_065251399T → A2 PublicationsCorresponds to variant dbSNP:rs71497223Ensembl.1
Natural variantiVAR_065252407L → F2 PublicationsCorresponds to variant dbSNP:rs2437257Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041340470 – 498DGYWA…GPEIV → AGVQWHNLGSMQPLPREFKR FSCLSLPSS in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_041341499 – 1456Missing in isoform 2. 1 PublicationAdd BLAST958

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05550 mRNA Translation: AAA59868.1
X55635 mRNA No translation available.
M93221
, M93192, M93193, M93194, M93195, M93196, M93197, M93198, M93199, M93200, M93201, M93202, M93203, M93204, M93205, M93206, M93207, M93208, M93209, M93210, M93211, M93212, M93213, M93214, M93215, M93216, M93217, M93218, M93219, M93220 Genomic DNA Translation: AAA60389.1
EF444997 Genomic DNA Translation: ACA06020.1
AL928729, AC069023 Genomic DNA Translation: CAH70733.1 Sequence problems.
AL928580, AL139238, BX255924 Genomic DNA Translation: CAH71176.1 Sequence problems.
BX255924, AL139238, AL928580 Genomic DNA Translation: CAI15339.1 Sequence problems.
BC142642 mRNA Translation: AAI42643.1
CCDSiCCDS7123.2 [P22897-1]
PIRiA36563
RefSeqiNP_002429.1, NM_002438.3 [P22897-1]
UniGeneiHs.743903
Hs.75182

Genome annotation databases

EnsembliENST00000569591; ENSP00000455897; ENSG00000260314 [P22897-1]
GeneIDi4360
KEGGihsa:4360
UCSCiuc031ptj.2 human [P22897-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Macrophage mannose receptor

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05550 mRNA Translation: AAA59868.1
X55635 mRNA No translation available.
M93221
, M93192, M93193, M93194, M93195, M93196, M93197, M93198, M93199, M93200, M93201, M93202, M93203, M93204, M93205, M93206, M93207, M93208, M93209, M93210, M93211, M93212, M93213, M93214, M93215, M93216, M93217, M93218, M93219, M93220 Genomic DNA Translation: AAA60389.1
EF444997 Genomic DNA Translation: ACA06020.1
AL928729, AC069023 Genomic DNA Translation: CAH70733.1 Sequence problems.
AL928580, AL139238, BX255924 Genomic DNA Translation: CAH71176.1 Sequence problems.
BX255924, AL139238, AL928580 Genomic DNA Translation: CAI15339.1 Sequence problems.
BC142642 mRNA Translation: AAI42643.1
CCDSiCCDS7123.2 [P22897-1]
PIRiA36563
RefSeqiNP_002429.1, NM_002438.3 [P22897-1]
UniGeneiHs.743903
Hs.75182

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EGGX-ray2.30A/B644-787[»]
1EGIX-ray2.30A/B644-787[»]
5XTSX-ray2.00A22-629[»]
5XTWX-ray3.20A/B/C/D/E/F/G/H22-490[»]
ProteinModelPortaliP22897
SMRiP22897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110500, 1 interactor
DIPiDIP-101N
IntActiP22897, 2 interactors
STRINGi9606.ENSP00000239761

Chemistry databases

BindingDBiP22897
ChEMBLiCHEMBL2176854

Protein family/group databases

UniLectiniP22897

PTM databases

iPTMnetiP22897
PhosphoSitePlusiP22897

Polymorphism and mutation databases

DMDMi126730

Proteomic databases

PaxDbiP22897
PeptideAtlasiP22897
PRIDEiP22897
ProteomicsDBi54048
54049 [P22897-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569591; ENSP00000455897; ENSG00000260314 [P22897-1]
GeneIDi4360
KEGGihsa:4360
UCSCiuc031ptj.2 human [P22897-1]

Organism-specific databases

CTDi4360
DisGeNETi4360
EuPathDBiHostDB:ENSG00000260314.2
GeneCardsiMRC1
H-InvDBiHIX0035369
HGNCiHGNC:7228 MRC1
HPAiCAB068203
HPA004114
HPA045134
MIMi153618 gene
neXtProtiNX_P22897
OpenTargetsiENSG00000260314
PharmGKBiPA134941260
PA30933
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS47 Eukaryota
ENOG410XRS3 LUCA
GeneTreeiENSGT00720000108514
HOGENOMiHOG000113647
HOVERGENiHBG107130
InParanoidiP22897
KOiK06560
OMAiVTLYACD
OrthoDBiEOG091G0EGC
PhylomeDBiP22897
TreeFamiTF316663

Enzyme and pathway databases

ReactomeiR-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
SIGNORiP22897

Miscellaneous databases

ChiTaRSiMRC1 human
EvolutionaryTraceiP22897
GenomeRNAii4360
PROiPR:P22897
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000260314 Expressed in 208 organ(s), highest expression level in upper lobe of lung
CleanExiHS_MRC1
GenevisibleiP22897 HS

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
PF00652 Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 6 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRC1_HUMAN
AccessioniPrimary (citable) accession number: P22897
Secondary accession number(s): A5PKW3, Q5VSJ2, Q5VSK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 7, 2018
This is version 209 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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